Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Abstract
The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH(-/-) mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells.
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The differentiation of HSPCs into hepatocytes has been fully demonstrated.
“The differentiation of HSPCs into hepatocytes has been fully demonstrated [57].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [57]
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“The differentiation of HSPCs into hepatocytes has been fully demonstrated [57].”
- Authors
- Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M.
- Affiliations
- StemCells (United States) (US)
- Oregon Health & Science University (US)
- Baylor College of Medicine (US)
- Stanford Medicine (US)
- Corresponding author
- Lagasse, Eric
- Venue
- Nature Medicine
- Published
- 2000-11
- Volume
- 6
- Issue
- 11
- Pages
- 1229-1234
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1542326554
- Cited by
- 2,314
- References
- 2
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 10 · 2023: 16 · 2022: 20 · 2021: 21 · 2020: 22 · 2019: 18 · 2018: 30 · 2017: 27 · 2016: 36 · 2015: 53 · 2014: 65 · 2013: 63 · 2012: 82
- FWCI
- 117.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- hematopoietic stem cells, hepatocyte differentiation, hepatic progenitor cells, bone marrow transplantation, tyrosinemia type I, liver regeneration, transdifferentiation, pluripotency, germ layer origin, multipotency
- MeSH terms
- Animals, Bone Marrow Cells, Cell Differentiation, Cell Separation, Hematopoietic Stem Cells, Hydrolases, Liver, Liver Regeneration, Mice, Inbred C57BL, Mice, Inbred Strains, Whole-Body Irradiation, Cell Transplantation, Mice, Knockout, Tyrosinemias, Hepatocytes, Mice
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