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Cited by 24Dementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesNeural and Behavioral Psychology Studies

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The INECO Frontal Screening tool differentiates behavioral variant - frontotemporal dementia (bv-FTD) from major depression

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Fiorentino, Natalia, Gleichgerrcht, Ezequiel, Roca, María, Cetkovich, Marcelo, Manes, Facundo, Torralva, Teresa·2013·Dementia & Neuropsychologia
DOI 10.1590/s1980-57642013dn70100006PMC PMC5619542
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Abstract

ABSTRACT Executive dysfunction may result from prefrontal circuitry involvement occurring in both neurodegenerative diseases and psychiatric disorders. Moreover, multiple neuropsychiatric conditions, may present with overlapping behavioral and cognitive symptoms, making differential diagnosis challenging, especially during earlier stages. In this sense, cognitive assessment may contribute to the differential diagnosis by providing an objective and quantifiable set of measures that has the potential to distinguish clinical conditions otherwise perceived in everyday clinical settings as quite similar. Objective: The goal of this study was to investigate the utility of the INECO Frontal Screening (IFS) for differentiating bv-FTD patients from patients with Major Depression. Methods: We studied 49 patients with bv-FTD diagnosis and 30 patients diagnosed with unipolar depression compared to a control group of 26 healthy controls using the INECO Frontal Screening (IFS), the Mini Mental State Examination (MMSE) and the Addenbrooke's Cognitive Examination-Revised (ACE-R). Results: Patient groups differed significantly on the motor inhibitory control (U=437.0, p<0.01), verbal working memory (U=298.0, p<0.001), spatial working memory (U=300.5, p<0.001), proverbs (U=341.5, p<0.001) and verbal inhibitory control (U=316.0, p<0.001) subtests, with bv-FTD patients scoring significantly lower than patients with depression. Conclusion: Our results suggest the IFS can be considered a useful tool for detecting executive dysfunction in both depression and bv-FTD patients and, perhaps more importantly, that it has the potential to help differentiate these two conditions.

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  • On the IFS, patients with bvFTD scored significantly worse on several sub-items than subjects with major depression and bipolar disorder.

    “On the IFS, however, patients with bvFTD scored significantly worse on several sub-items than subjects with major depression and bipolar disorder (Fiorentino et al. , 2013).”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Fiorentino et al., 2013

    The Results report significantly lower bv-FTD scores than depression scores on five IFS subtests. The Methods identify the comparison group as patients with unipolar depression; the cited study does not support the claim about bipolar disorder. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

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References 46 · Cited by 24

Research works printed but not linked: 27

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Metadata

Authors
Fiorentino, N., Gleichgerrcht, E., Roca, M., Cetkovich, M., Manes, F., & Torralva, T.
Affiliations
Instituto de Neurología Cognitiva (AR)
Corresponding author
Torralva, Teresa
ORCID
Venue
Dementia & Neuropsychologia
Publisher
FapUNIFESP (SciELO)
Published
2013-03
Volume
7
Issue
1
Pages
33-39
ISSN
1980-5764 (ISSN-L)
DOI
10.1590/s1980-57642013dn70100006
PMC
PMC5619542
OpenAlex
W2282955345
Cited by
24
References
46
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Dementia & Neuropsychologia (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Redalyc (Universidad Autónoma del Estado de México) (submittedVersion)
Funders
Fundación INECO
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
behavioral variant frontotemporal dementia, major depressive disorder, differential diagnosis, executive dysfunction, frontal lobe, inhibitory control, working memory, neuropsychiatric symptoms, cognitive assessment

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