The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
p53 and breast cancer, an update
Open accessAbstract
p53 plays a key role in mediating cell response to various stresses, mainly by inducing or repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA repair, and angiogenesis. According to this important function, p53 activity is controlled in a very complex manner, including several auto-regulatory loops, through the intervention of dozens of modulator proteins (the ‘p53 interactome’). p53 mutations are observed in a significant minority of breast tumours. In the remaining cases, alterations of interactome components or target genes could contribute, to some extent, to reduce the ability of p53 to efficiently manage stress events. While the prognostic and predictive value of p53 is still debated, there is an increasing interest for p53-based therapies. The present paper aims to provide updated information on p53 regulation and function, with specific interest on its role in breast cancer.
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
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p53 isoforms can regulate p53 transcriptional activity
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Cited by
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Metadata
- Authors
- Lacroix, M., Toillon, R.-A., & Leclercq, G.
- Venue
- Endocrine-Related Cancer
- Publisher
- Bioscientifica
- Published
- 2006-06
- Volume
- 13
- Issue
- 2
- Pages
- 293-325
- ISSN
- 1351-0088 (ISSN-L)
- 1479-6821
- OpenAlex
- W2106888057
- Cited by
- 380
- References
- 17
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lacroix, M., Toillon, R.-A., & Leclercq, G. (2006). p53 and breast cancer, an update. Endocrine-Related Cancer. https://doi.org/10.1677/erc.1.01172
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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