Microparticles as vaccine adjuvants and delivery systems

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

CpG motifs in bacterial DNA trigger direct B-cell activation

Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508 · see citing works

Approaching the asymptote? Evolution and revolution in immunology.Preprint

Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396 · see citing works

Innate Immunity: The Virtues of a Nonclonal System of Recognition

Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434 · see citing works

The Instructive Role of Innate Immunity in the Acquired Immune Response

Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,718 · see citing works

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

Amara, R. R. (2001) · Science · doi:10.1126/science.1058915 · Cited by 1,110 · see citing works

Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo

Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Müller, W. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80149-1 · Cited by 897 · see citing works

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G., & Hall, B. D. (1982) · Nature · doi:10.1038/298347a0 · Cited by 881 · see citing works

Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine

Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K., Charoenvit, Y., Jones, T. R., Hobart, P. M., Margalith, M., Ng, J., et al. (1998) · Science · doi:10.1126/science.282.5388.476 · Cited by 833 · see citing works

Biologically erodable microspheres as potential oral drug delivery systems

Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823 · see citing works

Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches

Eldridge, J. H., Hammond, C., Meulbroek, J. A., Staas, J. K., Gilley, R. M., & Tice, T. R. (1990) · Journal of Controlled Release · doi:10.1016/0168-3659(90)90133-e · Cited by 689 · see citing works

CpG islands as gene markers in the vertebrate nucleus

Bird, A. P. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90294-0 · Cited by 688 · see citing works

Development of a preventive vaccine for Ebola virus infection in primates

Sullivan, N. J., Sanchez, A., Rollin, P. E., Yang, Z., & Nabel, G. J. (2000) · Nature · doi:10.1038/35046108 · Cited by 655 · see citing works

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

Schneider, J., Gilbert, S. C., Blanchard, T. J., Hanke, T., Robson, K., Hannan, C. M., Becker, M. M., Sinden, R. E., Smith, G. L., & Hill, A. V. S. (1998) · Nature Medicine · doi:10.1038/nm0498-397 · Cited by 644 · see citing works

Aluminum compounds as vaccine adjuvants

Rk, G. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00008-8 · Cited by 628 · see citing works

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

Kovacsovics-Bankowski, M., Clark, K., D, B. B. M., & Rock, K. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.4942 · Cited by 590 · see citing works

Cationic microparticles: A potent delivery system for DNA vaccines

Singh, M., Briones, M., Ott, G. S., & O’Hagan, D. T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.811 · Cited by 489 · see citing works

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

Zinkernagel, R. M., Ehl, S. R., Aichele, P., Oehen, S., Kündig, T. M., & Hengartner, H. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00969.x · Cited by 488 · see citing works

Immunological adjuvants: a role for liposomes

Gregoriadis, G. C. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90034-7 · Cited by 469 · see citing works

Antitumor Activity of Deoxyribonucleic Acid Fraction From Mycobacterium bovis BCG. I. Isolation, Physicochemical Characterization, and Antitumor Activity 2

Tokunaga, T., Yamamoto, H., Shimada, S., Abe, H., Fukuda, T., Fujisawa, Y., Furutani, Y., Yano, O., Kataoka, T., Sudo, T., et al. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.4.955 · Cited by 466 · see citing works

Improving protein therapeutics with sustained-release formulations

Putney, S. D., & Burke, P. A. (1998) · Nature Biotechnology · doi:10.1038/nbt0298-153 · Cited by 461 · see citing works

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

Calarota, S. A., Bratt, G., Nordlund, S., Hinkula, J., Leandersson, A.-C., Sandström, E., & Wahrén, B. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09440-3 · Cited by 400 · see citing works

Biodegradable Microspheres in Drug Delivery

Okada, H., & Toguchi, H. (1995) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v12.i1.10 · Cited by 399 · see citing works

Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice

Broide, D. H., Schwarze, J., Tighe, H., Gifford, T., Nguyen, M.-D., Malek, S., Uden, J. H. V., Martín‐Orozco, E., Gelfand, E. W., & Raz, E. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.7054 · Cited by 383 · see citing works

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA

Messina, J. P., Gilkeson, G. S., & Pisetsky, D. S. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.6.1759 · Cited by 374 · see citing works

Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies

Eldridge, J. H., Staas, J. K., Meulbroek, J. A., Tice, T. R., & Gilley, R. M. (1991) · Infection and Immunity · doi:10.1128/iai.59.9.2978-2986.1991 · Cited by 368 · see citing works

Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity

Dickinson, B. L., & Clements, J. D. (1995) · Infection and Immunity · doi:10.1128/iai.63.5.1617-1623.1995 · Cited by 350 · see citing works

An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity

ALLISON, A. C., & Byars, N. E. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90402-3 · Cited by 319 · see citing works

CpG motifs as immune adjuvants

Klinman, D. M., Barnhart, K. M., & Conover, J. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00151-0 · Cited by 304 · see citing works

MF59 Design and Evaluation of a Safe and Potent Adjuvant for Human Vaccines

Ott, G. S., Barchfeld, G. L., Chernoff, D., Radhakrishnan, R., van Hoogevest, P., & Nest, G. V. (1995) · Pharmaceutical biotechnology · doi:10.1007/978-1-4615-1823-5_10 · Cited by 298 · see citing works

Saponins as vaccine adjuvants.

Kensil, C. R. (1996) · PubMed · Cited by 296 · see citing works

Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

Rappuoli, R., Pizza, M., Douce, G. R., & Gordon Dougan, B. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01523-6 · Cited by 284 · see citing works

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

Douce, G. R., Turcotte, C., Cropley, I. M., Roberts, M., Pizza, M., Domenghini, M., Rappuoli, R., & Gordon Dougan, B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1644 · Cited by 279 · see citing works

Monophosphoryl lipid A as an adjuvant. Past experiences and new directions.

Ulrich, J. T., & Myers, K. R. (1995) · PubMed · Cited by 278 · see citing works

Phagocytosis of polymer microspheres by macrophages

Tabata, Y., & Ikada, Y. (2006) · Springer eBooks · doi:10.1007/bfb0043062 · Cited by 271 · see citing works

Biodegradable microparticles as controlled release antigen delivery systems.

O’Hagan, D. T., Rahman, D., McGee, J. P., Jeffery, H., Davies, M. C., Williams, P. M., Davis, S. S., & Challacombe, S. (1991) · PubMed Central · Cited by 270 · see citing works

Seeking wisdom in innate immunity

Fearon, D. T. (1997) · Nature · doi:10.1038/40967 · Cited by 264 · see citing works

Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine

Marx, P. A., Compans, R. W., Gettie, A., Staas, J. K., Gilley, R. M., Mulligan, M. J., Yamshchikov, G. V., Chen, D., & Eldridge, J. H. (1993) · Science · doi:10.1126/science.8493576 · Cited by 261 · see citing works

Adjuvant-Guided Type-1 and Type-2 Immunity: Infectious/Noninfectious Dichotomy Defines the Class of Response

Yip, H. C., Karulin, A. Y., Tary‐Lehmann, M., Hesse, M. D., Radeke, H. H., Heeger, P. S., Trezza, R. P., Heinzel, F. P., Forsthuber, T. G., & Lehmann, P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3942 · Cited by 259 · see citing works

Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity

Giuliani, M. M., Giudice, G. D., Giannelli, V., Gordon Dougan, B., Douce, G. R., Rappuoli, R., & Pizza, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.7.1123 · Cited by 258 · see citing works

Microencapsulation of DNA using poly(dl-lactide-co-glycolide): stability issues and release characteristics

Walter, E., Moelling, K., Pavlovic, J., & Merkle, H. P. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00151-0 · Cited by 257 · see citing works

Poly(?-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration

Jones, D. (1997) · Vaccine · doi:10.1016/s0264-410x(96)00266-6 · Cited by 253 · see citing works

PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization

Ando, S., Putnam, D. A., Pack, D. W., & Langer, R. (1999) · Journal of Pharmaceutical Sciences · doi:10.1021/js9801687 · Cited by 243 · see citing works

Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines

O’Hagan, D. T. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00012-x · Cited by 243 · see citing works

The Common Vaccine Adjuvant Aluminum Hydroxide Up-Regulates Accessory Properties of Human Monocytes via an Interleukin-4-Dependent Mechanism

Ulanova, M., Tarkowski, A., Hahn‐Zoric, M., & Hanson, L. Å. (2001) · Infection and Immunity · doi:10.1128/iai.69.2.1151-1159.2001 · Cited by 239 · see citing works

Macrophage phagocytosis of biodegradable microspheres composed of L ‐lactic acid/glycolic acid homo‐ and copolymers

Tabata, Y., & Ikada, Y. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820221002 · Cited by 236 · see citing works

Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses

Hedley, M. L., Curley, J., & Urban, R. G. (1998) · Nature Medicine · doi:10.1038/nm0398-365 · Cited by 236 · see citing works

Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101.

Klencke, B. J., Matijevic, M., Urban, R. G., Lathey, J. L., Hedley, M. L., Berry, M. J., Thatcher, J., Weinberg, V., Wilson, J., Darragh, T. M., et al. (2002) · PubMed · Cited by 230 · see citing works

Monophosphoryl Lipid A as an Adjuvant

Ulrich, J. T., & Myers, K. R. (1995) · Pharmaceutical biotechnology · doi:10.1007/978-1-4615-1823-5_21 · Cited by 222 · see citing works

Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice

Schirmbeck, R., Böhm, W., Ando, K., Chisari, F. V., & Reimann, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.10.5929-5934.1995 · Cited by 210 · see citing works

Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant

Tommaso, A. D., Saletti, G., Pizza, M., Rappuoli, R., Gordon Dougan, B., Abrignani, S., Douce, G. R., & Magistris, M. T. D. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.974-979.1996 · Cited by 207 · see citing works

Uptake of poly( D,L ‐lactic‐co‐glycolic acid) microspheres by antigen‐presenting cells in vivo

Newman, K. D., Elamanchili, P., Kwon, G. S., & Samuel, J. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10019 · Cited by 195 · see citing works

A single-step immunization by sustained antigen release

Preis, I., & Langer, R. (1979) · Journal of Immunological Methods · doi:10.1016/0022-1759(79)90341-7 · Cited by 193 · see citing works

Enhanced Oral Uptake of Tomato Lectin-Conjugated Nanoparticles in the Rat

Hussain, N., Jani, P. U., & Florence, A. T. (1997) · Pharmaceutical Research · doi:10.1023/a:1012153011884 · Cited by 190 · see citing works

ISCOMs and other saponin based adjuvants

Barr, I. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00013-1 · Cited by 189 · see citing works

Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function

Soltysik, S., Wu, J., Recchia, J., Wheeler, D. A., Newman, M. J., Coughlin, R. T., & Kensil, C. R. (1995) · Vaccine · doi:10.1016/0264-410x(95)00077-e · Cited by 188 · see citing works

Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers

Chen, H., Torchilin, V. P., & Langer, R. (1996) · Pharmaceutical Research · doi:10.1023/a:1016030202104 · Cited by 186 · see citing works

Safety and immunogenicity of MF59-adjuvanted influenza vaccine in the elderly

DONATO, S. D., Granoff, D. M., Minutello, M., Lecchi, G., Faccini, M., Agnello, M., Senatore, F., Verweij, P., Fritzell, B., & Podda, A. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00138-3 · Cited by 185 · see citing works

Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.

