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Cited by 56Reproductive tract infections researchSyphilis Diagnosis and TreatmentBacterial Infections and Vaccines

Epidemiology, clinical features, diagnosis and treatment of Haemophilus ducreyi – a disappearing pathogen?

Lewis, David A·2014·Expert Review of Anti-infective Therapy
DOI 10.1586/14787210.2014.892414
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Abstract

Chancroid, caused by Haemophilus ducreyi, has declined in importance as a sexually transmitted pathogen in most countries where it was previously endemic. The global prevalence of chancroid is unknown as most countries lack the required laboratory diagnostic capacity and surveillance systems to determine this. H. ducreyi has recently emerged as a cause of chronic skin ulceration in some South Pacific islands. Although no antimicrobial susceptibility data for H. ducreyi have been published for two decades, it is still assumed that the infection will respond successfully to treatment with recommended cephalosporin, macrolide or fluoroquinolone-based regimens. HIV-1-infected patients require careful follow-up due to reports of treatment failure with single dose regimens. Buboes may need additional treatment with either aspiration or excision and drainage.

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  • Persons with HIV infection who have chancroid infection are more likely to experience chancroid treatment failure and to have ulcers that heal slowly.

    “Persons with HIV infection who have chancroid infection should be monitored closely because they are more likely to experience chancroid treatment failure and to have ulcers that heal slowly (430,432).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [432]

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Authors
Lewis, D. A.
Affiliations
National Center for Disease Control (IN)
Corresponding author
Lewis, David A
ORCID
Lewis, David A
Venue
Expert Review of Anti-infective Therapy
Publisher
Informa UK Limited
Published
2014-03-06
Volume
12
Issue
6
Pages
687-696
ISSN
  • 1478-7210 (ISSN-L)
  • 1744-8336
DOI
10.1586/14787210.2014.892414
OpenAlex
W2135679250
Cited by
56
References
90
Citations by year
2026: 2 · 2025: 9 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 1
FWCI
0.62
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Anti-infective Therapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords
Haemophilus ducreyi, chancroid, sexually transmitted infections, declining prevalence, South Pacific islands, antimicrobial susceptibility, cephalosporins, macrolides, fluoroquinolones, HIV-1 coinfection, treatment failure, buboes
MeSH terms
Anti-Bacterial Agents, Cephalosporins, Chancroid, Female, Haemophilus ducreyi, Humans, Male, Microbial Sensitivity Tests, HIV-1, HIV Infections, Treatment Failure, Macrolides, Fluoroquinolones

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