Interferon-based hepatitis C treatment in patients with pre-existing severe mental illness and substance use disorders
Abstract
Hepatitis C infection in patients with mental illness and drug addiction is highly prevalent and infrequently treated. Over the past 5 years, a wealth of studies specifically focused on these groups have demonstrated comparable rates of sustained virological response, compliance and adverse events. Optimization of psychotropic and opioid-replacement therapy with integrated psychiatric/addiction treatment prior to and during IFN-alpha initiation produces optimal results. Experience in treating these populations demonstrates clinical outcomes comparable with those without these comorbidities. Patients with mental illness and drug addiction should have routine screening and treatment for HCV infection to prevent associated morbidity and mortality.
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Today, respiratory diseases are still more prevalent in people with SMI.
“Today, respiratory diseases are still more prevalent in people with SMI (8,(410)(411)(412)(413)(414)(415)(416)(417).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [411]
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- Authors
- Freedman, K., & Nathanson, J.
- Affiliations
- Tufts University (US)
- University of Massachusetts Chan Medical School (US)
- Venue
- Expert Review of Anti-infective Therapy
- Publisher
- Informa UK Limited
- Published
- 2009-04
- Volume
- 7
- Issue
- 3
- Pages
- 363-376
- ISSN
- 1478-7210 (ISSN-L)
- 1744-8336
- OpenAlex
- W2114635652
- Cited by
- 16
- References
- 43
- Citations by year
- 2022: 1 · 2013: 1 · 2012: 4
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Anti-infective Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- hepatitis C, interferon-alpha, severe mental illness, substance use disorders, drug addiction, psychiatric comorbidity, sustained virological response, medication adherence, adverse events, psychotropic drugs, opioid substitution therapy, HCV screening, HCV treatment outcomes
- MeSH terms
- Antiviral Agents, Mental Disorders, Drug Therapy, Combination, Hepatitis C, Humans, Interferons, Polyethylene Glycols, Ribavirin, Hepacivirus, Treatment Outcome, Substance-Related Disorders
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