Mesenchymal stem/stromal cells in cancer therapy

Lan, Tianxia; Luo, Min; Wei, Xiawei

doi:10.1186/s13045-021-01208-w

Cited by 375Mesenchymal stem cell researchCancer Cells and MetastasisCancer Research and Treatments

Mesenchymal stem/stromal cells in cancer therapy

Open access

Lan, Tianxia, Luo, Min, Wei, Xiawei·2021·Journal of Hematology & Oncology

DOI 10.1186/s13045-021-01208-wPMC PMC8596342

Open this paper in CoChat — free account Open PDF

Abstract

The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone marrow in 1976, have been identified in nearly all tissues of human body now. The multipotency of MSCs allows them to give rise to osteocytes, chondrocytes, adipocytes, and other lineages. Moreover, armed with the immunomodulation capacity and tumor-homing property, MSCs are of special relevance for cell-based therapies in the treatment of cancer. However, hampered by lack of knowledge about the controversial roles that MSC plays in the crosstalk with tumors, limited progress has been made with regard to translational medicine. Therefore, in this review, we discuss the prospects of MSC-associated anticancer strategies in light of therapeutic mechanisms and signal transduction pathways. In addition, the clinical trials designed to appraise the efficacy and safety of MSC-based anticancer therapies will be assessed according to published data.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s13045-021-01208-w