Maloy, K. J., Donachie, A. M., O’Hagan, D. T., & Mowat, A. M. (1994) · PubMed Central · Cited by 183 · see citing works

A genetically engineered non-toxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit

Ågren, L. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)88001-7 · Cited by 180 · see citing works

Tetanus Toxoid Loaded Nanoparticles from Sulfobutylated Poly(Vinyl Alcohol)-Graft-Poly(Lactide-co-Glycolide): Evaluation of Antibody Response After Oral and Nasal Application in Mice

Jung, T., Kamm, W., Breitenbach, A., Hungerer, K., Hundt, E., & Kissel, T. (2001) · Pharmaceutical Research · doi:10.1023/a:1011063232257 · Cited by 177 · see citing works

Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles

O’Hagan, D. T., Jeffery, H., & Davis, S. S. (1993) · Vaccine · doi:10.1016/0264-410x(93)90387-d · Cited by 175 · see citing works

A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminum hydroxide

Ying, M. (1995) · Vaccine · doi:10.1016/0264-410x(94)00046-p · Cited by 171 · see citing works

Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant

Marchetti, M., Rossi, M., Giannelli, V., Giuliani, M. M., Pizza, M., Censini, S., Covacci, A., Massari, P., Pagliaccia, C., & Manetti, R. (1998) · Vaccine · doi:10.1016/s0264-410x(97)00153-9 · Cited by 170 · see citing works

Formulation of poly(d,l-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery

Tinsley-Bown, A., Fretwell, R., Dowsett, A. B., Davis, S., & Farrar, G. H. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00275-8 · Cited by 167 · see citing works

Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells

Denis-Mize, K. S., Dupuis, M., MacKichan, M. L., Singh, M., Doe, B., O’Hagan, D. T., Ulmer, J. B., Donnelly, J. J., McDonald, D. M., & Ott, G. S. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301347 · Cited by 167 · see citing works

Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin

Douce, G. R., Fontana, M. D., Pizza, M., Rappuoli, R., & Gordon Dougan, B. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2821-2828.1997 · Cited by 167 · see citing works

Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells

Moore, A. (1995) · Vaccine · doi:10.1016/0264-410x(95)00184-3 · Cited by 165 · see citing works

Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen.

Challacombe, S., Rahman, D., Jeffery, H., Davis, S. S., & O’Hagan, D. T. (1992) · PubMed Central · Cited by 164 · see citing works

Analysis of Poly(D,L-Lactic-Co-Glycolic Acid) Nanosphere Uptake by Human Dendritic Cells and Macrophages In Vitro

Lutsiak, M. E. C., Robinson, D. R., Coester, C., Kwon, G. S., & Samuel, J. (2002) · Pharmaceutical Research · doi:10.1023/a:1020452531828 · Cited by 163 · see citing works

QS-21: a water-soluble triterpene glycoside adjuvant

Kensil, C. R., & Kammer, R. B. (1998) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.7.9.1475 · Cited by 153 · see citing works

Controlled release microparticles for vaccine development

O’Hagan, D. T., Jeffery, H., Roberts, M. J. J., McGee, J. P., & Davis, S. S. (1991) · Vaccine · doi:10.1016/0264-410x(91)90295-h · Cited by 149 · see citing works

The intestinal uptake of particles and the implications for drug and antigen delivery.

O’Hagan, D. T. (1996) · Europe PMC (PubMed Central) · Cited by 148 · see citing works

A protein particle vaccine containing multiple malaria epitopes

Gilbert, S. C., Plebanski, M., Harris, S. J., Allsopp, C. E. M., Thomas, R., Layton, G. T., & Hill, A. V. S. (1997) · Nature Biotechnology · doi:10.1038/nbt1197-1280 · Cited by 147 · see citing works

Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo

Foster, N. M. (1998) · Vaccine · doi:10.1016/s0264-410x(97)00222-3 · Cited by 145 · see citing works

In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity.

