Apoptosis - the p53 network

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

Death Receptors: Signaling and Modulation

Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,303 · see citing works

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445 · see citing works

The Bcl2 family: regulators of the cellular life-or-death switch

Cory, S., & Adams, J. M. (2002) · Nature Reviews Cancer · doi:10.1038/nrc883 · Cited by 4,032 · see citing works

The Fas Death Factor

Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979 · see citing works

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., & Tanaka, †. N. (2000) · Science · doi:10.1126/science.288.5468.1053 · Cited by 2,112 · see citing works

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

p53 Has a Direct Apoptogenic Role at the Mitochondria

Mihara, M., Erster, S. H., Zaika, A. I., Petrenko, O., Chittenden, T. D., Pančoška, P., & Moll, U. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00050-9 · Cited by 1,771 · see citing works

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

Kuwana, T., Mackey, M. R., Perkins, G. A., Ellisman, M. H., Latterich, M., Schneiter, R., Green, D. R., & Newmeyer, D. D. (2002) · Cell · doi:10.1016/s0092-8674(02)01036-x · Cited by 1,480 · see citing works

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

Varfolomeev, E., Schuchmann, M., Luria, V., Chiannilkulchai, N., Beckmann, J., Mett, I., Rebrikov, D., Brodianski, V. M., Kemper, O., Kollet, O., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80609-3 · Cited by 1,332 · see citing works

The complexity of p53 modulation: emerging patterns from divergent signalsPreprint

Giaccia, A. J., & Kastan, M. B. (1998) · Genes & Development · doi:10.1101/gad.12.19.2973 · Cited by 1,303 · see citing works

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W., & Vogelstein, B. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00213-1 · Cited by 1,282 · see citing works

KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene

Wu, G. S., Burns, T. F., McDonald, E. R., Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D.-D., Zhou, J.-Y., Muschel, R. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-141 · Cited by 1,081 · see citing works

PKB/Akt

Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,071 · see citing works

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Bykov, V. J. N., Issaeva, N., Shilov, A., Hultcrantz, M., Pugacheva, E., Chumakov, P., Bergman, J., Wiman, K. G., & Selivanova, G. (2002) · Nature Medicine · doi:10.1038/nm0302-282 · Cited by 1,067 · see citing works

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

Gross, A., Yin, X.-M., Wang, K., Wei, M. C., Jockel, J., Milliman, C., Erdjument-Bromage, H., Tempst, P., & Korsmeyer, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1156 · Cited by 1,045 · see citing works

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

Huang, D. C. S., & Strasser, A. (2000) · Cell · doi:10.1016/s0092-8674(00)00187-2 · Cited by 1,044 · see citing works

AKT plays a central role in tumorigenesis

Testa, J. R., & Bellacosa, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211430998 · Cited by 944 · see citing works

Death Signal-induced Localization of p53 Protein to Mitochondria

Marchenko, N. D., Zaika, A. I., & Moll, U. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16202 · Cited by 902 · see citing works

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

Müller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Friedman, S. L., Galle, P. R., Stremmel, W., Oren, M., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.11.2033 · Cited by 878 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

Caelles, C., Helmberg, A., & Karin, M. (1994) · Nature · doi:10.1038/370220a0 · Cited by 843 · see citing works

Pharmacological Rescue of Mutant p53 Conformation and Function

Foster, B. A., Coffey, H. A., Morin, M. J., & Rastinejad, F. (1999) · Science · doi:10.1126/science.286.5449.2507 · Cited by 802 · see citing works

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 801 · see citing works

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

Bennett, M. R., Macdonald, K., Chan, S., Luzio, J. P., Simari, R. D., & Weissberg, P. L. (1998) · Science · doi:10.1126/science.282.5387.290 · Cited by 755 · see citing works

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

Seoane, J., Le, H.-V., & Massagué, J. (2002) · Nature · doi:10.1038/nature01119 · Cited by 683 · see citing works

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

Strasser, A. (1994) · Cell · doi:10.1016/0092-8674(94)90201-1 · Cited by 665 · see citing works

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664 · see citing works

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

Soengas, M. S., Alarcon, R. M., Yoshida, H., J., A., Giaccia, Hakem, R., Mak, T. W., & Lowe, S. W. (1999) · Science · doi:10.1126/science.284.5411.156 · Cited by 660 · see citing works

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

Kelekar, A., & Thompson, C. B. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01321-x · Cited by 654 · see citing works

