Induction of autophagy by spermidine promotes longevity
Open accessAbstract
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
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Spermidine, a natural polyamine, has shown promising autophagy-dependent effects on yeast, flies and worms longevity and on mouse health-span.
“recent studies with spermidine, a natural polyamine, have shown promising autophagy-dependent effects on yeast, flies and worms longevity and on mouse health-span (Eisenberg et al., 2009)”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Eisenberg et al., 2009
The section on autophagy and lifespan extension reports that autophagy is crucial for spermidine-mediated longevity in yeast, flies and worms. The mouse experiment in the Articles section reports reduced age-related oxidative stress after spermidine supplementation, but does not establish that a mouse health-span benefit was autophagy-dependent. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn 2009, Eisenberg et al. identified the use of spermidine, a polyamine compound, to promote longevity via autophagy, using PBMCs as a model.
“In 2009, Eisenberg et al. identified the use of spermidine, a polyamine compound, to promote longevity, via autophagy, using PBMCs as model.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [190]
After 12 days, 50% of the cells survived after addition of spermidine.
“After 12 days, 50% of the cells survived after addition of spermidine.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [190]
Cell death associated with membrane rupture was indicative of necrosis.
“In fact, cell death, associated with membrane rupture, was indicative of necrosis (190).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [190]
Spermidine is an effective antiaging agent.
“and has been shown to be an effective antiaging agent [275,276,277].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [275]
Spermidine is a naturally occurring polyamine that triggers autophagy and, thereby, lifespan extension when supplemented in the food supply of yeast, flies and worms.
“Spermidine is a naturally occurring polyamine that triggers autophagy and, thereby, lifespan extension when supplemented in the food supply of yeast, flies and worms (Eisenberg et al., 2009).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Eisenberg et al., 2009
Both HDAC10 and spermidine promote cellular survival through autophagy.
“Both HDAC10 and spermidine are known to promote cellular survival through autophagy.”
From Histone deacetylase 10 structure and molecular function as a polyamine deacetylase (2017) · cites this paper as [36]
Spermidine is a key factor in autophagy; increased levels of endogenous or exogenous spermidine induce autophagy and extend lifespan in a variety of cell types, including human immune cells.
“The polyamine spermidine is also a key factor in autophagy and increased levels of endogenous or exogenous spermidine induce autophagy and extend lifespan in a variety of cell types, including human immune cells3637.”
From Histone deacetylase 10 structure and molecular function as a polyamine deacetylase (2017) · cites this paper as [36]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,383 · see citing works
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 14,984 · see citing works
Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 14,952 · see citing works
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works
Self-citationVermes, I., Haanen, C., Steffens-Nakken, H. M., & Reutellingsperger, C. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00072-i · Cited by 5,437 · see citing works
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837 · see citing works
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
Lotze, M. T., & Tracey, K. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1594 · Cited by 2,490 · see citing works
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775 · see citing works
A Model-Based Background Adjustment for Oligonucleotide Expression Arrays
Wu, Z. J., Irizarry, R. A., Gentleman, R. C., Martínez-Murillo, F., & Spencer, F. A. (2004) · Journal of the American Statistical Association · doi:10.1198/016214504000000683 · Cited by 1,717 · see citing works
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>
Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270 · see citing works
Cell death by necrosis: towards a molecular definition
Golstein, P., & Kroemer, G. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.001 · Cited by 1,044 · see citing works
Oxygen Stress: A Regulator of Apoptosis in Yeast
Madeo, F., Fröhlich, E., Ligr, M., Grey, M., Sigrist, S. J., Wolf, D. H., & Fröhlich, K. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.757 · Cited by 1,017 · see citing works
Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works
A second set of loxP marker cassettes for Cre-mediated multiple gene knockouts in budding yeast
Güldener, U. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.6.e23 · Cited by 982 · see citing works
Necrotic death as a cell fatePreprint
Zong, W., & Thompson, C. B. (2006) · Genes & Development · doi:10.1101/gad.1376506 · Cited by 920 · see citing works
Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast
Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881 · cited 1× · see citing works
“Autophagy was monitored either by vacuolar localization of Atg8p using fluorescence microscopy of cells expressing an EGFP–Atg8 fusion protei”
MethodRegulation of Longevity and Stress Resistance by Sch9 in Yeast
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works
A Caspase-Related Protease Regulates Apoptosis in Yeast
Madeo, F., Herker, E., Maldener, C., Wissing, S., Lächelt, S., Herlan, M., Fehr, M., Lauber, K., Sigrist, S. J., Wesselborg, S., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00501-4 · Cited by 873 · see citing works
A Yeast Mutant Showing Diagnostic Markers of Early and Late Apoptosis
Madeo, F., Fröhlich, E., & Fröhlich, K. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.3.729 · Cited by 794 · see citing works
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.Preprint
Strahl‐Bolsinger, S., Hecht, A., Luo, K., & Grunstein, M. R. (1997) · Genes & Development · doi:10.1101/gad.11.1.83 · Cited by 679 · see citing works
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
Sirtuins in aging and age-related disease
Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575 · see citing works
Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4′-dithiodipyridine
Riener, C. K., Kada, G., & Gruber, H. J. (2002) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-002-1347-2 · Cited by 569 · see citing works
Chronological aging leads to apoptosis in yeast
Herker, E., Jungwirth, H., Lehmann, K. A., Maldener, C., Fröhlich, K.-U., Wissing, S., Büttner, S., Fehr, M., Sigrist, S., & Madeo, F. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310014 · Cited by 548 · see citing works
Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y., & Shadel, G. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.009 · Cited by 422 · see citing works
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis
Laun, P., Pichová, A., Madeo, F., Fuchs, J., Ellinger, A., Kohlwein, S. D., Dawes, I. W., Fröhlich, K., & Breitenbach, M. (2001) · Molecular Microbiology · doi:10.1111/j.1365-2958.2001.02317.x · Cited by 416 · see citing works
An AIF orthologue regulates apoptosis in yeast
Wissing, S., Ludovico, P., Herker, E., Büttner, S., Engelhardt, S. M., Decker, T., Link, A., Proksch, A., Rodrigues, F. J. S., Côrte‐Real, M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404138 · Cited by 398 · see citing works
Juhász, G., Érdi, B., Sass, M., & Neufeld, T. P. (2007) · Genes & Development · doi:10.1101/gad.1600707 · Cited by 396 · see citing works
Sir2 Blocks Extreme Life-Span Extension
Fabrizio, P., Gattazzo, C., Battistella, L., Wei, M., Cheng, C., McGrew, K., & Longo, V. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.042 · Cited by 390 · see citing works
Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation
Duncan, E. M., Muratore‐Schroeder, T. L., Cook, R. G., Garcia, B. A., Shabanowitz, J., Hunt, D. F., & Allis, C. D. (2008) · Cell · doi:10.1016/j.cell.2008.09.055 · Cited by 364 · see citing works
Superoxide is a mediator of an altruistic aging program in <i>Saccharomyces cerevisiae</i>
Fabrizio, P., Battistella, L., Vardavas, R., Gattazzo, C., Liou, L.-L., Diaspro, A., Dossen, J. W., Gralla, E. B., & Longo, V. D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404002 · Cited by 355 · see citing works
A molecular mechanism of chronological aging in yeast
Burtner, C. R., Murakami, C. J., Kennedy, B. K., & Kaeberlein, M. R. (2009) · Cell Cycle · doi:10.4161/cc.8.8.8287 · Cited by 348 · see citing works
Novel System for Monitoring Autophagy in the Yeast Saccharomyces cerevisiae
Noda, T., Matsuura, A., Wada, Y., & Ohsumi, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1636 · Cited by 344 · see citing works
Autophagy is Required for Dietary Restriction-Mediated Life Span Extension in<i>C. elegans</i>
Jia, K., & Levine, B. (2007) · Autophagy · doi:10.4161/auto.4989 · Cited by 341 · see citing works
Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures
Allen, C., Büttner, S., Aragon, A. D., Thomas, J., Meirelles, O., Jaetao, J. E., Benn, D., Ruby, S. W., Marten Veenhuis, A., Madeo, F., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604072 · Cited by 338 · see citing works
Endonuclease G Regulates Budding Yeast Life and Death
Büttner, S., Eisenberg, T., Carmona-Gutierrez, D., Ruli, D., Knauer, H., Ruckenstuhl, C., Sigrist, C., Wissing, S., Kollroser, M., Fröhlich, K.-U., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.021 · Cited by 331 · see citing works
Regulation of autophagy by the inositol trisphosphate receptor
Criollo, A., Maiuri, M. C., Tasdemir, E., Vitale, I., Fiebig, A. A., Andrews, D. W., Molgó, J., Dı́az, J., Lavandero, S., Harper, F., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402099 · Cited by 305 · see citing works
Winkler, G. S., Kristjuhan, A., Erdjument‐Bromage, H., Tempst, P., & Svejstrup, J. Q. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022042899 · Cited by 276 · see citing works
To Die or Not to Die: That is the Autophagic Question
Maiuri, M. C., Galluzzi, L., Vicencio, J. M., Kepp, O., Tasdemir, E., & Kroemer, G. (2008) · Current Molecular Medicine · doi:10.2174/156652408783769616 · Cited by 265 · see citing works
Senescence, Apoptosis or Autophagy?
