The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Lipolysis and lipases in white adipose tissue – An update
Open accessAbstract
Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and characterize the actions of this lipase, as well as of other proteins and possible regulatory mechanisms involved, which reformulated the concept of lipolysis. Novel findings from these studies include the identification of lipolytic products as signaling molecules regulating important metabolic processes in many non-adipose tissues, unveiling a previously underestimated aspect of lipolysis. Thus, we present here an updated review of concepts and regulation of white adipocyte lipolysis with a special emphasis in its role in metabolism homeostasis and as a source of important signaling molecules.
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“Similar AKG‐induced WAT lipolysis was also indicated by upregulated RER and increased expression of ATGL and p‐HSL, the main enzymes catalyzing lipolysis in WAT (Bolsoni‐Lopes & Alonso‐Vale, 2015).”
From Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation (2020) · cites this paper as Bolsoni‐Lopes & Alonso‐Vale, 2015
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Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375
FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S. D., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,169
Regulation of Lipolysis in Adipocytes
Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021
Brasaemle, D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 997
Lipolysis and lipid mobilization in human adipose tissue
Lafontan, M., & Langin, D. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.05.001 · Cited by 884
Jenkins, C. M., Mancuso, D. J., Yan, W., Sims, H. F., Gibson, B., & Gross, R. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407841200 · Cited by 778
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767
Adipose tissue as a buffer for daily lipid flux
Frayn, K. (2002) · Diabetologia · doi:10.1007/s00125-002-0873-y · Cited by 752
Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacobsen, P., Tornqvist, H. E., Zechner, R., & Zimmermann, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608048200 · Cited by 739
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Metadata
- Authors
- Bolsoni-Lopes, A., & Alonso-Vale, M. I. C.
- Affiliations
- Universidade de São Paulo, Brazil
- Universidade Federal de São Paulo, Brazil
- Venue
- Archives of Endocrinology and Metabolism
- Published
- 2015-08
- Volume
- 59
- Issue
- 4
- Pages
- 335-342
- ISSN
- 2359-3997 (ISSN-L)
- OpenAlex
- W2200889199
- Cited by
- 183
- References
- 69
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 29 · 2021: 33 · 2020: 24 · 2019: 17 · 2018: 16 · 2017: 7 · 2016: 7
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Archives of Endocrinology and Metabolism (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- lipolysis, white adipose tissue, adipocytes, hormone-sensitive lipase, monoacylglycerol lipase, adipose triglyceride lipase, lipid droplets, metabolic homeostasis
- MeSH terms
- Humans, Lipase, Lipolysis, Adipose Tissue, White
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