Hematopoietic Stem Cells and Their Roles in Tissue Regeneration
Open accessAbstract
Hematopoietic stem cells (HSCs) are regarded as one of essential cell sources for treating regenerative diseases. Among many stem cells, the feasibility of using adult-derived hematopoietic stem cells in therapeutic approaches is very diverse, and is unarguably regarded as an important cell source in stem cell biology. So far, many investigators are exploring HSCs and modified HSCs for use in clinical and basic science. In the present review, we briefly summarized HSCs and their application in pathophysiologic conditions, including non-hematopoietic tissue regeneration as well as blood disorders. HSCs and HSCs-derived progenitors are promising cell sources in regenerative medicine and their contributions can be properly applied to treat pathophysiologic conditions. Among many adult stem cells, HSCs are a powerful tool to treat patients with diseases such as hematologic malignancies and liver disease. Since HSCs can be differentiated into diverse progenitors including endothelial progenitors, they may be useful for constructing strategies for effective therapy.
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In myelosuppressive conditions induced by granulocyte colony-stimulating factor, HSPCs proliferate, mobilize, and emigrate rapidly from the bone marrow into peripheral blood, enabling their purification from harvested PB-MNCs based on positive expression of CD34 and CD133 surface markers.
“In myelosuppressive conditions induced by the administration of granulocyte colony-stimulating factor (G-CSF), they proliferate, mobilize, and emigrate rapidly from the BM into PB, thereby enabling their purification from harvested PB-MNCs based on their positive expression of the cluster of differentiation 34 (CD34) and CD133 surface markers [54, 55].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [55]
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Revolutionizing medicine: recent developments and future prospects in stem-cell therapy
Hussen, B. M., Taheri, M. N., Yashooa, R. K., Abdullah, G. H., Abdullah, S. R., Kheder, R. K., & Mustafa, S. A. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000002109 · Cited by 152 · see citing works
Health Effects of Ionizing Radiation on the Human Body
Talapko, J., Talapko, D., Katalinić, D., Kotris, I., Erić, I., Belić, D., Mihaljević, M. V., Vasilj, A., Erić, S., Flam, J., et al. (2024) · Medicina · doi:10.3390/medicina60040653 · Cited by 152 · see citing works
Application of 3D- printed hydrogels in wound healing and regenerative medicine
Deptuła, M., Zawrzykraj, M., Sawicka, J., Banach‐Kopeć, A., Tylingo, R., & Pikuła, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115416 · Cited by 87 · see citing works
Tuning Lipid Nanoparticles for RNA Delivery to Extrahepatic Organs
Song, D., Zhao, Y., Wang, Z., & Xu, Q. (2024) · Advanced Materials · doi:10.1002/adma.202401445 · Cited by 80 · see citing works
CAR-macrophages in solid tumors: promise, progress, and prospects
Alrehaili, M., Couto, P. S., Khalifé, R., & Rafiq, Q. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01170-7 · Cited by 54 · see citing works
Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies
Haddadin, L., & Sun, X. S. (2025) · Cells · doi:10.3390/cells14070538 · Cited by 44 · see citing works
Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis
Fernández-García, V., González-Ramos, S., Martín‐Sanz, P., Castrillo, A., & Boscá, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106386 · Cited by 34 · see citing works
Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study
Opasawatchai, A., Nguantad, S., Sriwilai, B., Matangkasombut, P., Matangkasombut, O., Srisatjaluk, R. L., & Charoensawan, V. (2022) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2021.806294 · Cited by 28 · see citing works
Fusobacterium nucleatum modulates the Wnt/β-catenin pathway in colorectal cancer development
Mondal, T., Chattopadhyay, D., Mondal, P. S., Das, S., Mondal, A., Das, A., Samanta, S., & Saha, T. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140196 · Cited by 27 · see citing works
The role of GATA4 in mesenchymal stem cell senescence: A new frontier in regenerative medicine
