The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Basic Fibroblast Growth Factor Controls Migration in Human Mesenchymal Stem Cells
Open accessAbstract
Little is known about the migration of mesenchymal stem cells (MSCs). Some therapeutic approaches had demonstrated that MSCs were able to regenerate injured tissues when applied from different sites of application. This implies that MSCs are not only able to migrate but also that the direction of migration is controlled. Factors that are involved in the control of the migration of MSCs are widely unknown. The migratory ability of isolated MSCs was tested in different conditions. The migratory capability was examined using Boyden chamber assay in the presence or absence of basic fibroblast growth factor (bFGF), erythropoietin, interleukin-6, stromal cell-derived factor-beta, and vascular endothelial growth factor. bFGF in particular was able to increase the migratory activity of MSCs through activation of the Akt/protein kinase B (PKB) pathway. The results were supported by analyzing the orientation of the cytoskeleton. In the presence of a bFGF gradient, the actin filaments developed a parallelized pattern that was strongly related to the gradient. Surprisingly, the influence of bFGF was not only an attraction but also routing of MSCs. The bFGF gradient experiment showed that low concentrations of bFGF lead to an attraction of the cells, whereas higher concentrations resulted in repulsion. This ambivalent effect of bFGF provides the possibility to a purposeful routing of MSCs.
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Cites
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Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
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Creation of long-lasting blood vessels
Koike, N., Fukumura, D., Gralla, O., Au, P., Schechner, J. S., & Jain, R. K. (2004) · Nature · doi:10.1038/428138a · Cited by 701
Cited by
Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells
Spaeth, E., Klopp, A., Dembinski, J., Andreeff, M., & Marini, F. (2008) · Gene Therapy · doi:10.1038/gt.2008.39 · Cited by 579
VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
Beckermann, B. M., Kallifatidis, G., Groth, A., Frommhold, D., Apel, A., Mattern, J., Salnikov, A. V., Moldenhauer, G., Wagner, W., Diehlmann, A., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604508 · Cited by 406
Concise Review: MSC Adhesion Cascade—Insights into Homing and Transendothelial Migration
Nitzsche, F., Müller, C., Lukomska, B., Jolkkonen, J., Deten, A., & Boltze, J. (2017) · Stem Cells · doi:10.1002/stem.2614 · Cited by 382
Roodhart, J. M. L., Daenen, L. G. M., Stigter, E. C. A., Prins, H.-J., Gerrits, J., Houthuijzen, J. M., Gerritsen, M. G., Schipper, H. S., Backer, M. J. G., van Amersfoort, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.010 · Cited by 305
Exploring the role of stem cells in cutaneous wound healing
Lau, K., Paus, R., Tiede, S., Day, P., & Bayat, A. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00942.x · Cited by 279
Metadata
- Authors
- Schmidt, A., Ladage, D., Schinköthe, T., Klausmann, U., Ulrichs, C., Klinz, F., Brixius, K., Arnhold, S., Desai, B., Mehlhorn, U., Schwinger, R. H. G., Staib, P., Addicks, K., & Bloch, W.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07
- Volume
- 24
- Issue
- 7
- Pages
- 1750-1758
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2062575512
- Cited by
- 237
- References
- 3
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schmidt, A., Ladage, D., Schinköthe, T., Klausmann, U., Ulrichs, C., Klinz, F., Brixius, K., Arnhold, S., Desai, B., Mehlhorn, U., Schwinger, R. H. G., Staib, P., Addicks, K., & Bloch, W. (2006). Basic Fibroblast Growth Factor Controls Migration in Human Mesenchymal Stem Cells. STEM CELLS. https://doi.org/10.1634/stemcells.2005-0191
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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