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MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1/TLR4/NF-κB pathway

HU, YUJIE, HU, CHONG, YIN, JIERONG, ZHONG, JIALING, DENG, YUAN, YANG, GUOSHUAI·2023·Anais da Academia Brasileira de Ciências
DOI 10.1590/0001-3765202320220750
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Abstract

Sleep deprivation (SD) can lead to cognitive impairment caused by neuroinflammation. MiR-181c-5p/HMGB1 axis plays a part in anti-inflammation effects. However, the mechanism that miR-181c-5p facilitates learning and memory in SD mice remains unclear. So we investigated the role of miR-181c-5p in learning and memory impairment induced by SD. We overexpressed miR-181c-5p in the mice hippocampus by injecting lentivirus vector-miR-181c-5p (LV-miR-181c-5p) particles. Mice were divided into four groups: control (Ctrl), SD, SD + miR-181c-5p and SD + vector. We found that mice in the third group showed ameliorated learning and memory compared with the fourth group. The content of ionized calcium binding adaptor molecule 1 (IBA-1) in the third group was decreased compared with the fourth group. Moreover, the expression levels of HMGB1, TLR4 and p-NF-κB in the hippocampus of overexpressed miR-181c-5p mice were reduced. In total, miR-181c-5p ameliorated learning and memory in SD mice via the HMGB1/TLR4/NF-κB pathway.

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Metadata

Authors
HU, Y., HU, C., YIN, J., ZHONG, J., DENG, Y., & YANG, G.
Affiliations
Central South University Xiangya School of Medicine Affiliated Haikou Hospital, China
ORCID
Venue
Anais da Academia Brasileira de Ciências
Publisher
FapUNIFESP (SciELO)
Published
2023
Volume
95
Issue
suppl 1
ISSN
  • 1678-2690
  • 0001-3765
DOI
10.1590/0001-3765202320220750
Cited by
4
References
3
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