The cellular response to p53: the decision between life and death

Sionov, R. V., & Haupt, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1203130 · Cited by 600 · see citing works

Apaf-1 is a transcriptional target for E2F and p53

Moroni, M. C., Hickman, E. S., Denchi, E. L., Caprara, G., Colli, E., Cecconi, F., Müller, H., & Helin, K. (2001) · Nature Cell Biology · doi:10.1038/35078527 · Cited by 593 · see citing works

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) · Nature · doi:10.1038/nature01101 · Cited by 578 · see citing works

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., & Zhang, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2627984100 · Cited by 565 · see citing works

Rescuing the function of mutant p53

Bullock, A. N., & Fersht, A. R. (2001) · Nature reviews. Cancer · doi:10.1038/35094077 · Cited by 565 · see citing works

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.Preprint

Haupt, Y., Rowan, S., Shaulian, E., Vousden, K. H., & Oren, M. (1995) · Genes & Development · doi:10.1101/gad.9.17.2170 · Cited by 547 · see citing works

Cytochrome c in the apoptotic and antioxidant cascades

Skulachev, V. P. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00061-1 · Cited by 504 · see citing works

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

Gottlieb, T. M., Martínez-Leal, J. F., Seger, R., Taya, Y., & Oren, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205181 · Cited by 473 · see citing works

BID regulation by p53 contributes to chemosensitivity

Sax, J. K., Fei, P., Murphy, M. E., Bernhard, E., Korsmeyer, S. J., & El-Deiry, W. S. (2002) · Nature Cell Biology · doi:10.1038/ncb866 · Cited by 420 · see citing works

The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network

Mayo, L. D., & Donner, D. B. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02166-7 · Cited by 408 · see citing works

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint

Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.14.6.704 · Cited by 394 · see citing works

BH3-only proteins — evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death

Bouillet, P., & Strasser, A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1567 · Cited by 379 · see citing works

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

McCurrach, M. E., Connor, T. M. F., Knudson, C. M., Korsmeyer, S. J., & Lowe, S. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2345 · Cited by 368 · see citing works

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

Kaeser, M., & Iggo, R. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012283399 · Cited by 346 · see citing works

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

Selivanova, G., Iotsova, V., Okan, İ., Fritsche, M., Ström, M., Groner, B., Grafström, R. C., & Wiman, K. G. (1997) · Nature Medicine · doi:10.1038/nm0697-632 · Cited by 343 · see citing works

The p53 functional circuit

Jin, S. V., & Levine, A. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4139 · Cited by 310 · see citing works

Activation and activities of the p53 tumour suppressor protein

Bálint, É., & Vousden, K. H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2128 · Cited by 310 · see citing works

Apoptosomes: engines for caspase activation

Adams, J. M., & Cory, S. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00381-2 · Cited by 305 · see citing works

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

Herold, S., Wanzel, M., Beuger, V., Frohme, C., Beul, D., Hillukkala, T., Syväoja, J. E., Saluz, H., Haenel, F., & Eilers, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00633-0 · Cited by 305 · see citing works

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

Seo, Y. R., Kelley, M. R., & Smith, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212319799 · Cited by 280 · see citing works

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer's Disease

LeBlanc, A. C., Liu, H., Goodyer, C. G., Bergeron, C., & Hammond, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23426 · Cited by 279 · see citing works

A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A., Dittmer, A., Koch, M. C., Roth, J., & Dobbelstein, M. (2002) · Nature Genetics · doi:10.1038/ng836 · Cited by 274 · see citing works

A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants

Friedler, A., Hansson, L. O., Veprintsev, D. B., Freund, S. M. V., Rippin, T. M., Nikolova, P. V., Proctor, M. R., Rüdiger, S., & Fersht, A. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241629998 · Cited by 268 · see citing works

Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice

Bouvard, V., Zaitchouk, T., Vacher, M., Duthu, A., Canivet, M., Choisy, C., Nieruchalski, M., & May, E. (2000) · Oncogene · doi:10.1038/sj.onc.1203366 · Cited by 219 · see citing works

Life and Death Decisions

Nicholson, D. W., & Thornberry, N. A. (2003) · Science · doi:10.1126/science.1081274 · Cited by 203 · see citing works

APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

Robles, A. I., Bemmels, N. A., Foraker, A. B., & Harris, C. C. (2001) · PubMed · Cited by 190 · see citing works

Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, T. K., & El‐Deiry, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132241599 · Cited by 162 · see citing works

DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1

Kannan, K., Kaminski, N., Rechavi, G., Jacob‐Hirsch, J., Amariglio, N., & Givol, D. (2001) · Oncogene · doi:10.1038/sj.onc.1204446 · Cited by 156 · see citing works

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

Chong, M. J., Murray, M. R., Gosink, E. C., Russell, H. R. C., Srinivasan, A. N., Kapsetaki, M., Korsmeyer, S. J., & McKinnon, P. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.889 · Cited by 148 · see citing works

PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression

Yin, Y., Liu, Y., Jin, Y. J., Hall, E. J., & Barrett, J. C. (2003) · Nature · doi:10.1038/nature01519 · Cited by 145 · see citing works

Stabilization of p53 by CP-31398 Inhibits Ubiquitination without Altering Phosphorylation at Serine 15 or 20 or MDM2 Binding

Wang, W., Takimoto, R., Rastinejad, F., & El‐Deiry, W. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.2171-2181.2003 · Cited by 144 · see citing works

Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

Selivanova, G., Ryabchenko, L. G., Jansson, E. Å., Iotsova, V., & Wiman, K. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3395 · Cited by 139 · see citing works

c-Abl: activation and nuclear targets

Shaul, Y. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400626 · Cited by 138 · see citing works

Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo

Burns, T. F., Bernhard, E. J., & El‐Deiry, W. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204484 · Cited by 133 · see citing works

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta.

Fuchs, E. J., Mckenna, K. A., & Bedi, A. (1997) · PubMed · Cited by 132 · see citing works

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

Thornborrow, E. C., Patel, S., Mastropietro, A. E., Schwartzfarb, E. M., & Manfredi, J. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205069 · Cited by 132 · see citing works

The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis

Takimoto, R., Wang, W., Dicker, D. T., Rastinejad, F., Lyssikatos, J. P., & El‐Deiry, W. S. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.1.41 · Cited by 128 · see citing works

SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis

Galande, S., Dickinson, L. A., Mian, S. I., Sikorska, M., & Kohwi-shigematsu, T. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5591-5604.2001 · Cited by 123 · see citing works

Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Buzek, J. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2340 · Cited by 117 · see citing works

Conformational and Molecular Basis for Induction of Apoptosis by a p53 C-terminal Peptide in Human Cancer Cells

Kim, A. L., Raffo, A. J., Brandt‐Rauf, P. W., Pincus, M. R., Monaco, R. R., Abarzúa, P., & Fine, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34924 · Cited by 114 · see citing works

Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo

Pritchard, D. M., Potten, C. S., Korsmeyer, S. J., Roberts, S. A., & Hickman, J. A. (1999) · Oncogene · doi:10.1038/sj.onc.1203150 · Cited by 102 · see citing works

Oncogene-dependent Regulation of Caspase Activation by p53 Protein in a Cell-free System

Ding, H., McGill, G. G., Rowan, S., Schmaltz, C., Shimamura, A., & Fisher, D. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28378 · Cited by 91 · see citing works

Regulation and activation of p53 and its family members

Lohrum, M. A. E., & Vousden, K. H. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400625 · Cited by 90 · see citing works

Signalling by proteolysis: death receptors induce apoptosis

Muzio, M. (1998) · International Journal of Clinical & Laboratory Research · doi:10.1007/s005990050035 · Cited by 80 · see citing works

Overexpression of c-Myc Alters G 1 /S Arrest following Ionizing Radiation

Sheen, J.-H., & Dickson, R. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1819-1833.2002 · Cited by 76 · see citing works

The p53 Stabilizing Compound CP-31398 Induces Apoptosis by Activating the Intrinsic Bax/Mitochondrial/Caspase-9 Pathway

Luu, Y., Bush, J., Cheung, K. J., & Li, G. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5526 · Cited by 74 · see citing works

A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72 · see citing works

A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis

Nelson, V., Davis, G. E., & Maxwell, S. A. (2001) · APOPTOSIS · doi:10.1023/a:1011392811628 · Cited by 69 · see citing works

Restoration of the transcription activation function to mutant p53 in human cancer cells.

Abarzúa, P., LoSardo, J. E., Gubler, M. L., Spathis, R., Lu, Y., Felix, A. L., & Neri, A. (1996) · PubMed · Cited by 65 · see citing works

CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types.

