The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Controlled, Scalable Embryonic Stem Cell Differentiation Culture
Abstract
Embryonic stem (ES) cells are of significant interest as a renewable source of therapeutically useful cells. ES cell aggregation is important for both human and mouse embryoid body (EB) formation and the subsequent generation of ES cell derivatives. Aggregation between EBs (agglomeration), however, inhibits cell growth and differentiation in stirred or high-cell-density static cultures. We demonstrate that the agglomeration of two EBs is initiated by E-cadherin-mediated cell attachment and followed by active cell migration. We report the development of a technology capable of controlling cell-cell interactions in scalable culture by the mass encapsulation of ES cells in size-specified agarose capsules. When placed in stirred-suspension bioreactors, encapsulated ES cells can be used to produce scalable quantities of hematopoietic progenitor cells in a controlled environment.
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Citations
Cites
HIF-1 is Essential for Multilineage Hematopoiesis in the Embryo
Adelman, D. M., Maltepe, E., & Simon, M. C. (2002) · Advances in Experimental Medicine and Biology · doi:10.1007/0-306-46825-5_26 · Cited by 25
Cited by
Gerecht, S., Burdick, J. A., Ferreira, L. S., Townsend, S. A., Langer, R., & Vunjak-Novakovic, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703723104 · Cited by 664
Spheroid Culture System Methods and Applications for Mesenchymal Stem Cells
Ryu, N.-E., Lee, S.-H., & Park, H. (2019) · Cells · doi:10.3390/cells8121620 · Cited by 517
Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics
Chen, K. G., Mallon, B. S., McKay, R. D. G., & Robey, P. G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.12.005 · Cited by 358
Advances and challenges in stem cell culture
McKee, C., & Chaudhry, G. R. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.07.051 · Cited by 323
The Systematic Production of Cells for Cell Therapies
Kirouac, D. C., & Zandstra, P. W. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.001 · Cited by 301
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Metadata
- Authors
- Dang, S. M., Gerecht‐Nir, S., Chen, J., Itskovitz‐Eldor, J., & Zandstra, P. W.
- Venue
- STEM CELLS
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-05
- Volume
- 22
- Issue
- 3
- Pages
- 275-282
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- OpenAlex
- W2032707537
- Cited by
- 313
- References
- 1
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dang, S. M., Gerecht‐Nir, S., Chen, J., Itskovitz‐Eldor, J., & Zandstra, P. W. (2004). Controlled, Scalable Embryonic Stem Cell Differentiation Culture. STEM CELLS. https://doi.org/10.1634/stemcells.22-3-275
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
