Cited by 214Immunotherapy and Immune ResponsesAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

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Microparticles as vaccine adjuvants and delivery systems

O’Hagan, Derek T, Singh, Manmohan·2003·Expert Review of Vaccines

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Abstract

Adjuvants can be broadly divided into two groups, based on their principal mechanisms of action: vaccine delivery systems and immunostimulatory adjuvants. Vaccine delivery systems are generally particulate (e.g., emulsions, microparticles, immunostimulatory complexes and liposomes) and function mainly to target associated antigens into antigen-presenting cells. However, increasingly, more complex formulations are being developed in which delivery systems are exploited both for the delivery of antigens and also for the delivery of coadministered immunostimulatory adjuvants. The rationale for this approach is to ensure that both antigen and adjuvant are delivered into the same population of antigen-presenting cells. In addition, delivery systems can focus the effect of the adjuvants onto the key cells of the immune system and limit the systemic distribution of the adjuvant, to minimize its potential to induce adverse effects. The formulation and delivery of potent adjuvants in microparticles may allow the development of prophylactic and therapeutic vaccines against cancers and chronic infectious diseases, which are currently poorly controlled. In addition, microparticle formulations may also allow vaccines to be delivered mucosally.

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A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,711
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
Amara, R. R. (2001) · Science · doi:10.1126/science.1058915 · Cited by 1,110
Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Müller, W. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80149-1 · Cited by 897
Synthesis and assembly of hepatitis B virus surface antigen particles in yeast
Valenzuela, P., Medina, A., Rutter, W. J., Ammerer, G., & Hall, B. D. (1982) · Nature · doi:10.1038/298347a0 · Cited by 881
Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine
Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K., Charoenvit, Y., Jones, T. R., Hobart, P. M., Margalith, M., Ng, J., et al. (1998) · Science · doi:10.1126/science.282.5388.476 · Cited by 833
Biologically erodable microspheres as potential oral drug delivery systems
Mathiowitz, E., Jacob, J. S., Jong, Y. S., Carino, G. P., Chickering, D. E., Chaturvedi, P., Santos, C. A., Vijayaraghavan, K., Montgomery, S., Bassett, M., et al. (1997) · Nature · doi:10.1038/386410a0 · Cited by 823

Flagged first, then by citations

Show all 155 references

Research works printed but not linked: 20

Ramon G, 1924, Ann. Inst. Pasteur, 38, 1
Medzhitov R, 1997, Ce, 1191, 295
Kensil CR, 1996, On. Rev Ther Drug Carrier Syst, 13, 1
Glaueri AM, 1962, Action of saponins on biological membranes. Nature, 196, 953
Heath AW., 1995, Phann Biotechnol, 6, 645
Ennis FA, 1999, Vimlogy, 259, 256
O'Hagan DT, 1991, Immunology, 73, 239
Maloy KJ, 1994, Immunol, 81, 661
Newman KD, 2002, Res, 60, 480
O'Hagan DT, 1993, Vaccine, 11, 965, 10.1016/0264-410X(93)90387-D · DOI
Ando S, 1999, Sci, 88, 126
Tabata Y, 1987, Pharmacol, 39, 698
Sasiak AB, 2001, Vaccine, 19, 694
Challacombe SJ, 1992, hnmunology, 76, 164
Seo JY, 2002, Infect. hnmun, 70, 1143
Tseng J, 1995, infect. hizmun, 63, 2880
Eyles JE, 2001, Pharmacol, 53, 601
Rappuoli R, 1999, humunol Toclay, 20, 493
Chen H, 1996, Priam. Res, 13, 1378
Agren LC, 1997, Iramunol, 158, 3936