O’Connor, L., Harris, A. W., & Strasser, A. (2000) · PubMed · Cited by 62 · see citing works

Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer

Wen, S. F., Mahavni, V., Quijano, E., Shinoda, J., Grace, M. J., Musco, M. L., Yang, T., Chen, Y., Runnenbaum, I., Horowitz, J. A., et al. (2003) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700562 · Cited by 45 · see citing works

Converting p53 from a killer into a healer

Gudkov, A. V. (2002) · Nature Medicine · doi:10.1038/nm1102-1196 · Cited by 42 · see citing works

p53 leans on its siblings

Urist, M. J., & Prives, C. L. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00064-8 · Cited by 38 · see citing works

Selectively replicating adenoviruses for cancer therapy: an update on clinical development.

Post, L. E. (2002) · PubMed · Cited by 22 · see citing works

A Fly with an Ointment: Bcl-2 as an Anti-Mutator in Humans

Gottlieb, E. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.1.40 · Cited by 20 · see citing works

Chemotherapeutic Targeting of p53

Smith, M. L., & Fornace, A. J. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.1.42 · Cited by 5 · see citing works

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Ayala, A., Muñoz, M., & Argüelles, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/360438 · Cited by 6,557 · see citing works

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Pistritto, G., Trisciuoglio, D., Ceci, C., Garufi, A., & D’Orazi, G. (2016) · Aging · doi:10.18632/aging.100934 · Cited by 1,670 · see citing works

Physiology of cell volume regulation in vertebrates

Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

Poeta, M. L., Manola, J. B., Goldwasser, M. A., Forastiere, A. A., Benoit, N. E., Califano, J. A., Ridge, J. A., Goodwin, J. W., Kenady, D. E., Saunders, J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073770 · Cited by 818 · see citing works

Major apoptotic mechanisms and genes involved in apoptosis

Kiraz, Y., Adan, A., Yandım, M. K., & Baran, Y. (2016) · Tumor Biology · doi:10.1007/s13277-016-5035-9 · Cited by 585 · see citing works

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

Xu, J., Reumers, J., Couceiro, J. R., De Smet, F., Gallardo, R., Rudyak, S., Cornelis, A., Rozenski, J., Zwolinska, A., Marine, J.-C., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.546 · Cited by 543 · see citing works

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

Brown, D., & Griendling, K. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303584 · Cited by 498 · see citing works

Resveratrol as an anticancer nutrient: molecular basis, open questions and promises

Signorelli, P., & Ghidoni, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.01.017 · Cited by 493 · see citing works

Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

Athar, M., Back, J. H., Kopelovich, L., Bickers, D. R., & Kim, A. L. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.01.018 · Cited by 462 · see citing works

p53: 25 years after its discovery

Hofseth, L. J., Hussain, S. P., & Harris, C. C. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.009 · Cited by 431 · see citing works

Mechanisms of drug resistance in colon cancer and its therapeutic strategies

Hu, T., Li, Z., Gao, C.-Y., & Cho, C. H. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i30.6876 · Cited by 381 · see citing works

p53 and breast cancer, an update

Lacroix, M., Toillon, R., & Leclercq, G. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01172 · Cited by 380 · see citing works

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer

Sugiura, R., Satoh, R., & Takasaki, T. (2021) · Cells · doi:10.3390/cells10102509 · Cited by 376 · see citing works

Life or death: Neuroprotective and anticancer effects of quercetin

Dajas, F. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.07.005 · Cited by 379 · see citing works

The First Approved Gene Therapy Product for Cancer Ad- p53 (Gendicine): 12 Years in the Clinic

Zhang, W., Li, L., Li, D., Liu, J., Li, X., Li, W., Xu, X., Zhang, M. J., Chandler, L. A., Lin, H., et al. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.218 · Cited by 320 · see citing works

Clinical Overview of MDM2/X-Targeted Therapies

Burgess, A., Chia, K. M., Haupt, S., Thomas, D., Haupt, Y., & Lim, E. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00007 · Cited by 315 · see citing works

p53 at the endoplasmic reticulum regulates apoptosis in a Ca 2+ -dependent manner

Giorgi, C., Bonora, M., Sorrentino, G., Missiroli, S., Poletti, F., Suski, J. M., Ramírez, F. G., Rizzuto, R., Virgilio, F. D., Zito, E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410723112 · Cited by 306 · see citing works

Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells

Urbańska, K., & Orzechowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092085 · Cited by 288 · see citing works

Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells

Chien, S. Y., Wu, Y., Chung, J., Yang, J., Lu, H.-F., Tsou, M., Wood, W., Kuo, S., & Chen, D. (2009) · Human & Experimental Toxicology · doi:10.1177/0960327109107002 · Cited by 269 · see citing works

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

Livesey, K. M., Kang, R., Vernon, P. J., Buchser, W., Loughran, P., Watkins, S. C., Zhang, L., Manfredi, J. J., Zeh, H. J., Li, L., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2291 · Cited by 261 · see citing works

MicroRNA regulation of core apoptosis pathways in cancer

Lima, R. T., Busacca, S., Almeida, G. M., Gaudino, G., Fennell, D. A., & Vasconcelos, M. H. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.005 · Cited by 260 · see citing works

Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation

Chen, T., & Wong, Y. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.014 · Cited by 231 · see citing works

Apoptosis: why and how does it occur in biology?

Ulukaya, E., Açılan, C., & Yilmaz, Y. N. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1774 · Cited by 229 · see citing works

Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging

Kaczanowski, S. (2016) · Physical Biology · doi:10.1088/1478-3975/13/3/031001 · Cited by 227 · see citing works

Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice

Liu, J., Thewke, D. P., Su, Y. R., Linton, M. F., Fazio, S., & Sinensky, M. S. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000148548.47755.22 · Cited by 225 · see citing works

PI3K/Akt-mediated regulation of p53 in cancer

Abraham, A., & O’Neill, E. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140070 · Cited by 219 · see citing works

A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis

Cavalcante, G. C., Schaan, A. P., Cabral, G. F., Santana-da-Silva, M. N., Pinto, P., Vidal, A. F., & Ribeiro‐dos‐Santos, Â. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174133 · Cited by 222 · see citing works

The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis

Babashah, S., & Soleimani, M. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.02.008 · Cited by 215 · see citing works

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Zuckerman, V., Wolyniec, K., Sionov, R. V., Haupt, S., & Haupt, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2584 · Cited by 210 · see citing works

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

Ahmadi, S. E., Rahimi, S., Zarandi, B., Chegeni, R., & Safa, M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01111-4 · Cited by 211 · see citing works

Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells

Lüpertz, R., Wätjen, W., Kahl, R., & Chovolou, Y. (2010) · Toxicology · doi:10.1016/j.tox.2010.03.012 · Cited by 197 · see citing works

Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis

Zhang, Q., Zhao, X., & Wang, Z.-J. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.049 · Cited by 191 · see citing works

Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis

Zhang, Q., Zhao, X., & Wang, Z. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.04.007 · Cited by 189 · see citing works

Dying cell clearance and its impact on the outcome of tumor radiotherapy

Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 186 · see citing works

Current concepts in clinical radiation oncology

Orth, M., Lauber, K., Niyazi, M., Friedl, A. A., Li, M., Maihöfer, C., Schüttrumpf, L., Ernst, A., Niemoeller, O. M., & Belka, C. (2013) · Radiation and Environmental Biophysics · doi:10.1007/s00411-013-0497-2 · Cited by 177 · see citing works

Chemoresistance in solid tumours

Wilson, T. R., Longley, D. B., & Johnston, P. G. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl280 · Cited by 171 · see citing works

Probiotic<i>Lactobacillus Acidophilus</i>and<i>L. Casei</i>Mix Sensitize Colorectal Tumoral Cells to 5-Fluorouracil-Induced Apoptosis

Baldwin∗, C., Millette∗, M., Oth †, D., Ruiz, M. T., Luquet, F.-M., & Lacroix, M. (2010) · Nutrition and Cancer · doi:10.1080/01635580903407197 · Cited by 170 · see citing works

Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

Mellor, H. R., & Callaghan, R. (2008) · Pharmacology · doi:10.1159/000115967 · Cited by 169 · see citing works

Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy

Efferth, T. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2005.04.003 · Cited by 169 · see citing works

HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression

Klase, Z. A., Winograd, R., Davis, J., Carpio, L., Hildreth, R. L., Heydarian, M., Fu, S. W., McCaffrey, T. A., Meiri, E., Ayash‐Rashkovsky, M., et al. (2009) · Retrovirology · doi:10.1186/1742-4690-6-18 · Cited by 166 · see citing works

Chloride Transport through Supramolecular Barrel-Rosette Ion Channels: Lipophilic Control and Apoptosis-Inducing Activity.

