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Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
Abstract
Amphiphilic polymers assemble into nanoscopic supramolecular core-shell structures, termed polymeric micelles, which are under extensive study for drug delivery. There are several reasons for this growing interest. Polymeric micelles maybe safe for parenteral administration relative to existing solubilizing agents (for instance, Cremophor EL), permitting an increase in the dose of potent yet toxic and poorly water soluble compounds. Polymeric micelles solubilize important poorly water-soluble compounds, such as amphotericin B (AmB), propofol, paclitaxel, and photosensitizers. A major factor in drug solubilization is the compatibility of a drug and a core of a polymeric micelle. In this context, we may consider Pluronics, poly(ethylene glycol) (PEG)-phospholipid conjugates, PEG-b-poly(ester)s, and PEG-b-poly(L-amino acid)s for drug delivery. Polymeric micelles may circulate for prolonged periods in blood, evade host defenses, and gradually release drug. Thus, they may show a preferential accumulation at sites of disease such as solid tumors. Polymeric micelles inhibit p-glycoprotein at drug-resistant tumors, gastrointestinal tract, and blood/brain barrier, perhaps providing a way to overcome drug resistance in cancer and increase drug absorption from the gut and drug absorption into the brain. Lastly, polymeric micelles may reduce the self-aggregation of polyene antibiotics, key membrane-acting drugs used to combat life-threatening systemic fungal diseases. In this way, they may reduce its dose-limiting toxicity without a loss of antifungal activity.
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“The major benefit of polyester over other polymers is that a wide range of polyesters was approved for biomedical usage, such as poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), poly(propylene oxide) (PPO), poly(trimethylene carbonate) (PTMC), and poly(lactic-co-glycolic acid) (PLGA) [69].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [69]
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Metadata
- Authors
- Kwon, G. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Kwon, Glen S.
- ORCID
- Kwon, Glen S.
- Venue
- Critical Reviews in Therapeutic Drug Carrier Systems
- Publisher
- Begell House
- Published
- 2003
- Volume
- 20
- Issue
- 5
- Pages
- 357-403
- ISSN
- 0743-4863 (ISSN-L)
- OpenAlex
- W2082105104
- Cited by
- 502
- References
- 0
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 12 · 2023: 15 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 20 · 2014: 28 · 2013: 36 · 2012: 35
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Therapeutic Drug Carrier Systems (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI-43346-06)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- polymeric micelles, poorly water-soluble drugs, drug solubilization, drug delivery, amphotericin B, propofol, paclitaxel, photosensitizers, poloxamer, tumor targeting, P-glycoprotein inhibition, drug resistance, polyene antibiotics, antifungal agents, parenteral administration
- MeSH terms
- Drug Stability, Pharmaceutical Preparations, Humans, Micelles, Pharmacokinetics, Polyethylene Glycols, Solubility, Surface-Active Agents, Water, Poloxamer
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