Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11β-hydroxysteroid dehydrogenase type 1

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (1909) · JAMA · doi:10.1001/jama.1909.02550020033007 · Cited by 7,889

Biochemical and Biophysical Research Communications

Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690

JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM

Hoskins, R. G. (1953) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-13-4-473 · Cited by 3,780

Investigative Ophthalmology and Visual Science

Frey, C. (2010) · Cited by 3,350

A transgenic model of visceral obesity and the metabolic syndrome

Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766

The Journal of Steroid Biochemistry and Molecular Biology

(2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(11)00143-9 · Cited by 1,233

Does central obesity reflect “Cushing's disease of the omentum”?

Bujalska, I. J., Kumar, S., & Stewart, P. M. (1997) · The Lancet · doi:10.1016/s0140-6736(96)11222-8 · Cited by 753

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity

Rask, E., Olsson, T., Söderberg, S., Andrew, R., Livingstone, D. E. W., Johnson, O., & Walker, B. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7453 · Cited by 657

Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase

Agarwal, A. K., Monder, C., Eckstein, B., & White, P. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47248-7 · Cited by 455

Metabolic syndrome without obesity: Hepatic overexpression of 11β-hydroxysteroid dehydrogenase type 1 in transgenic mice

Paterson, J. M., Morton, N. M., Fiévet, C., Kenyon, C. J., Holmes, M. C., Staels, B., Seckl, J. R., & Mullins, J. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305524101 · Cited by 430

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458

11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action

Chapman, K., Holmes, M., & Seckl, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00020.2012 · Cited by 887

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450

Hexose-6-phosphate dehydrogenase knock-out mice lack 11β-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation

Lavery, G. G., Walker, E. A., Draper, N., Jeyasuria, P., Marcos, J., Shackleton, C. H. L., Parker, K. L., White, P. C., & Stewart, P. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512635200 · Cited by 207

11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer?

Storbeck, K.-H., Bloem, L. M., Africander, D., Schloms, L., Swart, P., & Swart, A. C. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.006 · Cited by 198

Premature adrenarche: novel lessons from early onset androgen excess

Idkowiak, J., Lavery, G. G., Dhir, V., Barrett, T. G., Stewart, P. M., Krone, N., & Arlt, W. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0223 · Cited by 158

Minireview: Hexose-6-Phosphate Dehydrogenase and Redox Control of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

Hewitt, K. N., Walker, E. A., & Stewart, P. M. (2005) · Endocrinology · doi:10.1210/en.2005-0117 · Cited by 149

Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

Tomlinson, J., Finney, J., Gay, C., Hughes, B. A., Hughes, S. V., & Stewart, P. M. (2008) · Diabetes · doi:10.2337/db08-0495 · Cited by 132

11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione

Swart, A. C., Schloms, L., Storbeck, K.-H., Bloem, L. M., Toit, T. D., Quanson, J. L., Rainey, W. E., & Swart, P. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.04.010 · Cited by 125

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

Chapman, K. E., Coutinho, A. E., Zhang, Z., Kipari, T. M. J., Savill, J., & Seckl, J. R. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.002 · Cited by 125

11 β ‐Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus

Pereira, C., Azevedo, I., Monteiro, R., & Martins, M. J. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01582.x · Cited by 112

Enhanced Hippocampal Long-Term Potentiation and Spatial Learning in Aged 11β-Hydroxysteroid Dehydrogenase Type 1 Knock-Out Mice

Yau, J. L. W., McNair, K., Noble, J., Brownstein, D. G., Hibberd, C. J., Morton, N. M., Mullins, J. J., Morris, R., Cobb, S., & Seckl, J. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2190-07.2007 · Cited by 116

Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation

Hardy, R., Filer, A. D., Cooper, M. S., Parsonage, G. N., Raza, K., Hardie, D. L., Rabbitt, E. H., Stewart, P. M., Buckley, C. D., & Hewison, M. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1993 · Cited by 102

Deletion of Hexose-6-phosphate Dehydrogenase Activates the Unfolded Protein Response Pathway and Induces Skeletal Myopathy

Lavery, G. G., Walker, E. A., Turan, N., Rogoff, D., Ryder, J. W., Shelton, J. M., Richardson, J. A., Falciani, F., White, P. C., Stewart, P. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710067200 · Cited by 97

Rapid mechanisms of glucocorticoid signaling in the Leydig cell☆

Hu, G., Lian, Q., Lin, H., LATIF, S., Morris, D. J., HARDY, M., & GE, R. (2008) · Steroids · doi:10.1016/j.steroids.2007.12.020 · Cited by 100