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Ajay, V., Mittal, A. K., & Gupta, A. (2013) · Shodhganga · Cited by 5
Portal to the interior: viral pathogenesis and natural compounds that restore mucosal immunity and modulate inflammation.
WILLIAMS, J. E. J. (2003) · PubMed · Cited by 5
Enhanced Immunogenicity of Adjuvanted Microparticulate HPV16 Vaccines Administered via the Transdermal Route
Vo, T., Panicker, G., Gomes, K. B., Parenky, A. C., Rajbhandari, I., Rajeevan, M. S., Unger, E. R., D’Souza, M. J., & Uddin, M. N. (2022) · Pharmaceuticals · doi:10.3390/ph15091128 · Cited by 4
Fundamentals of Vaccine Delivery in Infectious Diseases
Şenel, S. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0881-9_16 · Cited by 4
Enhanced immunogenicity of recombinant pneumococcal protein delivered using thermostable polymer particles
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Self-citation
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Joshi, D., Shah, S., Chbib, C., & Uddin, M. N. (2024) · Pharmaceuticals · doi:10.3390/ph17020184 · Cited by 4
Adjuvant potential of Peyssonnelia caulifera extract on the efficacy of an influenza vaccine in a murine model
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Nanotechnology for Cancer Vaccine Delivery
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Mucosal Vaccination: Opportunities and Challenges
Borges, O., & Borchard, G. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5380-2_3 · Cited by 3
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Microparticles entrapping pneumococcal protein SP0845 show improved immunogenicity and temperature stability
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Gelatin nanoparticles for use as a vaccine adjuvant in intranasal immunizations
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D’Souza, B., Shastri, P. N., Hammons, G. M., Kolluru, L. P., Mulla, N. S., & Rajam, G. (2015) · Pan Stanford eBooks · doi:10.1201/b18096-6 · Cited by 2
Formulations and Delivery Systems for Mucosal Vaccines
Malyala, P., & Singh, M. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8412-6_19 · Cited by 2
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Delivery of Natural Products Using Polymeric Particles for Cancer Chemotherapeutics
Ahuja, R., Panwar, N., Meena, J., Sarkar, D. P., & Panda, A. K. (2020) · Sustainable agriculture reviews · doi:10.1007/978-3-030-41838-0_3 · Cited by 1
Infection Prevention: Oil- and Lipid-Containing Products in Vaccinology
Ebensen, T., Fuchs, B., Schulze, K., & Guzmán, C. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-15147-8_25 · Cited by 1
Discovery of Vaccine Adjuvants
Sharp, F. A., & Lavelle, E. C. (2011) · Pharmaceutical Sciences Encyclopedia · doi:10.1002/9780470571224.pse438 · Cited by 1
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Kalariya, M. (2012) · doi:10.17760/d20002974 · Cited by 1
Evaluation of genotoxic and cytogenetic effects of saponins and aluminum hydroxide adjuvant on viral vaccinePreprint
Magnelli, R. F., Stocco, R. D. C., da Silva, P. I., & Mendonça, R. Z. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.04.442590 · Cited by 1
Immunostimulatory Properties of Biodegradable Microparticles
Sharp, F. A., & Lavelle, E. C. (2012) · doi:10.1002/9781118345313.ch24
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Patel, J. D. (2006) · UKnowledge (University of Kentucky)
Nanopartikel als Trägersysteme für transepidermale Vakzinierung – Zielgerichteter Transport von Antigenen über die Hautbarriere
Amselgruber, S. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-7140

Authors: O’Hagan, D. T., & Singh, M.
ORCID: Singh, Manmohan
Venue: Expert Review of Vaccines
Publisher: Informa UK Limited
Published: 2003-04
Volume: 2
Issue: 2
Pages: 269-283
ISSN: 1476-0584 (ISSN-L)
1744-8395
DOI: 10.1586/14760584.2.2.269
OpenAlex: W2030951969
Cited by: 214
References: 155
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 23
FWCI: 1.12
Type: journal article
Language: en
Open access: closed
Locations: Expert Review of Vaccines (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: vaccine adjuvants, microparticles, vaccine delivery systems, immunostimulatory adjuvants, antigen-presenting cells, liposomes, emulsions, mucosal vaccine delivery, cancer vaccines
MeSH terms: Adjuvants, Immunologic, Animals, Antigens, Capsules, Humans, Immunity, Cellular, Lipid A, Microspheres, Oligodeoxyribonucleotides, Saponins, Vaccines, Cytokines, Drug Delivery Systems, Immunity, Mucosal, Vaccines, DNA

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Microparticles as vaccine adjuvants and delivery systems

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