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Fatty Acid Binding Protein: Localization and Functional Significance in the Brain
Open accessAbstract
Long chain fatty acids are important nutrients for brain development and function. However, the molecular basis of their actions in the brain is still to be clarified. Fatty acid-binding proteins (FABPs) belong to the multigene family of the intracellular lipid-binding protein. FABPs bind to long chain fatty acids, being involved in the promotion of cellular uptake and transport of fatty acids, the targeting of fatty acids to specific metabolic pathways, and the regulation of gene expression. FABPs are widely expressed in mammalian tissues, with distinct expression patterns for the individual protein. Although FABPs have been implicated to serve as regulators in systemic cellular metabolic pathways, recent studies have demonstrated the ability of FABPs to regulate functions of the brain, one of the most fat-enriched tissues in the body. This review summarizes the localization of FABPs in the brain, and recent progress in elucidating the function of FABPs in the brain.
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Metadata
- Authors
- Owada, Y.
- Affiliations
- Yamaguchi University (JP)
- Corresponding author
- Owada, Yuji
- ORCID
- Owada, Yuji
- Venue
- The Tohoku Journal of Experimental Medicine
- Publisher
- Tohoku University Medical Press
- Published
- 2008
- Volume
- 214
- Issue
- 3
- Pages
- 213-220
- ISSN
- 0040-8727 (ISSN-L)
- 1349-3329
- OpenAlex
- W2095555940
- Cited by
- 122
- References
- 54
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 2 · 2014: 11 · 2013: 4 · 2012: 7
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Tohoku Journal of Experimental Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- fatty acid binding protein, brain, long-chain fatty acids, fatty acid uptake, lipid metabolism, gene expression regulation, protein localization, brain development, intracellular lipid binding proteins
- MeSH terms
- Animals, Brain, Humans, Organ Specificity, Fatty Acid-Binding Proteins
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