Babu, M. A., Renuka Jyothi, S., Kaur, I., Kumar, S., Sharma, N., Kumar, M., Rajput, P., Ali, H., Gupta, G., Subramaniyan, V., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.017 · Cited by 24 · see citing works
Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes
Gomes, F. L., Jeong, S., Shin, S. R., Leijten, J., & Jonkheijm, P. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202315879 · Cited by 25 · see citing works
Sadiq, I. Z., Abubakar, F. S., Katsayal, B. S., Ibrahim, B., Adamu, A., Usman, M. A., Aliyu, M., Suleiman, M. A., & Muhammad, A. (2025) · Biomedical Engineering Advances · doi:10.1016/j.bea.2025.100172 · Cited by 21 · see citing works
Stem cell therapies for autoimmune hepatitis
Lotfy, A., Elgamal, A., Burdzińska, A., Swelum, A. A., Soliman, R., Hassan, A., & Shiha, G. E.-S. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02464-w · Cited by 22 · see citing works
Zheng, H., Vijg, J., Fard, A. T., & Mar, J. C. (2023) · Genome biology · doi:10.1186/s13059-023-03036-2 · Cited by 18 · see citing works
Organoid Model in Idiopathic Pulmonary Fibrosis
Lee, J. Y., Kim, J.-H., Hong, S., & Yang, S. (2020) · International Journal of Stem Cells · doi:10.15283/ijsc20093 · Cited by 19 · see citing works
Self-citationCell-Based Regeneration and Treatment of Liver Diseases
Hofmann, J. D., Hackl, V., Esser, H., Mészáros, A., Fodor, M., Öfner, D., Troppmair, J., Schneeberger, S., & Hautz, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910276 · Cited by 22 · see citing works
McGinnis, C. D., Jennings, E. Q., Harris, P. S., Galligan, J. J., & Fritz, K. S. (2022) · Cells · doi:10.3390/cells11132045 · Cited by 18 · see citing works
Stem cell therapy in sports medicine: current applications, challenges and future perspectives
Palermi, S., Gnasso, R., Belviso, I., Iommazzo, I., Vecchiato, M., Marchini, A., Corsini, A., Vittadini, F., Demeco, A., Luca, M. D., et al. (2023) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2023-0200 · Cited by 18 · see citing works
Naserpour, L., Jalise, S. Z., Khoshandam, M., & Hosseinzadeh, F. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114769 · Cited by 17 · see citing works
Brown, M. G., Brady, D. J., Healy, K. M., Henry, K. A., Ogunsola, A. S., & Ma, X. (2024) · Cells · doi:10.3390/cells13121045 · Cited by 15 · see citing works
Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification
Juan, C., Bancroft, A. C., Choi, J. H., Nunez, J. H., Pagani, C. A., Lin, Y., Hsiao, E. C., & Lévi, B. (2024) · Biomolecules · doi:10.3390/biom14030349 · Cited by 16 · see citing works
The Therapeutic Potential of Hematopoietic Stem Cells in Bone Regeneration
Oliveira, C. S., Carreira, M., Correia, C. R., & Mano, J. F. (2022) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2021.0019 · Cited by 14 · see citing works
Musgrove, L., Russell, F. D., & Ventura, T. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2342480 · Cited by 14 · see citing works
Stem Cell Therapy for Myocardial Infarction Recovery: Advances, Challenges, and Future Directions
Le, N. T., Dunleavy, M. W., Zhou, W., Bhatia, S. S., Kumar, R. D., Woo, S. T., Ramirez-Pulido, G., Ramakrishnan, K. S., & El-Hashash, A. H. K. (2025) · Biomedicines · doi:10.3390/biomedicines13051209 · Cited by 13 · see citing works
Cruz-Pavlovich, F. J. S., Bolaños-Chang, A. J., Rio-Murillo, X. I. D., Aranda-Preciado, G. A., Razura-Ruiz, E. M., Santos, A., & Navarro‐Partida, J. (2024) · Cells · doi:10.3390/cells13020179 · Cited by 13 · see citing works
Martins, R. A., Costa, F. R., Pires, L., dos Santos, M. E. B., Santos, G. S., Lana, J. V., Costa, B. R., Santos, N., de Macedo, A. P., Kruel, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011329 · Cited by 13 · see citing works
Nunes, J. J., & Loeffler, D. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1373554 · Cited by 13 · see citing works
Biomolecular Components of Blood and Their Role in Health and Diseases
Shah, A., Srivastava, S., & Chaturvedi, C. (2024) · Springer eBooks · doi:10.1007/978-981-97-4723-8_12 · Cited by 12 · see citing works
Sharma, M., Pondugala, P. K., Jaggaihgari, S., Mitnala, S., Krishna, V. V., Jaishetwar, G., Naik, P., Kumar, P., Kulkarni, A., Gupta, R., et al. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.03.010 · Cited by 12 · see citing works
Bone Marrow Changes in Septic Shock: A Comprehensive Review
Nagaraju, N., Varma, A. R., Taksande, A. M., & Meshram, R. J. (2023) · Cureus · doi:10.7759/cureus.42517 · Cited by 12 · see citing works