Saha, T., Gautam, A., Mukherjee, A., Lahiri, M., & Talukdar, P. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b10379 · Cited by 119 · see citing works

Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatment

Gupta, A., Shah, K., Oza, M. J., & Behl, T. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.155 · Cited by 166 · see citing works

Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis

He, Y., Wu, Y., Huang, C., Meng, X., Ma, T., Wu, B., Xu, F., Zhang, L., Lv, X., & Li, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.08.015 · Cited by 155 · see citing works

Pharmacogenetics for individualized cancer chemotherapy

Efferth, T., & Volm, M. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.02.005 · Cited by 153 · see citing works

Role of Ion Transport in Control of Apoptotic Cell Death

Lang, F. J. W., & Hoffmann, E. K. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110046 · Cited by 153 · see citing works

Multiple Molecular and Cellular Mechanisms of Action of Lycopene in Cancer Inhibition

Trejo‐Solís, C., Pedraza‐Chaverrí, J., Torres-Ramos, M., Jiménez‐Farfán, D., Cruz-Salgado, A., Serrano‐García, N., Osorio‐Rico, L., & Sotelo, J. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/705121 · Cited by 151 · see citing works

Resistance mechanisms to cancer chemotherapy

Redmond, K. M. (2008) · Frontiers in bioscience · doi:10.2741/3070 · Cited by 150 · see citing works

Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

Ma, P., Pan, H., Montgomery, R. L., Olson, E. N., & Schultz, R. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118403109 · Cited by 142 · see citing works

Chloride-Mediated Apoptosis-Inducing Activity of Bis(sulfonamide) Anionophores.

Saha, T., Hossain, M. S., Saha, D., Lahiri, M., & Talukdar, P. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b01723 · Cited by 96 · see citing works

Viruses and the Diversity of Cell Death

Danthi, P. (2016) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042435 · Cited by 141 · see citing works

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

Zhao, Z., Jin, G., Ge, Y., & Guo, Z. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00556-3 · Cited by 143 · see citing works

The cell death machinery governed by the p53 tumor suppressor in response to DNA damage

Yoshida, K., & Miki, Y. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01488.x · Cited by 143 · see citing works

Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts

Friis, M., Friborg, C. R., Schneider, L. H., Nielsen, M., Lambert, I. H., Christensen, S. T., & Hoffmann, E. K. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.087130 · Cited by 141 · see citing works

Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals.

Abbaszadeh, F., Fakhri, S., & Khan, H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105069 · Cited by 121 · see citing works

Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill

Luzio, A., Monteiro, S. M., Fontaínhas‐Fernandes, A., Pinto-Carnide, O., Matos, M., & Coimbra, A. M. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.12.018 · Cited by 140 · see citing works

Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis

Yogosawa, S., & Yoshida, K. (2018) · Cancer Science · doi:10.1111/cas.13792 · Cited by 139 · see citing works

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals

Mohan Shankar, G., Swetha, M., Keerthana, C. K., Rayginia, T. P., & Anto, R. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.809308 · Cited by 142 · see citing works

Circadian-Regulated Cell Death in Cardiovascular Diseases

Rabinovich-Nikitin, I., Lieberman, B., Martino, T. A., & Kirshenbaum, L. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036550 · Cited by 138 · see citing works

Cancer and Aging - the Inflammatory Connection

Zinger, A., Cho, W. C. S., & Ben‐Yehuda, A. (2017) · Aging and Disease · doi:10.14336/ad.2016.1230 · Cited by 137 · see citing works

Doxorubicin loaded polymeric gold nanoparticles targeted to human folate receptor upon laser photothermal therapy potentiates chemotherapy in breast cancer cell lines

Banu, H., Sethi, D. K., Edgar, A., Sheriff, A., Rayees, N., Renuka, N., Faheem, S. M., Premkumar, K., & Vasanthakumar, G. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.05.008 · Cited by 137 · see citing works

Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review

Mortezaee, K., Najafi, M., Farhood, B., Ahmadi, A., Potes, Y., Shabeeb, D., & Musa, A. E. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.009 · Cited by 136 · see citing works

Oleuropein, a Secoiridoid Derived from Olive Tree, Inhibits the Proliferation of Human Colorectal Cancer Cell Through Downregulation of HIF-1α

Cárdeno, A., Sánchéz‐Hidalgo, M., Rosillo, M. Á., & Alarcón‐de‐la‐Lastra, C. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.741758 · Cited by 135 · see citing works

The emerging roles of microRNAs in the molecular responses of metabolic rate depression.