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity in Vivo Limits Glucocorticoid Exposure to Human Adipose Tissue and Decreases Lipolysis

Tomlinson, J., Sherlock, M., Hughes, B., Hughes, S. V., Kilvington, F., Bartlett, W. A., Courtney, R., Rejto, P. A., Carley, W. W., & Stewart, P. M. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2325 · Cited by 98

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

Lavery, G. G., Walker, E. A., Tiganescu, A., Ride, J. P., Shackleton, C. H. L., Tomlinson, J. W., Connell, J. M. C., Ray, D. W., Biason-Lauber, A., Malunowicz, E. M., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0743 · Cited by 95

Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes

Gathercole, L., & Stewart, P. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.060 · Cited by 82

Pathogenesis of hepatic steatosis: The link between hypercortisolism and non-alcoholic fatty liver disease

Tarantino, G. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6735 · Cited by 81

Brain mineralocorticoid receptors in cognition and cardiovascular homeostasis

Gómez-Sánchez, E. P. (2014) · Steroids · doi:10.1016/j.steroids.2014.08.014 · Cited by 83

A rodent model of rapid-onset diabetes (ROD) induced by glucocorticoids and high-fat feeding

Shpilberg, Y., Beaudry, J. L., D'Souza, A., Campbell, J. E., Peckett, A., & Riddell, M. C. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008912 · Cited by 77

Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1

Muller, C., Pompon, D., Urban, P., & Morfin, R. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.12.001 · Cited by 77

Omental Adipose Tissue Type 1 11β-Hydroxysteroid Dehydrogenase Oxoreductase Activity, Body Fat Distribution, and Metabolic Alterations in Women

Veilleux, A., Rhéaume, C., Daris, M., Luu-The, V., & Tchernof, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2011 · Cited by 77

Depot‐specific Regulation of the Conversion of Cortisone to Cortisol in Human Adipose Tissue

Lee, M., Fried, S. K., Mundt, S. S., Wang, Y., Sullivan, S., Stefanni, A. C., Daugherty, B. L., & Hermanowski‐Vosatka, A. (2008) · Obesity · doi:10.1038/oby.2008.207 · Cited by 73

Local Amplification of Glucocorticoids by 11β‐Hydroxysteroid Dehydrogenase Type 1 and Its Role in the Inflammatory Response

Chapman, K. E., Coutinho, A. E., Gray, M., Gilmour, J. S., Savill, J., & Seckl, J. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1366.030 · Cited by 73

Mechanisms of Disease: selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

Tomlinson, J., & Stewart, P. M. (2005) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0023 · Cited by 73

Expression profiles of human 11β-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases

Stegk, J. P., Ebert, B., Martin, H.-J., & Maser, E. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.030 · Cited by 72

11β-hydroxysteroid dehydrogenases: A growing multi-tasking family

Gómez-Sánchez, E. P., & Gómez-Sánchez, C. E. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111210 · Cited by 72

Environmental Pollutants and Hydroxysteroid Dehydrogenases

Ye, L., Guo, J., & Ge, R. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800095-3.00013-4 · Cited by 70

Hexose-6-Phosphate Dehydrogenase and 11β-Hydroxysteroid Dehydrogenase-1 Tissue Distribution in the Rat

Gómez-Sánchez, E. P., Romero, D. G., de Rodriguez, A. F., Warden, M. P., Krozowski, Z. S., & Gómez-Sánchez, C. E. (2007) · Endocrinology · doi:10.1210/en.2007-0328 · Cited by 68

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake

McNelis, J., Manolopoulos, K. N., Gathercole, L., Bujalska, I. J., Stewart, P. M., Tomlinson, J., & Arlt, W. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2012 · Cited by 66

Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue

Veilleux, A., Laberge, P. Y., Morency, J., Noël, S., Luu-The, V., & Tchernof, A. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.024 · Cited by 64

11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets

Swali, A., Walker, E. A., Lavery, G. G., Tomlinson, J., & Stewart, P. M. (2008) · Diabetologia · doi:10.1007/s00125-008-1137-2 · Cited by 63

11β-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ and is stimulated by extracellular glucose

Dzyakanchuk, A. A., Balázs, Z., Nashev, L. G., Amrein, K. E., & Odermatt, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.009 · Cited by 62