Engineered hematopoietic and immune cells derived from human pluripotent stem cells
Chang, Y., Hummel, S. N., Jung, J., Jin, G., Deng, Q., & Bao, X. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.08.006 · Cited by 11 · see citing works
Yang, X.-Y., Vladimirovich, R. I., Beeraka, N., Satyavathi, A., Kamble, D., Nikolenko, V., Lakshmi, A. N., Basappa, B., Padmanabha Reddy, Y., Fan, R.-T., et al. (2024) · Stem cell research & therapeutics · doi:10.1186/s13287-024-04008-4 · Cited by 9 · see citing works
Regenerative Medicine of Liver: Promises, Advances and Challenges
Ali, S. W., Haque, N., Azhar, Z., Saeinasab, M., & Sefat, F. (2021) · Biomimetics · doi:10.3390/biomimetics6040062 · Cited by 12 · see citing works
Lana, J. F., Purita, J. R., Jeyaraman, M., de Souza, B. F., Rodrigues, B. L., Huber, S. C., Oliveira, C. C., Santos, G. S., da Fonseca, L. F., Dallo, I., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12122812 · Cited by 10 · see citing works
Adipose Stem Cells in Modern-Day Ophthalmology
Musa, M., Zeppieri, M., Enaholo, E. S., Salati, C., & Parodi, P. C. (2023) · Clinics and Practice · doi:10.3390/clinpract13010021 · Cited by 10 · see citing works
Navigating stem cell culture: insights, techniques, challenges, and prospects
Górska, A., Trubalski, M., Borowski, B., Brachet, A., Szymańczyk, S., & Markiewicz, R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1435461 · Cited by 10 · see citing works
Causal ALS genes impact the MHC class II antigen presentation pathway
Chi, B., Öztürk, M. M., Paraggio, C. L., Leonard, C. E., Sanita, M. E., Dastpak, M., O’Connell, J. D., Coady, J. A., Zhang, J., Gygi, S. P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305756120 · Cited by 9 · see citing works
Application of machine learning–based approaches in stem cell research
Yadav, M. K., Bhutani, K., Ahmad, S., Raza, K., Singh, A., & Kumar, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13222-3.00007-1 · Cited by 9 · see citing works
Looi, C.-K., Loo, E.-M., Lim, H.-C., Chew, Y.-L., Chin, K., Cheah, S., Goh, B. H., & Mai, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1484535 · Cited by 9 · see citing works
Stem Cell Therapy for Liver Diseases: Current Perspectives
Wang, J., Li, Q., Li, W., Méndez‐Sánchez, N., Liu, X., & Qi, X. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2812359 · Cited by 8 · see citing works
Biophysical cues involved in the stem cell niche for stemness maintenance
Li, C., Zheng, L., & Fan, Y. (2024) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2024.100301 · Cited by 7 · see citing works
Review on kidney diseases: types, treatment and potential of stem cell therapy
Singh, J., & Singh, S. (2023) · Renal Replacement Therapy · doi:10.1186/s41100-023-00475-2 · Cited by 7 · see citing works
The Long and Winding Road to Cardiac Regeneration
Sacco, A. M., Castaldo, C., Meglio, F. D., Nurzyńska, D., Palermi, S., Spera, R., Gnasso, R., Zinno, G., Romano, V., & Belviso, I. (2023) · Applied Sciences · doi:10.3390/app13169432 · Cited by 6 · see citing works
Camesi, A., Wettstein, R., Valido, E. M., Nyfeler, N., Stojic, S., Glišić, M., Stoyanov, J. V., & Bertolo, A. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231201071 · Cited by 6 · see citing works
Soe, Y. M., Sim, S.-L., & Kumari, S. (2025) · Viruses · doi:10.3390/v17020241 · Cited by 7 · see citing works
Exploring the potential of stem cell therapy: Applications, types, and future directions
Boopathy, K., Palaniyandi, T., Ravi, M., Wahab, M. R. A., Baskar, G., Rab, S. O., Saeed, M., & Balaramnavar, V. M. (2025) · Acta Histochemica · doi:10.1016/j.acthis.2025.152237 · Cited by 6 · see citing works
Gao, X., Qian, B., Yuan, T., Pan, D., Liang, Z., Yin, Y., Liu, S., Li, X., Zhao, D., & Zhang, H. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119798 · Cited by 6 · see citing works
Immune and Inflammatory Properties of Megakaryocytes
Singh, S. V., Lucerne, A. M., & Ravid, K. (2025) · Cells · doi:10.3390/cells14141053 · Cited by 7 · see citing works
LINC00265 maintains hepatocyte proliferation during liver regeneration by targeting miRNA-28-5p
Yu, S., Cui, Z., Zhou, J., Wang, K., Li, Q., Sun, H., & Hu, Z. (2021) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbaa049 · Cited by 6 · see citing works
