Activation of NF-κB Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis
Open accessAbstract
Hepatocyte growth factor (HGF) and its receptor, Met, regulate a number of biological functions in epithelial and nonepithelial cells, such as survival, motility, proliferation, and tubular morphogenesis. The transcription factor NF-kappaB is activated in response to a wide variety of stimuli, including growth factors, and is involved in biological responses in part overlapping with those triggered by HGF. In this work we used the liver-derived MLP29 cell line to study the possible involvement of NF-kappaB in HGF/Met signaling. HGF stimulates NF-kappaB DNA binding and transcriptional activation via the canonical IkappaB phosphorylation-degradation cycle and via the extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase cascades. Phosphatidylinositol 3-kinase is not involved in Met-mediated NF-kappaB activation. Blockage of NF-kappaB activation in MLP29 cells by forced expression of the NF-kappaB super-repressor IkappaB(alpha)2A does not interfere with HGF-induced scatter but inhibits proliferation and tubulogenesis. Surprisingly, in the same cells NF-kappaB appears to be dispensable for the antiapoptotic function of HGF.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HGF has been reported to mediate its effects in part via the NFκB pathway.
“HGF, a primary mitogen for hepatocytes, has also been reported to mediate its effects in part via the NFκB pathway [16].”
From Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli (2014) · cites this paper as [16]
Cites
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727 · see citing works
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179 · see citing works
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
Romashkova, J. A., & Makarov, S. S. (1999) · Nature · doi:10.1038/43474 · Cited by 1,847 · see citing works
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828 · see citing works
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Baldwin, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11991 · Cited by 1,427 · see citing works
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395 · see citing works
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337 · see citing works
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D, D. C. G., Albanese, C., Reuther, J. Y., Pestell, R. G., & Baldwin, A. S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5785 · Cited by 1,304 · see citing works
Zhong, H., Voll, R. E., & Ghosh, S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80066-0 · Cited by 1,210 · see citing works
Control of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,190 · see citing works
Pierce, J. W., Schoenleber, R. W., Jesmok, G. J., Best, J. L., Moore, S. A., Collins, T., & Gerritsen, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21096 · Cited by 1,044 · see citing works
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., Zonca, P. D., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 994 · see citing works
Self-citationHinz, M., Krappmann, D., Eichten, A., Heder, A., Scheidereit, C., & Strauss, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2690 · Cited by 788 · see citing works
Role of NF-κB in p53-mediated programmed cell death
Ryan, K. M., Ernst, M. K., Rice, N. R., & Vousden, K. H. (2000) · Nature · doi:10.1038/35009130 · Cited by 735 · see citing works
Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., & Green, D. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80054-4 · Cited by 721 · see citing works
Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation
Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., & Ballard, D. W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2809 · Cited by 684 · see citing works
Berghe, W. V., Plaisance, S., Boone, E., Bosscher, K. D., Schmitz, M. L., Fiers, W., & Haegeman, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3285 · Cited by 679 · see citing works
Emerging Multipotent Aspects of Hepatocyte Growth Factor
Matsumoto, K., & Nakamura, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021283 · Cited by 666 · see citing works
Sizemore, N., Leung, S., & Stark, G. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4798 · Cited by 650 · see citing works
The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation
Karin, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27339 · Cited by 640 · see citing works
Madrid, L. V., Wang, C.-Y., D, D. C. G., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1626-1638.2000 · Cited by 634 · see citing works
Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
Birchmeier, C., & Gherardi, E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01359-2 · Cited by 599 · see citing works
The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus
Rothwarf, D., & Karin, M. (1999) · Science's STKE · doi:10.1126/stke.1999.5.re1 · Cited by 553 · see citing works
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
Boccaccio, C., Andò, M., Tamagnone, L., Bardelli, A., Michieli, P., BATTISTINI, C., & Comoglio, P. M. (1998) · Nature · doi:10.1038/34657 · Cited by 521 · see citing works
Wang, D., Westerheide, S. D., Ostrander, J. H., & Baldwin, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001358200 · Cited by 454 · see citing works
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447 · see citing works
The p38 Mitogen-activated Protein Kinase Is Required for NF-κB-dependent Gene Expression
Carter, A. B., Knudtson, K. L., Monick, M. M., & Hunninghake, G. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30858 · Cited by 443 · see citing works
Fujita, T., Nolan, G. P., Liou, H. C., Scott, M. L., & Baltimore, D. (1993) · Genes & Development · doi:10.1101/gad.7.7b.1354 · Cited by 409 · see citing works
Wang, D., & Baldwin, A. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29411 · Cited by 375 · see citing works
The Rel/NF-κB family: friend and foe
Perkins, N. D. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01617-0 · Cited by 373 · see citing works
Bradham, C. A., Plümpe, J., Manns, M. P., Brenner, D. A., & Trautwein, C. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.3.g387 · Cited by 355 · see citing works
Ishiki, Y., Ohnishi, H., Muto, Y., Matsumoto, K., & Nakamura, T. (1992) · Hepatology · doi:10.1002/hep.1840160520 · Cited by 344 · see citing works
The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance
Mayo, M. W., & Baldwin, A. S. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00002-0 · Cited by 323 · see citing works
Hepatocyte growth factor: a multifunctional cytokine
Boros, P., & Miller, C. M. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90279-1 · Cited by 319 · see citing works
HGF receptor associates with the anti‐apoptotic protein BAG‐1 and prevents cell death.
