Cited by 165Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchPluripotent Stem Cells Research

Hematopoietic Stem Cells and Their Roles in Tissue Regeneration

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Lee, Ji Yoon, Hong, Seok-Ho·2020·International Journal of Stem Cells

Abstract

Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science. In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders. HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions. Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.

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  • In myelosuppressive conditions induced by granulocyte colony-stimulating factor, HSPCs proliferate, mobilize, and emigrate rapidly from the bone marrow into peripheral blood, enabling their purification from harvested PB-MNCs based on positive expression of CD34 and CD133 surface markers.

    “In myelosuppressive conditions induced by the administration of granulocyte colony-stimulating factor (G-CSF), they proliferate, mobilize, and emigrate rapidly from the BM into PB, thereby enabling their purification from harvested PB-MNCs based on their positive expression of the cluster of differentiation 34 (CD34) and CD133 surface markers [54, 55].”

    From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [55]

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Authors
Lee, J. Y., & Hong, S.-H.
Affiliations
  • CHA University (KR)
  • Kangwon National University (KR)
Corresponding author
Hong, Seok-Ho
Venue
International Journal of Stem Cells
Published
2020-03-30
Volume
13
Issue
1
Pages
1-12
ISSN
  • 2005-3606 (ISSN-L)
  • 2005-5447
OpenAlex
W2997983238
Cited by
165
References
84
Citations by year
2026: 26 · 2025: 42 · 2024: 44 · 2023: 31 · 2022: 11 · 2021: 8 · 2020: 3
FWCI
3.89
Type
journal article
Language
en
Open access
Locations
  • International Journal of Stem Cells (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
hematopoietic stem cells, tissue regeneration, regenerative medicine, hematologic disorders, hematologic malignancies, liver disease, endothelial progenitor cells, stem cell therapy

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