Tunable cell separation using a thermo-responsive deterministic lateral displacement device
Jiang, Z., Kanno, Y., & Nisisako, T. (2025) · Lab on a Chip · doi:10.1039/d5lc00783f · Cited by 5 · see citing works
Avazzadeh, Z., Hassani, H., Ebadi, M. J., Eshkaftaki, A. B., Katani, R., & Rezvani, A. (2024) · Physica Scripta · doi:10.1088/1402-4896/ad5e44 · Cited by 5 · see citing works
Yusoff, N. A., Hamid, Z. A., Budin, S. B., & Taib, I. S. (2025) · PeerJ · doi:10.7717/peerj.18854 · Cited by 5 · see citing works
Cell and cell-derivative-based therapy for liver diseases: current approaches and future promises
Zahmatkesh, E., Rad, N. K., Hossein‐Khannazer, N., Mohamadnejad, M., Gramignoli, R., Najimi, M., Malekzadeh, R., Hassan, M., & Vosough, M. (2023) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2023.2172398 · Cited by 5 · see citing works
Sokolova, N., Žílová, L., & Wittbrodt, J. (2023) · Cells and Development · doi:10.1016/j.cdev.2023.203848 · Cited by 5 · see citing works
Maytum, A., Edginton‐White, B., & Bonifer, C. (2023) · Stem Cell Investigation · doi:10.21037/sci-2023-011 · Cited by 3 · see citing works
Nucleic acid-induced inflammation on hematopoietic stem cells
Vu, G. T., Awad, V., Norberto, M. F., Bowman, T. V., & Trompouki, E. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.104148 · Cited by 5 · see citing works
Garrigós, M. M., Oliveira, F. A., Nucci, M. P., Mamani, J. B., Dias, O. F. M., Rego, G. N. A., Junqueira, M. D. S., Costa, C. J. S., Silva, L. R. R., Alves, A. H., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030828 · Cited by 5 · see citing works
In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
Sireesha, K., Samundeshwari, E. L., Kattaru, S., Chandrasekhar, C., & Sarma, P. V. G. K. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-00862-x · Cited by 6 · see citing works
Raghav, P. K., Banerjee, B., & Chadha, R. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1589823 · Cited by 4 · see citing works
Dennis, C. J., He, A. Z., Krishnaraj, A., Quan, A., Teoh, H., Connelly, K. A., Hess, D. A., & Verma, S. (2026) · Circulation Research · doi:10.1161/circresaha.126.327425 · Cited by 4 · see citing works
Pendse, S., Kale, V. P., & Vaidya, A. (2025) · Annals of Hematology · doi:10.1007/s00277-025-06652-z · Cited by 4 · see citing works
Stem cell therapy: a novel frontier in the treatment of liver fibrosis/cirrhosis
Liu, Y., Li, J., Su, W., & Wang, S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04821-5 · Cited by 4 · see citing works
Regenerative Medicines: Application to Degenerative Diseases and Disorders
Kumbhar, A. B., Nerkar, N. V., & Phuge, A. N. (2024) · Springer eBooks · doi:10.1007/978-981-97-2596-0_16 · Cited by 4 · see citing works
Computing hematopoiesis plasticity in response to genetic mutations and environmental stimulations
Wen, Y., He, H., Ma, Y., Bao, D., Cai, L. C., Wang, H., Li, Y., Zhao, B., & Cai, Z. (2024) · Life Science Alliance · doi:10.26508/lsa.202402971 · Cited by 4 · see citing works
From nucleated to ex vivo manipulated stem cells: An updated biological and clinical synopsis
Balint, B., Pavlović, M. D., & Todorović, M. (2020) · Medicinska rec · doi:10.5937/medrec2001001b · Cited by 4 · see citing works
Cellular therapies in liver and pancreatic diseases
Giuli, L., Santopaolo, F., Pallozzi, M., Pellegrino, A., Coppola, G., Gasbarrini, A., & Ponziani, F. R. (2022) · Digestive and Liver Disease · doi:10.1016/j.dld.2022.11.013 · Cited by 4 · see citing works
Saberi, F., Dehghan, Z., Mehdinejadiani, S., Khosravizadeh, Z., Noori, E., Pilehchi, T., Rezaee, D., Taheri, Z., Govahi, A., Goudarzi, N., et al. (2025) · Cellular Reprogramming · doi:10.1177/21524971251379699 · Cited by 3 · see citing works
Aging and vaccines: impact of immunosenescence and inflammaging in vaccine response
Albaloshi, J., Alnakhli, A., & Cham, L. B. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1797166 · Cited by 4 · see citing works
Overview of hematopoietic stem cell transplantation
Meriç, N. (2023) · Journal of Experimental and Clinical Medicine · doi:10.52142/omujecm.40.1.27 · Cited by 3 · see citing works
Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
Oliveira, C. S., & Tavaria, F. K. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00100 · Cited by 3 · see citing works
Melanocyte stem cells in skin diseases and their potential in cell-based therapy.
