Cited by 502Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsDrug Solubulity and Delivery Systems

The DOI matches its Crossref record.

Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

Kwon, Glen S.·2003·Critical Reviews in Therapeutic Drug Carrier Systems

DOI 10.1615/critrevtherdrugcarriersyst.v20.i5.20

Open this paper in CoChat — free account

Abstract

Amphiphilic polymers assemble into nanoscopic supramolecular core-shell structures, termed polymeric micelles, which are under extensive study for drug delivery. There are several reasons for this growing interest. Polymeric micelles maybe safe for parenteral administration relative to existing solubilizing agents (for instance, Cremophor EL), permitting an increase in the dose of potent yet toxic and poorly water soluble compounds. Polymeric micelles solubilize important poorly water-soluble compounds, such as amphotericin B (AmB), propofol, paclitaxel, and photosensitizers. A major factor in drug solubilization is the compatibility of a drug and a core of a polymeric micelle. In this context, we may consider Pluronics, poly(ethylene glycol) (PEG)-phospholipid conjugates, PEG-b-poly(ester)s, and PEG-b-poly(L-amino acid)s for drug delivery. Polymeric micelles may circulate for prolonged periods in blood, evade host defenses, and gradually release drug. Thus, they may show a preferential accumulation at sites of disease such as solid tumors. Polymeric micelles inhibit p-glycoprotein at drug-resistant tumors, gastrointestinal tract, and blood/brain barrier, perhaps providing a way to overcome drug resistance in cancer and increase drug absorption from the gut and drug absorption into the brain. Lastly, polymeric micelles may reduce the self-aggregation of polyene antibiotics, key membrane-acting drugs used to combat life-threatening systemic fungal diseases. In this way, they may reduce its dose-limiting toxicity without a loss of antifungal activity.

Integrity signals

Registry

Crossref · 10.1615/critrevtherdrugcarriersyst.v20.i5.20

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 301–400 of 502

Arthropod venom peptides: Nanotechnology-enabled delivery and therapeutic potential in cancer treatment
Ghodeif, S. K., El-Fahla, N. A., Abdel-Rahman, M. A., et al. (2025) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2025.03.005 · Cited by 16
“21,22 Owing to the side effects associated with traditional therapies, research is ongoing to focus on new drugs developed from natural sources.”
Polymeric micelle-based drug delivery systems for tuberculosis treatment
Gorain, B., Choudhury, H., Sisinthy, S. P., & Kesharwani, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819811-7.00011-4 · Cited by 20
Revolutionizing cancer treatment: the rise of personalized immunotherapies
Fayyaz, A., Haqqi, A., Khan, R., Irfan, M., Khan, K., Reiner, Ž., Sharifi‐Rad, J., & Călina, D. C. (2024) · Discover Oncology · doi:10.1007/s12672-024-01638-1 · Cited by 18
A Comprehensive Review on Targeted Cancer Therapy: New Face of Treatment Approach
Karati, D., & Kumar, D. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128272203231121034814 · Cited by 15
Nano-based Drug Delivery and Diagnostic Systems
Kumar, N., & Kumar, R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-323-26433-4.00002-6 · Cited by 17
Fluoridated hydroxyapatite: Eu 3+ nanorods-loaded folate-conjugated D- α -tocopheryl polyethylene glycol succinate (vitamin E TPGS) micelles for targeted imaging of cancer cells
Wan, D., Liu, W., Wang, L., Wang, H., & Pan, J. (2016) · Nanotechnology · doi:10.1088/0957-4484/27/10/105703 · Cited by 15
Hydrotropic Nanocarriers for Poorly Soluble Drugs
Ooya, T., Lee, S. C., Huh, K. M., & Park, K. (2006) · Springer eBooks · doi:10.1007/978-1-4020-5041-1_4 · Cited by 15
“For this reason, micelles from amphiphilic block copolymers are more stable and so they have attracted a lot of attention as vehicles for solubilization and delivery of poorly water-soluble drugs [ 36- 39 ].”