Cites

205 of 205 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The adaptability of mesenchymal stromal cells may elevate the risk of these cells unintentionally developing tumorigenic characteristics in the context of malignancy.
“The adaptability of MSCs, although beneficial in regenerative medicine, may elevate the risk of these cells unintentionally developing tumorigenic characteristics in the context of malignancy [300, 301].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [300]
The ‘Crosstalk between MSCs and tumor’ section (page unavailable) says MSCs can differentiate into cancer-associated fibroblasts in response to signals from cancer cells and can promote tumor growth. That supports a risk of acquiring a tumor-supporting role, but the paper does not say that MSCs themselves become malignant or explicitly link that risk to their adaptability. (LLM, conf=0.84)
Experimental — accuracy not yet measured
A recent meta-analysis of mesenchymal stromal cell therapies in oncology revealed that modified mesenchymal stromal cells may develop tumorigenic properties under prolonged culture conditions, especially with extensive passaging or exposure to pro-inflammatory cytokines.
“A recent meta-analysis of MSC therapies in oncology revealed that modified MSCs may develop tumorigenic properties under prolonged culture conditions, especially with extensive passaging or exposure to pro-inflammatory cytokines.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [300]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Genetic modifications intended to enhance the regenerative potential of mesenchymal stromal cells, such as overexpression of FGF-2 or HGF, may unintentionally promote tumor growth.
“Studies indicate that genetic modifications intended to enhance the regenerative potential of mesenchymal stem cells (MSCs), such as the overexpression of fibroblast growth factor-2 (FGF-2) or hepatocyte growth factor (HGF), may unintentionally promote tumor growth.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [300]
The 'Crosstalk between MSCs and tumor' section (page unavailable) reports that MSCs can support tumor angiogenesis and growth, and the therapy-delivery section says growth factors can regulate cancer development. But the paper does not describe regenerative-purpose MSC modifications overexpressing FGF-2 or HGF as promoting tumor growth; its HGF example instead concerns engineered MSCs expressing an HGF inhibitor to suppress tumors. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Mesenchymal stromal cells possess significant plasticity, enabling them to adapt dynamically to their microenvironment.
“Recent investigations have demonstrated that MSCs possess significant plasticity, enabling them to adapt dynamically to their microenvironment.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [300]
Mesenchymal stromal cells derived from multiple myeloma patients possess genetic mutations that increase their susceptibility to malignant transformation.
“Studies indicate that MSCs derived from MM patients possess genetic mutations that increase their susceptibility to malignant transformation.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [300]
The Immunomodulation of MSCs section mentions multiple myeloma in the context of transplantation, not mutations in patient-derived MSCs. Searches for genetic mutations, chromosomal abnormalities, and malignant transformation found no passage in our copy linking those features to MSCs from multiple myeloma patients. (LLM, conf=0.74)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052 · see citing works
Cancer Statistics, 2021
Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21654 · Cited by 16,522 · see citing works
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
Stöckl, S., Göttl, C., Grifka, J. K., & Grässel, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350089 · Cited by 4,670 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1× · see citing works
“The tumor homing property of MSCs Since the development of cancer shares multiple similarities with wound healing, tumors are also known as “wounds that do not heal” [109].”
Background
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.035 · Cited by 3,201 · see citing works
The complexity of NF-κB signaling in inflammation and cancer
Hoesel, B., & Schmid, J. A. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-86 · Cited by 3,194 · see citing works
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754 · see citing works
Wnt signaling in cancer
Zhan, T., Rindtorff, N., & Boutros, M. (2017) · Oncogene · doi:10.1038/onc.2016.304 · Cited by 2,626 · see citing works
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433 · see citing works
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
Bartholomew, A. M., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K. R., Patil, S., Hardy, W., Devine, S. M., Ucker, D. S., Deans, R., et al. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(01)00769-x · Cited by 2,296 · see citing works
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works
YAP/TAZ at the Roots of Cancer
Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works
Mesenchymal Stem Cells Derived from Dental Tissues vs . Those from Other Sources: Their Biology and Role in Regenerative Medicine
Huang, G. T. ‐., Gronthos, S., & Shi, S. (2009) · Journal of Dental Research · doi:10.1177/0022034509340867 · Cited by 1,876 · see citing works
The Hippo pathway and human cancer
Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,852 · see citing works
PI3K pathway alterations in cancer: variations on a theme
Yuan, T. L., & Cantley, L. C. (2008) · Oncogene · doi:10.1038/onc.2008.245 · Cited by 1,845 · see citing works
Concise review: MSC-derived exosomes for cell-free therapy
Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834 · see citing works
Immunomodulatory properties of mesenchymal stromal cells
Nauta, A. J., & Fibbe, W. E. (2007) · Blood · doi:10.1182/blood-2007-02-069716 · Cited by 1,787 · see citing works
Human mesenchymal stem cells modulate B-cell functions
Corcione, A., Benvenuto, F., Ferretti, E., Giunti, D., Cappiello, V., Cazzanti, F., Risso, M., Gualandi, F., Mancardi, G. L., Pistoia, V., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2657 · Cited by 1,767 · see citing works
ExoCarta: A Web-Based Compendium of Exosomal Cargo
Keerthikumar, S., Chisanga, D., Ariyaratne, D., Saffar, H. A., Anand, S., Zhao, K., Samuel, M., Pathan, M., Jois, M., Chilamkurti, N., et al. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.019 · Cited by 1,447 · see citing works
Angiogenesis in brain tumours
Jain, R. K., di Tomaso, E., Duda, D. G., Loeffler, J. S., Sorensen, A. G., & Batchelor, T. T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2175 · Cited by 1,408 · see citing works
Role for Interferon-γ in the Immunomodulatory Activity of Human Bone Marrow Mesenchymal Stem Cells
Krampera, M., Cosmi, L., Angeli, R., Pasini, A., Liotta, F., Andreini, A., Santarlasci, V., Mazzinghi, B., Pizzolo, G., Vinante, F., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0008 · Cited by 1,311 · see citing works
PI3K-Akt pathway: Its functions and alterations in human cancer
Osaki, M., Oshimura, M., & Ito, H. (2004) · APOPTOSIS · doi:10.1023/b:appt.0000045801.15585.dd · Cited by 1,266 · see citing works
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood
Wagner, W., Wein, F., Seckinger, A., Frankhauser, M., Wirkner, U., Krause, U., Blake, J., Schwager, C., Eckstein, V., Ansorge, W. J., et al. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.07.003 · Cited by 1,257 · see citing works
Gastric Cancer Originating from Bone Marrow-Derived Cells
Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J. E., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., & Wang, T. C. (2004) · Science · doi:10.1126/science.1099513 · Cited by 1,167 · see citing works
Mesenchymal stem cells and immunomodulation: current status and future prospects
Gao, F., Chiu, S., Motan, D., Zhang, Z., Chen, L., Ji, H.-L., Tse, H.-F., Fu, Q.-L., & Lian, Q. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.327 · Cited by 1,124 · see citing works
Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25highFOXP3+ Regulatory T Cells
Selmani, Z., Naji, A., Zidi, I., Favier, B., Gaiffe, É., Obert, L., Borg, C., Saas, P., Tiberghien, P., Rouas‐Freiss, N., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0554 · Cited by 1,078 · see citing works
Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
Spaggiari, G. M., Capobianco, A., Becchetti, S., Mingari, M. C., & Moretta, L. (2005) · Blood · doi:10.1182/blood-2005-07-2775 · Cited by 1,057 · see citing works
Concise Review: Adipose Tissue-Derived Stromal Cells—Basic and Clinical Implications for Novel Cell-Based Therapies
Schäffler, A., & Büchler, C. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0589 · Cited by 1,027 · see citing works
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Lv, F., Tuan, R. S., Cheung, K., & Leung, V. (2014) · Stem Cells · doi:10.1002/stem.1681 · Cited by 986 · see citing works
Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery
Pascucci, L., Coccè, V., Bonomi, A., Ami, D., Ceccarelli, P., Ciusani, E., Viganò, L., Locatelli, A., Sisto, F., Doglia, S. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.042 · Cited by 907 · see citing works
Untitled work
(2002) · PubMed · Cited by 903 · see citing works
Unravelling cancer stem cell potential
Beck, B., & Blanpain, C. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3597 · Cited by 895 · see citing works
c-Myc and Cancer Metabolism
Miller, D. M., Thomas, S. D., Islam, A., Muench, D. E., & Sedoris, K. C. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0977 · Cited by 844 · see citing works
Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery
Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works
Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation
Anker, P. S. I. `., Scherjon, S. A., der Keur, C. K., Noort, W. A., Claas, F. H. J., Willemze, R., Fibbe, W. E., & Kanhai, H. H. H. (2003) · Blood · doi:10.1182/blood-2003-04-1291 · Cited by 807 · see citing works
Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747 · see citing works
Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates
Devine, S. M., Cobbs, C., Jennings, M., Bartholomew, A. M., & Hoffman, R. (2003) · Blood · doi:10.1182/blood-2002-06-1830 · Cited by 740 · see citing works
Telomerase modulates Wnt signalling by association with target gene chromatin
Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · cited 1× · see citing works
“Mechanistically, as a crucial signaling molecule in Wnt pathway, β-catenin improves the expression of telomerase reverse transcriptase (TERT), a ribonucleoprotein that prevents the loss of telomeres in cancer stem cells [79].”
Background
Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism
Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J. H., Apolloni, E., Serafini, P., Zanovello, P., & Segal, D. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.689 · Cited by 692 · see citing works
Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells
Lee, J.-K., Park, S., Jung, B.-K., Jeon, Y., Lee, Y.-S., Kim, M.-K., Kim, Y.-G., Jang, J.-Y., & Kim, C.-W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084256 · Cited by 647 · see citing works
Human Placenta‐Derived Cells Have Mesenchymal Stem/Progenitor Cell Potential
Fukuchi, Y., Nakajima, H., Sugiyama, D., Hirose, I., Kitamura, T., & Tsuji, K. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-649 · Cited by 646 · see citing works
Biological functions of mesenchymal stem cells and clinical implications
Naji, A., Eitoku, M., Favier, B., Deschaseaux, F., Rouas‐Freiss, N., & Suganuma, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03125-1 · Cited by 628 · see citing works
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems
Walczak, H., & Krammer, P. H. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4840 · Cited by 624 · see citing works
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