Wang, Z., Liu, L., & Zheng, Y. (2022) · PubMed · doi:10.14670/hh-18-470 · Cited by 3 · see citing works
Age-Related Macular Degeneration: Therapeutic Strategies Based on Stem Cells
Mathivanan, I., Enzmann, V., Thyagarajan, K., Sivasubramanian, A. T., Raju, K., & Thangaraj, A. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10917-5 · Cited by 3 · see citing works
Pan, X., Gao, T., & Wang, B. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01520-9 · Cited by 2 · see citing works
“…of granulocyte colony-stimulating factor (G-CSF), they proliferate, mobilize, and emigrate rapidly from the BM into PB, thereby enabling their purification from harvested PB-MNCs based on their positive expression of the cluster of differentiation 34 (CD34) and CD133 surface markers [54, 55].”
The Role of Bone Marrow Cells and Peripheral Blood Cells in the Osteogenic Process
Vukelić-Nikolić, M. Đ., & Đorđević, L. (2024) · Acta veterinaria · doi:10.2478/acve-2024-0034 · Cited by 2 · see citing works
Khaseb, S., Karimi, R., Tavangar, F., Taghipour, N., & Atashi, A. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10730-w · Cited by 2 · see citing works
The Coming of Age of Gene Therapy for the Treatment of Human Diseases: A Regulatory Perspective
Rodríguez, L., de Felipe, P., Martín, R., Martínez, J., Ordóñez, D., Rojo, S., Martínez, J. F., Rincón, E., Cejalvo, T., Izquierdo, I., et al. (2025) · Human Gene Therapy · doi:10.1177/10430342251372047 · Cited by 2 · see citing works
Multipotent Elastomers via Tempering of Phase-Separated Dynamic Covalent Networks
Boynton, N. R., Bennett, C. M., Hagan, T. D., Solymosy, G. R., Lindberg, C. A., Schaller, N. A., Vivod, S. L., Patel, S. N., & Rowan, S. J. (2025) · ACS Macro Letters · doi:10.1021/acsmacrolett.5c00653 · Cited by 2 · see citing works
Kawai, H., Oo, M. W., Takabatake, K., Tosa, I., Soe, Y., Eain, H. S., Sanou, S., Fushimi, S., Sukegawa, S., Nakano, K., et al. (2023) · JBMR Plus · doi:10.1002/jbm4.10722 · Cited by 2 · see citing works
Karadbhajne, P., More, A., & Dzoagbe, H. Y. (2024) · Cureus · doi:10.7759/cureus.64068 · Cited by 2 · see citing works
Jovičić, S., Nikolic, I. R., Amidžić, L., Ljubojević, V., Barudžija, M., & Škrbić, R. (2025) · Journal of Developmental Biology · doi:10.3390/jdb13020016 · Cited by 2 · see citing works
The Role of CK19-Positive Portal Zone Cells in Thioacetamide-Induced Rat Liver Cirrhosis
Lebedeva, E. I. (2021) · Cell and Tissue Biology · doi:10.1134/s1990519x21060067 · Cited by 2 · see citing works
Tayuwijaya, K., Raharja, S. L., Rosana, M., & Nurhayati, R. W. (2022) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-022-00269-8 · Cited by 2 · see citing works
Time for a New Paradigm in Oncology? Viewpoint of the Radiobiologist
Shoutko, A. N. (2024) · Open Journal of Biophysics · doi:10.4236/ojbiphy.2024.141002 · Cited by 2 · see citing works
Suali, L., Chia, Y., Rustin, C., Lem, F. F., Ching, X. J., Mansur, M. A. B., Henry, Z. A., Chan, M. K. S., Wong, M. B. F., & Pan, S. Y. (2026) · Biotechnic & Histochemistry · doi:10.1080/10520295.2026.2714776 · Cited by 1 · see citing works
“…2017), epithelial and gastrointestinal (Andersson-Rolf et al. 2017; Miyashita et al. 2017; Zhang et al. 2018), hematopoietic (Bourgine et al. 2018; Lee and Hong 2020), musculoskeletal (Kangari et al. 2020), and hepatic systems (So et al. 2020; Li et al. 2021), as well as for immunomodulatory…”
