Cited by 288Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

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Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

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Zhu, M.-L., Kyprianou, N.·2008·Endocrine Related Cancer

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Abstract

Androgens promote the growth and differentiation of prostate cells through ligand activation of the androgen receptor (AR). Sensitization of the androgenic response by multifunctional growth factor signaling pathways is one of the mechanisms via which AR contributes to the emergence of androgen-independent prostate tumors. The ability of AR to cross-talk with key growth factor signaling events toward the regulation of cell cycle, apoptosis, and differentiation outcomes in prostate cancer cells is established. In this paper, we review the functional interaction between AR and an array of growth factor signal transduction events (including epidermal growth factor; fibroblast growth factor; IGF1; vascular endothelial growth factor; transforming growth factor-beta) in prostate tumors. The significance of this derailed cross-talk between androgens and key signaling networks in prostate cancer progression and its value as a therapeutic forum targeting androgen-independent metastatic prostate cancer is discussed.

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Authors: Zhu, M.-L., & Kyprianou, N.
Affiliations: University of Kentucky HealthCare (US)
ORCID: Zhu, M.-L.
Kyprianou, N.
Venue: Endocrine Related Cancer
Publisher: Bioscientifica
Published: 2008-09-10
Volume: 15
Issue: 4
Pages: 841-849
ISSN: 1351-0088 (ISSN-L)
1479-6821
DOI: 10.1677/erc-08-0084
PMC: PMC2740735
OpenAlex: W2167609397
Cited by: 286
References: 105
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 12 · 2021: 16 · 2020: 9 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 18 · 2015: 23 · 2014: 10 · 2013: 29 · 2012: 17
FWCI: 3.48
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrine Related Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-53525-08, R01DK053525)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, growth factor signaling, signaling crosstalk, prostate cancer, castration-resistant prostate cancer, metastatic prostate cancer, epidermal growth factor, fibroblast growth factor, insulin-like growth factor I, vascular endothelial growth factor, TGF-beta, cell cycle regulation, apoptosis, therapeutic target
MeSH terms: Animals, Humans, Male, Prostatic Neoplasms, Receptors, Androgen, Signal Transduction, Gene Expression Regulation, Neoplastic, Receptor Cross-Talk, Intercellular Signaling Peptides and Proteins

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Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

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