Bardelli, A., Longati, P., Albero, D., Goruppi, S., Schneider, C., Ponzetto, C., & Comoglio, P. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01009.x · Cited by 312 · see citing works
Self-citationUncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development
Maina, F., Casagranda, F., Audero, E., Simeone, A., Comoglio, P. M., Klein, R., & Ponzetto, C. (1996) · Cell · doi:10.1016/s0092-8674(00)81372-0 · Cited by 311 · see citing works
Self-citationAbsence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
Doi, T. S., Marino, M. W., Takahashi, T., Yoshida, T., Sakakura, T., Old, L. J., & Obata, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2994 · Cited by 299 · see citing works
Brinkmann, V., Foroutan, H. R., Sachs, M., Weidner, K. M., & Birchmeier, W. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.6.1573 · Cited by 298 · see citing works
Shono, T., Ono, M., Izumi, H., Jimi, S., Matsushima, K., Okamoto, T., Kohno, K., & Kuwano, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4231 · Cited by 272 · see citing works
Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer
Jiang, W. G. (1999) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(98)00019-5 · Cited by 264 · see citing works
Wesselborg, S., Bauer, M. K. A., Vogt, M., Schmitz, M. L., & Schulze‐Osthoff, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12422 · Cited by 237 · see citing works
IκB-independent control of NF-κB activity by modulatory phosphorylations
Schmitz, M. L., Bacher, S., & Kracht, M. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01753-9 · Cited by 234 · see citing works
Hepatocyte growth factor--scatter factor: mitogen, motogen, and met.
Gherardi, E., & Stoker, M. G. P. (1991) · PubMed · Cited by 232 · see citing works
Maina, F., Hilton, M., Ponzetto, C., Davies, A. M., & Klein, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3341 · Cited by 227 · see citing works
Self-citationNerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons
Maggirwar, S. B., Sarmiere, P. D., Dewhurst, S., & Freeman, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10356.1998 · Cited by 225 · see citing works
Whiteside, S. T., Ernst, M. K., Bail, O. L., Laurent‐Winter, C., Rice, N. R., & Israël, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5339 · Cited by 222 · see citing works
Khwaja, A., Lehmann, K. E., Marte, B. M., & Downward, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18793 · Cited by 213 · see citing works
Madge, L. A., & Pober, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001237200 · Cited by 205 · see citing works
Heck, S., Lezoualc’h, F., Engert, S., & Behl, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9828 · Cited by 200 · see citing works
Abrogation of Fas-Induced Fulminant Hepatic Failure in Mice by Hepatocyte Growth Factor
Kosai, K.-I., Matsumoto, K., Nagata, S., Tsujimoto, Y., & Nakamura, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8293 · Cited by 198 · see citing works
Maroun, C. R., Holgado-Madruga, M., Royal, I., Naujokas, M. A., Fournier, T. M., Wong, A. J., & Park, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1784 · Cited by 196 · see citing works
Bergmann, M., Hart, L. A., Lindsay, M. A., Barnes, P. J., & Newton, R. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6607 · Cited by 191 · see citing works
NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis
Xu, Y., Bialik, S., Jones, B., Iimuro, Y., Kitsis, R. N., Srinivasan, A. N., Brenner, D. A., & Czaja, M. J. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.4.c1058 · Cited by 187 · see citing works
Anrather, J., Csizmadia, V., Soares, M. P., & Winkler, H. J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13594 · Cited by 185 · see citing works
Stylianou, E., & Saklatvala, J. (1998) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00081-8 · Cited by 185 · see citing works
Bowers, D. C., Fan, S., Walter, K. A., Abounader, R., Williams, J. A., Rosen, E. M., & Laterra, J. (2000) · PubMed · Cited by 168 · see citing works
Boccaccio, C., Gaudino, G., Gambarotta, G., Galimi, F., & Comoglio, P. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99953-9 · Cited by 161 · see citing works
Gual, P., Giordano, S., Williams, T. A., Rocchi, S., OBBERGHEN, E. V., & Comoglio, P. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203514 · Cited by 160 · see citing works
Scatter factor and hepatocyte growth factor: activities, properties, and mechanism.
