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The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis

Open access
Mockenhaupt, Maja·2011·Expert Review of Clinical Immunology

Abstract

Stevens-Johnson syndrome has long been considered to resemble erythema multiforme with mucosal involvement, but is now thought to form a single disease entity with toxic epidermal necrolysis. Although Stevens-Johnson syndrome is less severe, etiology, genetic susceptibility and pathomechanism are the same for Stevens-Johnson syndrome/toxic epidermal necrolysis. The condition is mainly caused by drugs, but also by infections and probably other risk factors not yet identified. Identification of the cause is important for the individual patient and in cases of drug-induced disease withdrawal of the inducing drug(s) has an impact on the patient's prognosis. If an infectious cause is suspected, adequate anti-infective treatment is needed. Besides this, supportive management is crucial to improve the patient's state, probably more than specific immunomodulating treatments. Despite all of the therapeutic efforts, mortality is high and increases with disease severity, patients' age and underlying medical conditions. Survivors may suffer from long-term sequelae such as strictures of mucous membranes including severe eye problems.

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Metadata

Authors
Mockenhaupt, M.
Venue
Expert Review of Clinical Immunology
Published
2011-11
Volume
7
Issue
6
Pages
803-815
ISSN
  • 1744-666X (ISSN-L)
  • 1744-8409
OpenAlex
W1978598106
Cited by
347
References
27
FWCI
17.32
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis. https://app.cochat.ai/papers/10.1586/eci.11.66
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Mockenhaupt, M. (2011). The current understanding of Stevens–Johnson syndrome and toxic epidermal necrolysis. Expert Review of Clinical Immunology. https://doi.org/10.1586/eci.11.66

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.