Background
Formulation and evaluation of glimepiride solid dispersion tablets
Gill, B., Kaur, T., Kumar, S., et al. (2010) · Asian Journal of Pharmaceutics · doi:10.22377/ajp.v4i3.221 · Cited by 15
“Poloxamer 188 (PXM 188) is a nonionic block copolymer composed of two hydrophilic polyoxyethylene chains and connected by a hydrophobic polyoxypropylene chain, and has been used by researchers to increase the aqueous solubility of poorly water-soluble drugs.[21-23,2426] PXM 188 was thus selected as a carrier for disso…”
Background
All-trans retinoic acid loaded block copolymer nanoparticles efficiently induce cellular differentiation in HL-60 cells
Tiwari, M. D., Mehra, S., Jadhav, S., & Bellare, J. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.014 · Cited by 16
Nanotechnology in Vaccine Development
Panda, A. K. (2012) · Proceedings of the National Academy of Sciences India Section B Biological Sciences · doi:10.1007/s40011-012-0073-6 · Cited by 16
Bioactive Albumin-Based Carriers for Tumour Chemotherapy
Shahzad, Y., Khan, I. U., Hussain, T., et al. (2014) · Current Cancer Drug Targets · doi:10.2174/1568009614666141028100640 · Cited by 15
“Secondly, antineoplastic agents lack selectivity for tumour cells and cause significant damage to rapidly dividing normal cells [21, 22].”
Background
Ring-Opening Polymerization of ε-Caprolactone Initiated by Ganciclovir (GCV) for the Preparation of GCV-Tagged Polymeric Micelles
Sawdon, A. J., & Peng, C. (2015) · Molecules · doi:10.3390/molecules20022857 · Cited by 15
“In recent years, polymeric micelles have been the focus of much interest as alternative vehicles for the solubilization of poorly water-soluble molecules rendering clear advantages over current solubilizing agents in drug delivery [10].”
Background
Poly(vinyl alcohol)-based Amphiphilic Copolymer Aggregates as Drug Carrying Nanoparticles
Nagy, M., Szöllősi, L., Kéki, S., Faust, R., & Zsuga, M. (2009) · Journal of Macromolecular Science Part A · doi:10.1080/10601320902719370 · Cited by 15
The second annual symposium on nanomedicine and drug delivery: exploring recent developments and assessing major advances
Vinogradov, S. V. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.181 · Cited by 15
“Nanofibres formulated with growth factors and adhesion molecules may be combined for fabricating multilayers and networks with living cells [9,10].”
Background
Preparation, characterization and in vitro study of bellidifolin nano-micelles
Gao, F., Chen, Z., Zhou, L., Xiao, X., Wang, L., Liu, X., Wang, C., & Guo, Q.-H. (2022) · RSC Advances · doi:10.1039/d2ra02779h · Cited by 15
Pharmacokinetics and Renal Toxicity of Monomeric Amphotericin B in Rats after a Multiple Dose Regimen
Kang, J. Y., Gao, J., Shin, D. H., Alvarez, C., Zhong, W., & Kwon, G. S. (2016) · Pharmaceutical Nanotechnology · doi:10.2174/2211738504666160301233754 · Cited by 14
Self-citation
Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines
Gonçalves, C., Gomez, J., Même, W., Rasolonjatovo, B., Gosset, D., Nédellec, S., Hulin, P., Huin, C., Gall, T. L., Montier, T., et al. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.04.015 · Cited by 14
“Such copolymers have already received large attentions to solubilize hydrophobic molecules for drug delivery [4,5].”
