Hepatitis C Treatment for People With Severe Mental Illness
Abstract
Over 4 million people in the United States are chronically infected with hepatitis C virus (HCV), and, if untreated, over 20% of these will progress to more serious disease. Persons with severe mental illness (SMI) have markedly elevated rates of HCV infection, but treatment of persons with SMI and HCV has been controversial. Effective antiviral treatment is available, but side effects include depression and other neuropsychiatric symptoms. This article reviews the available data on neuropsychiatric side effects of interferon (IFN) treatment, discusses the limitations of the current research, and makes recommendations regarding HCV treatment in persons with SMI.
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In the largest study to date, prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients were approximately 5 and 11 times the overall estimated population rates for these infections.
“The largest study to date found prevalence rates of hepatitis B virus (23.4%) and hepatitis C virus (19.6%) in SMI patients to be approximately 5 and 11 times the overall estimated population rates for these infections.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [396]
Across different continents, rates of hepatitis virus infection are markedly elevated in persons with SMI compared to the general population.
“Across different continents, markedly elevated rates of hepatitis virus infection have been reported in persons with SMI compared to the general population (364,396-403).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [396]
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- Authors
- Mistler, L. A., Brunette, M. F., Marsh, B. J., Vidaver, R. M., Luckoor, R., & Rosenberg, S. D.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Mistler, Lisa A.
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 47
- Issue
- 2
- Pages
- 93-107
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W1990312230
- Cited by
- 39
- References
- 99
- Citations by year
- 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- hepatitis C, severe mental illness, antiviral therapy, interferon, neuropsychiatric adverse effects, depression, chronic hepatitis C, treatment guidelines
- MeSH terms
- Antiviral Agents, Mental Disorders, Major Depressive Disorder, Humans, Interferons, Hepatitis C, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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