The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
Diabetes and cancer
Open accessAbstract
Diabetes and cancer are two heterogeneous, multifactorial, severe, and chronic diseases. Because of their frequency, reciprocal influences - even minor influences - may have a major impact. Epidemiological studies clearly indicate that the risk of several types of cancer (including pancreas, liver, breast, colorectal, urinary tract, and female reproductive organs) is increased in diabetic patients. Mortality is also moderately increased. Several confounding factors, having general or site-specific relevance, make it difficult to accurately assess cancer risk in diabetic patients. These factors include diabetes duration, varying levels of metabolic control, different drugs used for therapy, and the possible presence of chronic complications. Hyperinsulinemia most likely favors cancer in diabetic patients as insulin is a growth factor with pre-eminent metabolic but also mitogenic effects, and its action in malignant cells is favored by mechanisms acting at both the receptor and post-receptor level. Obesity, hyperglycemia, and increased oxidative stress may also contribute to increased cancer risk in diabetes. While anti-diabetic drugs have a minor influence on cancer risk (except perhaps the biguanide metformin that apparently reduces the risk), drugs used to treat cancer may either cause diabetes or worsen a pre-existing diabetes. In addition to the well-known diabetogenic effect of glucocorticoids and anti-androgens, an increasing number of targeted anti-cancer molecules may interfere with glucose metabolism acting at different levels on the signaling substrates shared by IGF-I and insulin receptors. In conclusion, diabetes and cancer have a complex relationship that requires more clinical attention and better-designed studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Diabetes is associated with reduced risk of prostate cancer.”
From Diabetes and Cancer (2010) · cites this paper as [6]
In the citing paper
“Diabetes (primarily type 2) is associated with increased risk for some cancers (liver, pancreas, endometrium, colon and rectum, breast, bladder).”
From Diabetes and Cancer (2010) · cites this paper as [6]
In the citing paper
“Epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer.”
From Diabetes and Cancer (2010) · cites this paper as [6]
In the citing paper
“For some other cancer sites there appears to be no association or the evidence is inconclusive.”
From Diabetes and Cancer (2010) · cites this paper as [6]
In the citing paper
“Other cancers (e.g., lung) do not appear to be associated with an increased risk in diabetes, and the evidence for others (e.g., kidney, non-Hodgkin lymphoma) is inconclusive.”
From Diabetes and Cancer (2010) · cites this paper as [6]
In the citing paper
“The relative risks imparted by diabetes are greatest (about twofold or higher) for cancers of the liver, pancreas, and endometrium, and lesser (about 1.2–1.5 fold) for cancers of the colon and rectum, breast, and bladder.”
From Diabetes and Cancer (2010) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,780
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(1911) · JAMA · doi:10.1001/jama.1911.04260070032017 · Cited by 3,355
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Metformin and reduced risk of cancer in diabetic patients
Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ · doi:10.1136/bmj.38415.708634.f7 · Cited by 2,388
Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010) · Diabetes Care · doi:10.2337/dc10-0666 · Cited by 2,366
The American Journal of Gastroenterology
(2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.80003397.x · Cited by 2,202
Insulin and insulin-like growth factor signalling in neoplasia
Pollak, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2536 · Cited by 2,059
Archives of Biochemistry and Biophysics
Carter, H. E., Bhattacharyya, P., Weidman, K. R., & Fraenkel, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1981.tb06727.x · Cited by 1,895
Flagged first, then by citations
Research works printed but not linked: 1
- Lindblad P Adami HO 2002 Kidney cancer. In Textbook of Cancer Epidemiology, pp 467–485 Eds HunterDAdamiHOTrichopoulosD. New York: Oxford University Press.