Background
Switching from Conventional to Nano-natural Phytochemicals to Prevent and Treat Cancers: Special Emphasis on Resveratrol
Islam, S. U., Ahmed, M. B., Ul‐Islam, M., et al. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191009161018 · Cited by 14
Emerging Nanotechnology for the Treatment of Alzheimer’s Disease
Singh, A., Ansari, V. A., Mahmood, T., Ahsan, F., Wasim, R., Maheshwari, S., Shariq, M., Parveen, S., & Shamim, A. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230501232815 · Cited by 14
Biodegradable polymeric micelles for drug delivery applications
Bölgen, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-101997-9.00027-8 · Cited by 14
Evolution of Reactive mPEG Polymers for the Conjugation of Peptides and Proteins
González, M., & Vaillard, S. E. (2013) · Current Organic Chemistry · doi:10.2174/1385272811317090010 · Cited by 14
“Furthermore, the PEGylation of proteins: i) decreases the immunogenicity by shielding antigenic epitopes, a major drawback with heterologous proteins; ii) reduces the degradation by proteolytic enzymes and antibody recognition by covering the recognition sites [6]; iii) increases water solubility, which can be can be…”
Background
Biodegradable self-assembly micelles significantly enhanced the solubility, biological stability and in vivo antitumor efficacy of Hexylselen
Fang, J., Chen, Z., Song, J., Li, J., Han, Y., Hou, W., Wang, W., & Ruan, B. H. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00089f · Cited by 14
Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
Staroverov, S. A., Сидоркин, В. А., Fomin, A. S., et al. (2011) · Journal of Veterinary Science · doi:10.4142/jvs.2011.12.4.303 · Cited by 13
“In the past few years, research has shown that these may serve as a basis for the development of effective targeted delivery systems for high- and low-molecular weight compounds [1,3,5,9, 15].”
Background
Polymeric micelles with small lipophilic moieties for drug delivery
Li, D., Liang, Y., Lai, Y., Wang, G., He, B., & Gu, Z. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.10.032 · Cited by 13
In Vitro Release Test of Nano-drug Delivery Systems Based on Analytical and Technological Perspectives
Nemutlu, E., Eroğlu, İ., Eroğlu, H., & Kır, S. (2018) · Current Analytical Chemistry · doi:10.2174/1573411014666180912125931 · Cited by 13
pH Sensitive Chitosan-based Supramolecular Gel for Oral Drug Delivery of Insulin
A, S. M. M. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000170 · Cited by 13
“4) were prepared according to the method described in the literature [21].”
Method
Novel microencapsulated Pluronic–chitosan nanomicelles for lung delivery
Lin, H., Li, Y., & Lin, Y. (2016) · Colloid & Polymer Science · doi:10.1007/s00396-016-3879-6 · Cited by 13
“improve drug absorption and increase bioavailability [13, 14].”
Metal nanoparticles synthesis: an overview of different synthesis methods, mode of action and their biomedical application
Muthukrishnan, S., Bhakya, S., & Ramalingam, V. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-07210-y · Cited by 13
“Most of the anticancer drugs have poor solubility and low bioavailability, and are formulated with toxic solvents [12].”
Research progress of ophthalmic preparations of immunosuppressants
Liu, Y., Xu, H., Yan, N., Tang, Z., & Wang, Q. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2175925 · Cited by 15
Styrene maleic acid anhydride copolymer (SMA) for the encapsulation of sparingly water-soluble drugs in nanoparticles
Yamamoto, S., Kaneo, Y., & Maeda, H. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50035-9 · Cited by 12
AFM Characterization of Elastically Micropatterned Surfaces Fabricated by Fill‐Molding In Capillaries (FIMIC) and Investigation of the Topographical Influence on Cell Adhesion to the Patterns
Kelleher, S. M., Jongerius, A., Loebus, A., Strehmel, C., Zhang, Z., & Lensen, M. C. (2012) · Advanced Engineering Materials · doi:10.1002/adem.201180087 · Cited by 12
A Review On Polymeric Micellar Nanocarriers
Dhembre, G. N., & Kshirsagar, R. V. (2011) · International Journal of Pharma and Bio Sciences · Cited by 13
Preparation of core-crosslinked linear-dendritic copolymer micelles with enhanced stability and their application for drug solubilisation
Zhou, Z., Forbes, R. T., & D’Emanuele, A. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.03.032 · Cited by 12
Nanoparticles drug-delivery systems and antiangiogenic approaches in the treatment of gliomas
Caffo, M., Cardali, S., Fazzari, E., Barresi, V., & Caruso, G. (2018) · Glioma · doi:10.4103/glioma.glioma_43_18 · Cited by 12
“Moreover, most chemotherapeutic agents have poor solubility and are mixed with toxic solvents.[10] NP-based DDSs provide better penetration of therapeutic and diagnostic agents enabling achievement of efficacy with reduced doses and systemic concentration of drugs.”
