The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker
Open accessAbstract
Rev-erbα is a ubiquitously expressed orphan nuclear receptor which functions as a constitutive transcriptional repressor and is expressed in vertebrates according to a robust circadian rhythm. We report here that two Rev-erbα mRNA isoforms, namely Rev-erbα1 and Rev-erbα 2, are generated through alternative promoter usage and that both show a circadian expression pattern in an in vitro system using serum-shocked fibroblasts. Both promoter regions P1 (Rev-erbα1) and P2 (Rev-erbα2) contain several E-box DNA sequences which function as response elements for the core circadian-clock components: CLOCK and BMAL1. The CLOCK–BMAL1 heterodimer stimulates the activity of both P1 and P2 promoters in transient transfection assay by 3–6-fold. This activation was inhibited by the overexpression of CRY1, a component of the negative limb of the circadian transcriptional loop. Critical E-box elements were mapped within both promoters. This regulation is conserved in vertebrates since we found that the CLOCK–BMAL1 heterodimer also regulates the zebrafish Rev-erbα gene. In line with these data Rev-erbα circadian expression was strongly impaired in the livers of Clock mutant mice and in the pineal glands of zebrafish embryos treated with Clock and Bmal1 antisense oligonucleotides. Together these data demonstrate that CLOCK is a critical regulator of Rev-erbα circadian gene expression in evolutionarily distant vertebrates and suggest a role for Rev-erbα in the circadian clock output.
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Resetting central and peripheral circadian oscillators in transgenic rats
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Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
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Interacting molecular loops in the mammalian circadian clock
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Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
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Cited by
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658
Self-citationShimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536
T H 17 Cell Differentiation Is Regulated by the Circadian Clock
Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V. (2013) · Science · doi:10.1126/science.1243884 · Cited by 441
Self-citationImpact of Circadian Nuclear Receptor REV-ERBα on Midbrain Dopamine Production and Mood Regulation
Chung, S., Lee, E. J., Yun, S., Choe, H. K., Park, S.-B., Son, H. J., Kim, K.-S., Dluzen, D. E., Lee, I., Hwang, O., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.039 · Cited by 295
Metadata
- Authors
- Triqueneaux, G., Thenot, S., Kakizawa, T., Antoch, M. P., Safi, R., Takahashi, J. S., Delaunay, F., & Laudet, V.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2004-12
- Volume
- 33
- Issue
- 3
- Pages
- 585-608
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2102039847
- Cited by
- 166
- References
- 6
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker. https://app.cochat.ai/papers/10.1677/jme.1.01554
- The paper
- Triqueneaux, G., Thenot, S., Kakizawa, T., Antoch, M. P., Safi, R., Takahashi, J. S., Delaunay, F., & Laudet, V. (2004). The orphan receptor Rev-erbα gene is a target of the circadian clock pacemaker. Journal of Molecular Endocrinology. https://doi.org/10.1677/jme.1.01554
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