Liu, S., Ginestier, C., Ou, S. J., Clouthier, S. G., Patel, S. H., Monville, F., Korkaya, H., Heath, A., Dutcher, J., Kleer, C. G., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-0538 · Cited by 611 · see citing works
Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
Jiang, N., Dai, Q., Su, X., Fu, J., Feng, X., & Peng, J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05435-1 · Cited by 577 · see citing works
Recent progress in the battle between oncolytic viruses and tumours
Parato, K. A., Senger, D. L., Forsyth, P. A., & Bell, J. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1750 · Cited by 538 · see citing works
Mesenchymal stem cells: key players in cancer progression
Ridge, S. M., Sullivan, F. J., & Glynn, S. A. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0597-8 · Cited by 526 · see citing works
Roles for Growth Factors in Cancer Progression
Witsch, E., Sela, M., & Yarden, Y. (2010) · Physiology · doi:10.1152/physiol.00045.2009 · Cited by 525 · see citing works
Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity
Munoz, J. L., Bliss, S. A., Greco, S. J., Ramkissoon, S. H., Ligon, K. L., & Rameshwar, P. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.60 · Cited by 520 · see citing works
Mesenchymal stem cell-derived exosomes for clinical use
Mendt, M. C., Rezvani, K., & Shpall, E. J. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0616-z · Cited by 472 · see citing works
Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
Russell, J. O., & Monga, S. P. (2018) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-044010 · Cited by 471 · see citing works
Mesenchymal Stem Cells Inhibit Dendritic Cell Differentiation and Function by Preventing Entry Into the Cell Cycle
Ramasamy, R., Fazekasova, H., Lam, E. W. ‐., Soeiro, I., Lombardi, G., & Dazzi, F. (2007) · Transplantation · doi:10.1097/01.tp.0000244572.24780.54 · Cited by 468 · see citing works
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?
Becker, A. D., & Riet, I. V. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i3.73 · Cited by 460 · see citing works
Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow
Ugarte, D. A. D., Alfonso, Z., Zuk, P. A., Elbarbary, A. S., Zhu, M., Ashjian, P. H., Benhaim, P., Hedrick, M. H., & Fraser, J. K. (2003) · Immunology Letters · doi:10.1016/s0165-2478(03)00108-1 · Cited by 458 · see citing works
Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review
Berebichez‐Fridman, R., & Montero‐Olvera, P. R. (2018) · Sultan Qaboos University medical journal · doi:10.18295/squmj.2018.18.03.002 · Cited by 451 · see citing works
Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment
Zhou, W., Zhou, Y., Chen, X., Ning, T., Chen, H., Guo, Q., Zhang, Y., Liu, P., Zhang, Y., Li, C., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120546 · Cited by 449 · see citing works
Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment
Liu, T., Zhou, L., Li, D., Andl, T., & Zhang, Y. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00060 · Cited by 446 · see citing works
Mesenchymal Stem Cells Derived from CD133‐Positive Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression, and Plasticity
Tondreau, T., Meuleman, N., Delforge, A., Dejeneffe, M., Leroy, R., Massy, M., Mortier, C., Bron, D., & Lagneaux, L. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0330 · Cited by 438 · see citing works
Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy
Phinney, D. G. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24166 · Cited by 437 · see citing works
MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation
Kean, T. J., Lin, P. Y., Caplan, A. I., & Dennis, J. E. (2013) · Stem Cells International · doi:10.1155/2013/732742 · Cited by 434 · see citing works
Adipose Tissue–Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy
Kucerova, L., Altanerova, V., Matuskova, M., Tyciakova, S., & Altaner, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4024 · Cited by 431 · see citing works
Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer
Loebinger, M. R., Eddaoudi, A., Davies, D., & Janes, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4698 · Cited by 417 · see citing works
Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
Madden, S. K., de Araujo, A. D., Gerhardt, M., Fairlie, D. P., & Mason, J. M. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01291-6 · Cited by 404 · see citing works
Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review
Rodríguez-Fuentes, D. E., Fernández-Garza, L. E., Samia-Meza, J. A., Barrera-Barrera, S. A., Caplan, A. I., & Barrera-Saldaña, H. A. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.08.006 · Cited by 376 · see citing works
Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy
Hmadcha, A., Martín‐Montalvo, A., Gauthier, B. R., Soria, B., & Capilla‐González, V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00043 · Cited by 346 · see citing works
Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells
Otsu, K., Das, S., Houser, S., Quadri, S. K., Bhattacharya, S., & Bhattacharya, J. (2008) · Blood · doi:10.1182/blood-2008-09-176198 · Cited by 345 · see citing works
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
Bergfeld, S. A., & DeClerck, Y. A. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9222-7 · Cited by 345 · see citing works
Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1
Zhu, Y., Sun, Z., Han, Q., Liao, L., Wang, J., Bian, C., Li, J., Yan, X., Liu, Y., Shao, C., et al. (2009) · Leukemia · doi:10.1038/leu.2008.384 · Cited by 339 · see citing works
Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice
Shi, M., Li, J., Liao, L., Chen, B., Li, B., Chen, L., Jia, H., & Zhao, R. C. H. (2007) · Haematologica · doi:10.3324/haematol.10669 · Cited by 339 · see citing works
Markers Distinguishing Mesenchymal Stem Cells from Fibroblasts Are Downregulated with Passaging
Halfon, S., Abramov, N., Grinblat, B., & Ginis, I. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0040 · Cited by 327 · see citing works
Advances in mesenchymal stem cell exosomes: a review
Tang, Y., Zhou, Y., & Li, H.-J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02138-7 · Cited by 327 · see citing works
Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
Groner, B., & von Manstein, V. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.05.033 · Cited by 304 · see citing works
IL-12 Family Cytokines in Cancer and Immunotherapy
Mirlekar, B., & Pylayeva‐Gupta, Y. (2021) · Cancers · doi:10.3390/cancers13020167 · Cited by 296 · see citing works
Analysis of the role of the Hippo pathway in cancer
Han, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1869-4 · Cited by 290 · see citing works
Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic
Wu, H., Zhou, Y., Tabata, Y., & Gao, J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.019 · Cited by 288 · see citing works
Mechanisms of Regulation of the Chemokine-Receptor Network
Stone, M. J., Hayward, J. A., Huang, C., Huma, Z. E., & Sanchez, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020342 · Cited by 277 · see citing works
PI3K and AKT: Unfaithful Partners in Cancer
Faes, S., & Dormond, O. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921138 · Cited by 273 · see citing works
Requirement of IFN-γ–Mediated Indoleamine 2,3-Dioxygenase Expression in the Modulation of Lymphocyte Proliferation by Human Adipose–Derived Stem Cells
DelaRosa, O., Lombardo, E., Beraza, A., Mancheño‐Corvo, P., Ramirez, C., Menta, R., Rico, L., Camarillo‐Retamosa, E., García‐García, L., Abad, J. L., et al. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0630 · Cited by 271 · see citing works
Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
Gieseke, F., Böhringer, J., Bussolari, R., Dominici, M., Handgretinger, R., & Müller, I. (2010) · Blood · doi:10.1182/blood-2010-02-270777 · Cited by 269 · see citing works
Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses
Yang, X., Zhang, X., Fu, M. L., Weichselbaum, R. R., Gajewski, T. F., Guo, Y., & Fu, Y. (2014) · Cancer Cell · doi:10.1016/j.ccr.2013.12.004 · Cited by 269 · see citing works
Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine
Lau, T. T., & Wang, D. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.546338 · Cited by 268 · see citing works
Beyond IκBs: alternative regulation of NF‐KB activity
Neumann, M., & Naumann, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-7615rev · Cited by 267 · see citing works
Emerging Prospects of Exosomes for Cancer Treatment: From Conventional Therapy to Immunotherapy
Nam, G., Choi, Y., Kim, G. B., Kim, S., Kim, S. A., & Kim, I. (2020) · Advanced Materials · doi:10.1002/adma.202002440 · Cited by 266 · see citing works
WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
Ekström, E. J., Bergenfelz, C., von Bülow, V., Serifler, F., Carlemalm, E., Jönsson, G., Andersson, T., & Leandersson, K. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-88 · Cited by 262 · see citing works
Chronic graft-versus-host disease: clinical manifestation and therapy
Ratanatharathorn, V., Ayash, L. J., Lazarus, H. M., Fu, J., & Uberti, J. P. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703111 · Cited by 256 · see citing works
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
Voloshanenko, O., Erdmann, G., Dubash, T. D., Augustin, I., Metzig, M. O., Moffa, G., Hundsrucker, C., Kerr, G., Sandmann, T., Anchang, B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3610 · Cited by 251 · see citing works
Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.
Chawla‐Sarkar, M., Leaman, D. W., & Borden, E. C. (2001) · PubMed · Cited by 249 · see citing works
The roles of mesenchymal stem cells in tumor inflammatory microenvironment
Sun, Z., Wang, S., & Zhao, R. C. (2014) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-7-14 · Cited by 249 · see citing works
Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling
Zhang, X., Hu, F., Li, G., Li, G., Yang, X., Liu, L., Zhang, R., Zhang, B., & Feng, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0176-3 · Cited by 243 · see citing works
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
Chaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 241 · see citing works
Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer
Elbadawy, M., Usui, T., Yamawaki, H., & Sasaki, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092340 · Cited by 237 · see citing works
Human Bone Marrow-Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis
Ho, I. A. W., Toh, H. C., Ng, W. H., Teo, Y. L., Guo, C. M., Hui, K. M., & Lam, P. Y. P. (2012) · Stem Cells · doi:10.1002/stem.1247 · Cited by 236 · see citing works
Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors
Zhang, T., Lee, W., Rui, Y., Cheng, T.-Y., Jiang, X., & Li, G. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt221 · Cited by 235 · see citing works
Human Bone Marrow–Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus Δ24-RGD to Human Gliomas
Yong, R. L. M., Shinojima, N., Fueyo-Margareto, J., Gumin, J., Vecil, G. G., Marini, F. C., Bögler, O., Andreeff, M., & Lang, F. F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3873 · Cited by 234 · see citing works
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1
Barcellos‐de‐Souza, P., Comito, G., Segura, C. P., Taddei, M. L., Gori, V., Becherucci, V., Bambi, F., Margheri, F., Laurenzana, A., Rosso, M. D., et al. (2016) · Stem Cells · doi:10.1002/stem.2412 · Cited by 231 · see citing works
MYC protein expression and genetic alterations have prognostic impact in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
Valera, A., López‐Guillermo, A., Cardesa‐Salzmann, T. M., Climent, F., González-Barca, E. M., Mercadal, S., Espinosa, Í., Novelli, S., Briones, J., Mate, J. L., et al. (2013) · Haematologica · doi:10.3324/haematol.2013.086173 · Cited by 230 · see citing works
Mesenchymal Stem Cells Home to Sites of Injury and Inflammation
Rustad, K. C., & Gurtner, G. C. (2012) · Advances in Wound Care · doi:10.1089/wound.2011.0314 · Cited by 228 · see citing works
Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application