Background
Structural Aspect of Hydroxyethyl-Starch–Anticancer-Drug-Conjugates as State-of-the-Art Drug Carriers
Chandra, K., Dutta, S., Kolya, H., & Kang, C. (2023) · Scientia Pharmaceutica · doi:10.3390/scipharm91030032 · Cited by 11
Uptake of Imatinib-Loaded Polyelectrolyte Complexes by BCR-ABL + Cells: A Long-Acting Drug-Delivery Strategy for Targeting Oncoprotein Activity
Palamà, I. E., Coluccia, A. M. L., & Gigli, G. (2013) · Nanomedicine · doi:10.2217/nnm.13.147 · Cited by 11
Nanotechnology and Its Applications in Drug Delivery: A Review
Gupta, A. K., Arora, A., Menakshi, A., Sehgal, A., & Sehgal, R. (2012) · Cited by 11
Adipocytes differentiation in the presence of Pluronic F127–coated carbon nanotubes
Bardi, G., Vittorio, O., Maffei, M., et al. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.01.016 · Cited by 11
Buccal absorption of propofol when dosed in 1-perfluorobutylpentane to anaesthetised and conscious Wistar rats and Göttingen mini-pigs
Tsagogiorgas, C., Theisinger, S., Holm, P., et al. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.06.013 · Cited by 11
Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs
Gu, J., Cheng, W. P., Hoskins, C., Lin, P. K. T., Zhao, L., Zhu, L., Qu, X., & Yang, Z. (2011) · Journal of Microencapsulation · doi:10.3109/02652048.2011.615951 · Cited by 11
Glycosylated paclitaxel mixed nanomicelles: Increasing drug brain accumulation and enhancing its in vitro antitumoral activity in glioblastoma cell lines
Riedel, J., Pibuel, M. A., Bernabeu, E., Poodts, D., Díaz, M., Allo, M. Á., Parola, L., Hajos, S. E., Martínez, J. M. L., Salgueiro, M. J., et al. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.103046 · Cited by 11
CTAB induced growth and shrinkage of Pluronics® P103 micelles: Experimental and theoretical rationale
Patel, D., Tripathi, N., Ray, D., et al. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123315 · Cited by 10
Nanobiomaterials
Singh, T. G., Dhiman, S., Jindal, M. K., et al. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-41533-0.00013-1 · Cited by 10
Interaction of an Amphiphilic Drug Trifluoperazine Dihydrochloride with Pluronic Triblock Copolymers: A Physicochemical Study
Mahajan, R. K., Chabba, S., & Sharma, R. (2014) · Industrial & Engineering Chemistry Research · doi:10.1021/ie403828u · Cited by 10
Nanotherapeutic Platforms for Cancer Treatment: From Preclinical Development to Clinical Application
Egusquiaguirre, S. P., Pedraz, J. L., Hernández, R. M., & Igartua, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-47347-7.00029-x · Cited by 12
Exploring Aqueous Solution Dynamics of an Amphiphilic Diblock Copolymer: Dielectric Relaxation and Time-Resolved Fluorescence Measurements
Tarif, E., Saha, B., Mukherjee, K., De, P., & Biswas, R. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b00889 · Cited by 10
Development and Challenges of Synthetic Retinoid Formulations in Cancer
Assi, S., Hajj, H. E., Hayar, B., Pisano, C., Saad, W., & Darwiche, N. (2022) · Current Drug Delivery · doi:10.2174/1567201819666220810094708 · Cited by 10
Negative Impact of Paclitaxel Crystallization on Hydrogels and Novel Approaches for Anticancer Drug Delivery Systems
Javier, S., Tapia-Lopez, L. V., Rocio, A., Carlos, A., & Pierre, A. (2011) · InTech eBooks · doi:10.5772/23372 · Cited by 10
“…the nanospheres are systems that perform in vivo by presenting better retention properties of the drug, they have a burst effect when the drug is readily released; in this sense, the nanospheres are overcome by the micelles who exhibit more stable behaviors (Gaucher et al., 2010; Kwon, 2003).”
