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Cited by 168

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Oxytetracycline Treatment Reduces Bacterial Diversity of Intestinal Microbiota of Atlantic Salmon

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Navarrete, Paola, Mardones, Pamela, Opazo, Rafael, Espejo, Romilio, Romero, Jaime·2008·Journal of Aquatic Animal Health
DOI 10.1577/h07-043.1
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Abstract

The effect of oxytetracycline (OTC) treatment on intestinal bacterial populations in juvenile Atlantic salmon Salmo salar was evaluated. Oxytetracycline was administered by way of medicated feed to fish held in experimental tanks. Restriction fragment length polymorphism and sequencing of 16S rDNA from isolates were used to analyze the intestinal microbiota before, during, and after OTC administration. The microbiota from untreated fish was more diverse, consisting mainly of Pseudomonas, Acinetobacter, Bacillus, Flavobacterium, Psycrobacter, and Brevundimonas spp. In contrast, the microbiota of the OTC-treated group was characterized by lower diversity and consisted only of Aeromonas, clustering with A. sobria and A. salmonicida. Antibiotic-resistant isolates were identified as Aeromonas spp.; sequencing the resistance determinant showed it to be the tetE gene. Overall, OTC treatment changed the composition of the intestinal microbiota of Atlantic salmon, as evidenced by a reduction in bacterial diversity. These results support the current concern that antibiotic treatment can facilitate the proliferation of opportunistic bacteria by eradicating competing microorganisms.

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Cited by

Metadata

Authors
Navarrete, P., Mardones, P., Opazo, R., Espejo, R., & Romero, J.
Venue
Journal of Aquatic Animal Health
Publisher
Oxford University Press (OUP)
Published
2008-09-01
Volume
20
Issue
3
Pages
177-183
ISSN
  • 0899-7659 (ISSN-L)
  • 1548-8667
DOI
10.1577/h07-043.1
OpenAlex
W2025562988
Cited by
168
References
2
FWCI
0.85
Type
journal article
Language
en
Open access
green
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Funders
  • FONDECYT (1061121)
  • CONICYT-Chile

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