Bozorgmehr, M., Gurung, S., Darzi, S., Nikoo, S., Kazemnejad, S., Zarnani, A., & Gargett, C. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00497 · Cited by 223 · see citing works
Mesenchymal stem cells as a vehicle for targeted delivery of CRAds to lung metastases of breast carcinoma
Stoff‐Khalili, M. A., Rivera, Á. A., Mathis, J. M., Banerjee, N. S., Moon, A. S., Hess, A., Rocconi, R. P., Numnum, T. M., Everts, M., Chow, L. T., et al. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9449-8 · Cited by 205 · see citing works
Stem cells in cancer therapy: opportunities and challenges
Zhang, C.-L., Huang, T., Wu, B.-L., He, W., & Liu, D. (2017) · Oncotarget · doi:10.18632/oncotarget.20798 · Cited by 204 · see citing works
Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review
Sensebé, L., Gadelorge, M., & Fleury‐Cappellesso, S. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt217 · Cited by 197 · see citing works
Mesenchymal Stem Cells Transmigrate Between and Directly Through Tumor Necrosis Factor‐α‐Activated Endothelial Cells Via Both Leukocyte‐Like and Novel Mechanisms
Teo, G. S. L., Ankrum, J. A., Martinelli, R., Boetto, S. E., Simms, K., Sciuto, T. E., Dvořàk, A. M., Karp, J. M., & Carman, C. V. (2012) · Stem Cells · doi:10.1002/stem.1198 · Cited by 196 · see citing works
Characterization of human adult stem‐cell populations isolated from visceral and subcutaneous adipose tissue
Baglioni, S., Francalanci, M., Squecco, R., Lombardi, A., Cantini, G., Angeli, R., Gelmini, S., Guasti, D., Benvenuti, S., Annunziato, F., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-126946 · Cited by 194 · see citing works
Adipose Tissue–derived Mesenchymal Stem Cells Expressing Prodrug-converting Enzyme Inhibit Human Prostate Tumor Growth
Cavarretta, I. T. R., Altanerová, V., Matúšková, M., Kučerová, L., Čulig, Z., & Altaner, Č. (2009) · Molecular Therapy · doi:10.1038/mt.2009.237 · Cited by 186 · see citing works
Interaction of MSC with tumor cells
Melzer, C., Yang, Y., & Hass, R. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0143-0 · Cited by 183 · see citing works
Functions and application of exosomes.
Qin, J., & Xu, Q. R. (2014) · PubMed · Cited by 182 · see citing works
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
Kucerova, L., Matuskova, M., Pastorakova, A., Tyciakova, S., Jakubikova, J., Bohovic, R., Altanerova, V., & Altaner, C. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1239 · Cited by 171 · see citing works
Mesenchymal Stem Cells and Cancer: Clinical Challenges and Opportunities
Lin, W., Huang, L., Li, Y., Fang, B., Li, G., Chen, L., & Xu, L. (2019) · BioMed Research International · doi:10.1155/2019/2820853 · Cited by 165 · see citing works
Mesenchymal stromal cells in cancer: A review of their immunomodulatory functions and dual effects on tumor progression
Galland, S., & Stamenkovic, I. (2020) · The Journal of Pathology · doi:10.1002/path.5357 · Cited by 165 · see citing works
JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma
Bouchekioua, A., Scourzic, L., Wever, O. D., Zhang, Y., Cervera, P., Aline-Fardin, A., Mercher, T., Gaulard, P., Nyga, R., Jeziorowska, D., et al. (2013) · Leukemia · doi:10.1038/leu.2013.157 · Cited by 161 · see citing works
Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma
Gao, P., Ding, Q., Wu, Z., Jiang, H., & Fang, Z. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.08.031 · Cited by 159 · see citing works
Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells
Kanehira, M., Xin, H., Hoshino, K., Maemondo, M., Mizuguchi, H., Hayakawa, T., Matsumoto, K., Nakamura, T., Nukiwa, T., & Saijo, Y. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701079 · Cited by 155 · see citing works
NK4 (HGF‐antagonist/angiogenesis inhibitor) in cancer biology and therapeutics
Matsumoto, K., & Nakamura, T. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01440.x · Cited by 153 · see citing works
YAP is a critical oncogene in human cholangiocarcinoma
Pei, T., Li, Y., Wang, J., Wang, H., Liang, Y., Shi, H., Sun, B., Yin, D., Sun, J., Song, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4043 · Cited by 151 · see citing works
Bone marrow transplantation: a review.
Thomas, E. D. (1999) · PubMed · Cited by 150 · see citing works
Human Bone Marrow Mesenchymal Stem Cells Display Anti-Cancer Activity in SCID Mice Bearing Disseminated Non-Hodgkin's Lymphoma Xenografts
Secchiero, P., Zorzet, S., Tripodo, C., Corallini, F., Melloni, E., Caruso, L., Bosco, R., Ingrao, S., Zavan, B., & Zauli, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011140 · Cited by 149 · see citing works
The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity
Seo, S. H., Kim, K. S., Park, S. H., Suh, Y. S., Kim, S. J., Jeun, S.-S., & Sung, Y. C. (2011) · Gene Therapy · doi:10.1038/gt.2010.170 · Cited by 148 · see citing works
Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway
Yan, X., Fu, C., Chen, L., Qin, J., Zeng, Q., Yuan, H., Nan, X., Chen, H., Zhou, J., Lin, Y.-L., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1577-0 · Cited by 142 · see citing works
Prodrug cancer gene therapy
Altaner, Č. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.023 · Cited by 137 · see citing works
Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma
Danks, M. K., Yoon, K. J., Bush, R. A., Remack, J. S., Wierdl, M., Tsurkan, L. G., Kim, S. U., Garcia, E. P., Metz, M. Z., Najbauer, J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3607 · Cited by 136 · see citing works
The regulation and function of YAP transcription co-activator
Zhu, C., Li, L., & Zhao, B. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu110 · Cited by 136 · see citing works
Differentiation potential of stem cells from human dental origin - promise for tissue engineering.
Kádár, K., Király, M., Porcsalmy, B., Molnár, B., Rácz, G., Blazsek, J., Kálló, K., Szabo, E. L., Gera, I., Gerber, G., et al. (2009) · PubMed · Cited by 135 · see citing works
PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model
Kim, S., Cargioli, T. G., Machluf, M., Yang, W., Sun, Y., Al-Hashem, R., Kim, S. U., Black, P. M., & Carroll, R. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0371 · Cited by 134 · see citing works
Cancer-associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF-κB activation
Avnet, S., Pompo, G. D., Chano, T., Errani, C., Ibrahim‐Hashim, A., Gillies, R. J., Donati, D. M., & Baldini, N. (2016) · International Journal of Cancer · doi:10.1002/ijc.30540 · Cited by 133 · see citing works
Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells
Poggi, A. D., Musso, A., Dapino, I., & Zocchi, M. R. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.03.001 · Cited by 123 · see citing works
Evolution of Cytokine Receptor Signaling
Liongue, C., Sertori, R., & Ward, A. C. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600372 · Cited by 116 · see citing works
Role of MSC in the Tumor Microenvironment
Hass, R. (2020) · Cancers · doi:10.3390/cancers12082107 · Cited by 116 · see citing works
Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions
Riekstiņa, U., Muceniece, R., Čakstiņa, I., Muižnieks, I., & Ancāns, J. (2008) · Cytotechnology · doi:10.1007/s10616-009-9183-2 · Cited by 115 · see citing works
Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial
Nieß, H., von Einem, J. C., Thomas, M. N., Michl, M., Angele, M. K., Huss, R., Günther, C., Nelson, P. J., Bruns, C. J., & Heinemann, V. (2015) · BMC Cancer · doi:10.1186/s12885-015-1241-x · Cited by 111 · see citing works
Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics
Schüring, A. N., Schulte, N., Kelsch, R., Röpke, A., Kiesel, L., & Götte, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.08.035 · Cited by 109 · see citing works
Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review
Zhou, J., Tan, X., Tan, Y., Li, Q., Ma, J., & Wang, G. (2018) · Journal of Cancer · doi:10.7150/jca.25376 · Cited by 109 · see citing works
Mechanoresponsive stem cells to target cancer metastases through biophysical cues
Liu, L., Zhang, S. X., Liao, W., Farhoodi, H. P., Wong, C. W., Chen, C. C., Ségaliny, A. I., Chacko, J. V., Nguyen, L., Lu, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan2966 · Cited by 104 · see citing works
Cell-based Delivery of Oncolytic Viruses: A New Strategic Alliance for a Biological Strike Against Cancer
Power, A., & Bell, J. C. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300098 · Cited by 103 · see citing works
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells
Gong, A., Wei, P. Y., Zhang, S., Yao, J., Yuan, Y., Zhou, A., Lang, F. F., Heimberger, A. B., Rao, G., & Huang, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2800 · Cited by 101 · see citing works
MSCs inhibit tumor progression and enhance radiosensitivity of breast cancer cells by down-regulating Stat3 signaling pathway
He, N., Kong, Y., Lei, X., Liu, Y., Wang, J., Xu, C., Wang, Y., Du, L., Ji, K., wang, Q., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0949-3 · Cited by 100 · see citing works
Mesenchymal stem cell signaling in cancer progression
Torsvik, A., & Bjerkvig, R. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.03.005 · Cited by 100 · see citing works
Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells
Kuhbier, J. W., Weyand, B., Radtke, C., Vogt, P. M., Kasper, C., & Reimers, K. (2010) · Springer eBooks · doi:10.1007/10_2009_24 · Cited by 99 · see citing works
TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo
Mueller, L. P., Luetzkendorf, J., Widder, M., Nerger, K., Caysa, H., & Mueller, T. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.68 · Cited by 99 · see citing works
Comparative cellular and molecular analyses of pooled bone marrow multipotent mesenchymal stromal cells during continuous passaging and after successive cryopreservation
Mamidi, M. K., Nathan, K. G., Singh, G., Thrichelvam, S. T., Yusof, N. A. N. M., Fakharuzi, N. A., Zakaria, Z., Bhonde, R. R., Das, A. K., & Majumdar, A. S. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24193 · Cited by 98 · see citing works
Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer
Chen, Y., González, M. E., Burman, B., Zhao, X., Anwar, T., Tran, M., Medhora, N., Hiziroglu, A. B., Lee, W., Cheng, Y.-H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.084 · Cited by 96 · see citing works
A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer
Schweizer, M. T., Wang, H., Bivalacqua, T. J., Partin, A. W., Lim, S. J., Chapman, C. G., Abdallah, R. H., Levy, O., Bhowmick, N. A., Karp, J. M., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0230 · Cited by 96 · see citing works
Treatment of advanced gastrointestinal cancer with genetically modified autologous mesenchymal stem cells: Results from the phase 1/2 TREAT‐ME‐1 trial
von Einem, J. C., Guenther, C., Volk, H., Grütz, G., Hirsch, D. D., Salat, C., Stoetzer, O. J., Nelson, P. J., Michl, M., Modest, D. P., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32230 · Cited by 93 · see citing works
Mesenchymal Stem Cell–Mediated Delivery of an Oncolytic Adenovirus Enhances Antitumor Efficacy in Hepatocellular Carcinoma
Yoon, A. R., Hong, J., Li, Y., Shin, H. C., Lee, H., Kim, H., & Yun, C. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3900 · Cited by 93 · see citing works
Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma
Wang, W., Zhong, W., Yuan, J., Yan, C., Hu, S., Tong, Y., Mao, Y., Hu, T., Zhang, B., & Song, G. (2015) · Oncotarget · doi:10.18632/oncotarget.5514 · Cited by 92 · see citing works
c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia
Xia, B., Tian, C., Guo, S., Zhang, L., Zhao, D., Qu, F., Zhao, W., Wang, Y., Wu, X., Da, W.-M., et al. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.11.004 · Cited by 86 · see citing works
NF-κB Activity Regulates Mesenchymal Stem Cell Accumulation at Tumor Sites
Uchibori, R., Tsukahara, T., Mizuguchi, H., Saga, Y., Urabe, M., Mizukami, H., Kume, A., & Ozawa, K. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0088 · Cited by 83 · see citing works
Hippo pathway - brief overview of its relevance in cancer.
Zygulska, A. L., Krzemieniecki, K., & Pierzchalski, P. (2017) · PubMed · Cited by 82 · see citing works