Cited by
Sorted by citations
Items 301–400 of 1,000
Tseng, C. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr334 · Cited by 42
DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment
Moreli, J. B., Santos, J. H., Rocha, C. R. R., Damasceno, D. C., Morceli, G., Rudge, M. V. C., Bevilacqua, E. M. A. F., & Calderon, I. D. M. P. (2014) · BioMed Research International · doi:10.1155/2014/676758 · Cited by 44
Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus
Westermeier, F., Sáez, T., Arroyo, P., Toledo, F., Gutiérrez, J., Sanhueza, C., Pardo, F., Leiva, A., & Sobrevía, L. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2729 · Cited by 42
Lin, H., Hsu, Y.-H., Kachingwe, B. H., Hsu, C., Uang, Y., & Wang, L.-H. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12151 · Cited by 40
Arboatti, A., Lambertucci, F., Sedlmeier, M. G., Pisani, G. B., Monti, J., Álvarez, M. D. L., Francés, D. E., Ronco, M. T., & Carnovale, C. E. (2018) · BioMed Research International · doi:10.1155/2018/9472939 · Cited by 42
Diabetes mellitus as a risk factor for retinal vein occlusion
Wang, Y., Wu, S., Wen, F., & Cao, Q. (2020) · Medicine · doi:10.1097/md.0000000000019319 · Cited by 42
“4% in 2030,([6]) is an increasingly severe epidemic health problem globally related with serious acute and chronic complications, resulting from the changing lifestyle and aging population.([7]) Components of metabolic syndrome as risk factors for RVO have been controversial with only some prior studies showing an ass…”
ResultChanging patterns of sexually transmitted infections in India.
Sharma, V., & Khandpur, S. (2004) · PubMed · Cited by 42
Sleep Disruption and Cancer: Chicken or the Egg?
Berisha, A., Shutkind, K., & Borniger, J. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856235 · Cited by 44
“Furthermore, liver, pancreatic, colorectal, and breast cancer all show an association with Type II diabetes mellitus (Vigneri et al., 2009; Suh and Kim, 2011).”
BackgroundCapasso, I., Esposito, E., Pentimalli, F., Montella, M., Crispo, A., Maurea, N., D’Aiuto, M., Fucito, A., Grimaldi, M., Cavalcanti, E., et al. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-14 · Cited by 43
W arburg effect regulated by amphiregulin in the development of colorectal cancer
Nam, S. O., Yotsumoto, F., Miyata, K., Fukagawa, S., Yamada, H., Kuroki, M., & Miyamoto, S. (2015) · Cancer Medicine · doi:10.1002/cam4.416 · Cited by 44
Intensive glucose control and risk of cancer in patients with type 2 diabetes
Stefansdottir, G., Zoungas, S., Chalmers, J. P., Kengne, A. P., Knol, M. J., Leufkens, H. G. M., Patel, A. A., Woodward, M., Grobbee, D. E., & Bruin, M. L. D. (2011) · Diabetologia · doi:10.1007/s00125-011-2104-x · Cited by 41
Effect of diabetes on endometrial cancer recurrence and survival
Zanders, M. M. J., Boll, D., van Steenbergen, L. N., van de Poll-Franse, L. V., & Haak, H. R. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.10.007 · Cited by 41
Chronic Diseases among Older Cancer Survivors
Deckx, L., van den Akker, M., Metsemakers, J. F. M., Knottnerus, J. A., Schellevis, F., & Buntinx, F. (2012) · Journal of Cancer Epidemiology · doi:10.1155/2012/206414 · Cited by 41
Yan, J.-B., Lai, C.-C., Jhu, J.-W., Gongol, B., Marin, T., Lin, S., Chiu, H.-Y., Yen, C., Wang, L.-Y., & Peng, I. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.06.010 · Cited by 44
Stott-Miller, M., Chen, C., & Schwartz, S. (2013) · Cancer Epidemiology · doi:10.1016/j.canep.2013.03.006 · Cited by 38
“On the other hand, diabetes was not found to be associated with lung cancer, and was inversely associated with prostate cancer [1].”
BackgroundHense, H., Kajüter, H., Wellmann, J., & Batzler, W. U. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-15 · Cited by 40
Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma
Saengboonmee, C., Seubwai, W., Wongkham, C., & Wongkham, S. (2015) · Cancer Epidemiology · doi:10.1016/j.canep.2015.04.002 · Cited by 43
“DM can increase the risk of cancer in many organs such as pancreas, liver, breast, thyroid, urinary bladder and endometrium (review in [5]).”