Vignesh Balaji, E., & Pai, K. S. R. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230220101052 · Cited by 1 · see citing works
Chilmi, S., Airlangga, D. I., Susianti, H., & Handono, K. (2024) · Folia Medica Indonesiana · doi:10.20473/fmi.v60i2.56828 · Cited by 1 · see citing works
Iem, D., Carney, G., Munsie, M., & Nayagam, B. A. (2024) · Regenerative Medicine · doi:10.1080/17460751.2024.2402650 · Cited by 1 · see citing works
Al-Asadi, A. B., & Alsaffar, J. M. J. (2025) · Iraqi Journal of Hematology · doi:10.4103/ijh.ijh_34_25 · Cited by 1 · see citing works
Mechanism of Wound Healing by Hematopoietic Stem Cells
Parkhideh, S., Lasemi, M. V., Mehravar, M., Asadi, M., Majidi, M., Salimi, M., & Roshandel, E. (2025) · Journal of Skin and Stem Cell · doi:10.5812/jssc-162196 · Cited by 1 · see citing works
Challenges and Prospects for Cell Therapy Regulation in China
Feng, R., Yin, J., & Peng, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-97297-3_6 · Cited by 1 · see citing works
Human stem cells for decompensated cirrhosis in adults
Aung, H. H., Naing, C. M., Ni, H., Aye, S. N., Htet, N. H., Kew, S. T., & Pavlov, C. S. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015173.pub2 · Cited by 1 · see citing works
BiCLUM: Bilateral contrastive learning for unpaired single-cell multi-omics integration
Guo, Y., Mallona, I., Robinson, M. D., & Li, L. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013932 · Cited by 1 · see citing works
Mochahari, J., Gibo, R., Syiem, P., & Chetia, P. (2026) · European Journal of Clinical and Experimental Medicine · doi:10.15584/ejcem.2026.1.10 · Cited by 1 · see citing works
From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation
Prasad, A., Kushwaha, R., Alugoju, P., Pospı́šil, P., & Rathi, D. (2026) · Journal of Immunology Research · doi:10.1155/jimr/2847417 · Cited by 1 · see citing works
The maintenance mechanism of hematopoietic stem cell dormancy: role for a subset of macrophages
Chae, C.-W., Choi, G., Kim, Y. J., Cho, M., Kwon, Y., & Kim, H.-S. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0092 · Cited by 1 · see citing works
Cell Sources for Tissue Engineering
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The next frontier in multiple sclerosis therapies: Current advances and evolving targets
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- Authors
- Lee, J. Y., & Hong, S.-H.
- Affiliations
- CHA University (KR)
- Kangwon National University (KR)
- Corresponding author
- Hong, Seok-Ho
- Venue
- International Journal of Stem Cells
- Published
- 2020-03-30
- Volume
- 13
- Issue
- 1
- Pages
- 1-12
- ISSN
- 2005-3606 (ISSN-L)
- 2005-5447
- PMC
- PMC7119209
- OpenAlex
- W2997983238
- Cited by
- 165
- References
- 84
- Citations by year
- 2026: 26 · 2025: 42 · 2024: 44 · 2023: 31 · 2022: 11 · 2021: 8 · 2020: 3
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- International Journal of Stem Cells (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- hematopoietic stem cells, tissue regeneration, regenerative medicine, hematologic disorders, hematologic malignancies, liver disease, endothelial progenitor cells, stem cell therapy
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