Vicencio, J. M., Galluzzi, L., Tajeddine, N., Ortiz, C., Criollo, A., Tasdemir, E., Morselli, E., Younes, A. B., Maiuri, M. C., Lavandero, S., et al. (2008) · Gerontology · doi:10.1159/000129697 · Cited by 259 · see citing works
Recent developments in yeast aging
Kaeberlein, M., Burtner, C. R., & Kennedy, B. K. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030084 · Cited by 239 · see citing works
Lefranc, F., Facchini, V., & Kiss, R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-12-1395 · Cited by 237 · see citing works
Eating the enemy within: autophagy in infectious diseases
Orvedahl, A., & Levine, B. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.130 · Cited by 232 · see citing works
HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction
Lamming, D. W., Latorre‐Esteves, M., Medvedik, O., Wong, S. N., Tsang, F. A., Wang, C., Lin, S.-J., & Sinclair, D. A. (2005) · Science · doi:10.1126/science.1113611 · Cited by 228 · see citing works
CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis
Rainer, J., Sánchez‐Cabo, F., Stocker, G., Sturn, A., & Trajanoski, Z. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl038 · Cited by 224 · see citing works
Histone H3 specific acetyltransferases are essential for cell cycle progressionPreprint
Howe, L. J., Auston, D. A., Grant, P. A., John, S., Cook, R. G., Workman, J. L., & Pillus, L. (2001) · Genes & Development · doi:10.1101/gad.931401 · Cited by 222 · see citing works
Smith, D. L., McClure, J. M., Matecic, M., & Smith, J. S. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00326.x · Cited by 218 · see citing works
TheS. cerevisiaeHtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis
Fahrenkrog, B., Sauder, U., & Aebi, U. (2003) · Journal of Cell Science · doi:10.1242/jcs.00848 · Cited by 210 · see citing works
Autophagy: An emerging target for cancer therapy
Høyer-Hansen, M., & Jäättelä, M. (2008) · Autophagy · doi:10.4161/auto.5921 · Cited by 192 · see citing works
Autophagy is required for necrotic cell death in Caenorhabditis elegans
Samara, C., Syntichaki, P., & Tavernarakis, N. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402231 · Cited by 178 · see citing works
The effects of p53 on whole organism longevity are mediated by autophagy
Tavernarakis, N., Pasparaki, A., Tasdemir, E., Maiuri, M. C., & Kroemer, G. (2008) · Autophagy · doi:10.4161/auto.6730 · Cited by 132 · see citing works
Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes
Fahrenkrog, B., Hurt, E. C., Aebi, U., & Panté, N. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.577 · Cited by 116 · see citing works
Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae.