Bhargava, M., Joseph, A., Knesel, J., Halaban, R., Li, Y., Pang, S. Y.-Y., Goldberg, I. D., Setter, E., Donovan, M. A., & Zarnegar, R. (1992) · PubMed · Cited by 139 · see citing works
Wojta, J., Kaun, C., Breuss, J. M., Koshelnick, Y., Beckmann, R., Hattey, E., Mildner, M., Weninger, W., Nakamura, T., Tschachler, E., et al. (1999) · PubMed · Cited by 139 · see citing works
Médico, E., Mongiovì, A. M., Huff, J. L., Jelinek, M. A., Follenzi, A., Gaudino, G., Parsons, J. T., & Comoglio, P. M. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.4.495 · Cited by 135 · see citing works
Kinase regulation in inflammatory response
Delhase, M., Li, N., & Karin, M. (2000) · Nature · doi:10.1038/35019154 · Cited by 132 · see citing works
Norris, J. L., & Baldwin, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13841 · Cited by 132 · see citing works
Habib, A. A., Chatterjee, S., Park, S.-K., Ratan, R. R., Lefebvre, S., & Vartanian, T. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008458200 · Cited by 130 · see citing works
Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms
Liu, Y. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.4.f624 · Cited by 129 · see citing works
Phosphorylation by p44 MAP Kinase/ERK1 Stimulates CBP Histone Acetyl Transferase Activity in Vitro
Ait‐Si‐Ali, S., Carlisi, D., Ramírez-Clavijo, S. R., Upegui-Gonzalez, L.-C., Duquet, A., Robin, P., Rudkin, B. B., Harel‐Bellan, A., & Trouche, D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1132 · Cited by 125 · see citing works
Suzuki, A., Hayashida, M., Kawano, H., Sugimoto, K., Nakano, T., & Shiraki, K. (2000) · Hepatology · doi:10.1053/jhep.2000.17738 · Cited by 121 · see citing works
Carter, A. B., & Hunninghake, G. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003599200 · Cited by 119 · see citing works
Schraer, L., Borum, I., & Sathyan, T. G. (1995) · Cited by 113 · see citing works
A Role for Nuclear Factor κB in the Antiapoptotic Function of Insulin
Bertrand, F., Atfi, A., Cadoret, A., L’Allemain, G., Robin, H., Lascols, O., Capeau, J., & Cherqui, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2931 · Cited by 107 · see citing works
Seol, D., Chen, Q., & Zarnegar, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203404 · Cited by 87 · see citing works
Jefferies, C. A., & O'Neill, L. A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3114 · Cited by 85 · see citing works
Lee, P.-P. H., Hwang, J.-J., Murphy, G., & Ip, M. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7697 · Cited by 80 · see citing works
Liu, R. Y., Fan, C. L., Liu, G., Olashaw, N., & Zuckerman, K. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001281200 · Cited by 72 · see citing works
A gene trap vector system for identifying transcriptionally responsive genes
Médico, E., Gambarotta, G., Gentile, A., Comoglio, P. M., & Soriano, P. M. (2001) · Nature Biotechnology · doi:10.1038/89343 · Cited by 68 · see citing works
Senaldi, G., Shaklee, C. L., Simon, B., Rowan, C. G., Lacey, D. L., & Härtung, T. (1998) · Hepatology · doi:10.1002/hep.510270618 · Cited by 54 · see citing works
Rauch, B. H., Weber, A., Braun, M., Zimmermann, N., & Schrör, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01957-8 · Cited by 51 · see citing works
The NF- B Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
Rothwarf, D. M., & Karin, M. (1999) · Science Signaling · doi:10.1126/scisignal.51999re1 · Cited by 49 · see citing works
Pomérance, M., Multon, M.-C., Parker, F., Venot, C., Blondeau, J., Tocqué, B., & Schweighoffer, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24301 · Cited by 48 · see citing works
Bennett, J. H., Morgan, M. J., Whawell, S. A., Atkin, P., Roblin, P., Furness, J., & Speight, P. M. (2000) · European Journal Of Oral Sciences · doi:10.1034/j.1600-0722.2000.108004281.x · Cited by 44 · see citing works
Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors
Castagnino, P. A., Lorenzi, M. V., Yeh, J., Breckenridge, D., Sakata, H., Munz, B., Werner, S., & Bottaro, D. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203357 · Cited by 28 · see citing works
Met signaling mutants as tools for developmental studies
Ponzetto, C., Panté, G., Prunotto, C., Ieraci, A., & Maina, F. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.11061428 · Cited by 19 · see citing works
Self-citationGoodrum (2000) · doi:10.1002/(sici)1097-4547(20000215)59:4
Flagged first, then by citations
1 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Met, metastasis, motility and more
Birchmeier, C., Birchmeier, W., Gherardi, E., & Woude, G. V. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1261 · Cited by 2,667 · see citing works
MET signalling: principles and functions in development, organ regeneration and cancer
Trusolino, L., Bertotti, A., & Comoglio, P. M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3012 · Cited by 1,244 · see citing works
Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
Conde‐Vancells, J., Rodríguez‐Suárez, E., Embade, N., Gil‐Carton, D., Matthiesen, R., Valle, M., Elortza, F., Lu, S. C.-L., Mato, J. M., & Falcón‐Pérez, J. M. (2008) · Journal of Proteome Research · doi:10.1021/pr8004887 · Cited by 644 · see citing works