Cortisone-reductase deficiency associated with heterozygous mutations in 11β-hydroxysteroid dehydrogenase type 1

Lawson, A. J., Walker, E. A., Lavery, G. G., Bujalska, I. J., Hughes, B., Arlt, W., Stewart, P. M., & Ride, J. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014934108 · Cited by 61

Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum

Senesi, S., Csala, M., Marcolongo, P., Fulceri, R., Mandl, J., Bánhegyi, G., & Benedetti, A. (2009) · Biological Chemistry · doi:10.1515/bc.2009.146 · Cited by 63

11β-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function

Walker, E. A., Ahmed, A., Lavery, G. G., Tomlinson, J., Kim, S. Y., Cooper, M. S., Ride, J. P., Hughes, B. A., Shackleton, C. H. L., McKiernan, P. J., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704144200 · Cited by 60

Insulin and Dexamethasone Dynamically Regulate Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1

Balachandran, A., Guan, H., Sellan, M. E., Uum, S. H. M. V., & Yang, K. (2008) · Endocrinology · doi:10.1210/en.2008-0088 · Cited by 57

Modulation of glucocorticoid action and the treatment of type-2 diabetes

Tomlinson, J., & Stewart, P. M. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.07.003 · Cited by 56

The multifaceted mineralocorticoid receptor

Gomez‐Sanchez, E., & Gomez‐Sanchez, C. E. (2014) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2014.tb00569.x · Cited by 55

Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen

Atanasov, A. G., Nashev, L. G., Gelman, L., Legeza, B., Sack, R., Portmann, R., & Odermatt, A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.03.001 · Cited by 57

The native anti-glucocorticoid paradigm

Muller, C., Hennebert, O., & Morfin, R. F. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.03.001 · Cited by 53

Hexose-6-Phosphate Dehydrogenase Contributes to Skeletal Muscle Homeostasis Independent of 11β-Hydroxysteroid Dehydrogenase Type 1

Semjonous, N. M., Sherlock, M., Jeyasuria, P., Parker, K. L., Walker, E. A., Stewart, P. M., & Lavery, G. G. (2010) · Endocrinology · doi:10.1210/en.2010-0957 · Cited by 51

Abnormalities of Glucose Homeostasis and the Hypothalamic-Pituitary-Adrenal Axis in Mice Lacking Hexose-6-Phosphate Dehydrogenase

Rogoff, D., Ryder, J. W., Black, K., Yan, Z., Burgess, S. C., McMillan, D. R., & White, P. C. (2007) · Endocrinology · doi:10.1210/en.2007-0593 · Cited by 50

Expression of mineralocorticoid and glucocorticoid receptors in preautonomic neurons of the rat paraventricular nucleus

Chen, J., Gómez-Sánchez, C. E., Penman, A. D., May, P. J., & Gómez-Sánchez, E. P. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00506.2013 · Cited by 49

Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism in the endoplasmic reticulum

Bánhegyi, G., Csala, M., & Benedetti, A. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0156 · Cited by 51

11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes

Morgan, S., & Tomlinson, J. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.504713 · Cited by 47

7-Oxysterols Modulate Glucocorticoid Activity in Adipocytes through Competition for 11β-Hydroxysteroid Dehydrogenase Type

Wamil, M., Andrew, R., Chapman, K. E., Street, J. M., Morton, N. M., & Seckl, J. R. (2008) · Endocrinology · doi:10.1210/en.2008-0420 · Cited by 46

Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in Vivo

Peixoto, R. D. S., Turban, S., Battle, J. H., Chapman, K. E., Seckl, J. R., & Morton, N. M. (2008) · Endocrinology · doi:10.1210/en.2007-1028 · Cited by 45

Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism

White, P. C., Rogoff, D., McMillan, D. R., & Lavery, G. G. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.022 · Cited by 48

Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?