Balasundaram, D., Tabor, C. W., & Tabor, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5872 · Cited by 115 · see citing works
Lambert, L., Qiao, N., Hunt, K. K., Lambert, D. H., Mills, G. B., Meijer, L., & Keyomarsi, K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1333 · Cited by 113 · see citing works
DNA Replication Stress Is a Determinant of Chronological Lifespan in Budding Yeast
Weinberger, M., Li, F., Paul, A., Smith, D. L., Hontz, R. D., Smith, J. S., Vujcic, M., Singh, K. K., Huberman, J. A., & Burhans, W. C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000748 · Cited by 109 · see citing works
Syntichaki, P., Samara, C., & Tavernarakis, N. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.057 · Cited by 106 · see citing works
Lysosomal biogenesis and function is critical for necrotic cell death in Caenorhabditis elegans
Artal‐Sanz, M., Samara, C., Syntichaki, P., & Tavernarakis, N. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511103 · Cited by 100 · see citing works
Evans, E., Sugawara, N., Haber, J. E., & Alani, E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80319-6 · Cited by 95 · see citing works
Polyamines in mammalian ageing: An oncological problem, too? A review
Scalabrino, G., & Ferioli, M. E. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90090-3 · Cited by 91 · see citing works
Gianotti, V., Chiuminatto, U., Mazzucco, E., Gosetti, F., Bottaro, M., Frascarolo, P., & Gennaro, M. C. (2008) · Journal of Chromatography A · doi:10.1016/j.chroma.2008.02.038 · Cited by 91 · see citing works
Apoptosis in budding yeast caused by defects in initiation of DNA replication
Weinberger, M., Ramachandran, L., Li, F., Sharma, K., Sun, X., Marchetti, M. A., Huberman, J. A., & Burhans, W. C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02477 · Cited by 89 · see citing works
Minocha, R., Shortle, W. C., Long, S. L., & Minocha, S. C. (1994) · Journal of Plant Growth Regulation · doi:10.1007/bf00226036 · Cited by 84 · see citing works
Chattopadhyay, M. K., Tabor, C. W., & Tabor, H. (2006) · Yeast · doi:10.1002/yea.1393 · Cited by 71 · see citing works
Hobbs, C. A., Paul, B. A., & Gilmour, S. K. (2002) · PubMed · Cited by 66 · see citing works
Acetic acid effects on aging in budding yeast: Are they relevant to aging in higher eukaryotes?
Burhans, W. C., & Weinberger, M. (2009) · Cell Cycle · doi:10.4161/cc.8.14.8852 · Cited by 49 · see citing works
A Yeast Polyamine Acetyltransferase
Liu, B., Sutton, A., & Sternglanz, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414008200 · Cited by 42 · see citing works
Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats
Schraml, E., Quan, P., Stelzer, I., Fuchs, R., Skalicky, M., Viidik, A., & Schauenstein, K. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.08.003 · Cited by 32 · see citing works
Hobbs, C. A., Paul, B. A., & Gilmour, S. K. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00352-5 · Cited by 30 · see citing works
Flagged first, then by citations
1 of the 77 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Weinberger, M. et al. DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS ONE 2, e748 (2007).
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Self-citationAutophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works
Self-citationKlionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works
Self-citationRubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Eaten alive: a history of macroautophagy
Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
Palikaras, K., Lionaki, E., & Tavernarakis, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0176-2 · Cited by 1,505 · see citing works
Autophagy modulation as a potential therapeutic target for diverse diseases
Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works
Self-citationOliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327 · see citing works
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works
Spermidine in health and disease
Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154 · see citing works
Self-citationEpigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956 · see citing works
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013 · see citing works
Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
Loewith, R., & Hall, M. (2011) · Genetics · doi:10.1534/genetics.111.133363 · Cited by 894 · see citing works
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works
Metabolic control of autophagy
Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855 · see citing works
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842 · see citing works
Self-citationMeasuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works
Senescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798 · see citing works
Autophagy as a promoter of longevity: insights from model organisms
Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767 · see citing works