BackgroundInfluentialLynch, B. M., & Leitzmann, M. F. (2017) · Current Epidemiology Reports · doi:10.1007/s40471-017-0119-7 · Cited by 44
Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity
Kim, Y., Kim, J., Seo, Y. R., Park, J. H. Y., Choi, M., & Sung, M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400293 · Cited by 39
Hepatic glycogenosis: An underdiagnosed complication of diabetes mellitus?
Julián, M. T. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i2.321 · Cited by 39
Effect of Elevated Basal Insulin on Cancer Incidence and Mortality in Cancer Incident Patients
Dankner, R. S., Shanik, M. H., Keinan‐Boker, L., Cohen, C., & Chetrit, A. (2012) · Diabetes Care · doi:10.2337/dc11-1513 · Cited by 40
Different types of diabetes mellitus and risk of thyroid cancer: A meta-analysis of cohort studies
Dong, W., Zhang, D.-L., Wang, Z., Lv, C.-Z., Zhang, P., & Zhang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.971213 · Cited by 38
“The intracellular anti-oxidant capacity reduced by prolonged inflammatory responses may increase the risk of carcinogenesis of susceptible cells (49).”
BackgroundSciacca, L., Cassarino, M. F., Genua, M., Vigneri, P. G., Pennisi, M. G., Malandrino, P., Squatrito, S., PEZZINO, V., & Vigneri, R. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24635 · Cited by 38
“For instance, in diabetic patients, liver cancer is increased 2–3 times, breast cancer is increased 1.2– 1.5 times and prostate cancer incidence is reduced (Vigneri et al., 2009).”
BackgroundInfluentialGPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts
Marco, P. D., Romeo, E., Vivacqua, A., Malaguarnera, R., Abonante, S., Romeo, F., Pezzi, V., Belfiore, A., & Maggiolini, M. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0245 · Cited by 38
“Expression of INSR-A has been predominantly detected in fetal tissues and tumors as found in leiomyosarcoma cells (Vigneri et al. 2009, Morcavallo et al. 2011).”
BackgroundLin, H., Kachingwe, B. H., Lin, H., Cheng, H. W., Uang, Y., & Wang, L. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1334 · Cited by 39
Risks of Breast and Endometrial Cancer in Women with Diabetes: A Population-Based Cohort Study
Chen, H.-F., Liu, M.-D., Chen, P., Chen, L.-H., Chang, Y., Wen, P.-C., & Li, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067420 · Cited by 38
Retinoid X receptor ligands: a patent review (2007 – 2013)
Yamada, S., & Kakuta, H. (2014) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2014.880692 · Cited by 39
Adrenocortical tumors and insulin resistance: What is the first step?
Altieri, B., Tirabassi, G., Casa, S. D., Ronchi, C. L., Balercia, G., Orio, F., Pontecorvi, A., Colao, A., & Muscogiuri, G. (2015) · International Journal of Cancer · doi:10.1002/ijc.29950 · Cited by 39
Wei, M., Duan, P., Wang, Z., Ding, M., & Tu, P. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7420 · Cited by 37
Du, J., Feng, B., Dong, Y., Zhao, M., & Yang, X. (2020) · Nanoscale · doi:10.1039/d0nr00810a · Cited by 38
Cancer with Diabetes: Prevalence, Metabolic Control, and Survival in an Academic Oncology Practice
Karlin, N. J., Dueck, A. C., & Cook, C. B. (2012) · Endocrine Practice · doi:10.4158/ep12128.or · Cited by 37
Magliano, D. J., Davis, W. A., Shaw, J. E., Bruce, D. G., & Davis, T. M. E. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0053 · Cited by 38
Metformin with Everolimus and Octreotide in Pancreatic Neuroendocrine Tumor Patients with Diabetes
Pusceddu, S., Buzzoni, R., Vernieri, C., Concas, L., Marceglia, S. R. F., Giacomelli, L., Milione, M., Leuzzi, L., Femia, D., Formisano, B., et al. (2016) · Future Oncology · doi:10.2217/fon-2015-0077 · Cited by 38
Insulin priming effect on estradiol-induced breast cancer metabolism and growth
