The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Characterization and Clinical Application of Human CD34 + Stem/Progenitor Cell Populations Mobilized into the Blood by Granulocyte Colony‐Stimulating Factor
Open accessAbstract
A phase I study was performed to determine the safety and tolerability of injecting autologous CD34(+) cells into five patients with liver insufficiency. The study was based on the hypothesis that the CD34(+) cell population in granulocyte colony-stimulating factor (G-CSF)-mobilized blood contains a subpopulation of cells with the potential for regenerating damaged tissue. We separated a candidate CD34(+) stem cell population from the majority of the CD34(+) cells (99%) by adherence to tissue culture plastic. The adherent and nonadherent CD34(+) cells were distinct in morphology, immunophenotype, and gene expression profile. Reverse transcription-polymerase chain reaction-based gene expression analysis indicated that the adherent CD34(+) cells had the potential to express determinants consistent with liver, pancreas, heart, muscle, and nerve cell differentiation as well as hematopoiesis. Overall, the characteristics of the adherent CD34(+) cells identify them as a separate putative stem/progenitor cell population. In culture, they produced a population of cells exhibiting diverse morphologies and expressing genes corresponding to multiple tissue types. Encouraged by this evidence that the CD34(+) cell population contains cells with the potential to form hepatocyte-like cells, we gave G-CSF to five patients with liver insufficiency to mobilize their stem cells for collection by leukapheresis. Between 1 x 10(6) and 2 x 10(8) CD34(+) cells were injected into the portal vein (three patients) or hepatic artery (two patients). No complications or specific side effects related to the procedure were observed. Three of the five patients showed improvement in serum bilirubin and four of five in serum albumin. These observations warrant further clinical trials.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedA Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2011) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,708
Friedenstein, A. J., Chailakhyan, R. K., Latsinik, N. V., Panasyuk, A. F., & Keiliss-Borok, I. V. (1974) · Transplantation · doi:10.1097/00007890-197404000-00001 · Cited by 1,431
Kögler, G., Sensken, S., Airey, J. A., Trapp, T., Müschen, M., Feldhahn, N., Liedtke, S., Sorg, R. V., Fischer, J., Rosenbaum, C., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040440 · Cited by 1,029
Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow
Colter, D. C., Class, R., DiGirolamo, C. M., & Prockop, D. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070034097 · Cited by 1,019
Colter, D. C., Sekiya, I., & Prockop, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141221698 · Cited by 938
Characterization of Multipotent Adult Progenitor Cells, a Subpopulation of Mesenchymal Stem Cells
REYES, M., & VERFAILLIE, C. M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03593.x · Cited by 346
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Cited by
Stem cell-based therapy for human diseases
Hoang, D. M., Pham, P. T., Bach, T. Q., Ngo, A. T. L., Nguyen, Q. T., Phan, T. T. K., Nguyen, G. H., Le, P. T. T., Hoang, V. T., Forsyth, N. R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01134-4 · Cited by 1,074
Kharaziha, P., Hellström, P. M., Noorinayer, B., Farzaneh, F., Aghajani, K., Jafari, F., Telkabadi, M., Atashi, A., Honardoost, M., Zali, M. R., et al. (2009) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832a1f6c · Cited by 492
Self-citationMohamadnejad, M., Alimoghaddam, K., Bagheri, M., Ashrafi, M., Abdollahzadeh, L., Akhlaghpoor, S., Bashtar, M., Ghavamzadeh, A., & Malekzadeh, R. (2013) · Liver International · doi:10.1111/liv.12228 · Cited by 182
Mohamadnejad, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i24.3359 · Cited by 179
Hematopoietic Stem Cells and Their Roles in Tissue Regeneration
Lee, J. Y., & Hong, S.-H. (2020) · International Journal of Stem Cells · doi:10.15283/ijsc19127 · Cited by 165
Metadata
- Authors
- Gordon, M. Y., Levičar, N., Pai, M., Bachellier, P., Dimarakis, I., Al‐Allaf, F., M'Hamdi, H., Thalji, T., Welsh, J. P., Marley, S. B., Davies, J., Dazzi, F., Marelli‐Berg, F., Tait, P., Playford, R., Jiao, L., Jensen, S., Nicholls, J. P., Ayav, A., Nohandani, M., Farzaneh, F., Gaken, J., Dodge, R., Alison, M., Apperley, J. F., Lechler, R., & Habib, N. A.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07
- Volume
- 24
- Issue
- 7
- Pages
- 1822-1830
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2034885353
- Cited by
- 275
- References
- 21
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Characterization and Clinical Application of Human CD34 + Stem/Progenitor Cell Populations Mobilized into the Blood by Granulocyte Colony‐Stimulating Factor. https://app.cochat.ai/papers/10.1634/stemcells.2005-0629
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- Gordon, M. Y., Levičar, N., Pai, M., Bachellier, P., Dimarakis, I., Al‐Allaf, F., M'Hamdi, H., Thalji, T., Welsh, J. P., Marley, S. B., Davies, J., Dazzi, F., Marelli‐Berg, F., Tait, P., Playford, R., Jiao, L., Jensen, S., Nicholls, J. P., Ayav, A., . . . Habib, N. A. (2006). Characterization and Clinical Application of Human CD34 + Stem/Progenitor Cell Populations Mobilized into the Blood by Granulocyte Colony‐Stimulating Factor. STEM CELLS. https://doi.org/10.1634/stemcells.2005-0629
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