Overexpression of Atg5 in mice activates autophagy and extends lifespan
Pyo, J.-O., Yoo, S.-M., Ahn, H.-H., Nah, J., Hong, S.-H., Kam, T.-I., Jung, S., & Jung, Y.-K. (2013) · Nature Communications · doi:10.1038/ncomms3300 · Cited by 721 · see citing works
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Remaining mysteries of molecular biology: the role of polyamines in the cell
Miller-Fleming, L., Olin-Sandoval, V., Campbell, K., & Ralser, M. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.06.020 · Cited by 658 · see citing works
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works
Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630 · see citing works
Anti-apoptosis and cell survival: A review
Portt, L., Norman, G., Clapp, C., Greenwood, M., & Greenwood, M. T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.010 · Cited by 640 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death & Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works
Self-citationInterventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Replicative and chronological aging in Saccharomyces cerevisiae
Longo, V. D., Shadel, G. S., Kaeberlein, M., & Kennedy, B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.002 · Cited by 595 · see citing works
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice
Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1832857 · Cited by 596 · see citing works
Caloric restriction mimetics enhance anticancer immunosurveillance
Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.016 · Cited by 542 · see citing works
Aging as an event of proteostasis collapse
Taylor, R. C., & Dillin, A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004440 · Cited by 538 · see citing works
Cell death assays for drug discovery
Kepp, O., Galluzzi, L., Lipinski, M. M., Yuan, J., & Kroemer, G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3373 · Cited by 556 · see citing works
Anticancer effects of the microbiome and its products
Zitvogel, L., Daillère, R., Roberti, M. P., Routy, B., & Kroemer, G. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.44 · Cited by 538 · see citing works
Polyamines in aging and disease
Minois, N., Carmona‐Gutiérrez, D., & Madeo, F. (2011) · Aging · doi:10.18632/aging.100361 · Cited by 516 · see citing works
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E. V., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008167 · Cited by 495 · see citing works
Regulation of autophagy by cytosolic acetyl-coenzyme A
Mariño, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.016 · Cited by 500 · see citing works
The quest to slow ageing through drug discovery
Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works
Apoptosis in yeast: triggers, pathways, subroutines
Carmona‐Gutiérrez, D., Eisenberg, T., Büttner, S., Meisinger, C., Kroemer, G., & Madeo, F. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2009.219 · Cited by 483 · see citing works
Protein Homeostasis and Aging: the importance of exquisite quality control
Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476 · see citing works
The return of the nucleus: transcriptional and epigenetic control of autophagy
Füllgrabe, J., Klionsky, D. J., & Joseph, B. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3716 · Cited by 463 · see citing works
Autophagy: for better or for worse
Wirawan, E., Berghe, T. V., Lippens, S., Agostinis, P., & Vandenabeele, P. (2011) · Cell Research · doi:10.1038/cr.2011.152 · Cited by 468 · see citing works
Essential role for autophagy in life span extension
Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works
Self-citationLou, G., Palikaras, K., Lautrup, S., Scheibye‐Knudsen, M., Tavernarakis, N., & Fang, E. F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.07.002 · Cited by 449 · see citing works
Aging and Autophagy in the Heart
Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 443 · see citing works
The roles of polyamines during the lifespan of plants: from development to stress
Tiburcio, A. F., Altabella, T., Bitrián, M., & Alcázar, R. (2014) · Planta · doi:10.1007/s00425-014-2055-9 · Cited by 435 · see citing works
Can autophagy promote longevity?
Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 433 · see citing works
Ågren, R., Bordel, S., Mardinoğlu, A., Pornputtapong, N., Nookaew, I., & Nielsen, J. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002518 · Cited by 430 · see citing works
Autophagy and the cell biology of age-related disease
Leidal, A. M., Levine, B., & Debnath, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0235-8 · Cited by 424 · see citing works
Lessons on longevity from budding yeast
Kaeberlein, M. R. (2010) · Nature · doi:10.1038/nature08981 · Cited by 420 · see citing works
Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Gassen, N. C., Papies, J., Bajaj, T., Emanuel, J., Dethloff, F., Chua, R. L., Trimpert, J., Heinemann, N., Niemeyer, C., Weege, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24007-w · Cited by 401 · see citing works