Wairagu, P. M., Phan, A. N. H., Kim, M., Han, J., Kim, H.-W., Choi, J.-W., Kim, K. W., Cha, S., Park, K. H., & Jeong, Y. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016660 · Cited by 40
Report of the JDS/JCA Joint Committee on Diabetes and Cancer
Kasuga, M., Ueki, K., Tajima, N., Noda, M., Ohashi, K., Noto, H., Goto, A., Ogawa, W., Sakai, R., Tsugane, S., et al. (2013) · Diabetology International · doi:10.1007/s13340-013-0121-3 · Cited by 37
Type 2 Diabetes: A Protective Factor for Prostate Cancer? An Overview of Proposed Mechanisms
Rastmanesh, R., Hejazi, J., Marotta, F., & Hara, N. (2014) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2014.01.001 · Cited by 38
Diabetes treatments and cancer risk: the importance of considering aspects of drug exposure
Walker, J. J., Johnson, J. A., & Wild, S. H. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70028-7 · Cited by 37
Xiao, Z., Gaertner, S., Morresi‐Hauf, A., Genzel, R., Duell, T., Ullrich, A., & Knyazev, P. G. (2017) · Neoplasia · doi:10.1016/j.neo.2017.02.011 · Cited by 37
RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice
Nakamara, N., Matsui, T., Ishibashi, Y., Sotokawauchi, A., Fukami, K., Higashimoto, Y., & Yamagishi, S. (2017) · Molecular Medicine · doi:10.2119/molmed.2017.00099 · Cited by 37
Yarahmadi, A., Khademi, F., Mostafavi‐Pour, Z., & Zal, F. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1470654 · Cited by 37
Abudawood, M., Tabassum, H., Almaarik, B. M., & Aljohi, A. O. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.06.015 · Cited by 37
Evaluation of novel coumarin-proline sulfonamide hybrids as anticancer and antidiabetic agents
Durgapal, S. D., & Soman, S. S. (2019) · Synthetic Communications · doi:10.1080/00397911.2019.1647439 · Cited by 37
Metformin suppresses breast cancer growth via inhibition of cyclooxygenase‑2
Shi, B., Hu, X., He, H., & Fang, W. (2021) · Oncology Letters · doi:10.3892/ol.2021.12876 · Cited by 40
Diabetes therapy and cancer risk
Vigneri, R. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.219 · Cited by 37
Occurrence of comorbidities among African-American and Latina breast cancer survivors
Ashing, K. T., Rosales, M., Lai, L. L., & Hurria, A. (2014) · Journal of Cancer Survivorship · doi:10.1007/s11764-014-0342-x · Cited by 37
Associations between Diabetes and Quality of Life among Breast Cancer Survivors
Tang, Z., Wang, J., Zhang, H., Sun, L., Tang, F., Deng, Q., & Yu, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157791 · Cited by 37
Diabetes and cancer: Findings from the REACTION study 糖尿病与恶性肿瘤：来自REACTION研究的发现
Ning, G., & Bloomgarden, Z. T. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12240 · Cited by 37
Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products
Talib, W. H., Mahmod, A. I., Abuarab, S. F., Hasen, E., Munaim, A. A., Haif, S. K., Ayyash, A. M., Khater, S. H., Al-Yasari, I. H., & Kury, L. T. A. (2021) · Molecules · doi:10.3390/molecules26082179 · Cited by 38
Hirsh, V., Ko, A., Pilot, R., Renschler, M. F., & Socinski, M. A. (2016) · Clinical Lung Cancer · doi:10.1016/j.cllc.2016.04.002 · Cited by 36
Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes
Broedbaek, K., Siersma, V., Henriksen, T., Weimann, A., Petersen, M. A., Andersen, J. T., Jimenez‐Solem, E., Hansen, L. J., Henriksen, J. E., Bonnema, S. J., et al. (2014) · Redox Biology · doi:10.1016/j.redox.2014.11.010 · Cited by 36
Vernieri, C., Galli, F., Ferrari, L., Marchetti, P., Lonardi, S., Maiello, E., Iaffaioli, R. V., Zampino, M. G., Zaniboni, A., Placido, S. D., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0442 · Cited by 36
“In observational studies, hyperglycemia and diabetes have been associated with increased colorectal cancer incidence and mortality [1, 2].”
