The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses
Open accessAbstract
The development of novel immune adjuvants is emerging as a significant area of vaccine delivery based on the continued necessity to amplify immune responses to a wide array of new antigens that are poorly immunogenic. This article specifically focuses on the application of nanoparticles and microparticles as vaccine adjuvants. Many investigators are in agreement that the size of the particles is crucial to their adjuvant activities. However, reports on correlating the size of particle-based adjuvants and the resultant immune responses have been conflicting, with investigators on both sides of the fence with impressive data in support of the effectiveness of particles with small sizes (submicron) over those with larger sizes (micron) and vice versa, while other investigators reported data that showed submicron- and micron-sized particles are effective to the same degree as immune adjuvants. We have generated a list of biological, immunological and, more importantly, vaccine formulation parameters that may have contributed to the inconsistency from different studies and made recommendations on future studies attempting to correlate the size of particulate adjuvants and the immune responses induced. The information gathered could lead to strategies to optimize the performance of nano-microparticles as immune adjuvants.
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Cites
Freitas, S., Merkle, H. P., & Gander, B. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.015 · Cited by 923
Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research · doi:10.1023/a:1011922819926 · Cited by 402
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Microparticles as vaccine adjuvants and delivery systems
O’Hagan, D. T., & Singh, M. (2003) · Expert Review of Vaccines · doi:10.1586/14760584.2.2.269 · Cited by 214
Konan, Y. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00128-5 · Cited by 152
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Cited by
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
Self-assembling protein nanoparticles in the design of vaccines
López-Sagaseta, J., Malito, E., Rappuoli, R., & Bottomley, M. J. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.11.001 · Cited by 353
Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines
Goswami, R., Chatzikleanthous, D., Lou, G., Giusti, F., Bonci, A., Taccone, M., Brazzoli, M., Gallorini, S., Ferlenghi, I., Berti, F., et al. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00084 · Cited by 113
Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation
Silva, A. L., Peres, C., Conniot, J., Matos, A. I., Moura, L., Carreira, B., Sainz, V., Scomparin, A., Satchi-Fainaro, R., Préat, V., et al. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.003 · Cited by 95
Luo, L., Qin, T., Huang, Y., Zheng, S., Bo, R., Liu, Z., Xing, J., Hu, Y., Liu, J., & Wang, D. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1359861 · Cited by 47
Metadata
- Authors
- Oyewumi, M. O., Kumar, A., & Cui, Z.
- Venue
- Expert Review of Vaccines
- Publisher
- Informa UK Limited
- Published
- 2010-09
- Volume
- 9
- Issue
- 9
- Pages
- 1095-1107
- ISSN
- 1476-0584 (ISSN-L)
- 1744-8395
- OpenAlex
- W2106183630
- Cited by
- 547
- References
- 6
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Oyewumi, M. O., Kumar, A., & Cui, Z. (2010). Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses. Expert Review of Vaccines. https://doi.org/10.1586/erv.10.89
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
