Cited by 502Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsDrug Solubulity and Delivery Systems

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Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

Kwon, Glen S.·2003·Critical Reviews in Therapeutic Drug Carrier Systems

DOI 10.1615/critrevtherdrugcarriersyst.v20.i5.20

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Abstract

Amphiphilic polymers assemble into nanoscopic supramolecular core-shell structures, termed polymeric micelles, which are under extensive study for drug delivery. There are several reasons for this growing interest. Polymeric micelles maybe safe for parenteral administration relative to existing solubilizing agents (for instance, Cremophor EL), permitting an increase in the dose of potent yet toxic and poorly water soluble compounds. Polymeric micelles solubilize important poorly water-soluble compounds, such as amphotericin B (AmB), propofol, paclitaxel, and photosensitizers. A major factor in drug solubilization is the compatibility of a drug and a core of a polymeric micelle. In this context, we may consider Pluronics, poly(ethylene glycol) (PEG)-phospholipid conjugates, PEG-b-poly(ester)s, and PEG-b-poly(L-amino acid)s for drug delivery. Polymeric micelles may circulate for prolonged periods in blood, evade host defenses, and gradually release drug. Thus, they may show a preferential accumulation at sites of disease such as solid tumors. Polymeric micelles inhibit p-glycoprotein at drug-resistant tumors, gastrointestinal tract, and blood/brain barrier, perhaps providing a way to overcome drug resistance in cancer and increase drug absorption from the gut and drug absorption into the brain. Lastly, polymeric micelles may reduce the self-aggregation of polyene antibiotics, key membrane-acting drugs used to combat life-threatening systemic fungal diseases. In this way, they may reduce its dose-limiting toxicity without a loss of antifungal activity.

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Background

Authors: Kwon, G. S.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Kwon, Glen S.
ORCID: Kwon, Glen S.
Venue: Critical Reviews in Therapeutic Drug Carrier Systems
Publisher: Begell House
Published: 2003
Volume: 20
Issue: 5
Pages: 357-403
ISSN: 0743-4863 (ISSN-L)
DOI: 10.1615/critrevtherdrugcarriersyst.v20.i5.20
OpenAlex: W2082105104
Cited by: 502
References: 0
Citations by year: 2026: 8 · 2025: 11 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 20 · 2014: 28 · 2013: 36 · 2012: 35
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Therapeutic Drug Carrier Systems (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-43346-06)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: polymeric micelles, poorly water-soluble drugs, drug solubilization, drug delivery, amphotericin B, propofol, paclitaxel, photosensitizers, poloxamer, tumor targeting, P-glycoprotein inhibition, drug resistance, polyene antibiotics, antifungal agents, parenteral administration
MeSH terms: Drug Stability, Pharmaceutical Preparations, Humans, Micelles, Pharmacokinetics, Polyethylene Glycols, Solubility, Surface-Active Agents, Water, Poloxamer

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Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

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