The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Perils and pitfalls of long-term effects of proton pump inhibitors
Abstract
This review summarizes the literature regarding long-term adverse effects of proton pump inhibitors (PPIs). A PubMed search (1966 to February 2013) for English language studies was conducted using key terms PPI: omeprazole, esomeprazole, pantoprazole, lansoprazole, dexlansoprazole, rabeprazole, pneumonia, Clostridium difficile, osteoporosis, risk of fractures, thrombocytopenia, rhabdomyolysis, anemia, iron deficiency, hypomagnesemia, vitamin B₁₂ and nephritis. The risk of pneumonia was increased 27-39% in short-term use of PPIs in three meta-analyses. C. difficile infections were also associated with the use of PPIs (odds ratio: 2.15; 95% CI: 1.81-2.55; p < 0.00001). This effect appears to be dose related. The US FDA has recently issued a warning regarding fractures and the impaired magnesium absorption associated with the use of PPI. Thrombocytopenia, iron deficiency, vitamin B12 deficiency, rhabdomyolysis and acute interstitial nephritis have also been reported with the use of PPIs. There is mounting evidence that PPIs are associated with serious adverse effects. Practitioners should be vigilant and counsel patients accordingly.
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In the citing paper
“While PPIs are generally considered safe and well tolerated, they have been associated with adverse events, especially in the long term.”
From Proton pump inhibitors for functional dyspepsia (2017) · cites this paper as Wilhelm 2013
Citations
Cites
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Cited by
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615
Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency
Hannibal, L., Lysne, V., Bjørke-Monsen, A.-L., Behringer, S., Grünert, S. C., Spiekerkoetter, U., Jacobsen, D. W., & Blom, H. J. (2016) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2016.00027 · Cited by 355
Proton pump inhibitors for functional dyspepsia
Pinto-Sanchez, M. I., Yuan, Y., Hassan, A., Bercik, P., & Moayyedi, P. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011194.pub3 · Cited by 195
Marlicz, W., Łoniewski, I., Grimes, D. S., & Quigley, E. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.07.015 · Cited by 91
Metadata
- Authors
- Wilhelm, S. M., Rjater, R. G., & Kale-Pradhan, P. B.
- Venue
- Expert Review of Clinical Pharmacology
- Publisher
- Informa UK Limited
- Published
- 2013-07
- Volume
- 6
- Issue
- 4
- Pages
- 443-451
- ISSN
- 1751-2433
- 1751-2441
- Cited by
- 104
- References
- 92
- Language
- en
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- Wilhelm, S. M., Rjater, R. G., & Kale-Pradhan, P. B. (2013). Perils and pitfalls of long-term effects of proton pump inhibitors. Expert Review of Clinical Pharmacology. https://doi.org/10.1586/17512433.2013.811206
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