BackgroundPeng, Y., Lin, J., Cheng, B., Ho, C., Lin, Y., Shen, C.-H., & Tsai, M.-H. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-024583 · Cited by 37
Durrani, I. A., Bhatti, A., & John, P. C. L. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02040-5 · Cited by 46
Aberrant DNA Damage Response and DNA Repair Pathway in High Glucose Conditions
Zhong, A. X., Chang, M. I., Yu, T., Gau, R., Riley, D. J., Chen, Y., & Chen, P. (2018) · Journal of cancer research updates · doi:10.6000/1929-2279.2018.07.03.1 · Cited by 36
Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
Chartoumpekis, D. V., Yagishita, Y., Fazzari, M., Palliyaguru, D. L., Rao, U. N. M., Zaravinos, A., Khoo, N. K. H., Schopfer, F. J., Weiss, K. R., Michalopoulos, G. K., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97735 · Cited by 36
Human Pathway-Based Disease Network
Yu, L., & Gao, L. (2017) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2017.2774802 · Cited by 35
Crujeiras, A. B., Fernández, B. C., Carreira, M. C., Amil, M., Cueva, J. F., Andrade, S., Seoane, L. M., Pardo, M., Sueiro, A. M., Baltar, J., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.208 · Cited by 35
Du, R., Lin, L., Cheng, D., Xu, Y. H., Xu, M., Chen, Y., Wang, W., Bi, Y., Li, D., & Lu, J. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2961 · Cited by 35
Long-acting insulin analogs and cancer
Sciacca, L., Vella, V., Frittitta, L., Tumminia, A., Manzella, L., Squatrito, S., Belfiore, A., & Vigneri, R. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.02.010 · Cited by 35
Diabetes and Clinical Outcome in Patients With Metastatic Colorectal Cancer: CALGB 80405 (Alliance)
Brown, J. C., Zhang, S., Ou, F., Venook, A. P., Niedzwiecki, D., Lenz, H., Innocenti, F., O’Neil, B. H., Shaw, J. E., Polite, B. N., et al. (2019) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkz078 · Cited by 35
“The physiologic mechanisms that link diabetes with cancer outcomes may include hyperinsulinemia (including insulin-like growth factors and their binding proteins), hyperglycemia, and inflammation (32).”
BackgroundUse of metformin and aspirin is associated with delayed cancer incidence
Sung, J. J. �., Ho, M.-W., Lam, A. S. M., Yau, S. T., & Tsoi, K. K. F. (2020) · Cancer Epidemiology · doi:10.1016/j.canep.2020.101808 · Cited by 34
Jin, H., Lee, S., & Won, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.597420 · Cited by 35
“dyslipidemia, a relationship between the diseases has not been fully demonstrated (Vigneri et al., 2009).”
BackgroundSex differences in cancer risk and outcomes after kidney transplantation
Buxeda, A., Redondo‐Pachón, D., Pérez‐Sáez, M. J., Crespo, M., & Pascual, J. (2021) · Transplantation Reviews · doi:10.1016/j.trre.2021.100625 · Cited by 36
Life-style and metformin for the prevention of endometrial pathology in postmenopausal women
Campagnoli, C., Abbà, C., Ambroggio, S., Brucato, T., & Pasanisi, P. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.706671 · Cited by 35
Vilchez, J. A., Martínez‐Ruiz, A., Sancho‐Rodríguez, N., Martínez‐Hernández, P., & Velasco, J. A. N. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12185 · Cited by 35
Kang, Y.-L., Kim, J., Kwak, S.-B., KIM, Y., Huh, J., & Park, J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01153-3 · Cited by 34
Davidson, J. A. (2013) · Endocrine Practice · doi:10.4158/ep12303.ra · Cited by 34
Mayer, D., & Chantelau, E. A. (2010) · Archives of Physiology and Biochemistry · doi:10.3109/13813451003631439 · Cited by 34
Insulin, carbohydrate restriction, metabolic syndrome and cancer
Fine, E. J., & Feinman, R. D. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.960392 · Cited by 34
Habel, L. A., Danforth, K. N., Quesenberry, C. P., Capra, A. M., Eeden, S. K. V. D., Weiss, N. S., & Ferrara, A. M. (2013) · Diabetes Care · doi:10.2337/dc13-0140 · Cited by 34
Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment,
Chevalier, S., & Farsijani, S. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0369 · Cited by 36