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway
Lü, L., Chen, G., Yang, J., Ma, Z., Yang, Y., Hu, Y., Lu, Y., Cao, Z., Wang, Y., & Wang, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108625 · Cited by 81 · see citing works
The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming
Liu, Y., Ren, H., Zhou, Y., Shang, L., Zhang, Y., Yang, F., & Shi, X. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1219-7 · Cited by 81 · see citing works
Both human and mouse mesenchymal stem cells promote breast cancer metastasis
Albarenque, S. M., Zwacka, R. M., & Mohr, A. (2011) · Stem Cell Research · doi:10.1016/j.scr.2011.05.002 · Cited by 80 · see citing works
Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation
Wu, X., Liu, Y., Wang, G., Xu, X., Cai, Y., Wang, H., Li, Y., Meng, H., Dai, F., & Jin, J.-D. (2016) · Scientific Reports · doi:10.1038/srep21420 · Cited by 78 · see citing works
Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors
Bajetto, A., Pattarozzi, A., Corsaro, A., Barbieri, F., Daga, A., Bosio, A. G., Gatti, M., Pisaturo, V., Sirito, R., & Florio, T. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00312 · Cited by 78 · see citing works
Expression of hippo pathway in colorectal cancer
Zhang, C., Liang, K., Zhou, G., Zhang, Q., & Li, J. (2014) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.133025 · Cited by 78 · see citing works
Comprehensive Characterization of Mesenchymal Stem Cells from Human Placenta and Fetal Membrane and Their Response to Osteoactivin Stimulation
Raynaud, C. M., Maleki, M., Lis, R., Ahmed, B., Al-Azwani, I. K., Malek, J. A., Safadi, F. F., & Rafii, A. (2012) · Stem Cells International · doi:10.1155/2012/658356 · Cited by 77 · see citing works
Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts
Fathi, E., Sanaat, Z., & Farahzadi, R. (2019) · Blood Research · doi:10.5045/br.2019.54.3.165 · Cited by 76 · see citing works
Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression
Luo, T., Liu, Q., Tan, A., Duan, L., Jia, Y., Li, N., Tang, J. Y., Zhou, W., Xie, W., Lu, Y., et al. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.10.008 · Cited by 73 · see citing works
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors
van Eekelen, M., Sasportas, L. S., Kasmieh, R., Yip, S. S. F., Figueiredo, J.-L., Louis, D. N., Weissleder, R., & Shah, K. (2010) · Oncogene · doi:10.1038/onc.2010.75 · Cited by 72 · see citing works
Mesenchymal stromal cells induce epithelial‐to‐mesenchymal transition in human colorectal cancer cells through the expression of surface‐bound TGF‐β
Mele, V., Muraro, M. G., Calabrese, D., Pfaff, D., Amatruda, N., Amicarella, F., Kvinlaug, B. T., Bocelli‐Tyndall, C., Martín, I., Resink, T. J., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28598 · Cited by 71 · see citing works
Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature
Surendar, A., Ejam, S. S., Lafta, M. H., Markov, A. A., Yumashev, A. V., & Ahmadi, M. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01836-9 · Cited by 71 · see citing works
Directing systemic oncolytic viral delivery to tumors via carrier cells☆
Nakashima, H., Kaur, B., & Chiocca, E. A. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.02.004 · Cited by 69 · see citing works
Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin‐mediated phosphoinositide 3‐kinase/ Akt /mammalian target of rapamycin
Liu, C., Feng, X., Wang, B., Wang, X., Wang, C., Yu, M., Cao, G., & Wang, H. (2017) · Cancer Science · doi:10.1111/cas.13479 · Cited by 68 · see citing works
Cytokine gene therapy for malignant glioma
Okada, H., & Pollack, I. F. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.10.1609 · Cited by 64 · see citing works
MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential
D’souza, N., Burns, J. S., Grisendi, G., Candini, O., Veronesi, E., Piccinno, M. S., Horwitz, E. M., Paolucci, P., Conte, P., & Dominici, M. (2012) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2012_150 · Cited by 62 · see citing works
Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-κB signaling and is associated with metastasis and poor prognosis in gastric cancer patients
Li, J., Deng, Z., Wang, Z., Wang, D., Zhang, L., Su, Q., Lai, Y., Ли, Б., Luo, Z., Xu, C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3200 · Cited by 62 · see citing works
Nonadherent cell population of human marrow culture is a complementary source of mesenchymal stem cells (MSCs)
Wan, C., He, Q., McCaigue, M. D., Marsh, D., & Li, G. (2005) · Journal of Orthopaedic Research® · doi:10.1002/jor.20023 · Cited by 62 · see citing works
Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model
Fernández-García, M., Yañez, R. M., Sánchez‐Domínguez, R., Hernando-Rodríguez, M., Peces-Barba, M., Herrera, G., O’Connor, J., Segovia, J. C., Bueren, J. A., & Lamana, M. L. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0155-5 · Cited by 60 · see citing works
Mesenchymal stem cells from tumor microenvironment favour breast cancer stem cell proliferation, cancerogenic and metastatic potential, via ionotropic purinergic signalling
Maffey, A., Storini, C., Diceglie, C., Martelli, C., Sironi, L., Calzarossa, C., Tonna, N., Lovchik, R. D., Delamarche, E., Ottobrini, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13460-7 · Cited by 60 · see citing works
Reshaping the Immune Microenvironment by Oncolytic Herpes Simplex Virus in Murine Pancreatic Ductal Adenocarcinoma
Zhang, L., Wang, W., Wang, R., Zhang, N., Shang, H., Bi, Y., Chen, D., Zhang, C., Li, L., Yin, J., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.10.027 · Cited by 58 · see citing works
Mesenchymal stem cells in inflammatory microenvironment potently promote metastatic growth of cholangiocarcinoma via activating Akt/NF-κB signaling by paracrine CCL5
Zhong, W., Tong, Y., Li, Y., Yuan, J., Hu, S., Hu, T., & Song, G. (2017) · Oncotarget · doi:10.18632/oncotarget.17793 · Cited by 55 · see citing works
Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis
Li, L., Li, J.-C., Yang, H., Zhang, X., Liu, L., Li, Y., Zeng, T., Zhu, Y.-H., Li, X.-D., Li, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806219115 · Cited by 53 · see citing works
Mechanisms of measles virus oncolytic immunotherapy
Pidelaserra-Martí, G., & Engeland, C. E. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.07.009 · Cited by 53 · see citing works
Influence of inflammation on the immunological profile of adult-derived human liver mesenchymal stromal cells and stellate cells
Raicevic, G., Najar, M., Najimi, M., Taghdouini, A. E., van Grunsven, L. A., Sokal, E. M., & Toungouz, M. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.10.001 · Cited by 51 · see citing works
Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFβ and in cooperation with PDGF
Belotti, D., Capelli, C., Resovi, A., Introna, M., & Taraboletti, G. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.03.003 · Cited by 50 · see citing works
Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
McGuire, J., Frieling, J. S., Lo, C. H., Li, T., Muhammad, A., Lawrence, H. R., Lawrence, N. J., Cook, L. M., & Lynch, C. C. (2021) · Nature Communications · doi:10.1038/s41467-021-20962-6 · Cited by 50 · see citing works
Prostaglandin E 2 secreted by mesenchymal stem cells protects against acute liver failure via enhancing hepatocyte proliferation
Liu, Y., Ren, H., Wang, J., Yang, F., Li, J., Zhou, Y., Yuan, X., Zhu, W., & Shi, X. (2018) · The FASEB Journal · doi:10.1096/fj.201801349rr · Cited by 49 · see citing works
Characterization of Mononucleated Human Peripheral Blood Cells
Kadir, R. A., Ariffin, S. H. Z., Wahab, R. M. A., Kermani, S., & Senafi, S. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/843843 · Cited by 48 · see citing works
PDGF regulated migration of mesenchymal stem cells towards malignancy acts via the PI3K signaling pathway
Salha, S., Gehmert, S., Brébant, V., Anker, A., Loibl, M., Prantl, L., & Gehmert, S. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189319 · Cited by 48 · see citing works
Mesenchymal Stem Cells: Characteristics, Function, and Application
Li, Z., Hu, X., & Zhong, J. F. (2019) · Stem Cells International · doi:10.1155/2019/8106818 · Cited by 48 · see citing works
Nuclear Stat5a/b predicts early recurrence and prostate cancer–specific death in patients treated by radical prostatectomy
Mirtti, T. K., Leiby, B. E., Abdulghani, J., Aaltonen, E., Pavela, M., Mamtani, A., Alanen, K. A., Egevad, L., Granfors, T., Josefsson, A., et al. (2012) · Human Pathology · doi:10.1016/j.humpath.2012.06.001 · Cited by 44 · see citing works
The response of human ectomesenchymal dental pulp stem cells to cisplatin treatment
Seifrtová, M., Havelek, R., Ćmielová, J., Jiroutová, A., Soukup, T., Brůčková, L., Mokrý, J., English, D. K., & Řezáčová, M. (2011) · International Endodontic Journal · doi:10.1111/j.1365-2591.2011.01990.x · Cited by 43 · see citing works
PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts
Chen, H., Mei, L., Zhou, L., Shen, X., Guo, C., Zheng, Y., Zhu, H., Zhu, Y., & Huang, L. (2010) · Journal of Neuro-Oncology · doi:10.1007/s11060-010-0492-2 · Cited by 42 · see citing works
Mesenchymal stem cells for graft-versus-host disease: a double edged sword?
Vianello, F., & Dazzi, F. (2008) · Leukemia · doi:10.1038/leu.2008.25 · Cited by 39 · see citing works
Growth‐inhibitory activity of interferon‐beta against human colorectal carcinoma cell lines
Wong, V. L. Y., Rieman, D. J., Aronson, L., Dalton, B. J., GREIG, R. G., & Anzano, M. A. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910430331 · Cited by 36 · see citing works
Sequential Interferon β-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner
Yang, P., Hsieh, Y., Du, J.-L., Yen, S.-C., & Hung, C. (2020) · Biomolecules · doi:10.3390/biom10040643 · Cited by 35 · see citing works
Mesenchymal Stem Cells in Gastric Cancer: Vicious but Hopeful
Li, Y., Zhong, X., Zhang, Y., & Lu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.617677 · Cited by 34 · see citing works
Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma
Dührsen, L., Hartfuß, S., Hirsch, D. D., Geiger, S., Maire, C. L., Sedlacik, J., Guenther, C., Westphal, M., Lamszus, K., Hermann, F. G., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.27071 · Cited by 34 · see citing works
Can neural stem cells be used as therapeutic vehicles in the treatment of brain tumors?
Noble, M. (2000) · Nature Medicine · doi:10.1038/74610 · Cited by 33 · see citing works
REC8is a novel tumor suppressor gene epigenetically robustly targeted by the PI3K pathway in thyroid cancer
Liu, D., Shen, X., Zhu, G., & Xing, M. (2015) · Oncotarget · doi:10.18632/oncotarget.5391 · Cited by 32 · see citing works
Mesenchymal stem cells inhibit proliferation of lymphoid origin haematopoietic tumour cells by inducing cell cycle arrest.
Sarmadi, V. H., Tong, C. K., Vidyadaran, S., Abdullah, M., Seow, H. F., & Ramasamy, R. (2010) · PubMed · Cited by 27 · see citing works
Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways
Ai, J., Ketabchi, N., Verdi, J., Gheibi, N., Haghighian, H. K., & Kavianpour, M. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1038-0 · Cited by 26 · see citing works
[Study on culture and in vitro osteogenesis of blood-derived human mesenchymal stem cells].
Cao, C., Dong, Y., & Dong, Y. (2005) · PubMed · Cited by 26 · see citing works
Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc
Chen, B., Yu, J. Q., Wang, Q., Zhao, Y., Sun, L., Xu, C., Zhao, X., Shen, B., Wang, M., Xu, W., et al. (2018) · Stem Cells International · doi:10.1155/2018/9501747 · Cited by 26 · see citing works
Role of MSC-derived galectin 3 in the AML microenvironment
Ruvolo, P. P., Ruvolo, V. R., Burks, J. K., Qiu, Y., Wang, R., Shpall, E. J., Mirandola, L., Hail, N., Zeng, Z., McQueen, T. J., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.04.005 · Cited by 25 · see citing works
MYC modulators in cancer: a patent review
Wang, X., Su, X., Cheng, S.-Q., Zhi-yin, S., Huang, Z., & Ou, T. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1612878 · Cited by 25 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

