Cited by 186Lipid metabolism and biosynthesisLipid metabolism and disordersAdipose Tissue and Metabolism

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Lipolysis and lipases in white adipose tissue – An update

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Bolsoni-Lopes, Andressa, Alonso-Vale, Maria Isabel C.·2015·Archives of Endocrinology and Metabolism

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Abstract

Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and characterize the actions of this lipase, as well as of other proteins and possible regulatory mechanisms involved, which reformulated the concept of lipolysis. Novel findings from these studies include the identification of lipolytic products as signaling molecules regulating important metabolic processes in many non-adipose tissues, unveiling a previously underestimated aspect of lipolysis. Thus, we present here an updated review of concepts and regulation of white adipocyte lipolysis with a special emphasis in its role in metabolism homeostasis and as a source of important signaling molecules.

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Authors: Bolsoni-Lopes, A., & Alonso-Vale, M. I. C.
Affiliations: Universidade de São Paulo, Brazil
Universidade Federal de São Paulo, Brazil
Venue: Archives of Endocrinology and Metabolism
Publisher: Archives of Endocrinology and Metabolism
Published: 2015-08
Volume: 59
Issue: 4
Pages: 335-342
ISSN: 2359-3997 (ISSN-L)
DOI: 10.1590/2359-3997000000067
OpenAlex: W2200889199
Cited by: 183
References: 69
Citations by year: 2026: 8 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 29 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 16 · 2017: 7 · 2016: 7
FWCI: 0.94
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
Locations: Archives of Endocrinology and Metabolism (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, cc-by-nc)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: lipolysis, white adipose tissue, adipocytes, hormone-sensitive lipase, monoacylglycerol lipase, adipose triglyceride lipase, lipid droplets, metabolic homeostasis
MeSH terms: Humans, Lipase, Lipolysis, Adipose Tissue, White

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Lipolysis and lipases in white adipose tissue – An update

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