Background
Role of Unimers to Polymersomes Transition in Pluronic Blends for Controlled and Designated Drug Conveyance
Patel, D., Tripathi, N., Vaswani, P., Pérez‐Sánchez, G., Bhatia, D. D., Kuperkar, K. C., Coutinho, J. A. P., & Bahadur, P. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c00561 · Cited by 10
Delivery of nano-objects to functional Sub-domains of healthy and failing Cardiac myocytes
Lukyanenko, V. I. (2007) · Nanomedicine · doi:10.2217/17435889.2.6.831 · Cited by 9
“Nano-objects can be used in a variety of biomedical and biotechnological applications, including drug and therapeutic gene delivery [1–15].”
Background
Evaluation of physicochemical and antioxidant properties of nanosized copolymeric micelles loaded with kaempferol
Yoncheva, K., Hristova-Avakumova, N. G., Hadjimitova, V. A., Traykov, T. T., & Petrov, P. D. (2020) · Pharmacia · doi:10.3897/pharmacia.67.e38648 · Cited by 9
“The hydrophilic shell of micelles is typically based on poly(ethylene glycol) (PEG), poly(acrylic acid) (PAA) or their combination (Kwon 2003; Andre et al. 2005; Yoncheva et al. 2015a).”
Background
In-vitro Modeling of the Release Kinetics of Micron and Nano-Sized Polymer Drug Carriers
Razavilar, N., & Choi, P. (2014) · International Journal of Phytomedicine · Cited by 9
Supramolecular association of recombinant human growth hormone with hydrophobized polyhydroxyethylaspartamides
Salmaso, S. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2007.07.004 · Cited by 9
Polymeric Micelles for Targeted Drug Delivery Systems
Guliy, O. I., Fomin, A. S., Григорьевна, Ж. Е., Kozlov, S., Staroverov, S. A., & Dykman, L. A. (2022) · Nanotechnology in the life sciences · doi:10.1007/978-3-031-12658-1_18 · Cited by 8
The Impact of Drug Delivery Systems on Pharmacokinetics and Drug-Drug Interactions in Neuropsychiatric Treatment
Nammas, M. (2025) · Cureus · doi:10.7759/cureus.85563 · Cited by 15
“Liposomal risperidone formulations, for example, enhance CNS delivery while reducing extrapyramidal and metabolic side effects, likely through prolonged systemic circulation and preferential accumulation in brain tissues [30].”
Micellar Encapsulation of Propofol Reduces its Adsorption on Extracorporeal Membrane Oxygenator (ECMO) Circuit
Khurana, N., Sünner, T., Hubbard, O., Imburgia, C. E., Stoddard, G. J., Yellepeddi, V., Ghandehari, H., & Watt, K. (2023) · The AAPS Journal · doi:10.1208/s12248-023-00817-2 · Cited by 8
“Hydrophobic drugs or drugs with poor water solubility can be encapsulated in micelles, overcoming their limited water solubility [18, 19].”
