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Cited by 244Mesenchymal stem cell researchLiver physiology and pathologyTissue Engineering and Regenerative Medicine

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Portal Application of Autologous CD133 + Bone Marrow Cells to the Liver: A Novel Concept to Support Hepatic Regeneration

am Esch, Jan Schulte, Knoefel, Wolfram Trudo, Klein, Michael, Ghodsizad, Ali, Fuerst, Guenter, Poll, Ludger W., Piechaczek, Christoph, Burchardt, Elmar R., Feifel, Niko, Stoldt, Volker, Stockschläder, Marcus, Stoecklein, Nikolas, Tustas, Roy Y., Eisenberger, Claus F., Peiper, Matthias, Häussinger, Dieter, Hosch, Stefan B.·2005·STEM CELLS
DOI 10.1634/stemcells.2004-0283
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Abstract

The liver has a large capacity for regeneration after resection. However, below a critical level of future liver remnant volume (FLRV), partial hepatectomy is accompanied by a significant increase of postoperative liver failure. There is accumulating evidence for the contribution of bone marrow stem cells (BMSCs) to participate in liver regeneration. Here we report on three patients subjected to intraportal administration of autologous CD133(+) BMSCs subsequent to portal venous embolization of right liver segments, used to expand left lateral hepatic segments as FLRV. Computerized tomography scan volumetry revealed 2.5-fold increased mean proliferation rates of left lateral segments compared with a group of three consecutive patients treated without application of BMSCs. This early experience with portovenous application of CD133(+) BMSCs could suggest that this novel therapeutic approach bears the potential of enhancing and accelerating hepatic regeneration in a clinical setting.

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References 44 · Cited by 244

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Metadata

Authors
am Esch, J. S., Knoefel, W. T., Klein, M., Ghodsizad, A., Fuerst, G., Poll, L. W., Piechaczek, C., Burchardt, E. R., Feifel, N., Stoldt, V., Stockschläder, M., Stoecklein, N., Tustas, R. Y., Eisenberger, C. F., Peiper, M., Häussinger, D., & Hosch, S. B.
Affiliations
  • Departments of General Surgery, Heinrich‐Heine‐University of Duesseldorf, Duesseldorf, Germany
  • Heinrich Heine University Düsseldorf (DE)
  • Witten/Herdecke University (DE)
Corresponding author
Knoefel, Wolfram Trudo
ORCID
Venue
STEM CELLS
Publisher
Oxford University Press (OUP)
Published
2005-04
Volume
23
Issue
4
Pages
463-470
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
DOI
10.1634/stemcells.2004-0283
OpenAlex
W1993065115
Cited by
244
References
44
Citations by year
2025: 3 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 12 · 2014: 21 · 2013: 20 · 2012: 17
FWCI
8.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Stem Cells (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
autologous stem cell transplantation, intraportal administration, liver regeneration, partial hepatectomy, future liver remnant volume, postoperative liver failure, stem cell proliferation, hepatectomy
MeSH terms
AC133 Antigen, Aged, Bone Marrow Cells, Embolization, Therapeutic, Female, Glycoproteins, Hepatectomy, Humans, Liver Neoplasms, Liver Regeneration, Male, Middle Aged, Peptides, Portal Vein, Transplantation, Autologous, Antigens, CD, Bone Marrow Transplantation

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