c-Met: Structure, functions and potential for therapeutic inhibition
Ma, P. C., Maulik, G., Christensen, J. G., & Salgia, R. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023768811842 · Cited by 506 · see citing works
Forte, G., Minieri, M., Cossa, P., Antenucci, D., Sala, M., Gnocchi, V. F., Fiaccavento, R., Carotenuto, F., Vito, P. D., Baldini, P. M., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0176 · Cited by 401 · see citing works
How to make tubes: signaling by the Met receptor tyrosine kinase
Rosário, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00104-1 · Cited by 240 · see citing works
Li, F., Zhang, J., Arfuso, F., Chinnathambi, A., Zayed, M. E., Alharbi, S. A., Kumar, A. P., Ahn, K. S., & Sethi, G. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1470-4 · Cited by 198 · see citing works
Lee, W.-J., Chen, W.-K., Wang, C., Lin, W.-L., & Tseng, T. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.09.013 · Cited by 183 · see citing works
Proliferation and invasion: Plasticity in tumor cells
Gao, C.-F., Xie, Q. R., Su, Y., Koeman, J. M., Khoo, S. K., Gustafson, M. F., Knudsen, B. S., Hay, R. V., Shinomiya, N., & Woude, G. F. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504367102 · Cited by 175 · see citing works
Activation of stem cells in hepatic diseases
Bird, T. G., Lorenzini, S., & Forbes, S. J. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0542-z · Cited by 170 · see citing works
Nuclear factor-κB and liver carcinogenesis
Arsura, M., & Cavin, L. G. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.008 · Cited by 169 · see citing works
Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions
Chauhan, A., Islam, A., Prakash, H., & Singh, S. K. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.07.002 · Cited by 160 · see citing works
Zeng, Q., Chen, S., You, Z., Yang, F., Carey, T. E., Saims, D., & Wang, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201598200 · Cited by 140 · see citing works
c-Met as a Target for Personalized Therapy
Garajová, I., Giovannetti, E., Biasco, G., & Peters, G. J. (2015) · Translational Oncogenomics · doi:10.4137/tog.s30534 · Cited by 138 · see citing works
Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
Norris, C. A., He, M., Kang, L.-I., Ding, M. Q., Radder, J. E., Haynes, M. M., Yang, Y., Paranjpe, S., Bowen, W. C., Orr, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096053 · Cited by 132 · see citing works
“HGF, a primary mitogen for hepatocytes, has also been reported to mediate its effects in part via the NFkB pathway [16].”
BackgroundMET: A Critical Player in Tumorigenesis and Therapeutic Target
Graveel, C. R., Tolbert, D., & Vande Woude, G. F. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009209 · Cited by 128 · see citing works
Huang, M., Liu, T., Ma, P., Mitteer, R. A., Zhang, Z., Kim, H. J., Yeo, E., Zhang, D., Cai, P., Li, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84876 · Cited by 128 · see citing works
InlB, a surface protein ofListeria monocytogenesthat behaves as an invasin and a growth factor
Bierne, H., & Cossart, P. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.17.3357 · Cited by 126 · see citing works
Morris, M. R., Gentle, D., Abdulrahman, M., Maina, E. N., Gupta, K., Banks, R. E., Wiesener, M. S., Kishida, T., Yao, M., Teh, B. T., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3371 · Cited by 123 · see citing works
Molecular process in acute liver injury and regeneration induced by carbon tetrachloride
Taniguchi, M., Takeuchi, T., Nakatsuka, R., Watanabe, T., & Sato, K. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.02.030 · Cited by 117 · see citing works
Role of NF-κB signaling in hepatocyte growth factor/scatter factor-mediated cell protection
Fan, S., Gao, M., Meng, Q., Laterra, J., Symons, M. H., Coniglio, S. J., Pestell, R. G., Goldberg, I. D., & Rosen, E. M. (2005) · Oncogene · doi:10.1038/sj.onc.1208327 · Cited by 112 · see citing works
Okano, J., Shiota, G., Matsumoto, K., Yasui, S., Kurimasa, A., Hisatome, I., Steinberg, P., & Murawaki, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.04.002 · Cited by 110 · see citing works
Gómez-Quiroz, L. E., Factor, V. M., Kaposi-Novák, P., Coulouarn, C., Conner, E. A., & Thorgeirsson, S. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707733200 · Cited by 107 · see citing works
MET: roles in epithelial-mesenchymal transition and cancer stemness
Jeon, H.-M., & Lee, J. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2016.12.67 · Cited by 101 · see citing works
Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction
Bertotti, A., Burbridge, M. F., Gastaldi, S., Galimi, F., Torti, D., Médico, E., Giordano, S., Corso, S., Rolland-Valognes, G., Lockhart, B. P., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000643 · Cited by 98 · see citing works
Bianchi, A. S., Gasparri, F., Galvani, A. P., Nici, L. L., Darnowski, J. W., Barbone, D., Fennell, D. A., Gaudino, G., Porta, C., & Mutti, L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0536 · Cited by 94 · see citing works
