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Cited by 581

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Colistin: an update on the antibiotic of the 21st century

Biswas, Silpak, Brunel, Jean-Michel, Dubus, Jean-Christophe, Reynaud-Gaubert, Martine, Rolain, Jean-Marc·2012·Expert Review of Anti-infective Therapy

Abstract

The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial infections is a growing problem worldwide. Colistin was first introduced in 1952 and was used until the early 1980s for the treatment of infections caused by Gram-negative bacilli. In vitro, colistin has demonstrated excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Recent clinical findings regarding colistin activity, pharmacokinetic properties, clinical uses, emerging resistance, toxicities and combination therapy have been reviewed. Recent approaches to the use of colistin in combination with other antibiotics hold promise for increased antibacterial efficacy. It is probable that colistin will be the 'last-line' therapeutic drug against multidrug-resistant Gram-negative pathogens in the 21st century.

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Crossref · 10.1586/eri.12.78

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Metadata

Authors
Biswas, S., Brunel, J.-M., Dubus, J.-C., Reynaud-Gaubert, M., & Rolain, J.-M.
Venue
Expert Review of Anti-infective Therapy
Published
2012-08
Volume
10
Issue
8
Pages
917-934
ISSN
  • 1478-7210 (ISSN-L)
  • 1744-8336
OpenAlex
W2096250787
Cited by
581
References
3
FWCI
9.61
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.