The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action
Open accessAbstract
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization and mass production, leading to their global application on a large scale. This enormous progress was achieved with fundamentally different vaccine technologies used in parallel. mRNA, adenoviral vector as well as inactivated whole-virus vaccines are now in widespread use, and a subunit vaccine is in a final stage of authorization. They all rely on the native viral spike protein (S) of SARS-CoV-2 for inducing potently neutralizing antibodies, but the presentation of this key antigen to the immune system differs substantially between the different categories of vaccines. In this article, we review the relevance of structural modifications of S in different vaccines and the different modes of antigen expression after vaccination with genetic adenovirus-vector and mRNA vaccines. Distinguishing characteristics and unknown features are highlighted in the context of protective antibody responses and reactogenicity of vaccines.
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Cites
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
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Cited by
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis
Trougakos, I. P., Terpos, E., Alexopoulos, H., Politou, M., Paraskevis, D., Scorilas, A., Kastritis, E., Andreakos, E., & Dimopoulos, M. A. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.04.007 · Cited by 273
Shedding Light on Mechanisms of Myocarditis With COVID-19 mRNA Vaccines
Bozkurt, B. (2023) · Circulation · doi:10.1161/circulationaha.123.063396 · Cited by 20
Bignon, E., Marazzi, M., Grandemange, S., & Monari, A. (2022) · Chemical Science · doi:10.1039/d2sc00108j · Cited by 13
Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines
Manabe, Y., & Fukase, K. (2023) · Methods in Molecular Biology · doi:10.1007/978-1-0716-2910-9_5 · Cited by 5
Metadata
- Authors
- Heinz, F. X., & Stiasny, K.
- Venue
- npj Vaccines
- Published
- 2021-08-16
- Volume
- 6
- Issue
- 1
- Pages
- 104-104
- ISSN
- 2059-0105 (ISSN-L)
- OpenAlex
- W3193676801
- Cited by
- 363
- References
- 143
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- gold
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