[45]Khakoo AY Pati S Anderson SA Reid W Elshal MF Rovira II Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma J Exp Med 2006 203 5 1235 1247 16636132 PMC2121206
[81]Wang W Zhong W Yuan J Yan C Hu S Tong Y Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma Oncotarget 2015 6 39 42276 42289 26474277 PMC4747224
[102]Neumann M Naumann M Beyond IkappaBs: alternative regulation of NF-kappaB activity Faseb j 2007 21 11 2642 2654 17431096

Sorted by citations

Stromal cells in the tumor microenvironment: accomplices of tumor progression?
Zhao, Y. F., Shen, M., Wu, L., Yang, H., Yao, Y., Yang, Q., Du, J., Liu, L., Li, Y., & Bai, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06110-6 · Cited by 443 · see citing works
Emerging role of exosomes in cancer therapy: progress and challenges
Li, J., Wang, J., & Chen, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02215-4 · Cited by 278 · see citing works
Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials
Yu, L., Zhu, G., Zhang, Z., Yu, Y., Zeng, L., Xu, Z., Weng, J., Xia, J., Li, J., & Pathak, J. L. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01969-1 · Cited by 196 · see citing works
Cancer Resistance to Immunotherapy: Comprehensive Insights with Future Perspectives
Said, S. S., & Ibrahim, W. N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041143 · Cited by 127 · see citing works
Hallmarks of cancer resistance
Tufail, M., Hu, J.-J., Liang, J., He, C., Wan, W., Huang, Y., Jiang, C., Wu, H., & Li, N. (2024) · iScience · doi:10.1016/j.isci.2024.109979 · Cited by 121 · see citing works
Carcinoma-Associated Mesenchymal Stem/Stromal Cells: Architects of the Pro-tumorigenic Tumor Microenvironment
Frisbie, L. G., Buckanovich, R. J., & Coffman, L. G. (2022) · Stem Cells · doi:10.1093/stmcls/sxac036 · Cited by 107 · see citing works
Quantitative Comparison of Gold Nanoparticle Delivery via the Enhanced Permeation and Retention (EPR) Effect and Mesenchymal Stem Cell (MSC)-Based Targeting
Xu, L., Xu, M., Sun, X., Feliu, N., Feng, L., Parak, W. J., & Liu, S. (2023) · ACS Nano · doi:10.1021/acsnano.2c07295 · Cited by 89 · see citing works
Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial
Zhao, K., Lin, R., Fan, Z., Chen, X., Wang, Y., Huang, F., Xu, N., Zhang, X., Zhang, X., Xuan, L., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01240-4 · Cited by 89 · see citing works
Mesenchymal stem cells in the treatment of spinal cord injury: Mechanisms, current advances and future challenges
Xia, Y., Zhu, J., Yang, R., Wang, H., Li, Y., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1141601 · Cited by 87 · see citing works
Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies
Lu, Q., Liang, Y., Tian, S., Jin, J., Zhao, Y., & Fan, H. (2023) · Toxics · doi:10.3390/toxics11121011 · Cited by 76 · see citing works
Mesenchymal stromal cells as cancer promoters
Antoon, R., Overdevest, N., Saleh, A. H., & Keating, A. (2024) · Oncogene · doi:10.1038/s41388-024-03183-1 · Cited by 75 · see citing works
Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy
Sun, Y., Sun, F., Xu, W., & Qian, H. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00503-y · Cited by 69 · see citing works
Exosome crosstalk between cancer stem cells and tumor microenvironment: cancer progression and therapeutic strategies
Li, Q., He, G., Yu, Y., Li, X., Peng, X., & Yang, L. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04061-z · Cited by 63 · see citing works
The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy
Li, D., Cao, D., Sun, Y., Cui, Y., Zhang, Y., Jiang, J., & Cao, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1331641 · Cited by 61 · see citing works
Targeting Tumor Heterogeneity with Neoantigen-Based Cancer Vaccines
Pounraj, S., Chen, S., Ma, L., Mazzieri, R., Dolcetti, R., & Rehm, B. H. A. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2042 · Cited by 59 · see citing works
HucMSC-Ex carrying miR-203a-3p.2 ameliorates colitis through the suppression of caspase11/4-induced macrophage pyroptosis
Xu, Y., Tang, X., Fang, A., Yan, J., Ocansey, D. K. W., Zhang, X., & Mao, F. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108925 · Cited by 59 · see citing works
Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy
Fan, L., Wei, A., Gao, Z., & Mu, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114451 · Cited by 57 · see citing works
The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential
Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713511 · Cited by 57 · see citing works
Tissue Engineering and Regenerative Medicine: Perspectives and Challenges
Hoang, V. T., Nguyen, Q. T., Phan, T. T. K., Pham, T. H., Dinh, N. T. H., Anh, L. P. H., Dao, L. T. M., Bui, V. D., Dao, H., Le, D. S., et al. (2025) · MedComm · doi:10.1002/mco2.70192 · Cited by 62 · see citing works
Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis
Shen, X., Qin, J., Wei, Z., & Liu, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115488 · Cited by 56 · see citing works
Mesenchymal stem/stromal cells in breast cancer development and management
Tu, Z., & Karnoub, A. E. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.002 · Cited by 48 · see citing works
Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma
Cao, Z., Li, P., Li, Y., Zhang, M., Meng, H., Li, W., Mao, X., Mo, L., Yang, C., Ding, X., et al. (2023) · Small · doi:10.1002/smll.202301748 · Cited by 48 · see citing works
Evolving trends in stem cell therapy: an emerging and promising approach against various diseases
Abusalah, M. A. H., Priyanka, Rahman, E. N. S. E. A., & Choudhary, O. P. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001948 · Cited by 46 · see citing works
Mesenchymal stem cells-derived secretome and extracellular vesicles: perspective and challenges in cancer therapy and clinical applications
Gemayel, J., Chaker, D., Hachem, G. E., Mhanna, M., Salemeh, R., Hanna, C., Harb, F., Ibrahim, A., Chebly, A., & Khalil, C. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03115-7 · Cited by 44 · see citing works
Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine
Wu, D., Zhao, X., Xie, J., Yuan, R., Li, Y., Yang, Q., Cheng, X., Wu, C., Wu, J., & Zhu, N. (2024) · Cell Proliferation · doi:10.1111/cpr.13630 · Cited by 41 · see citing works
Mesenchymal Stem Cell-Derived Extracellular Vesicles: An Emerging Diagnostic and Therapeutic Biomolecules for Neurodegenerative Disabilities
Kandeel, M. K., Morsy, M. A., Alkhodair, K. M., & Alhojaily, S. (2023) · Biomolecules · doi:10.3390/biom13081250 · Cited by 39 · see citing works
Current status and future perspectives of research on intra-articular drug delivery systems for osteoarthritis therapy
Wu, M., Chen, Z., Song, B., Wang, X., & Liang, W. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.07.057 · Cited by 41 · see citing works
Clinical trials using dental stem cells: 2022 update
Song, W., Jin, L., Zhu, M., Wang, H., & Xia, D. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i3.31 · Cited by 39 · see citing works
Current Status and Prospect of Delivery Vehicle Based on Mesenchymal Stem Cell-Derived Exosomes in Liver Diseases
Lu, X., Guo, H., Wei, X., Lu, D., Shu, W., Song, Y., Qiu, N., & Xu, X. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s404925 · Cited by 38 · see citing works
Self-citation
Engineered mesenchymal stem cell exosomes loaded with miR-34c-5p selectively promote eradication of acute myeloid leukemia stem cells
Wen, J., Chen, Y., Liao, C., Ma, X., Wang, M., Li, Q., Wang, D., Li, Y., Zhang, X., Li, L., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216407 · Cited by 37 · see citing works
Different origin-derived exosomes and their clinical advantages in cancer therapy
Jin, X., Zhang, J., Zhang, Y., He, J., Wang, M., Hei, Y., Guo, S., Xu, X., & Liu, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1401852 · Cited by 34 · see citing works
Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos
Zhou, R., Guo, J., & Jin, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02713-z · Cited by 35 · see citing works
Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements
Wang, Y., Zhu, N., Liu, J., Chen, F., Song, Y., Ma, Y., Yang, Z., & Wang, D. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06508-0 · Cited by 41 · see citing works
Extracellular vesicles derived from menstrual blood-derived mesenchymal stem cells suppress inflammatory atherosclerosis by inhibiting NF-κB signaling
Yu, J., Liu, X., Jin, L., Li, H., Wang, S., Yang, Y., Chen, X., Wang, H., Li, Y., Lian, J., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04390-7 · Cited by 33 · see citing works
Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury
Jerkić, M., Szászi, K., Laffey, J. G., Rotstein, O. D., & Zhang, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043376 · Cited by 33 · see citing works
Exosomes with overexpressed miR 147a suppress angiogenesis and infammatory injury in an experimental model of atopic dermatitis
Shi, C., Pei, S., Ding, Y., Tao, C., Zhu, Y., Peng, Y., Li, W., & Yi, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-34418-y · Cited by 32 · see citing works
Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury
Liu, W., Liu, Q., Li, Z., Zhang, C., Li, Z., Ke, H., Xu, X. P., Wang, X., Du, H., Talifu, Z., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.02.034 · Cited by 32 · see citing works
MSC-NPRA loop drives fatty acid oxidation to promote stemness and chemoresistance of gastric cancer
Chen, Z., Xu, P., Wang, X., Li, Y., Yang, J., Xia, Y., Wang, S., Liu, H., Xu, Z., & Li, Z. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216235 · Cited by 32 · see citing works
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Cancer Therapy Resistance: from Biology to Clinical Opportunity
Shan, C., Yan, L., Wang, K., & Li, P. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88500 · Cited by 32 · see citing works
Mesenchymal stem cells-derived exosomes: novel carriers for nanoparticle to combat cancer
Abbasi, R., Momen-Mesgin, R., Nazari‐Khanamiri, F., Abdyazdani, N., Imani, Z., Talatapeh, S. P., Nourmohammadi, A., Nejati, V., & Rezaie, J. (2023) · European journal of medical research · doi:10.1186/s40001-023-01556-y · Cited by 30 · see citing works
Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment
Tang, L., Xie, M., Li, J., Mei, Y., Cao, Y., Xiao, Q., Dong, H., Zhang, Y., & Wang, W. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.107801 · Cited by 29 · see citing works
Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy
Xia, Z., Mu, W., Yuan, S., Fu, S., Liu, Y., & Zhang, N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15122770 · Cited by 29 · see citing works
Theoretical basis, state and challenges of living cell-based drug delivery systems
Liu, W., Cheng, G., Cui, H., Tian, Z., Li, B., Han, Y., Wu, J., Sun, J., Zhao, Y., Chen, T., et al. (2024) · Theranostics · doi:10.7150/thno.99257 · Cited by 30 · see citing works
Apoptotic mesenchymal stem cells and their secreted apoptotic extracellular vesicles: therapeutic applications and mechanisms
Wang, R., Fu, J., He, J., Wang, X., Xing, W., Liu, X., Yao, J., Ye, Q., & He, Y. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04211-x · Cited by 29 · see citing works
The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression
Buruiană, A., Gheban, B., Gheban-Roşca, I. A., Georgiu, C., Crișan, D., & Crişan, M. (2024) · Cancers · doi:10.3390/cancers16091727 · Cited by 28 · see citing works
Liposome-anchored mesenchymal stem cells for radiation pneumonia/fibrosis treatment
Zhou, H., Zhang, Y., Pei, P., Shen, W., Yi, X., & Yang, K. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122202 · Cited by 28 · see citing works
Nanoghosts: Harnessing Mesenchymal Stem Cell Membrane for Construction of Drug Delivery Platforms Via Optimized Biomimetics
Xiao, Y., Xu, R., & Dai, Y. (2023) · Small · doi:10.1002/smll.202304824 · Cited by 28 · see citing works
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword
Kamrani, S., Naseramini, R., Khani, P., Razavi, Z. S., Afkhami, H., Atashzar, M. R., Nasri, F., Alavimanesh, S., Saeidi, F., & Ronaghi, H. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03741-x · Cited by 27 · see citing works
“The adaptability of MSCs, although beneficial in regenerative medicine, may elevate the risk of these cells unintentionally developing tumorigenic characteristics in the context of malignancy [300, 301].”
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
Radandish, M., Mashhadi, N., Aghayan, A. H., Taghizadeh, M., Salehianfard, S., Yahyazadeh, S., Vakili, O., & Igder, S. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00695-8 · Cited by 27 · see citing works
From Garden to Clinic: Plant‑Derived Exosome‑Like Nanovesicles for Precision Oxidative Stress Therapy
Yang, T., He, M., Huang, J., Zhang, D., Song, T., Tan, J., Wang, X., Lu, Y., Kong, Q., & Zhang, J. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s569204 · Cited by 30 · see citing works