Wu, X., Li, J., Zhu, M. J., Fletcher, J. A., & Hodi, F. S. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0121 · Cited by 88 · see citing works
Epstein–Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation
Hu, H., Luo, M., Desmedt, C., Nabavi, S., Yadegarynia, S., Hong, A., Konstantinopoulos, P. A., Gabrielson, E., Hines‐Boykin, R., Pihan, G. A., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.05.025 · Cited by 86 · see citing works
Conjugated polymers optically regulate the fate of endothelial colony-forming cells
Lodola, F., Rosti, V., Tullii, G., Desii, A., Tapella, L., Catarsi, P., Lim, D., Moccia, F. D., & Antognazza, M. R. (2019) · Science Advances · doi:10.1126/sciadv.aav4620 · Cited by 85 · see citing works
Panté, G., Thompson, J., Lamballe, F., Iwata, T., Ferby, I., Barr, F. A., Davies, A. M., Maina, F., & Klein, R. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502013 · Cited by 85 · see citing works
Beuret, L., Flori, E., Denoyelle, C., Bille, K., Buscà, R., Picardo, M., Bertolotto, C., & Ballotti, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611563200 · Cited by 84 · see citing works
Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation
Syed, D. N., Afaq, F., Sarfaraz, S., Khan, N., Kedlaya, R., Setaluri, V., & Mukhtar, H. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.03.023 · Cited by 83 · see citing works
Satellite cell activation on fibers: modeling events in vivo — an invited review
Anderson, J. E., & Wozniak, A. C. (2004) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y04-020 · Cited by 82 · see citing works
Targeting the MET gene for the treatment of non-small-cell lung cancer
Gelsomino, F., Facchinetti, F., Haspinger, E. R., Garassino, M. C., Trusolino, L., de Braud, F., & Tiseo, M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.11.006 · Cited by 77 · see citing works
Quan, Y., Gong, L., He, J., Zhou, Y., Liu, M., Cao, Z., Li, Y., & Peng, C. Y. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.02.007 · Cited by 77 · see citing works
Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes
Buhrmann, C., Shayan, P., Aggarwal, B. B., & Shakibaei, M. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4393 · Cited by 73 · see citing works
Wang, X., Zhou, Y., Kim, H. P., Song, R., Zarnegar, R., Ryter, S. W., & Choi, A. M. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309271200 · Cited by 70 · see citing works
cMET Exon 14 Skipping: From the Structure to the Clinic
Steen, N. V. D., Giovannetti, E., Pauwels, P., Peters, G. J., Hong, D. S., Cappuzzo, F., Hirsch, F. R., & Rolfo, C. D. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.05.005 · Cited by 65 · see citing works
MET receptor tyrosine kinase as a therapeutic anticancer target
Stellrecht, C. M., & Gandhi, V. V. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.10.045 · Cited by 59 · see citing works
von Montfort, C., Beier, J. I., Kaiser, J. P., Guo, L., Joshi‐Barve, S., Pritchard, M. T., States, J. C., & Arteel, G. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00107.2009 · Cited by 56 · see citing works
Physiological Signaling and Structure of the HGF Receptor MET
Baldanzi, G., & Graziani, A. (2014) · Biomedicines · doi:10.3390/biomedicines3010001 · Cited by 56 · see citing works
Fajardo-Puerta, A. B., Prado, M. M., Frampton, A. E., & Jiao, L. R. (2016) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2015-203575 · Cited by 51 · see citing works
Cellular crosstalk during liver regeneration: unity in diversity
Shu, W., Yang, M., Yang, J., Lin, S., Wei, X., & Xu, X. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00918-z · Cited by 50 · see citing works
NF‐kB inhibition as a strategy to enhance etoposide‐induced apoptosis in K562 cell line
Morotti, A., Cilloni, D., Pautasso, M., Messa, F., Arruga, F., Defilippi, I., Carturan, S., Catalano, R., Rosso, V., Chiarenza, A., et al. (2006) · American Journal of Hematology · doi:10.1002/ajh.20732 · Cited by 48 · see citing works
Self-citationOrlando, E., Aebersold, D. M., Medová, M., & Zimmer, Y. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.12.001 · Cited by 46 · see citing works
Cabezas, R., Vega-Vela, N. E., González-Sanmiguel, J., González, J., Esquinas, P., Echeverrı́a, V., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0567-6 · Cited by 47 · see citing works
Zhang, P., Li, S., Lv, C., Si, J., Xiong, Y., Ding, L., Ma, Y., & Yang, Y. (2018) · Theranostics · doi:10.7150/thno.27667 · Cited by 47 · see citing works
Neural differentiation of mesenchymal stem cells influences chemotactic responses to HGF
Zheng, B., Wang, C., He, L., Xu, X., Qu, J., Hu, J., & Zhang, H. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24114 · Cited by 46 · see citing works
Moghaddam, M. Z., Ansariniya, H., Seifati, S. M., Zare, F., & Fesahat, F. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13537 · Cited by 47 · see citing works
Yang, C., Kuo, T., & Ting, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510981200 · Cited by 46 · see citing works
Cancer morphogenesis: role of mitochondrial failure.