Interfacial molecular interactions based on the conformation recognition between the insoluble antitumor drug AD-1 and DSPC
Yin, T., Cao, X., Liu, X., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.07.040 · Cited by 8
Nanoscale Materials in Targeted Drug Delivery
Kumari, A., Singla, R., Guliani, A., Walia, S., Acharya, A., & Yadav, S. K. (2016) · Springer eBooks · doi:10.1007/978-981-10-0818-4_1 · Cited by 7
Introduction to Active, Smart, and Intelligent Nanomaterials for Biomedical Application
Ahlawat, J., & Narayan, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817830-0.00001-1 · Cited by 11
PREPARATION AND CHARACTERIZATION OF THERMO-SENSITIVE MIXED MICELLES AND IN VITRO DRUG RELEASE
Tan, S., Han, C. C., Wang, H., Liu, D., Tu, K., Jiang, H., Meihua, Z., & Liqun, W. A. N. G. (2011) · Acta Polymerica Sinica · doi:10.3724/sp.j.1105.2011.10301 · Cited by 8
3.20 Molecular Imaging ☆
Crayton, S. H., Chen, A. K., Liu, J. F., Higbee-Dempsey, E. M., Huang, C., Tsourkas, A., & Cheng, Z. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803581-8.10222-x · Cited by 8
Nanoparticles in Drug Delivery Systems
Castro, E., & Kumar, A. (2013) · CRC Press eBooks · doi:10.1201/b14802-4 · Cited by 8
Coexistence of oil droplets and lipid vesicles in propofol drug products
Wu, Y. C., Manna, S., Petrochenko, P. E., et al. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118998 · Cited by 8
Polymers in Drug Delivery: Fundamentals
Díaz-Gómez, L. A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2014) · Springer eBooks · doi:10.1007/978-3-319-12478-0_11 · Cited by 7
Triblock polymeric micelles as carriers for anti-inflammatory drug delivery
Yoncheva, K., Petrov, P. D., Pencheva, I. P., et al. (2014) · Journal of Microencapsulation · doi:10.3109/02652048.2014.995729 · Cited by 7
“This structure is associated with high capacity for loading of poorly soluble drugs into hydrophobic core of the micelles (Kwon, 2003; Torchilin, 2004; Lu and Park, 2013).”
Background
The Role of Nanotechnologies in Brain Tumors
Caffo, M., Caruso, G., Curcio, A., Laera, R., Crisafulli, C., Fazzari, E., Passalacqua, M., & Germanò, A. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-14732-6_11 · Cited by 7
Complement Activation-Related Pseudoallergy
Szebeni, J. (2004) · Springer eBooks · doi:10.1007/1-4020-8056-5_17 · Cited by 7
Nafion as Cosurfactant: Solubilization of Nafion in Water in the Presence of Pluronics
Kelarakis, A., & Giannelis, E. P. (2010) · Langmuir · doi:10.1021/la103318u · Cited by 7
Micellization and Drug Solubility Enhancement Part II
Liu, R., Forrest, M. L., & Kwon, G. S. (2008) · CRC Press eBooks · doi:10.1201/9781420009552.ch13 · Cited by 7
Self-citation
Block Co-polymer Nanoparticles with Degradable Cross-Linked Core and Low-Molecular-Weight PEG Corona for Anti-tumour Drug Delivery
Abraham, G., McCarroll, J. A., Byrne, F. L., et al. (2011) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/092050610x497872 · Cited by 6
Preparation, evaluation and metabolites study in rats of novel Isoginkgetin-loaded TPGS/soluplus mixed nanomicelles
Feng, X., Chen, Y., Li, L.-Y., Sun, Y., Wang, H., & Zhang, L. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.1065 · Cited by 6
“Secondly, Polymeric micelles are kinetically stable so they dissociate slowly, even at concentrations below the critical micelle concentration (CMC), extending circulation time in blood [19].”
