The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Concise Review: Adipose Tissue-Derived Stromal Cells—Basic and Clinical Implications for Novel Cell-Based Therapies
Open accessAbstract
Compared with bone marrow-derived mesenchymal stem cells, adipose tissue-derived stromal cells (ADSC) do have an equal potential to differentiate into cells and tissues of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle. However, the easy and repeatable access to subcutaneous adipose tissue and the simple isolation procedures provide a clear advantage. Since extensive reviews focusing exclusively on ADSC are rare, it is the aim of this review to describe the preparation and isolation procedures for ADSC, to summarize the molecular characterization of ADSC, to describe the differentiation capacity of ADSC, and to discuss the mechanisms and future role of ADSC in cell therapy and tissue engineering. An initial effort has also been made to differentiate ADSC into hepatocytes, endocrine pancreatic cells, neurons, cardiomyocytes, hepatocytes, and endothelial/vascular cells. Whereas the lineage-specific differentiation into cells of mesodermal origin is well understood on a molecular basis, the molecular key events and transcription factors that initially allocate the ADSC to a lineage-specific differentiation are almost completely unknown. Decoding these molecular mechanisms is a prerequisite for developing novel cell therapies. Disclosure of potential conflicts of interest is found at the end of this article.
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Cites
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Cited by
Lou, G., Song, X., Yang, F., Wu, S., Wang, J., Chen, Z., & Liu, Y. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0220-7 · Cited by 651
Defining stem and progenitor cells within adipose tissue
Lin, G., Garcia, M., Ning, H., Banie, L., Guo, Y.-L., Lue, T. F., & Lin, C.-S. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0117 · Cited by 398
Biomaterial technology for tissue engineering applications
Tabata, Y. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0448.focus · Cited by 384
Mesenchymal stem/stromal cells in cancer therapy
Lan, T., Luo, M., & Wei, X. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01208-w · Cited by 374
BOARD-INVITED REVIEW: The biology and regulation of preadipocytes and adipocytes in meat animals1,2
Hausman, G. J., Dodson, M. V., Ajuwon, K., Azain, M., Barnes, K. M., Guan, L. L., Jiang, Z., Poulos, S. P., Sainz, R. D., Smith, S., et al. (2009) · Journal of Animal Science · doi:10.2527/jas.2008-1427 · Cited by 342
Metadata
- Authors
- Schäffler, A., & Büchler, C.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04-01
- Volume
- 25
- Issue
- 4
- Pages
- 818-827
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2095085916
- Cited by
- 1,027
- References
- 7
- FWCI
- 28.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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