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Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells: Proliferation, Migration, and Differentiation
Open accessAbstract
Hepatocyte growth factor (HGF), a pleiotropic cytokine of mesenchymal origin promoting migration, proliferation, and survival in a wide spectrum of cells, can also modulate different biological responses in stem cells, but the mechanisms involved are not completely understood so far. In this context, we show that short-term exposure of mesenchymal stem cells (MSCs) to HGF can induce the activation of its cognate Met receptor and the downstream effectors ERK1/2, p38MAPK, and PI3K/Akt, while long-term exposure to HGF resulted in cytoskeletal rearrangement, cell migration, and marked inhibition of proliferation through the arrest in the G1-S checkpoint. When added to MSCs, the K252A tyrosine kinase inhibitor prevented HGF-induced responses. HGF's effect on MSC proliferation was reversed by p38 inhibitor SB203580, while the effects on cell migration were abrogated by PI3K inhibitor Wortmannin, suggesting that HGF acts through different pathways to determine its complex effects on MSCs. Prolonged treatment with HGF induced the expression of cardiac-specific markers (GATA-4, MEF2C, TEF1, desmin, α-MHC, β-MHC, and nestin) with the concomitant loss of the stem cell markers nucleostemin, c-kit, and CD105.
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Baeza-Raja, B., & Muñoz-Cánoves, P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-08-0585 · Cited by 247
Müller, M., Morotti, A., & Ponzetto, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1060-1072.2002 · Cited by 129
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Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles
Hall, B., Dembinski, J., Sasser, A., Studeny, M., Andreeff, M., & Marini, F. (2007) · International Journal of Hematology · doi:10.1532/ijh97.06230 · Cited by 171
The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases
Liu, W., Song, F., Ren, L., Guo, W., Wang, T., Feng, Y., Tang, L., & Li, K. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12482 · Cited by 139
Lim, C. S., & Walikonis, R. S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.013 · Cited by 80
Shi, Y., Xia, Y.-Y., Wang, L., Liu, R., Khoo, K.-S., & Feng, Z.-W. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.05.029 · Cited by 45
Metadata
- Authors
- Forte, G., Minieri, M., Cossa, P., Antenucci, D., Sala, M., Gnocchi, V., Fiaccavento, R., Carotenuto, F., De Vito, P., Baldini, P. M., Prat, M., & Di Nardo, P.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-08-11
- Volume
- 24
- Issue
- 1
- Pages
- 23-33
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2004435141
- Cited by
- 401
- References
- 4
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Forte, G., Minieri, M., Cossa, P., Antenucci, D., Sala, M., Gnocchi, V., Fiaccavento, R., Carotenuto, F., De Vito, P., Baldini, P. M., Prat, M., & Di Nardo, P. (2006). Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells: Proliferation, Migration, and Differentiation. Stem Cells. https://doi.org/10.1634/stemcells.2004-0176
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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