Häussinger, Dieter

Sorafenib in advanced hepatocellular carcinoma

Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine

Hepatocellular Carcinoma Treatment and PrognosisColorectal Cancer Treatments and Studies

Cited by 13,097

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 2,230

Functional significance of cell volume regulatory mechanisms

LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews

Ion Transport and Channel RegulationElectrolyte and hormonal disorders

Cited by 1,891

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Expression and function of the bile acid receptor TGR5 in Kupffer cells

Keitel, V., Donner, M., Winandy, S., Kubitz, R., & Häussinger, D. (2008) · Biochemical and Biophysical Research Communications

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 418

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

Bode, J. G., Albrecht, U., Häussinger, D., Heinrich, P. C., & Schaper, F. (2012) · European Journal of Cell Biology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 379

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia

Neuroscience and Neuropharmacology ResearchDrug Transport and Resistance Mechanisms

Cited by 274

Portal Application of Autologous CD133 + Bone Marrow Cells to the Liver: A Novel Concept to Support Hepatic Regeneration

am Esch, J. S., Knoefel, W. T., Klein, M., Ghodsizad, A., Fuerst, G., Poll, L. W., Piechaczek, C., Burchardt, E. R., Feifel, N., Stoldt, V., et al. (2005) · STEM CELLS

Mesenchymal stem cell researchLiver physiology and pathology

Cited by 244

Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival

Lorenz, L., Axnick, J., Buschmann, T., Henning, C., Urner, S., Fang, S., Nurmi, H., Eichhorst, N., Holtmeier, R., Bódis, K., et al. (2018) · Nature

Liver physiology and pathologyAngiogenesis and VEGF in Cancer

Cited by 171

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

Haselow, K., Bode, J. G., Wammers, M., Ehlting, C., Keitel, V., Kleinebrecht, L., Schupp, A.-K., Häussinger, D., & Graf, D. (2013) · Journal of Leukocyte Biology

Immune Response and InflammationImmune cells in cancer

Cited by 164

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

Jensen, B.-E. O., Knops, E., Cords, L., Lübke, N., Salgado, M., Busman-Sahay, K., Estes, J. D., Huyveneers, L. E. P., Perdomo-Celis, F., Wittner, M., et al. (2023) · Nature Medicine

HIV Research and TreatmentVirus-based gene therapy research

Cited by 158

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adebayo Michael, A. O., Ko, S., Tao, J., Moghe, A., Yang, H., Xu, M., Russell, J. O., Pradhan-Sundd, T., Liu, S., Singh, S., et al. (2019) · Cell Metabolism

PI3K/AKT/mTOR signaling in cancerWnt/β-catenin signaling in development and cancer

Cited by 155

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

Keitel, V., Ullmer, C., & Häussinger, D. (2010) · Biological Chemistry

Drug Transport and Resistance MechanismsGenetic and Kidney Cyst Diseases

Cited by 129

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

Reich, M., Spomer, L., Klindt, C., Fuchs, K., Stindt, J., Deutschmann, K., Höhne, J., Liaskou, E., Hov, J. R., Karlsen, T. H., et al. (2021) · Journal of Hepatology

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 121

IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Fazel Modares, N., Polz, R., Haghighi, F., Lamertz, L., Behnke, K., Zhuang, Y., Kordes, C., Häussinger, D., Sorg, U. R., Pfeffer, K., et al. (2019) · Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 113

Role of TGR5 (GPBAR1) in Liver Disease

Häussinger, D., & Keitel, V. (2018) · Seminars in Liver Disease

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 106

Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors

Keitel, V., Stindt, J., & Häussinger, D. (2019) · Handbook of Experimental Pharmacology

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 98

Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase

Qvartskhava, N., Lang, P. A., Görg, B., Pozdeev, V. I., Ortiz, M. P., Lang, K. S., Bidmon, H. J., Lang, E., Leibrock, C. B., Herebian, D., et al. (2015) · Proceedings of the National Academy of Sciences

Amino Acid Enzymes and MetabolismMetabolism and Genetic Disorders

Cited by 98

Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial

Traussnigg, S., Schattenberg, J. M., Demir, M., Wiegand, J., Geier, A., Teuber, G., Hofmann, W. P., Kremer, A. E., Spreda, F., Kluwe, J., et al. (2019) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 88

Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock

Gatsios, P., Terstegen, L., Schliess, F., Häussinger, D., Kerr, I. M., Heinrich, P. C., & Graeve, L. (1998) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 85

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

Gohlke, H., Schmitz, B., Sommerfeld, A., Reinehr, R., & Häussinger, D. (2013) · Hepatology

Cell Adhesion Molecules ResearchDrug Transport and Resistance Mechanisms

Cited by 77

Taurine is an osmolyte in rat liver macrophages (Kupffer cells)

Warskulat, U., Zhang, F., & Häussinger, D. (1997) · Journal of Hepatology

Aldose Reductase and TaurineLiver physiology and pathology

Cited by 56

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration

Behnke, K., Zhuang, Y., Xu, H. C., Sundaram, B., Reich, M., Shinde, P. V., Huang, J., Modares, N. F., Tumanov, A. V., Polz, R., et al. (2018) · Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 34

Efficiently Restored Thrombopoietin Production by Ashwell-Morell Receptor and IL-6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy

Reusswig, F., Fazel Modares, N., Brechtenkamp, M., Wienands, L., Krüger, I., Behnke, K., Lee‐Sundlov, M. M., Herebian, D., Scheller, J., Hoffmeister, K. M., et al. (2021) · Hepatology

Platelet Disorders and TreatmentsLiver physiology and pathology

Cited by 28