Background
Polymeric Micelles
van Gaal, E. V. B., & Crommelin, D. J. A. (2015) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-16241-6_2 · Cited by 7
Self-assembled polymeric nanostructures: a promising platform for bioimaging and therapeutic applications
Singh, M., Sharma, B., Chauhan, M., Kaur, G., Sharma, R., Kumar, R., & Chaudhary, G. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821240-0.00011-1 · Cited by 6
Brownian dynamics simulation of amphiphilic block copolymers with different tail lengths, comparison with theory and comicelles
Hafezi, M., & Sharif, F. (2015) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2015.09.005 · Cited by 6
Synthesis of Amphiphilic Polyhedral Oligomeric Silsesquioxane Having a Hydrophobic Fluorescent Dye Group and Its Formation of Fluorescent Nanoparticles in Water
Kuwahara, S.-Y., Yamamoto, K., & Kadokawa, J. (2010) · Chemistry Letters · doi:10.1246/cl.2010.1045 · Cited by 6
Coupled mutual diffusion in solutions of micelles and solubilizates
Everist, M., MacNeil, J. A., Moulins, J. R., et al. (2009) · Physical Chemistry Chemical Physics · doi:10.1039/b906452d · Cited by 6
Antimicrobial Photodynamic Inactivation and Antitumor Photodynamic Therapy with Fullerenes
de Freitas, L. F., & Hamblin, M. R. (2016) · Morgan & Claypool Publishers eBooks · doi:10.1088/978-1-6817-4247-2 · Cited by 6
Polymeric Micelles Stabilized by Electrostatic Interactions for Drug Delivery
Ohya, Y. (2013) · ACS symposium series · doi:10.1021/bk-2013-1135.ch007 · Cited by 7
A new modality in targeted delivery of epirubicin for tumor theranosis based on PEGylated silver nanoparticles: Design, radiolabeling and bioevaluation
Abdel-Hameed, M. E., Farrag, N. S., Aglan, H., Amin, A. M., & Mahdy, M. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122358 · Cited by 7
Drug Delivery in Biotechnology: Present and Future
Yadav, S., Palei, N. N., Dinda, S. C., & Dhar, A. K. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-1148-2_7 · Cited by 9
Excipient Selection and Criteria for Injectable Dosage Forms
Chaubal, M. V., Kipp, J., & Rabinow, B. E. (2006) · CRC Press eBooks · doi:10.1201/9781420004137-19 · Cited by 6
Chitosan-coated PLA/poloxamer nanoparticles stimulate immunologic cancer cell death and synergistic chemo-immunotherapeutic efficacy
Lee, J. S., Cho, S. H., Park, S. Y., Oh, H., Son, P., Lee, Y.-R., & Choi, W. I. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138346 · Cited by 5
Thermochemistry of hydrogen bonding of ethers with aliphatic alcohols
Rakipov, I. T., Semenov, K. N., Petrov, А. А., et al. (2022) · Thermochimica Acta · doi:10.1016/j.tca.2022.179203 · Cited by 5
Hydrophobized poly(vinyl alcohol) for encapsulation of amphotericin B in nanoparticles
Yamamoto, S., Kaneo, Y., & Maitani, Y. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50020-7 · Cited by 5
Thermodynamic properties of aqueous PEO–PPO–PEO micelles of varying hydrophilicity with added cisplatin determined by differential scanning calorimetry
Thompson, A. L., & Love, B. J. (2016) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-016-5411-0 · Cited by 5
PEO-Modified Poly(L -Amino Acid) Micelles for Drug Delivery
Xiong, X.-B., Aliabadi, H. M., & Lavasanifar, A. (2006) · CRC Press eBooks · doi:10.1201/9781420006636-18 · Cited by 7
Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs
Hughey, J. R., & McGinity, J. W. (2011) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-1144-4_13 · Cited by 5
Pluronic-chitosan-folate nano-micelles incorporated with quantum dots for anti-cancer drug therapy
Lin, Y., Huang, K.-B., Wu, Y.-C., et al. (2018) · International Journal of Polymeric Materials · doi:10.1080/00914037.2018.1525543 · Cited by 5
Potential Approaches of Nanotechnology for Cancer Therapy: An Insight
Mishra, V. K., Pavani, S., & Suttee, A. (2021) · Journal of Drug Delivery · Cited by 5
FTIR Spectroscopy of Intermolecular Interactions of Ethers with Methanol: Cooperativity Effect
Rakipov, I. T., Semenov, K. N., Petrov, А. А., et al. (2022) · Journal of Solution Chemistry · doi:10.1007/s10953-022-01193-9 · Cited by 5
“Since the linear correlations were observed for (3) exp = a + b × SVW.”