Disulfide exchange: exposing supramolecular reactivity through dynamic covalent chemistry
BLACK, S. P. W., Sanders, J. K. M., & Stefankiewicz, A. R. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60326a · Cited by 406 · see citing works
Autophagy in metabolic disease and ageing
Kitada, M., & Koya, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00551-9 · Cited by 413 · see citing works
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Puleston, D. J., Buck, M. D., Geltink, R. I. K., Kyle, R. L., Caputa, G., O’Sullivan, D., Cameron, A. M., Castoldi, Â., Musa, Y., Kabat, A. M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.003 · Cited by 391 · see citing works
Nuclear DNA damage signalling to mitochondria in ageing
Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.14 · Cited by 387 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
Gupta, V., Scheunemann, L., Eisenberg, T., Mertel, S., Bhukel, A., Koemans, T. S., Kramer, J. M., Liu, K. S. Y., Schroeder, S., Stunnenberg, H. G., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3512 · Cited by 374 · see citing works
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives
Zhang, Z., Yang, X., Song, Y., & Tu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101464 · Cited by 378 · see citing works
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
Chen, G., Kroemer, G., & Kepp, O. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00200 · Cited by 359 · see citing works
MicroRNAs and their roles in aging
Smith-Vikos, T., & Slack, F. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.099200 · Cited by 371 · see citing works
Sarkar, S. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130134 · Cited by 367 · see citing works
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
Sun, L., Suo, C., Li, S., Zhang, H., & Gao, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.005 · Cited by 366 · see citing works
Portune, K. J., Beaumont, M., Davila, A.-M., Tomé, D., Blachier, F., & Sanz, Y. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.08.011 · Cited by 356 · see citing works
Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence
Zhang, H., Alsaleh, G., Feltham, J., Sun, Y., Napolitano, G., Riffelmacher, T., Charles, P., Frau, L., Hublitz, P., Yu, Z., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.005 · Cited by 341 · see citing works
Spermidine induces autophagy by inhibiting the acetyltransferase EP300
Pietrocola, F., Lachkar, S., Enot, D. P., Niso-Santano, M., Bravo-San Pedro, J. M., Sica, V, Izzo, V, Maiuri, M. C., Madeo, F., Mariño, G., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.215 · Cited by 357 · see citing works
Autophagy is a critical regulator of memory CD8+ T cell formation
Puleston, D. J., Zhang, H., Powell, T. J., Lipina, E., Sims, S., Panse, I., Watson, A. S., Cerundolo, V., Townsend, A. R., Klenerman, P., et al. (2014) · eLife · doi:10.7554/elife.03706 · Cited by 360 · see citing works
Polyamines in cancer: integrating organismal metabolism and antitumour immunity
Holbert, C. E., Cullen, M., Casero, R. A., & Stewart, T. M. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00473-2 · Cited by 370 · see citing works
Chemical modulators of autophagy as biological probes and potential therapeutics
Fleming, A., Noda, T., Yoshimori, T., & Rubinsztein, D. C. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.500 · Cited by 347 · see citing works
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339 · see citing works
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N., & Madeo, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.031 · Cited by 345 · see citing works
Self-citationHale, A. N., Ledbetter, D., Gawriluk, T. R., & Rucker, E. B. (2013) · Autophagy · doi:10.4161/auto.24273 · Cited by 336 · see citing works
Impact of intestinal microbiota on intestinal luminal metabolome
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334 · see citing works
Transcriptional and epigenetic regulation of autophagy in aging
Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 339 · see citing works
Autophagy and Alzheimer’s Disease
Li, Q., Liu, Y., & Sun, M. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0386-8 · Cited by 331 · see citing works
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Greene, C. M., Marciniak, S. J., Teckman, J. H., Ferrarotti, I., Brantly, M., Lomas, D. A., Stoller, J. K., & McElvaney, N. G. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.51 · Cited by 326 · see citing works
The Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323 · see citing works
Molecular and biological hallmarks of ageing
Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 322 · see citing works
Wang, C., Wu, S., Wu, Y., & Wei, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213493069 · Cited by 315 · see citing works
Posttranslational modification of autophagy-related proteins in macroautophagy