Fosslien, E. (2008) · PubMed · Cited by 45 · see citing works
Ogihara, T., Watada, H., Kanno, R., Ikeda, F., Nomiyama, T., Tanaka, Y., Nakao, A., German, M. S., Kojima, I., & Kawamori, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302684200 · Cited by 44 · see citing works
Zhang, Y., Lu, T., Wong, M. S., Wang, X., Stodieck, L., Karouia, F., Story, M. D., & Wu, H. (2016) · The FASEB Journal · doi:10.1096/fj.201500121 · Cited by 40 · see citing works
Dahlman, J. M., Wang, J., Bakkar, N., & D, D. C. G. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21976 · Cited by 40 · see citing works
cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance
Steen, N. V. D., Pauwels, P., Bazo, I. G., Álvarez, E. C., Raez, L. E., Cappuzzo, F., & Rolfo, C. D. (2015) · Cancers · doi:10.3390/cancers7020556 · Cited by 39 · see citing works
Magliozzi, R., Low, T. Y., Weijts, B. G. M. W., Cheng, T., Spanjaard, E., Mohammed, S., van Veen, A., Ovaa, H., de Rooij, J., Zwartkruis, F. J. T., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.10.023 · Cited by 37 · see citing works
Understanding and Targeting MET Signaling in Solid Tumors - Are We There Yet?
Ariyawutyakorn, W., Saichaemchan, S., & Varella‐Garcia, M. (2016) · Journal of Cancer · doi:10.7150/jca.12663 · Cited by 37 · see citing works
Matsuo, H., Tamura, M., Kabashima, N., Serino, R., Tokunaga, M., Shibata, T., Matsumoto, M., Aijima, M., Oikawa, S., Anai, H., et al. (2006) · Kidney International · doi:10.1038/sj.ki.5000131 · Cited by 37 · see citing works
Valproate enhances imatinib‐induced growth arrest and apoptosis in chronic myeloid leukemia cells
Morotti, A., Cilloni, D., Messa, F., Arruga, F., Defilippi, I., Carturan, S., Catalano, R., Rosso, V., Chiarenza, A., Pilatrino, C., et al. (2006) · Cancer · doi:10.1002/cncr.21725 · Cited by 36 · see citing works
Self-citationInoue, T., Kobayashi, K., Inoguchi, T., Sonoda, N., Fujii, M., Maeda, Y., Fujimura, Y., Miura, D., Hirano, K., & Takayanagi, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.285650 · Cited by 36 · see citing works
Repression of hepatitis B viral gene expression by transcription factor nuclear factor-kappaB
Lin, Y.-C., Hsu, E., & Ting, L. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01280.x · Cited by 36 · see citing works
MET and Small-Cell Lung Cancer
Gelsomino, F., Rossi, G., & Tiseo, M. (2014) · Cancers · doi:10.3390/cancers6042100 · Cited by 33 · see citing works
Boissinot, M., Vilaine, M., & Hermouet, S. (2014) · Cancers · doi:10.3390/cancers6031631 · Cited by 33 · see citing works
Carrà, G., Torti, D., Crivellaro, S., Panuzzo, C., Taulli, R., Cilloni, D., Guerrasio, A., Saglio, G. N., & Morotti, A. (2016) · Oncotarget · doi:10.18632/oncotarget.11507 · Cited by 33 · see citing works
Self-citationParr, C., & Ali, A. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1660-y · Cited by 30 · see citing works
MET receptor in oncology: From biomarker to therapeutic target
Malik, R., Mambetsariev, I., Fricke, J., Chawla, N. S., Nam, A., Pharaon, R. R., & Salgia, R. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.04.006 · Cited by 29 · see citing works
Bersani, F., Taulli, R., Accornero, P., Morotti, A., Miretti, S., Crepaldi, T., & Ponzetto, C. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.02.022 · Cited by 29 · see citing works
Self-citationPei, M., Pei, Y. A., Zhou, S., Mikaeiliagah, E., Erickson, C. B., Giertych, B. F., Akhter, H., Wang, L., Stewart, A. B., Parenti, J., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.012 · Cited by 27 · see citing works
The p105/50 NF-κB pathway is essential for Mallory body formation
Li, N., Wu, Y., Bardag‐Gorce, F., Li, ., French, B. A., Wilson, L. T., & French, S. W. (2005) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2004.12.002 · Cited by 26 · see citing works
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts
Romoser, A. A., Figueroa, D. E., Sooresh, A., Scribner, K. C., Chen, P. L., Porter, W. W., Criscitiello, M. F., & Sayes, C. M. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.01.022 · Cited by 26 · see citing works
Conditional Activation of MET in Differentiated Skeletal Muscle Induces Atrophy
Crepaldi, T., Bersani, F., Scuoppo, C., Accornero, P., Prunotto, C., Taulli, R., Forni, P. E., Leo, C., Chiarle, R., Griffiths, J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610916200 · Cited by 26 · see citing works
Self-citationLizárraga, F., Maldonado, V., & Meléndez-Zajgla, J. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.004 · Cited by 25 · see citing works
Kaibori, M., Yanagida, H., Nakanishi, H., Ozaki, T., Yoshida, H., Matsui, K., Hijikawa, T., Kamiyama, Y., & Okumura, T. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.09.025 · Cited by 24 · see citing works
Research Resource: Aorta- and Liver-Specific ERα-Binding Patterns and Gene Regulation by Estrogen
Gordon, F. K., Vallaster, C. S., Westerling, T., Iyer, L. K., Brown, M. A., & Schnitzler, G. R. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1395 · Cited by 24 · see citing works
Cell Motility in Cancer Invasion and Metastasis
Qin, Z., Tan, S. X. D., & Cheng, C.-K. (2006) · Cancer metastasis · doi:10.1007/b103440 · Cited by 25 · see citing works
Han, X., Yu, R., Ji, L., Zhen, D., Tao, S., Li, S., Sun, Y., Huang, L., Feng, Z., Li, X., et al. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07726.x · Cited by 23 · see citing works
Stankevič, E., Israelsen, M. E., Juel, H. B., Madsen, A. L., Ängquist, L. H., Aldiss, P., Torp, N., Johansen, S., Hansen, C. D., Hansen, J. K., et al. (2023) · Liver International · doi:10.1111/liv.15692 · Cited by 22 · see citing works
Zineldeen, D. H., Tahoon, N., & Sarhan, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043367 · Cited by 21 · see citing works
da Silva, C. G., Maccariello, E. R., Wilson, S., Putheti, P., Daniel, S., Damrauer, S. M., Peterson, C. R., Siracuse, J. J., Kaczmarek, E., & Ferran, C. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22851 · Cited by 21 · see citing works
Association of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancer
Спирина, Л. В., Yunusova, N. V., Кондакова, И. В., Коломиец, Л. А., Koval, V. D., Чернышова, А. Л., & Shpileva, O. V. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1720-y · Cited by 19 · see citing works
Crivellaro, S., Panuzzo, C., Carrà, G., Volpengo, A., Crasto, F., Gottardi, E. M., Familiari, U., Papotti, M. G., Torti, D., Piazza, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4611 · Cited by 19 · see citing works
Self-citationAune, G., Stunes, A. K., Lian, A., Reseland, J. E., Tingulstad, S., TORP, S. H., & Syversen, U. (2012) · Results in Immunology · doi:10.1016/j.rinim.2012.10.003 · Cited by 18 · see citing works
Yuan, J., Fan, Y., Ognjanovic, S., Wang, R., Berg, D. V. D., Govindarajan, S., & Yu, M. C. (2013) · BMC Gastroenterology · doi:10.1186/1471-230x-13-32 · Cited by 18 · see citing works
Gliotoxin‐induced changes in rat liver regeneration after partial hepatectomy
Nejak‐Bowen, K. N., Orr, A. V., Bowen, W. C., & Michalopoulos, G. K. (2013) · Liver International · doi:10.1111/liv.12164 · Cited by 18 · see citing works
Therapeutic Targeting of the Receptor Tyrosine Kinase Met
Sattler, M., Ma, P. C., & Salgia, R. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_7 · Cited by 18 · see citing works
Oberbach, A., Schlichting, N. S., Heinrich, M., Till, H., Stolzenburg, J., & Neuhaus, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041026 · Cited by 16 · see citing works
Regulation of insulin-like growth NF-κB proteasome system in endometrial cancer
Спирина, Л. В., Валерьевна, Б. Н., Кондакова, И. В., Коломиец, Л. А., Евгеньевна, Ш. Е., Koval, V. D., Чернышова, А. Л., & Асадчикова, О. Н. (2012) · Molecular Biology · doi:10.1134/s0026893312020173 · Cited by 15 · see citing works
Cellular mechanisms underlying the regulation of dendritic development by hepatocyte growth factor