Background
The Effectivity Analysis of Accumulation of Liposomal, Micellar, and Water-Soluble Forms of Diminazene in Cells and in Organs
Staroverov, S. A., Pristensky, D. V., Yermilov, D. N., et al. (2006) · Drug Delivery · doi:10.1080/10717540500459084 · Cited by 5
“…substances (Aboofazeli and Lawrence 1993; Fubini et al. 1989; Pattarino et al. 1994; Comoglu and Gonul 1997; Torchilin et al. 1982; Kwon 2003) The drug directional transportation is a topical interdisciplinary problem, and approaches to it are being actively developed at the…”
Background
In vitro release of rifampicin and biocompatibility of oleoylchitosan nanoparticles
Li, Y. Y., Chen, X. G., Zhang, J., et al. (2008) · Journal of Applied Polymer Science · doi:10.1002/app.29175 · Cited by 5
Polymeric Micelles
Taboada, P., Barbosa, S., Concheiro, Á., & Alvarez‐Lorenzo, C. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782625216-00157 · Cited by 5
Excipient Selection and Criteria for Injectable Dosage Forms
Chaubal, M. V., Kipp, J., Rabinow, B. E., & Gokarn, Y. R. (2006) · CRC Press eBooks · doi:10.1201/9781420004137.ch16 · Cited by 5
Polymeric Nanoencapsulation of Indocyanine green for Photodynamic Therapy Technique
Saboktakin, M. R. (2019) · American Journal of Biomedical Science & Research · doi:10.34297/ajbsr.2019.03.000630 · Cited by 4
Dissolution of Cellulose and Synthesis of Cellulose-Graft-Poly (L-Lactide) via Ring-Opening Polymerization in an Ionic Liquid
Xiao, S., Dai, L., & He, J. (2012) · Advanced materials research · doi:10.4028/www.scientific.net/amr.476-478.1897 · Cited by 4
Radiolabeling Method: Core/Surface Labeling, Chemical and Physical Labeling
Lee, D. S., Suh, M., & Lee, Y. (2018) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-319-67720-0_11 · Cited by 4
Polymeric micelles in biomedical science
Bhawani, S. A., Ahmad, F. B., Ibrahim, M. N. M., & Yakout, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816504-1.00005-3 · Cited by 4
Engineering of Amphiphilic Block Copolymers for Drug and Gene Delivery
Xiong, X.-B., Uludağ, H., & Lavasanifar, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-77668-2_13 · Cited by 5
Thermochemistry of Solution, Solvation and Hydrogen Bonding of Chloroform in Linear and Cyclic Ethers
Rakipov, I. T., Semenov, K. N., Petrov, А. А., et al. (2021) · Journal of Solution Chemistry · doi:10.1007/s10953-021-01059-6 · Cited by 4
“Ethers and their derivatives are used as antitumor therapy [4], as drug carriers [5, 6], are used for the extraction of metals [7], etc.”
Background

Authors: Kwon, G. S.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Kwon, Glen S.
ORCID: Kwon, Glen S.
Venue: Critical Reviews in Therapeutic Drug Carrier Systems
Publisher: Begell House
Published: 2003
Volume: 20
Issue: 5
Pages: 357-403
ISSN: 0743-4863 (ISSN-L)
DOI: 10.1615/critrevtherdrugcarriersyst.v20.i5.20
OpenAlex: W2082105104
Cited by: 502
References: 0
Citations by year: 2026: 8 · 2025: 11 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 20 · 2014: 28 · 2013: 36 · 2012: 35
FWCI: 8.13
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Therapeutic Drug Carrier Systems (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI-43346-06)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: polymeric micelles, poorly water-soluble drugs, drug solubilization, drug delivery, amphotericin B, propofol, paclitaxel, photosensitizers, poloxamer, tumor targeting, P-glycoprotein inhibition, drug resistance, polyene antibiotics, antifungal agents, parenteral administration
MeSH terms: Drug Stability, Pharmaceutical Preparations, Humans, Micelles, Pharmacokinetics, Polyethylene Glycols, Solubility, Surface-Active Agents, Water, Poloxamer

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks