Cited by 238Autophagy in Disease and TherapyCell death mechanisms and regulationGlioma Diagnosis and Treatment

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Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

Lefranc, Florence, Facchini, Vincenzo, Kiss, Robert·2007·The Oncologist

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Abstract

Learning Objectives: After completing this course, the reader will be able to: Describe the pathways involved in the natural resistance of cancer cells to cytotoxic insults including radio-/chemotherapy.Explain autophagic cell death as a potent alternative tumor-suppressing mechanism.Identify the common targets in apoptosis and autophagy resistance pathways and the surrogate markers that could be used in clinical practice for proautophagic therapy.Discuss the rationale for incorporating endoplasmic reticulum stress inhibitors as adjuvant chemotherapies against apoptosis-resistant cancers. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com

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Authors: Lefranc, F., Facchini, V., & Kiss, R.
Affiliations: Université Libre de Bruxelles (BE)
c Unibioscreen SA, Brussels, Belgium
b Laboratory of Toxicology, Institute of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium
Corresponding author: Lefranc, Florence
Venue: The Oncologist
Publisher: Oxford University Press (OUP)
Published: 2007-12-01
Volume: 12
Issue: 12
Pages: 1395-1403
ISSN: 1083-7159 (ISSN-L)
1549-490X
DOI: 10.1634/theoncologist.12-12-1395
OpenAlex: W2099551830
Cited by: 237
References: 93
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 13 · 2014: 13 · 2013: 21 · 2012: 19
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: The Oncologist (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Keywords: autophagic cell death, apoptosis resistance, glioblastoma, temozolomide, mTOR inhibitors, PI3K/Akt signaling, endoplasmic reticulum stress, combination chemotherapy, caspase-independent cell death
MeSH terms: Temozolomide, Antineoplastic Agents, Autophagy, Dacarbazine, Glioblastoma, Humans, Neoplasms, Drug Delivery Systems, Apoptosis, Drug Resistance, Neoplasm

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Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

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