Finsterwald, C., & Martin, J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07839.x · Cited by 14 · see citing works
Ray, S., Saha, D., Alam, N., Mustafi, S. M., Mandal, S., Sarkar, A., Majumder, B., & Murmu, N. (2021) · International Journal of Experimental Pathology · doi:10.1111/iep.12386 · Cited by 14 · see citing works
HAUSP compartmentalization in chronic myeloid leukemia
Morotti, A., Panuzzo, C., Crivellaro, S., Carrà, G., Guerrasio, A., & Saglio, G. N. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12422 · Cited by 14 · see citing works
Self-citationEffects of Nuclear Factor-κB Small Interfering RNA on Posterior Capsule Opacification
Park, H.-Y. L., Kim, I.-T., Lee, K., Choi, J., Park, M.-O., & Joo, C. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4984 · Cited by 13 · see citing works
The Role of Nuclear Factor Kappa B in Lens Epithelial Cell Proliferation Using a Capsular Bag Model
Lee, S., Bae, S., Seomun, Y., Son, M., & Joo, C. (2008) · Ophthalmic Research · doi:10.1159/000128162 · Cited by 11 · see citing works
The MET Oncogene: An Update on Targeting Strategies
Gallo, S., Folco, C. B., & Crepaldi, T. (2024) · Pharmaceuticals · doi:10.3390/ph17111473 · Cited by 9 · see citing works
MACC1 revisited – an in-depth review of a master of metastasis
Schöpe, P. C., Torke, S., Kobelt, D., Kortüm, B., Treese, C., Dumbani, M., Güllü, N., Walther, W., & Stein, U. (2024) · Biomarker Research · doi:10.1186/s40364-024-00689-4 · Cited by 9 · see citing works
The HGF/MET Signaling and Therapeutics in Cancer
Thewke, D. P., Kou, J., Fulmer, M. L., & Xie, Q. R. (2017) · Current human cell research and applications · doi:10.1007/978-981-10-7296-3_8 · Cited by 8 · see citing works
Yang, T., Wang, Y., Jiang, S., Liu, X., & Yu, Z. (2016) · Cell Biology International · doi:10.1002/cbin.10630 · Cited by 8 · see citing works
Rezaei, M., Cavaco, A. C. M., Seebach, J., Niland, S., Zimmermann, J., Hanschmann, E.-M., Hallmann, R., Schillers, H., & Eble, J. A. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801346 · Cited by 7 · see citing works
Santamaría, E., Mora, M. I., Muñoz, J., Sánchez‐Quiles, V., Fernández‐Irigoyen, J., Prìeto, J., & Corrales, F. J. (2009) · PROTEOMICS · doi:10.1002/pmic.200900110 · Cited by 7 · see citing works
NFκB: cell survival or cell death?
Strozyk, E. A., & Kulms, D. (2005) · Signal Transduction · doi:10.1002/sita.200500070 · Cited by 6 · see citing works
Hepatocyte Growth Factor in Normal and Diseased Bone and Joint Tissues
Adamopoulos, I. E., & Athanasou, N. A. (2006) · Current Rheumatology Reviews · doi:10.2174/157339706775697017 · Cited by 6 · see citing works
- Authors
- Müller, M., Morotti, A., & Ponzetto, C.
- Affiliations
- University of Turin (IT)
- Corresponding author
- Ponzetto, Carola
- ORCID
- Morotti, Alessandro
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-02-01
- Volume
- 22
- Issue
- 4
- Pages
- 1060-1072
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC134627
- OpenAlex
- W2136690190
- Cited by
- 129
- References
- 89
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondazione CRT
- Compagnia di San Paolo
- Centre National de la Recherche Scientifique
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB activation, hepatocyte growth factor, c-Met, tubulogenesis, cell proliferation, ERK signaling, p38 MAPK signaling, phosphatidylinositol 3-kinase, IκBα super-repressor, cell scattering, antiapoptotic function, liver
- MeSH terms
- NF-KappaB Inhibitor alpha, Animals, Cell Division, Cell Line, Cell Movement, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Liver, Morphogenesis, Phosphorylation, Protein Binding, Proto-Oncogene Proteins, Transcription, Genetic, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Hepatocyte Growth Factor, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-met, I-kappa B Proteins, Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review