Egilmez, N. K., Jong, Y. S., Sabel, M. S., Jacob, J. S., Mathiowitz, E., & Bankert, R. B. (2000) · PubMed · Cited by 143 · see citing works

Microparticles and polymers for the mucosal delivery of vaccines

O’Hagan, D. T. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00045-3 · Cited by 143 · see citing works

Immunogenicity and protectivity of a new liposomal hepatitis A vaccine

Ambrosch, F. (1997) · Vaccine · doi:10.1016/s0264-410x(97)00015-7 · Cited by 140 · see citing works

A novel bioadhesive intranasal delivery system for inactivated influenza vaccines

Singh, M., Briones, M., & O’Hagan, D. T. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00330-8 · Cited by 135 · see citing works

Synthetic peptides entrapped in microparticles can elicit cytotoxic T cell activity

Nixon, D. F., Hioe, C. E., Chen, P., Bian, Z., Kuebler, P., Li, M.-L., Qiu, H., Li, X.-M., Singh, M., Richardson, J. L., et al. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00099-0 · Cited by 133 · see citing works

Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells

Conway, M. A., Madrigal-Estebas, L., McClean, S., Brayden, D. J., & Mills, K. H. G. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00433-3 · Cited by 130 · see citing works

Novel anionic microparticles are a potent adjuvant for the induction of cytotoxic T lymphocytes against recombinant p55 gag from HIV-1

Kazzaz, J., Neidleman, J. A., Singh, M., Ott, G. S., & O’Hagan, D. T. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00226-1 · Cited by 124 · see citing works

Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.

Schwendeman, S. P., Costantino, H. R., Rk, G., Siber, G. R., Klibanov, A. M., & Langer, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11234 · Cited by 116 · see citing works

Cationic Microparticles Are an Effective Delivery System for Immune Stimulatory CpG DNA

Singh, M., Ott, G. S., Kazzaz, J., Ugozzoli, M., Briones, M., Donnelly, J., & O’Hagan, D. T. (2001) · Pharmaceutical Research · doi:10.1023/a:1012269226066 · Cited by 115 · see citing works

Microparticles for intranasal immunization

Vajdy, M., & O’Hagan, D. T. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00167-3 · Cited by 115 · see citing works

A Th1-Inducing Adjuvant, MPL®, Enhances Antibody Profiles in Experimental Animals Suggesting It Has the Potential to Improve the Efficacy of Allergy Vaccines

Wheeler, A. W., Marshall, J. S., & Ulrich, J. T. (2001) · International Archives of Allergy and Immunology · doi:10.1159/000049504 · Cited by 115 · see citing works

Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres

Tacket, C. O., Reid, R. H., Boedeker, E. C., Losonsky, G. A., Nataro, J. P., Bhagat, H. R., & Edelman, R. (1994) · Vaccine · doi:10.1016/s0264-410x(94)80038-2 · Cited by 114 · see citing works

Immunologic aspects of liposomes: presentation and processing of liposomal protein and phospholipid antigens

Alving, C. R. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(92)90004-t · Cited by 111 · see citing works

Augmentation of Human Influenza A Virus-Specific Cytotoxic T Lymphocyte Memory by Influenza Vaccine and Adjuvanted Carriers (ISCOMS)

Ennis, F. A., Cruz, J., Jameson, J., Klein, M. H., Burt, D. S., & Thipphawong, J. (1999) · Virology · doi:10.1006/viro.1999.9765 · Cited by 109 · see citing works

Induction of protective immunity against influenza virus in a macaque model: comparison of conventional and iscom vaccines.

Rimmelzwaan, G. F., van Beek, R., van Amerongen, G., Claas, E. C., L√∂vgren-Bengtsson, K., Osterhaus, A. D. M. E., & Baars, M. M. J. W. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-4-757 · Cited by 108 · see citing works

Poly[di(carboxylatophenoxy)phosphazene] (PCPP) is a potent immunoadjuvant for an influenza vaccine

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HIV‐1‐specific cell‐mediated immune responses induced by DNA vaccination were enhanced by mannan‐coated liposomes and inhibited by anti‐interferon‐γ antibody

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