Targeting the dopamine system in the treatment of attention-deficit/hyperactivity disorder
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable condition that affects a significant number of children and adults worldwide. During the past 30 years, the diagnosis and treatment of ADHD has relied on clinical assessment and empirical experience with stimulant medications. More recently, advances in family genetic studies, molecular genetic studies, preclinical research, radiographic imaging techniques and neuropsychological evaluation have significantly enhanced our understanding of the neurobiology of ADHD. This review highlights the current central role of dopamine in the pathophysiology and treatment of ADHD and implications for future advances in diagnosis and treatment.
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DA plays an essential role in mediating regulation of the cortical system, memory, mood, vascular structure, anticipation of events, motivation, behaviour inhibition, decision-making and problem-solving.
“DA plays an essential role in mediating regulation of the cortical system, memory, mood, vascular structure, anticipation of events, motivation, behaviour inhibition, decision-making and problem-solving [16, 81, 82].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [82]
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“DA Deficiency DA plays an essential role in mediating regulation of the cortical system, memory, mood, vascular structure, anticipation of events, motivation, behaviour inhibition, decision-making and problem-solving [16, 81, 82].”
BackgroundDramsdahl, M., Westerhausen, R., Haavik, J., Hugdahl, K., & Plessen, K. J. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.08.005 · Cited by 66 · see citing works
- Authors
- Staller, J. A., & Faraone, S. V.
- Affiliations
- SUNY Upstate Medical University (US)
- ORCID
- Faraone, Stephen V
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2007-04
- Volume
- 7
- Issue
- 4
- Pages
- 351-362
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W2059595475
- Cited by
- 44
- References
- 9
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- attention deficit hyperactivity disorder, dopaminergic system, ADHD pathophysiology, ADHD treatment, stimulant medication, neurobiology of ADHD, neuropsychological assessment
- MeSH terms
- Central Nervous System Stimulants, Animals, Attention Deficit Disorder with Hyperactivity, Brain, Clinical Trials as Topic, Dopamine, Humans, Neural Pathways, Genetic Predisposition to Disease
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