Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain
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Oligomerization and/or aggregation of α-synuclein (α-Syn) triggers α-synucleinopathies such as Parkinson’s disease and dementia with Lewy bodies. It is known that α-Syn can spread in the brain like prions; however, the mechanism remains unclear. We demonstrated that fatty acid binding protein 3 (FABP3) promotes propagation of α-Syn in mouse brain. Animals were injected with mouse or human α-Syn pre-formed fibrils (PFF) into the bilateral substantia nigra pars compacta (SNpc). Two weeks after injection of mouse α-Syn PFF, wild-type (WT) mice exhibited motor and cognitive deficits, whereas FABP3 knock-out (Fabp3−/−) mice did not. The number of phosphorylated α-Syn (Ser-129)-positive cells was significantly decreased in Fabp3−/− mouse brain compared to that in WT mice. The SNpc was unilaterally infected with AAV-GFP/FABP3 in Fabp3−/− mice to confirm the involvement of FABP3 in the development of α-Syn PFF toxicity. The number of tyrosine hydroxylase (TH)- and phosphorylated α-Syn (Ser-129)-positive cells following α-Syn PFF injection significantly decreased in Fabp3−/− mice and markedly increased by AAV-GFP/FABP3 infection. Finally, we confirmed that the novel FABP3 inhibitor MF1 significantly antagonized motor and cognitive impairments by preventing α-Syn spreading following α-Syn PFF injection. Overall, FABP3 enhances α-Syn spreading in the brain following α-Syn PFF injection, and the FABP3 ligand MF1 represents an attractive therapeutic candidate for α-synucleinopathy.
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FABP3 is critical for α-synuclein uptake into dopaminergic neurons and enhances α-synuclein spreading.
“Very recently, we showed that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake into dopaminergic neurons [144] and enhancement of α-synuclein spreading [145].”
From Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia (2020) · cites this paper as [145]
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BindingDB Entry 50021299: Recent Advances on Small-Molecule Inhibitors of Lipocalin-like Proteins.
BindingDB (2025) · UC San Diego · doi:10.7270/q2x3533h
- Authors
- Yabuki, Y., Matsuo, K., Kawahata, I., Fukui, N., Mizobata, T., Kawata, Y., Owada, Y., Shioda, N., & Fukunaga, K.
- Affiliations
- Tohoku University (JP)
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan
- Tottori University (JP)
- Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
- Corresponding author
- Fukunaga, Kohji
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-23
- Volume
- 21
- Issue
- 6
- Pages
- 2230
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7139546
- OpenAlex
- W3012697258
- Cited by
- 49
- References
- 63
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 3 · 2019: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Agency for Medical Research and Development (JP17dm0107071, JP19dm0107071, JP18dm0107071)
- Ono Medical Research Foundation
- Japan Society for the Promotion of Science (20H03393, 15H06036, 20K21400, 19K07097, 20K11609, 16H05219, 18J20651)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- fatty acid binding protein 3, alpha-synuclein, synucleinopathies, Parkinson's disease, dementia with Lewy bodies, preformed fibrils, prion-like propagation, substantia nigra pars compacta, alpha-synuclein phosphorylation, tyrosine hydroxylase, AAV gene transfer, motor impairment, cognitive impairment, therapeutic target
- MeSH terms
- Fatty Acid Binding Protein 3, Synucleinopathies, Animals, Brain, Cognition, Disease Models, Animal, Fluorescent Antibody Technique, Humans, Immunohistochemistry, Neurons, Phosphorylation, Tyrosine 3-Monooxygenase, Mice, Knockout, Mice, alpha-Synuclein
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