The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
T-Cell Factor 3 Regulates Embryonic Stem Cell Pluripotency and Self-Renewal by the Transcriptional Control of Multiple Lineage Pathways
Open accessAbstract
The Wnt signaling pathway is necessary both for maintaining undifferentiated stem cells and for directing their differentiation. In mouse embryonic stem cells (ESCs), Wnt signaling preferentially maintains “stemness” under certain permissive conditions. T-cell factor 3 (Tcf3) is a component of the Wnt signaling and a dominant downstream effector in ESCs. Despite the wealth of knowledge regarding the importance of Wnt signaling underlying stem cells functions, the precise mechanistic explanation by which the effects are mediated is unknown. In this study, we identified new regulatory targets of Tcf3 using a whole-genome approach and found that Tcf3 transcriptionally represses many genes important for maintaining pluripotency and self-renewal, as well as those involved in lineage commitment and stem cell differentiation. This effect is in part mediated by the corepressors transducin-like enhancer of split 2 and C-terminal Binding Protein (CtBP). Notably, Tcf3 binds to and represses the Oct4 promoter, and this repressive effect requires both the Groucho and CtBP interacting domains of Tcf3. Interestingly, we find that in mouse preimplantation development embryos, Tcf3 expression is coregulated with Oct4 and Nanog and becomes localized to the inner cell mass of the blastocyst. These data demonstrate an important role for Tcf3 in modulating the appropriate level of gene transcription in ESCs and during embryonic development. Disclosure of potential conflicts of interest is found at the end of this article.
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A gene atlas of the mouse and human protein-encoding transcriptomes
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Self-citationWnt proteins are lipid-modified and can act as stem cell growth factors
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A role for Wnt signalling in self-renewal of haematopoietic stem cells
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Rational siRNA design for RNA interference
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The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells
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Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo
Ricci, M. A., Manzo, C., García-Parajo, M. F., Lakadamyali, M., & Cosma, M. P. (2015) · Cell · doi:10.1016/j.cell.2015.01.054 · Cited by 736
Tbx3 improves the germ-line competency of induced pluripotent stem cells
Han, J., Yuan, P., Yang, H., Zhang, J., Soh, B. S., Li, P., Lim, S. L., Cao, S., Tay, J., Orlov, Y. L., et al. (2010) · Nature · doi:10.1038/nature08735 · Cited by 285
Self-citationMaintaining embryonic stem cell pluripotency with Wnt signaling
Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257
Lim, C. Y., Tam, W.-L., Zhang, J., Ang, H. S., Jia, H., Lipovich, L., Ng, H.-H., Wei, C.-L., Sung, W. K., Robson, P., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.004 · Cited by 224
Self-citationAtlasi, Y., Noori, R., Gaspar, C., Franken, P., Sacchetti, A., Rafati, H., Mahmoudi, T., Decraene, C., Calin, G. A., Merrill, B. J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003424 · Cited by 84
Metadata
- Authors
- Tam, W.-L., Lim, C. Y., Han, J., Zhang, J., Ang, Y.-S., Ng, H.-H., Yang, H., & Lim, B.
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-08
- Volume
- 26
- Issue
- 8
- Pages
- 2019-2031
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W1990577927
- Cited by
- 188
- References
- 6
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Tam, W.-L., Lim, C. Y., Han, J., Zhang, J., Ang, Y.-S., Ng, H.-H., Yang, H., & Lim, B. (2008). T-Cell Factor 3 Regulates Embryonic Stem Cell Pluripotency and Self-Renewal by the Transcriptional Control of Multiple Lineage Pathways. Stem Cells. https://doi.org/10.1634/stemcells.2007-1115
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