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The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development

Kurtz, Andreas, Zimmer, Andreas, Schnütgen, Frank, Brüning, Gerold, Spener, Friedrich, Müller, Thomas·1994·Development
DOI 10.1242/dev.120.9.2637
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Abstract

Fatty acid binding proteins (FABPs) are a multigene family of small intracellular proteins that bind hydrophobic ligands. In this report we describe the cloning and expression pattern of a novel member of this gene family that is specifically expressed in the developing and adult nervous system and thus was designated brain (B)-FABP. B-FABP is closely related to heart (H)-FABP with 67% amino acid identity. B-FABP expression was first detected at mouse embryonic day 10 in neuroepithelial cells and its pattern correlates with early neuronal differentiation. Upon further development, B-FABP was confined to radial glial cells and immature astrocytes. B-FABP mRNA and protein were found in glial cells of the peripheral nervous system such as satellite cells of spinal and cranial ganglia and ensheathing cells of the olfactory nerve layer from as early as embryonic day 11 until adulthood. In the adult mouse brain, B-FABP was found in the glia limitans, in radial glial cells of the hippocampal dentate gyrus and Bergman glial cells. These findings suggest a function of B-FABP during neurogenesis or neuronal migration in the developing nervous system. The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabo-lism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development.

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Metadata

Authors
Kurtz, A., Zimmer, A., Schnütgen, F., Brüning, G., Spener, F., & Müller, T.
Affiliations
  • 1 Unit on Developmental Biology, National Institute of Mental Health, Bethesda, USA
  • University of Münster 2 Department of Biochemistry , , Germany
  • Free University of Berlin 3 Department of Anatomy , , Berlin, Germany
  • 4 Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
Venue
Development
Publisher
The Company of Biologists
Published
1994-09-01
Volume
120
Issue
9
Pages
2637-2649
ISSN
  • 0950-1991
  • 1477-9129
DOI
10.1242/dev.120.9.2637
Cited by
339
References
0
Language
en
Licence
www.biologists.com/user-licence-1-1/ (vor)

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