Cold atmospheric plasma: Novel opportunities for tumor microenvironment targeting
Dai, X., & Zhu, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5491 · Cited by 27 · see citing works
Unlocking the adenosine receptor mechanism of the tumour immune microenvironment
Han, Y., Dong, C., Hu, M., Wang, X., & Wang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1434118 · Cited by 26 · see citing works
Extracellular vesicles in cancer drug resistance: Mechanistic insights and therapeutic implications
Zuo, J., Yan, H., Qin, S., Yan, Y., Wang, S., Yang, L., Yang, J., & Yang, J. H. (2024) · MedComm – Oncology · doi:10.1002/mog2.94 · Cited by 26 · see citing works
Mesenchymal stromal cell-mediated mitochondrial transfer unveils new frontiers in disease therapy
Chen, H., Chen, X., Zhou, Z., Zheng, J., Lu, Y., Lin, P., Lin, Y.-F., Zheng, Y., Xiong, B., Xu, R., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04675-x · Cited by 26 · see citing works
Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol-Based Precipitation than by Ultracentrifugation
Jia, L., Li, B., Fang, C., Liang, X., Xie, Y., Sun, X., Wang, W., Zheng, L., & Wang, D. (2022) · Stem Cells International · doi:10.1155/2022/3577015 · Cited by 26 · see citing works
Application of mesenchymal stem cells for anti-senescence and clinical challenges
Wang, Y., Gao, T., & Wang, B. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03497-z · Cited by 27 · see citing works
Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency
Zhang, S., Yahaya, B. H., Pan, Y. H., Liu, Y., & Lin, J. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03551-w · Cited by 25 · see citing works
Engineered Biomimetic Nanovesicles Derived From Bone Marrow Stromal Cells With Innate Homing Capability for Targeted Delivery
Ma, W., Yang, Y., Yang, B., Tang, B., Bai, L., He, Y., Li, Y., & Lin, Y. (2025) · Advanced Materials · doi:10.1002/adma.202505714 · Cited by 24 · see citing works
Lipid-hybrid cell-derived biomimetic functional materials: A state-of-the-art multifunctional weapon against tumors
Liu, W.-S., Wu, L., Chen, C.-M., Zheng, H., Gao, J., Lu, Z., & Li, M. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100751 · Cited by 24 · see citing works
Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma
Wang, C., Zhang, Y., Kong, W., Rong, X., Zhong, Z., Jiang, L., Chen, S., Li, C., Zhang, F., & Jiang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s471900 · Cited by 24 · see citing works
Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases
Li, H., & Bai, L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04318-1 · Cited by 23 · see citing works
Mesenchymal stem cells and cancer‐associated fibroblasts as a therapeutic strategy for breast cancer
Borzone, F. R., Giorello, M. B., Sanmartin, M. C., Yannarelli, G., Martinez, L. M., & Chasseing, N. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15861 · Cited by 24 · see citing works
YAP Inhibition Alleviates Simulated Microgravity-Induced Mesenchymal Stem Cell Senescence via Targeting Mitochondrial Dysfunction
Lv, W., Peng, X., Tu, Y., Shi, Y., Song, G., & Luo, Q. (2023) · Antioxidants · doi:10.3390/antiox12050990 · Cited by 24 · see citing works
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging
Luo, P., Chen, X., Gao, F., Xiang, A. P., Deng, C., Xia, K., & Gao, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12010098 · Cited by 22 · see citing works
Safety evaluation of human umbilical cord-mesenchymal stem cells in type 2 diabetes mellitus treatment: A phase 2 clinical trial
Lian, X.-F., Lu, D.-H., Liu, H., Liu, Y.-J., Yang, Y., Lin, Y., Xie, F., Huang, C.-H., Wu, H., Long, A.-M., et al. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i21.5083 · Cited by 25 · see citing works
Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics
Rosu, A., Ghaemi, B., Bulte, J. W. M., & Shakeri‐Zadeh, A. (2023) · Theranostics · doi:10.7150/thno.90187 · Cited by 21 · see citing works
Role of Mesenchymal Stem/Stromal Cells in Head and Neck Cancer—Regulatory Mechanisms of Tumorigenic and Immune Activity, Chemotherapy Resistance, and Therapeutic Benefits of Stromal Cell-Based Pharmacological Strategies
Starska, K. (2024) · Cells · doi:10.3390/cells13151270 · Cited by 20 · see citing works
Neural Stem Cell-Derived Small Extracellular Vesicles: key Players in Ischemic Stroke Therapy – A Comprehensive Literature Review
Zhu, Z., Zhang, Q., Feng, J., Dongmo, S. Z., Zhang, Q., Huang, S., Liu, X., Zhang, G., & Chen, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s451642 · Cited by 21 · see citing works
How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?
Cao, Y., Zhao, X., Miao, Y., Wang, X., & Deng, D. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403715 · Cited by 20 · see citing works
Mesenchymal stem cell-derived exosomes as cell-free therapeutics: mechanistic insights and engineering strategies for liver disease treatment
Yu, S., Kong, D., Lu, B., Pan, Y., Zeng, Z., Fu, Y., Zhao, Z., He, K., Tang, R., & Xia, Q. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04747-y · Cited by 22 · see citing works
Stem Cells for Cancer Therapy: Translating the Uncertainties and Possibilities of Stem Cell Properties into Opportunities for Effective Cancer Therapy
Aldoghachi, A. F., Chong, Z. X., Yeap, S. K., Cheong, S. K., Ho, W. Y., & Ong, H. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021012 · Cited by 19 · see citing works
The characteristics and medical applications of antler stem cells
Liu, Q., Li, J., Chang, J., Guo, Y. L., & Wen, D. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03456-8 · Cited by 19 · see citing works
Identification of exosomal miR-484 role in reprogramming mitochondrial metabolism in pancreatic cancer through Wnt/MAPK axis control
Lin, T., Pu, X., Zhou, S., Huang, Z., Chen, Q., Zhang, Y., Mao, Q., Liang, Y., & Ding, G. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106980 · Cited by 19 · see citing works
Exosome-based advances in pancreatic cancer: The potential of mesenchymal stem cells
Rahimian, S., Mirkazemi, K., Nejad, A. K., & Doroudian, M. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104594 · Cited by 18 · see citing works
Neutrophil membrane engineered human umbilical cord MSC-derived sEVs enhance anti-tumor efficacy for gastric cancer via delivering pentraxin 3
Tang, Y., Shen, Y., Zang, X., Wu, P., Li, L., Qian, H., Zhang, X., Xu, W., & Jiang, J. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113828 · Cited by 18 · see citing works
Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration
Hu, W., Wang, W., Jiang, X., Wang, Z., & Lin, R. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04028-3 · Cited by 18 · see citing works
Single‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)
Tan, D., Huang, Z., Zhao, Z., Chen, X., Liu, J., Wang, D., Deng, Z., & Li, W. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5326 · Cited by 18 · see citing works
A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)
Alshahrani, M. Y., Jasim, S. A., Altalbawy, F. M. A., Bansal, P., Kaur, H., Al‐Hamdani, M. M., Deorari, M., Abosaoda, M. K., Hamzah, H. F., & Mohammed, B. A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4029 · Cited by 18 · see citing works
Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases
Liu, L., Chen, S., Song, Y., Cui, L., Chen, Y., Xia, J., Fan, Y., Yang, L., & Yang, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107618 · Cited by 20 · see citing works
Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method
Feng, Q.-S., Shan, X., Yau, V., Cai, Z., & Xie, S. (2025) · Pharmaceuticals · doi:10.3390/ph18010062 · Cited by 20 · see citing works
Tumor microenvironment and macroenvironment: A new perspective on holistic oncology
Chen, Q., Jiang, K., Bronze, M. S., Li, M., Houchen, C. W., & Zhang, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218076 · Cited by 18 · see citing works
Cellular-Based Therapies in Systemic Sclerosis: From Hematopoietic Stem Cell Transplant to Innovative Approaches
Xue, E., Minniti, A., Alexander, T., Papa, N. D., Greco, R., & on behalf of The Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT) (2022) · Cells · doi:10.3390/cells11213346 · Cited by 17 · see citing works
Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy
Chen, C., Han, P., & Qing, Y. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103579 · Cited by 17 · see citing works
Mesenchymal Stromal Cell-Based Targeted Therapy Pancreatic Cancer: Progress and Challenges
Ma, Z., Hua, J., Liu, J., Zhang, B., Wang, W., Yu, X., & Xu, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043559 · Cited by 17 · see citing works
New insights into allergic rhinitis treatment: MSC nanovesicles targeting dendritic cells
Liu, J., Wang, M., Tian, X., Wu, S., Peng, H., Zhu, Y., & Liu, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02748-2 · Cited by 17 · see citing works
RETRACTED ARTICLE: Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review
Zare, S., Jafarzadeh, A., Zare, S., & Shamloo, A. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04311-8 · Cited by 16 · see citing works
Retracted
Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies
Guo, R., Zhuang, H., Chen, X., Ben, Y., Fan, M., Wang, Y., & Zheng, P. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231187956 · Cited by 16 · see citing works
Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats
Wang, X., Yang, Y., Li, W., Hao, M., & Xu, Y. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101497 · Cited by 16 · see citing works
Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects
Gil-Chinchilla, J. I., Zapata, A. G., Moraleda, J. M., & García‐Bernal, D. (2024) · Biomolecules · doi:10.3390/biom14070734 · Cited by 16 · see citing works
Synergistic Enhancement of Photodynamic Cancer Therapy with Mesenchymal Stem Cells and Theranostic Nanoparticles
Jarockytė, G., Daugelaite, A. M., Poderys, V., Marin, R., Steponkienė, S., Kazlauskė, E., Uzielienè, I., Daunoravičius, D., Jaque, D., Rotomskis, R., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c10098 · Cited by 15 · see citing works
Cell Membranes from Tumor‐Tropic MSCs Screened by a Microfluidic Chip for Drug Nanoparticles Encapsulation and Cancer Targeted Therapy
Song, Y., Shou, X., Sheng, B., Mei, J., Shi, K., Shang, L., & Zhu, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202904 · Cited by 15 · see citing works
Human umbilical cord mesenchymal stem cells ameliorate acute graft-versus-host disease by elevating phytosphingosine
Hong, T., Wang, R., Yang, G., Wang, X., Zeng, L., Yang, S., Wei, J., Gao, Q., & Zhang, X. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.03.002 · Cited by 15 · see citing works
Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer
Gundersen, R. A., Chu, T., Abolfathi, K., Gokcen, S., Blair, P., Nago, N., Hamblin, M., Brooke, G. N., Zwacka, R. M., Hoshiar, A. K., et al. (2023) · Cancer Nanotechnology · doi:10.1186/s12645-023-00203-9 · Cited by 15 · see citing works
Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view
Arab, F. L., Hoseinzadeh, A., Hafezi, F., Mohammadi, F. S., Zeynali, F., Tehran, M. H., & Rostami, A. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112171 · Cited by 16 · see citing works
CD34+CLDN5+ tumor associated senescent endothelial cells through IGF2-IGF2R signaling increased cholangiocellular phenotype in hepatocellular carcinoma
Zhu, X.-Y., Liu, W., Hou, X., Zong, C., Yu, W., Shen, Z.-M., Qu, S., Tao, M., Xue, M., Zhou, D.-Y., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.12.008 · Cited by 15 · see citing works
Immunomodulatory effect of mesenchymal stem cells‐derived extracellular vesicles to modulate the regulatory T cells and Th1/Th2 imbalance in peripheral blood mononuclear cells of patients with allergic rhinitis
Wang, Z., Shahzad, K. A., Li, X., Cai, B., Xu, M., Li, J., & Tan, F. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13416 · Cited by 14 · see citing works
Natural bioactive compounds modified with mesenchymal stem cells: new hope for regenerative medicine
Wu, J., Ge, Y., Huang, W., Zhang, L., Huang, J., Huang, N., & Luo, Y. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1446537 · Cited by 16 · see citing works
Exosome-mediated macrophage polarization: Pioneering pathways in diabetic wound healing
Zheng, Y., Ruan, Z., Liu, S., Yang, X., & Chen, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115058 · Cited by 15 · see citing works
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Song, Y., Liu, H., Pan, S., Xiang, X., Ye, M., & Zhu, X. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03585-0 · Cited by 14 · see citing works
Cellular-Membrane-Derived Vesicles for Cancer Immunotherapy
An, X., Zeng, Y., Liu, C., & Liu, G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010022 · Cited by 15 · see citing works

