Effect of highly active antiretroviral therapy on vaginal candida spp. isolation in HIV-infected compared to HIV-uninfected women
Open accessAbstract
Vulvovaginal candidiasis (VVC) in HIV-infected women contributed to the impairment of their quality of life. The aim of this study was to evaluate the effect of highly active antiretroviral therapy (HAART) use on the vaginal Candida spp. isolation in HIV-infected compared to HIV-uninfected women. This cross-sectional study included 178 HIV-infected (HIV group) and 200 HIV-uninfected women (control) that were studied at the Specialized Assistance Service (SAE) for sexually transmitted diseases (STD)/AIDS of the city of Maringá, Brazil, from April 1 to October 30, 2011. The yeasts were isolated and identified by phenotypic and molecular methods. The in vitro antifungal susceptibility to fluconazole, itraconazole, nystatin and amphotericin B was tested by the reference microdilution method. Higher frequencies of total vaginal Candida spp. isolation were found in the HIV-infected group than in the control group. However, both groups showed a similar frequency of colonization and VVC. Although C. albicans was the most frequent and sensitive to azolics and polyenes in both HIV-infected and uninfected women, the emerging resistance of C. glabrata to amphotericin B in the HIV-infected women was observed. Although higher frequency of vaginal Candida spp. isolation had been observed in the HIV-infected than in HIV-uninfected women, colonization and VVC showed similar frequency in both groups, indicating that HAART appears to protect against vaginal colonization and VVC.
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HIV infection is associated with more frequent episodes of RVVC.
“Infection with the human immunodeficiency virus (HIV) is also associated with more frequent episodes of RVVC (Fischer and Bradford, 2011; Alczuk Sde et al., 2015; Mohammed et al., 2021).”
From Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion (2022) · cites this paper as Alczuk Sde et al., 2015
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- Authors
- ALCZUK, S. D. S. D., BONFIM-MENDONÇA, P. D. S., ROCHA-BRISCHILIARI, S. C., SHINOBU-MESQUITA, C. S., MARTINS, H. P. R., GIMENES, F., ABREU, A. L. P. D., CARVALHO, M. D. D. B., PELLOSO, S. M., SVIDZINSKI, T. I. E., & CONSOLARO, M. E. L.
- Affiliations
- Universidade Estadual de Maringá (BR)
- State University of Maringá, Brazil
- ORCID
- Venue
- Revista do Instituto de Medicina Tropical de São Paulo
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2015-04
- Volume
- 57
- Issue
- 2
- Pages
- 169-174
- ISSN
- 0036-4665 (ISSN-L)
- PMC
- PMC4435017
- OpenAlex
- W1981545977
- Cited by
- 15
- References
- 26
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Revista do Instituto de Medicina Tropical de São Paulo (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The Scientific Electronic Library Online (Fundação de Amparo à Pesquisa do Estado de São Paulo) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (AUX-PE-PRODOC 2571/2010)
- Fundação Araucária
- Ministério da Saúde
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- highly active antiretroviral therapy, HIV infection, vaginal candidiasis, Candida albicans, Candida glabrata, antifungal susceptibility, amphotericin B resistance, vaginal colonization, women
- MeSH terms
- Adolescent, Adult, Antifungal Agents, Candida, Candidiasis, Vulvovaginal, Cross-Sectional Studies, Female, Humans, Microbial Sensitivity Tests, Socioeconomic Factors, Case-Control Studies, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Young Adult
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