Biggar, K., & Storey, K. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq045 · Cited by 118 · see citing works

Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action

Shakya, B., & Yadav, P. N. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666191029130310 · Cited by 134 · see citing works

ASPPs and cancer

Trigiante, G., & Lü, X. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1818 · Cited by 133 · see citing works

The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts

Todorovicç, V., Chen, C.-C., Hay, N., & Lau, L. F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504015 · Cited by 132 · see citing works

The complexity of apoptotic cell death in mollusks: An update

Romero, A., Novoa, B., & Figueras, A. J. (2015) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2015.03.038 · Cited by 132 · see citing works

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

Kumar, G. H., Priyadarsini, R. V., Vinothini, G., Letchoumy, P. V., & Nagini, S. (2009) · Investigational New Drugs · doi:10.1007/s10637-009-9263-3 · Cited by 131 · see citing works

Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?

Sena-dos-Santos, C., Braga-da-Silva, C., Marques, D., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Cavalcante, G. C. (2021) · Cells · doi:10.3390/cells10020479 · Cited by 130 · see citing works

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: A review

Hector, S., & Prehn, J. H. M. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.12.002 · Cited by 130 · see citing works

Trp53-dependent DNA-repair is affected by the codon 72 polymorphism

Siddique, M. M., & Sabapathy, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209405 · Cited by 130 · see citing works

Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM–p53 cascade in colon cancer cell lines

Fini, L., Hotchkiss, E. C., Fogliano, V., Graziani, G., Romano, M., Vol, E. B. D., Qin, H., Selgrad, M., Boland, C. R., & Ricciardiello, L. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm255 · Cited by 129 · see citing works

Third row transition metals for the treatment of cancer

Johnstone, T. C., Suntharalingam, K., & Lippard, S. J. (2015) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2014.0185 · Cited by 129 · see citing works

Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression

Song, G., Mao, Y., Cai, Q., Yao, L., Ouyang, G., & Bao, S. D. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005001200007 · Cited by 127 · see citing works

Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells

Nguyen, T. M. B., Subramanian, I. V., Kelekar, A., & Ramakrishnan, S. (2007) · Blood · doi:10.1182/blood-2006-11-059352 · Cited by 125 · see citing works

High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.

Pauloin, T., Dutot, M., Joly, F., Warnet, J., & Rat, P. (2009) · PubMed Central · Cited by 121 · see citing works

Lead-induced apoptosis in PC 12 cells: Involvement of p53, Bcl-2 family and caspase-3

Xu, J., Ji, L., & Xu, L. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.06.643 · Cited by 120 · see citing works

Metallomics insights into the programmed cell death induced by metal-based anticancer compounds

Tan, C., Lu, Y., Ji, L., & Mao, Z. (2014) · Metallomics · doi:10.1039/c3mt00225j · Cited by 120 · see citing works

Neurotoxicity of Copper

Bulcke, F., Dringen, R., & Scheiber, I. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-60189-2_16 · Cited by 117 · see citing works

Small heat shock protein αB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis

Liu, S., Li, J., Tao, Y., & Xiao, X. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.152 · Cited by 120 · see citing works

Protective Effects of Catalase Overexpression on UVB-induced Apoptosis in Normal Human Keratinocytes

Rezvani, H. R., Mazurier, F., Cario, M., Pain, C., Ged, C., Taı̈eb, A., & de Verneuil, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600536200 · Cited by 120 · see citing works

Ionizing Radiation-Induced Responses in Human Cells with Differing TP53 Status

Mirzayans, R., Andrais, B., Scott, A., Wang, Y., & Murray, D. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122409 · Cited by 119 · see citing works

Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes

Gu, W., Tom, L. N., Hengst, K., Minto, K., Saunders, N. A., Leggatt, G. R., & McMillan, N. A. J. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700971 · Cited by 119 · see citing works

Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma

Hirata, H., Hinoda, Y., Nakajima, K., Kawamoto, K., Kikuno, N., Ueno, K., Yamamura, S., Zaman, M. S., Khatri, G., Chen, Y., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25507 · Cited by 118 · see citing works

Strategy to enhance efficacy of doxorubicin in solid tumor cells by methyl-β-cyclodextrin: Involvement of p53 and Fas receptor ligand complex

Mohammad, N., Singh, S. V., Malvi, P., Chaube, B., Athavale, D., Vanuopadath, M., Nair, S. S., Nair, B. G., & Bhat, M. K. (2015) · Scientific Reports · doi:10.1038/srep11853 · Cited by 116 · see citing works

Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells

Hall, E. H., Schoenbach, K. H., & Beebe, S. J. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0083-7 · Cited by 113 · see citing works

Regulatory non-coding RNA: new instruments in the orchestration of cell death

Su, Y., Wu, H., Pavlosky, A., Zou, L., Deng, X., Zhang, Z., & Jevnikar, A. M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.210 · Cited by 112 · see citing works

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—Persistent pollutants affect programmed cell death

Chopra, M., & Schrenk, D. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.524635 · Cited by 113 · see citing works

Induction of Competing Apoptotic and Survival Signaling Pathways in the Macrophage by the Ribotoxic Trichothecene Deoxynivalenol

Zhou, H.-R., Islam, Z., & Pestka, J. J. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi234 · Cited by 111 · see citing works

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53

Shin, H., Kwon, H., Lee, J.-H., Gui, X., Achek, A., Kim, J. H., & Choi, S. (2015) · Scientific Reports · doi:10.1038/srep15798 · Cited by 108 · see citing works

Live and Let Die – Regulation of Villous Trophoblast Apoptosis in Normal and Abnormal Pregnancies

Heazell, A. E. P., & Crocker, I. P. (2008) · Placenta · doi:10.1016/j.placenta.2008.07.003 · Cited by 108 · see citing works

TP53 Status and Response to Chemotherapy in Breast Cancer

Bertheau, P., Espié, M., Turpin, E., Lehmann‐Che, J., Plassa, L., Varna, M., Janin, A., & de Thé, H. (2008) · Pathobiology · doi:10.1159/000123851 · Cited by 108 · see citing works

Signatures of human regulatory T cells: an encounter with old friends and new players

Pfoertner, S., Jeron, A., Probst‐Kepper, M., Guzmán, C. A., Hansen, W., Westendorf, A. M., Toepfer, T., Schrader, A. J., Franzke, A., Buer, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-7-r54 · Cited by 105 · see citing works

Apoptosis: molecular mechanisms and pathogenicity

Rastogi, R. P., R., & Sinha, R. P. (2010) · Technische Universität Dortmund · doi:10.17877/de290r-8930 · Cited by 106 · see citing works

p53 Biological Network: At the Crossroads of the Cellular-Stress Response Pathway and Molecular Carcinogenesis

Hussain, S. P., & Harris, C. C. (2006) · Journal of Nippon Medical School · doi:10.1272/jnms.73.54 · Cited by 107 · see citing works

Versican: signaling to transcriptional control pathwaysThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

Rahmani, M., Wong, B. W., Ang, L. S., Cheung, C., Carthy, J. M., Walinski, H., & McManus, B. M. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-154 · Cited by 105 · see citing works

Various methods available for detection of apoptotic cells- A review

Kumaraswamy, K., Archana, M., Bastian, B., & Yogesh, T. L. (2013) · Indian Journal of Cancer · doi:10.4103/0019-509x.118720 · Cited by 103 · see citing works

Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells

Wu, H. L., Yang, F., Li, L.-H., Rao, Y. K., Ju, T., Wong, W.-T., Hsieh, C., Викторович, П. М., Hua, K., & Wu, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-36411-2 · Cited by 104 · see citing works

P53 and Cell Death

Wolyniec, K., Haupt, S., & Haupt, Y. (2009) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021824 · Cited by 2 · see citing works

The transcriptional targets of p53 in apoptosis control

Yu, J., & Zhang, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.189 · Cited by 421 · see citing works

The role of p53 as a transcription factor in the induction of apoptosis.

Yonish-Rouach, E., Choisy, C., Deguin, V., Breugnot, C., & May, E. (1996) · PubMed · Cited by 12 · see citing works

Control of apoptosis by p53

Fridman, J. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1207116 · Cited by 1,401 · see citing works

p53-Dependent apoptosis pathways

Shen, Y., & White, E. (2001) · Advances in cancer research · doi:10.1016/s0065-230x(01)82002-9 · Cited by 415 · see citing works