Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis
Open accessAbstract
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cognitive processes, and cognitive impairment in Parkinson's disease (PD), but with contradictory findings. Thus, this meta-analysis was performed to clarify the possible association. Relevant studies were identified by a systematic search of PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases. The strength of the association was evaluated using crude odds ratios and 95% confidence interval. Finally, six studies involving 532 cases and 802 controls were included. Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. In conclusion, BDNF G196A (Val66Met) is confirmed to be a risk factor for cognitive impairment in PD.
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The BDNF Val66Met polymorphism is associated with cognitive processes and cognitive impairment in neurodegenerative disease such as Parkinson's disease and Alzheimer's disease, and with several brain disorders including MDD, bipolar disorder, epilepsy, schizophrenia, aging and dementia, and stroke.
“More specifically, BDNF Val66Met polymorphism is associated with cognitive processes [112,123,124,125,126,127], and cognitive impairment in neurodegenerative disease, such as Parkinson’s disease (PD) [128,129] and AD [130,131], and even more with several brain disorders, including MDD and bipolar disorder [132,133,134,135,136,137], epilepsy [138,139,140], schizophrenia [125,141,142,143,144], aging”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [129]
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- Authors
- Wang, Q., Liu, J., Guo, Y., Dong, G., Zou, W., & Chen, Z.
- Affiliations
- Changzhou No.2 People's Hospital (CN)
- Venue
- Brazilian Journal of Medical and Biological Research
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2019
- Volume
- 52
- Issue
- 8
- Pages
- e8443-e8443
- ISSN
- 0100-879X (ISSN-L)
- 1414-431X
- PMC
- PMC6668960
- OpenAlex
- W2965523024
- Cited by
- 45
- References
- 40
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 4 · 2021: 7 · 2020: 5
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brazilian Journal of Medical and Biological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, Parkinson's disease, cognitive impairment, genetic risk factors, dopaminergic neurons, substantia nigra, Caucasian population
- MeSH terms
- Alzheimer Disease, Female, Genotype, Humans, Male, Parkinson Disease, Risk Factors, Odds Ratio, Case-Control Studies, Brain-Derived Neurotrophic Factor, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, White People, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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