Mesenchymal Stem Cells in Cancer Therapy
Baran, Z., Çetinkaya, M., & Baran, Y. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_824 · Cited by 1 · see citing works
Mesenchymal stem cells: A promising weapon for cancer therapy
Zhou, X., Zhang, W., Liu, Y., Zhang, L., & Li, Z. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95346-7.00001-4 · Cited by 1 · see citing works
Mesenchymal stem cells: an emerging tool for cancer targeting and therapy
Fritz, V., & Jorgensen, C. (2008) · Current Stem Cell Research & Therapy · doi:10.2174/157488808783489462 · Cited by 79 · see citing works
Multipotent Mesenchymal Stromal Cells: Clinical Applications and Cancer Modeling
Rodrı́guez, R., Garcı́a-Castro, J., Trigueros, C., Arranz, M. G., & Menéndez, P. R. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-2098-9_13 · Cited by 36 · see citing works
Mesenchymal stem cells‐ an excellent therapeutic agent for cancer
TomyTomcy, A., & Sindhu, E. R. (2023) · Asia-Pacific Journal of Clinical Oncology · doi:10.1111/ajco.13969 · Cited by 14 · see citing works

Authors: Lan, T., Luo, M., & Wei, X.
Affiliations: Sichuan University (CN)
Corresponding author: Luo, Min
Wei, Xiawei
ORCID: Luo, Min
Wei, Xiawei
Venue: Journal of Hematology & Oncology
Publisher: Springer Science and Business Media LLC
Published: 2021-11-17
Volume: 14
Issue: 1
Pages: 195-195
ISSN: 1756-8722 (ISSN-L)
DOI: 10.1186/s13045-021-01208-w
PMC: PMC8596342
OpenAlex: W3211554128
Cited by: 374
References: 205
Citations by year: 2026: 63 · 2025: 105 · 2024: 103 · 2023: 91 · 2022: 12
FWCI: 7.34
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Journal of Hematology & Oncology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation Regional Innovation and Development (U19A2003)
National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2018ZX09733001)
Excellent Youth Foundation of the Sichuan Scientific Committee Grant in China (2019JDJQ008)
Development Program of China (2016YFA0201402)
National Natural Science Foundation of China (31800773)
Sichuan Science and Technology Program (2019YJ0063)
Topics: Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Keywords: mesenchymal stem cells, cancer therapy, cell therapy, immunomodulation, tumor homing, signaling pathways, clinical trials, translational medicine
MeSH terms: Translational Science, Biomedical, Animals, Humans, Neoplasms, Mesenchymal Stem Cell Transplantation, Immunomodulation, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mesenchymal stem/stromal cells in cancer therapy

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks