The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges
Open accessAbstract
The aim of this review is to make researchers aware of the benefits of an efficient quality control system for prediction of a developed vaccine's efficacy. Two major goals should be addressed when inactivating a virus for vaccine purposes: first, the infectious virus should be inactivated completely in order to be safe, and second, the viral epitopes important for the induction of protective immunity should be conserved after inactivation in order to have an antigen of high quality. Therefore, some problems associated with the virus inactivation process, such as virus aggregate formation, protein crosslinking, protein denaturation and degradation should be addressed before testing an inactivated vaccine in vivo.
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Cites
Li, Y., & Breaker, R. R. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990592p · Cited by 587
Cited by
Heinz, F. X., & Stiasny, K. (2021) · npj Vaccines · doi:10.1038/s41541-021-00369-6 · Cited by 363
COVID-19 Vaccine Frontrunners and Their Nanotechnology Design
Chung, Y. H., Beiss, V., Fiering, S. N., & Steinmetz, N. F. (2020) · ACS Nano · doi:10.1021/acsnano.0c07197 · Cited by 346
Nabel, G. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1204186 · Cited by 271
Sanitizing agents for virus inactivation and disinfection
Lin, Q., Lim, J. Y. C., Xue, K., Yew, P. Y. M., Owh, C., Chee, P. L., & Loh, X. J. (2020) · VIEW · doi:10.1002/viw2.16 · Cited by 271
Metadata
- Authors
- Delrue, I., Verzele, D., Madder, A., & Nauwynck, H. J.
- Venue
- Expert Review of Vaccines
- Publisher
- Informa UK Limited
- Published
- 2012-06
- Volume
- 11
- Issue
- 6
- Pages
- 695-719
- ISSN
- 1476-0584 (ISSN-L)
- 1744-8395
- OpenAlex
- W2156728669
- Cited by
- 196
- References
- 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Delrue, I., Verzele, D., Madder, A., & Nauwynck, H. J. (2012). Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges. Expert Review of Vaccines. https://doi.org/10.1586/erv.12.38
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