“Diabetes may influence the neoplastic progress through several mechanisms, including endogenous and medication-stimulated hyperinsulinemia via direct growth effect of insulin on cancer cells, hyperglycemia, and (or) chronic inflammation (Bowker et al. 2006; Coughlin et al. 2004; Monami et al. 2007; Vigneri et al. 2009…”
BackgroundAssociation Between Insulin Resistance and Luminal B Subtype Breast Cancer in Postmenopausal Women
Nam, S., Park, S., Park, H. S., Kim, S., Kim, J. Y., & Kim, S. I. (2016) · Medicine · doi:10.1097/md.0000000000002825 · Cited by 34
Rathmann, W., & Kostev, K. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.01.012 · Cited by 36
Toi, M., Ohashi, Y., Seow, A., Moriya, T., Tse, G. M.-K., Sasano, H., Park, B., Chow, L. W., Laudico, A. V., Yip, C. H., et al. (2010) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyq122 · Cited by 35
Dool, C. J., Mashhedi, H., Zakikhani, M., David, S., Zhao, Y., Birman, E., Carboni, J. M., Gottardis, M. M., Blouin, M., & Pollak, M. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0136 · Cited by 33
Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling
Gill, B. S., Sharma, P., Kumar, R., & Kumar, S. (2015) · Tumor Biology · doi:10.1007/s13277-015-4709-z · Cited by 33
Hyperglycemic memory in metabolism and cancer
Lee, C., An, D., & Park, J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0022 · Cited by 33
Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics
Chen, C., Notkins, A. L., & Lan, M. S. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0286 · Cited by 36
Wynn, A., Vacheron, A. B., Zuber, J. K., & Solomon, S. S. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.06.002 · Cited by 33
Dabo, B., Pelucchi, C., Rota, M., Jain, H., Bertuccio, P., Bonzi, R., Palli, D., Ferraroni, M., Zhang, Z., Sanchez-Anguiano, A., et al. (2021) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000703 · Cited by 33
Does use of metformin protect against cancer in Type 2 diabetes mellitus?
Bo, S., Benso, A. S., Durazzo, M., & Ghigo, E. (2012) · Journal of Endocrinological Investigation · doi:10.1007/bf03345423 · Cited by 33
Shi, S., He, Y., Koya, D., & Kanasaki, K. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12208 · Cited by 33
Wennberg, P., Rolandsson, O., van der A, D. L., Spijkerman, A. M. W., Kaaks, R., Boeing, H., Feller, S., Bergmann, M. M., Langenberg, C., Sharp, S. J., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002436 · Cited by 34
GDF-15 Is Associated with Cancer Incidence in Patients with Type 2 Diabetes
Pávó, N., Wurm, R., Neuhold, S., Adlbrecht, C., Vila, G., Strunk, G., Clodi, M., Resl, M., Brath, H., Prager, R., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.257212 · Cited by 33
Naeimzadeh, Y., Tajbakhsh, A., Nemati, M., & Fallahi, J. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176803 · Cited by 32
Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia
Paragomi, P., Zhang, Z., Abe, S. K., Islam, M. R., Rahman, M. S., Saito, E., Shu, X., Dabo, B., Pham, Y. T., Chen, Y., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.29494 · Cited by 32
Kok, V. C., Chen, Y., Chien, C.-H., Horng, J., & Tsai, J. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s91513 · Cited by 32
Safety of antidiabetes medications: An update
Bailey, C. J. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.125 · Cited by 33
Kenzik, K. M., Kent, E. E., Martin, M. Y., Bhatia, S., & Pisu, M. (2016) · Journal of Cancer Survivorship · doi:10.1007/s11764-016-0553-4 · Cited by 33
Gallo, M., Adinolfi, V., Morviducci, L., Acquati, S., Tuveri, E., Ferrari, P., Zatelli, M. C., Faggiano, A., Argentiero, A., Natalicchio, A., et al. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100155 · Cited by 33
“Indeed, T2DM has been associated with an increased risk for several human cancers, such as liver, colorectal, endometrial, bladder, breast, and PC.(8,17) Medications used in the treatment of T2DM may independently modify the risk of PC, even if evidence is poor.”
BackgroundPrediabetes, Diabetes, and Risk of Breast Cancer: A Case-Control Study
Salinas-Martı́nez, A. M., Flores-Cortés, L. I., Cardona-Chavarría, J. M., Hernández-Gutiérrez, B., Abundis, A. R., Vázquez-Lara, J., & González-Guajardo, E. E. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.06.004 · Cited by 32
The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis
Malaguarnera, R., Morcavallo, A., & Belfiore, A. (2012) · Journal of Oncology · doi:10.1155/2012/635614 · Cited by 33
Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma
Dugnani, E., Balzano, G., Pasquale, V., Scavini, M., Aleotti, F., Liberati, D., Terlizzi, G. D., Gandolfi, A., Petrella, G., Reni, M., et al. (2016) · Acta Diabetologica · doi:10.1007/s00592-016-0893-6 · Cited by 32
Dixon, J. L., Copeland, L. A., Zeber, J. E., MacCarthy, A. A., Reznik, S. I., Smythe, W. R., & Rascoe, P. A. (2015) · Diseases of the Esophagus · doi:10.1111/dote.12402 · Cited by 31
Cure of Type 2 Diabetes by Metabolic Surgery? A Critical Analysis of the Evidence in 2010
Schernthaner, G., Brix, J. M., Kopp, H.-P., & Schernthaner, G.-H. (2011) · Diabetes Care · doi:10.2337/dc11-s253 · Cited by 30
Biondo, L. A., Teixeira, A. A. S., Ferreira, K. C. D. O. S., & Neto, J. C. R. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200122124116 · Cited by 31
Impact of diabetes on colorectal cancer stage and mortality risk: a population-based cohort study
Qiang, J. K., Sutradhar, R., Giannakeas, V., Bhatia, D., Singh, S., & Lipscombe, L. L. (2020) · Diabetologia · doi:10.1007/s00125-020-05094-8 · Cited by 31
Prediction of Heart Diseases and Cancer in Diabetic Patients Using Data Mining Techniques
Kalaiselvi, C., & Nasira, G. M. (2015) · Indian Journal of Science and Technology · doi:10.17485/ijst/2015/v8i14/72688 · Cited by 31
Functional Alterations of Intestinal P-Glycoprotein under Diabetic Conditions
Kobori, T., Harada, S., Nakamoto, K., & Tokuyama, S. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00369 · Cited by 32
Type of Diabetes Mellitus and the Odds of Gleason Score 8 to 10 Prostate Cancer
Kang, J., Chen, M., Zhang, Y., Moran, B. J., Dosoretz, D. E., Katin, M. J., Braccioforte, M. H., Salenius, S. A., & D'Amico, A. V. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.07.003 · Cited by 31
Metadata
- Authors
- Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R.
- Affiliations
- Section of General Pathology 1
- University of Catania (IT)
- Corresponding author
- Vigneri, Paolo
- Venue
- Endocrine Related Cancer
- Publisher
- Bioscientifica
- Published
- 2009-12-01
- Volume
- 16
- Issue
- 4
- Pages
- 1103-1123
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2163691729
- Cited by
- 1,009
- References
- 183
- Citations by year
- 2026: 20 · 2025: 43 · 2024: 54 · 2023: 49 · 2022: 49 · 2021: 46 · 2020: 50 · 2019: 57 · 2018: 60 · 2017: 75 · 2016: 59 · 2015: 68 · 2014: 85 · 2013: 97 · 2012: 80
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Related Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- diabetes mellitus, cancer risk, hyperinsulinemia, insulin-like growth factor I, insulin receptor, metformin, antidiabetic drugs, glucocorticoids, androgen receptor antagonists, obesity, hyperglycemia, oxidative stress, pancreatic cancer, liver cancer, breast cancer, colorectal cancer, cancer mortality, confounding factors
- MeSH terms
- Humans, Neoplasms, Risk Factors, Survival Rate, Diabetes Complications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
