Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 5

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation?

Scuarcialupi, Maria Enedina Aquino, Berton, Danilo Cortozi, Cordoni, Priscila Kessar, Squassoni, Selma Denis, Fiss, Elie, Neder, José Alberto·2014·Jornal Brasileiro de Pneumologia
DOI 10.1590/s1806-37132014000200003
Open this paper in CoChat — free account

Abstract

OBJECTIVE: To investigate the modulatory effects that dynamic hyperinflation (DH), defined as a reduction in inspiratory capacity (IC), has on exercise tolerance after bronchodilator in patients with COPD. METHODS: An experimental, randomized study involving 30 COPD patients without severe hypoxemia. At baseline, the patients underwent clinical assessment, spirometry, and incremental cardiopulmonary exercise testing (CPET). On two subsequent visits, the patients were randomized to receive a combination of inhaled fenoterol/ipratropium or placebo. All patients then underwent spirometry and submaximal CPET at constant speed up to the limit of tolerance (Tlim). The patients who showed ΔIC(peak-rest) < 0 were considered to present with DH (DH+). RESULTS: In this sample, 21 patients (70%) had DH. The DH+ patients had higher airflow obstruction and lower Tlim than did the patients without DH (DH-). Despite equivalent improvement in FEV1 after bronchodilator, the DH- group showed higher ΔIC(bronchodilator-placebo) at rest in relation to the DH+ group (p < 0.05). However, this was not found in relation to ΔIC at peak exercise between DH+ and DH- groups (0.19 ± 0.17 L vs. 0.17 ± 0.15 L, p > 0.05). In addition, both groups showed similar improvements in Tlim after bronchodilator (median [interquartile range]: 22% [3-60%] vs. 10% [3-53%]; p > 0.05). CONCLUSIONS: Improvement in TLim was associated with an increase in IC at rest after bronchodilator in HD- patients with COPD. However, even without that improvement, COPD patients can present with greater exercise tolerance after bronchodilator provided that they develop DH during exercise.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1590/s1806-37132014000200003

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 8 references

Research works printed but not linked: 22

  1. O'Donnell DE, 2006, Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease, Proc Am Thorac Soc, 3, 180, 10.1513/pats.200508-093DO · DOI · Paper page
  2. O'Donnell DE, 2000, Assessment of bronchodilator efficacy in symptomatic COPD: is spirometry useful?, Chest, 117, 42S, 10.1378/chest.117.2_suppl.42S · DOI · Paper page
  3. Casaburi R, 2006, Reduction of hyperinflation by pharmacologic and other interventions, Proc Am Thorac Soc, 3, 185, 10.1513/pats.200508-095DO · DOI · Paper page
  4. Yan S, 1997, Reliability of inspiratory capacity for estimating end-expiratory lung volume changes during exercise in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 156, 55, 10.1164/ajrccm.156.1.9608113 · DOI
  5. Stubbing DG, 1980, Pulmonary mechanics during exercise in subjects with chronic airflow obstruction, J Appl Physiol Respir Environ Exerc Physiol, 49, 511
  6. Albuquerque AL, 2006, Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III, Eur Respir J, 28, 939, 10.1183/09031936.06.00040506 · DOI · Paper page
  7. O'Donnell DE, 2012, Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise, Chest, 141, 753, 10.1378/chest.11-0787 · DOI · Paper page
  8. Vestbo J, 2013, Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary, Am J Respir Crit Care Med, 187, 347, 10.1164/rccm.201204-0596PP · DOI · Paper page
  9. Neder JA, 1999, Reference values for lung function tests: II. Maximal respiratory pressures and voluntary ventilation, Braz J Med Biol Res, 32, 719, 10.1590/S0100-879X1999000600007 · DOI
  10. Borg GA, 1982, Psychophysical bases of perceived exertion, Med Sci Sports Exerc, 14, 377
  11. Johnson BD, 2009, Emerging concepts in the evaluation of ventilatory limitation during exercise: the exercise tidal flow-volume loop, Chest, 116, 488, 10.1378/chest.116.2.488 · DOI
  12. Pereira CA, 2002, Espirometria, J Pneumol, 28, S1
  13. Neder JA, 2007, Effects of formoterol on exercise tolerance in severely disabled patients with COPD, Respir Med, 101, 2056, 10.1016/j.rmed.2007.06.006 · DOI · Paper page
  14. Berton DC, 2010, Effects of tiotropium and formoterol on dynamic hyperinflation and exercise endurance in COPD, Respir Med, 104, 1288, 10.1016/j.rmed.2010.05.017 · DOI · Paper page
  15. O'Donnell DE, 2006, Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD, J Appl Physiol, 101, 1025, 10.1152/japplphysiol.01470.2005 · DOI · Paper page
  16. Laveneziana P, 2011, Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints, Am J Respir Crit Care Med, 184, 1367, 10.1164/rccm.201106-1128OC · DOI
  17. Takara LS, 2012, Dynamics of chest wall volume regulation during constant work rate exercise in patients with chronic obstructive pulmonary disease, Braz J Med Biol Res, 45, 1276, 10.1590/S0100-879X2012001200024 · DOI
  18. Cordoni PK, 2012, Dynamic hyperinflation during treadmill exercise testing in patients with moderate to severe COPD, J Bras Pneumol, 38, 13
  19. Guenette JA, 2012, Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD, Eur Respir J, 40, 322, 10.1183/09031936.00157711 · DOI · Paper page
  20. O'Donnell DE, 1998, General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation, Am J Respir Crit Care Med, 157, 1489, 10.1164/ajrccm.157.5.9708010 · DOI
  21. O'Donnell DE, 1997, Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation, Am J Respir Crit Care Med, 155, 530, 10.1164/ajrccm.155.2.9032190 · DOI
  22. Aliverti A, 2005, Effect of salbutamol on lung function and chest wall volumes at rest and during exercise in COPD, Thorax, 60, 916, 10.1136/thx.2004.037937 · DOI

Cited by

See all 5

Metadata

Authors
Scuarcialupi, M. E. A., Berton, D. C., Cordoni, P. K., Squassoni, S. D., Fiss, E., & Neder, J. A.
Venue
Jornal Brasileiro de Pneumologia
Publisher
FapUNIFESP (SciELO)
Published
2014-04
Volume
40
Issue
2
Pages
111-118
ISSN
1806-3713
DOI
10.1590/s1806-37132014000200003
Cited by
5
References
8

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation? https://app.cochat.ai/papers/10.1590/s1806-37132014000200003
The paper
Scuarcialupi, M. E. A., Berton, D. C., Cordoni, P. K., Squassoni, S. D., Fiss, E., & Neder, J. A. (2014). Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation? Jornal Brasileiro de Pneumologia. https://doi.org/10.1590/s1806-37132014000200003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.