Cited by 123Fatty Acid Research and HealthProtein Interaction Studies and Fluorescence AnalysisPeroxisome Proliferator-Activated Receptors

Fatty Acid Binding Protein: Localization and Functional Significance in the Brain

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Owada, Yuji·2008·The Tohoku Journal of Experimental Medicine

Abstract

Long chain fatty acids are important nutrients for brain development and function. However, the molecular basis of their actions in the brain is still to be clarified. Fatty acid-binding proteins (FABPs) belong to the multigene family of the intracellular lipid-binding protein. FABPs bind to long chain fatty acids, being involved in the promotion of cellular uptake and transport of fatty acids, the targeting of fatty acids to specific metabolic pathways, and the regulation of gene expression. FABPs are widely expressed in mammalian tissues, with distinct expression patterns for the individual protein. Although FABPs have been implicated to serve as regulators in systemic cellular metabolic pathways, recent studies have demonstrated the ability of FABPs to regulate functions of the brain, one of the most fat-enriched tissues in the body. This review summarizes the localization of FABPs in the brain, and recent progress in elucidating the function of FABPs in the brain.

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Authors
Owada, Y.
Affiliations
Yamaguchi University (JP)
Corresponding author
Owada, Yuji
Venue
The Tohoku Journal of Experimental Medicine
Published
2008
Volume
214
Issue
3
Pages
213-220
ISSN
  • 0040-8727 (ISSN-L)
  • 1349-3329
OpenAlex
W2095555940
Cited by
122
References
54
Citations by year
2026: 4 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 2 · 2014: 11 · 2013: 4 · 2012: 7
FWCI
0.62
Type
journal article
Language
en
Open access
Locations
  • The Tohoku Journal of Experimental Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
fatty acid binding protein, brain, long-chain fatty acids, fatty acid uptake, lipid metabolism, gene expression regulation, protein localization, brain development, intracellular lipid binding proteins
MeSH terms
Animals, Brain, Humans, Organ Specificity, Fatty Acid-Binding Proteins

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