Xie, Y., Kang, R., Sun, X., Zhong, M., Huang, J. L., Klionsky, D. J., & Tang, D. (2014) · Autophagy · doi:10.4161/15548627.2014.984267 · Cited by 309 · see citing works
Matsumoto, M., Kurihara, S., Kibe, R., Ashida, H., & Benno, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023652 · Cited by 290 · see citing works
Oxidative Stress and Programmed Cell Death in Yeast
Farrugia, G., & Balzan, R. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00064 · Cited by 303 · see citing works
Moschou, P. N., Wu, J., Cona, A., Tavladoraki, P., Angelini, R., & Roubelakis–Angelakis, K. A. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers202 · Cited by 302 · see citing works
Epigenetic changes during aging and their reprogramming potential
Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283 · see citing works
A comprehensive glossary of autophagy-related molecules and processes (2ndedition)
Klionsky, D. J., Baehrecke, E. H., Brumell, J. H., Chu, C. T., Codogno, P., Cuervo, A. M., Debnath, J., Deretic, V. P., Elazar, Z., Eskelinen, E., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.17661 · Cited by 293 · see citing works
Lipid droplet autophagy in the yeast Saccharomyces cerevisiae
van Zutphen, T., Todde, V., de Boer, R., Kreim, M., Hofbauer, H. F., Wolinski, H., Marten Veenhuis, A., van der Klei, I. J., & Kohlwein, S. D. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-08-0448 · Cited by 293 · see citing works
Drosophila as a model for ageing
Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273 · see citing works
Autophagy and the hallmarks of aging
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285 · see citing works
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan
Schosserer, M., Minois, N., Angerer, T. B., Amring, M., Dellago, H., Harreither, E., Calle-Perez, A., Pircher, A., Gerstl, M. P., Pfeifenberger, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7158 · Cited by 281 · see citing works
Parkhitko, A. A., Jouandin, P., Mohr, S. E., & Perrimon, N. (2019) · Aging Cell · doi:10.1111/acel.13034 · Cited by 276 · see citing works
Phosphatidylethanolamine positively regulates autophagy and longevity
Rockenfeller, P., Koska, M., Pietrocola, F., Minois, N., Knittelfelder, O. L., Sica, V., Franz, J., Carmona‐Gutiérrez, D., Kroemer, G., & Madeo, F. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.219 · Cited by 276 · see citing works
Proteostasis, oxidative stress and aging
Korovila, I., Hugo, M., Castro, J. P., Weber, D., Höhn, A., Grune, T., & Jung, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.008 · Cited by 274 · see citing works
- Authors
- Eisenberg, T., Knauer, H., Schauer, A., Büttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., Fussi, H., Deszcz, L., Hartl, R., Schraml, E., Criollo, A., Megalou, E., Weiskopf, D., Laun, P., Heeren, G., Breitenbach, M., Grubeck-Loebenstein, B., Herker, E., Fahrenkrog, B., Fröhlich, K.-U., Sinner, F., Tavernarakis, N., Minois, N., Kroemer, G., & Madeo, F.
- Affiliations
- University of Graz (AT)
- Joanneum Research (AT)
- Institute of Molecular Biotechnology (AT)
- BOKU University (AT)
- Université Paris-Sud (FR)
- Foundation for Research and Technology Hellas (GR)
- Austrian Academy of Sciences (AT)
- University of Salzburg (AT)
- Gladstone Institutes (US)
- University of Basel (CH)
- Corresponding author
- Kroemer, Guido
- Madeo, Frank
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2009-10-04
- Volume
- 11
- Issue
- 11
- Pages
- 1305-1314
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2045611938
- Cited by
- 1,680
- References
- 77
- Citations by year
- 2026: 115 · 2025: 116 · 2024: 99 · 2023: 118 · 2022: 125 · 2021: 129 · 2020: 121 · 2019: 104 · 2018: 124 · 2017: 76 · 2016: 93 · 2015: 74 · 2014: 91 · 2013: 99 · 2012: 69
- FWCI
- 19.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- edoc (University of Basel) (submittedVersion)
- Oesterreichisches Musiklexikon online (Institut für kunst- und musikhistorische Forschungen der Österreichischen Akademie der Wissenschaften) (submittedVersion, other-oa)
- Austrian Biographical Dictionary (Austrian Academy of Sciences) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- European Commission (FP6 036894)
- Austrian Science Fund (S9304-B05, S9302-B05, S-9303-B05)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- spermidine, polyamines, autophagy, longevity, lifespan extension, aging, histone H3 acetylation, histone acetyltransferase, oxidative stress, necrosis, reactive oxygen species, chromatin, immune cells, yeast, Drosophila, Caenorhabditis elegans, mice
- MeSH terms
- Acetylation, Adult, Animals, Autophagy, Drosophila melanogaster, Female, HeLa Cells, Histones, Humans, Hydrogen-Ion Concentration, Longevity, Male, Mice, Inbred C57BL, Necrosis, Saccharomyces cerevisiae, Spermidine, Caenorhabditis elegans, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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