Thieringer, R., & Hermanowski‐Vosatka, A. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.5.911 · Cited by 43

The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations

Odermatt, A., & Nashev, L. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.007 · Cited by 41

Hexose-6-phosphate Dehydrogenase Modulates 11β-Hydroxysteroid Dehydrogenase Type 1-Dependent Metabolism of 7-keto- and 7β-hydroxy-neurosteroids

Nashev, L. G., Chandsawangbhuwana, C., Balázs, Z., Atanasov, A. G., Dick, B., Frey, F. J., Baker, M. E., & Odermatt, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000561 · Cited by 41

Hepatic 11beta‐HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis

Kotsias-Konopelska, S., Kienitz, T., Hughes, B. A., Pirlich, M., Bauditz, J., Lochs, H. H., Strasburger, C. J., Stewart, P. M., & Quinkler, M. O. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03358.x · Cited by 40

Isocitrate dehydrogenase: A NADPH-generating enzyme in the lumen of the endoplasmic reticulum

Margittai, É., & Bánhegyi, G. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.12.017 · Cited by 41

Altered Activity of 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 in Skeletal Muscle Confers Metabolic Protection in Subjects with Type 2 Diabetes

Jang, C., Obeyesekere, V. R., Dilley, R. J., Krozowski, Z. S., Inder, W. J., & ALFORD, F. P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2729 · Cited by 41

11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases

Kupczyk, D., Bilski, R., Kozakiewicz, M., Studzińska, R., Kędziora–Kornatowska, K., Kosmalski, T., Pedrycz, A., & Głowacka, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168984 · Cited by 42

High Fructose Diets Increase 11β‐Hydroxysteroid Dehydrogenase Type 1 in Liver and Visceral Adipose in Rats Within 24‐h Exposure

London, E., & Castonguay, T. W. (2010) · Obesity · doi:10.1038/oby.2010.284 · Cited by 40

Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily

Zemanová, L., & Wsól, V. (2011) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.638304 · Cited by 41

Lack of Hexose-6-Phosphate Dehydrogenase Impairs Lipid Mobilization from Mouse Adipose Tissue

Bujalska, I. J., Hewitt, K., Hauton, D., Lavery, G. G., Tomlinson, J., Walker, E. A., & Stewart, P. M. (2008) · Endocrinology · doi:10.1210/en.2007-1705 · Cited by 38

Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium

Gray, G. A., White, C. I., Castellan, R. F. P., McSweeney, S. J., & Chapman, K. E. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0128 · Cited by 39

Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat

Bujalska, I. J., Durrani, O. M., Abbott, J. A., Onyimba, C., Khosla, P., Moosavi, A., Reuser, T. T. Q., Stewart, P. M., Tomlinson, J., Walker, E. A., et al. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0042 · Cited by 42

11β-HSD1, Inflammation, Metabolic Disease and Age-related Cognitive (dys)Function

Chapman, K. E., & Seckl, J. R. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9504-9 · Cited by 37

Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats

Beaudry, J. L., Dunford, E. C., Teich, T., Zaharieva, D. P., Hunt, H., Belanoff, J. K., & Riddell, M. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091248 · Cited by 37

Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration

Do, T. T. H., Garcia, M., Dalle, H., Dorothée, G., Moldes, M., Fève, B., & Buyse, M. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.08.010 · Cited by 36

An ERRβ/γ agonist modulates GRα expression, and glucocorticoid responsive gene expression in skeletal muscle cells

Wang, S.-C., Myers, S., Dooms, C., Capon, R. J., & Muscat, G. E. O. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.012 · Cited by 38

Hypoglycemia with Enhanced Hepatic Glycogen Synthesis in Recombinant Mice Lacking Hexose-6-Phosphate Dehydrogenase

Lavery, G. G., Hauton, D., Hewitt, K. N., Brice, S. M., Sherlock, M., Walker, E. A., & Stewart, P. M. (2007) · Endocrinology · doi:10.1210/en.2007-0963 · Cited by 37

H6PDH interacts directly with 11β-HSD1: Implications for determining the directionality of glucocorticoid catalysis

Zhang, Y., Zhong, X., Gjoka, Z., Li, Y., Stochaj, W. R., Stahl, M., Kriz, R., Tobin, J. F., Erbe, D. V., & Suri, V. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.12.004 · Cited by 37

A Novel Promoter for the 11β-Hydroxysteroid Dehydrogenase Type 1 Gene Is Active in Lung and Is C/EBPα Independent

Bruley, C., Lyons, V., Worsley, A. G. F., Wilde, M. D., Darlington, G., Morton, N. M., Seckl, J. R., & Chapman, K. E. (2006) · Endocrinology · doi:10.1210/en.2005-1621 · Cited by 34

Alterations of Cortisol Metabolism in Human Disorders

White, P. C. (2018) · Hormone Research in Paediatrics · doi:10.1159/000485508 · Cited by 36

Diet and the role of 11β-hydroxysteroid dehydrogenase-1 on obesity

London, E., & Castonguay, T. W. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.012 · Cited by 32

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 in Obesity

Wake, D. J., & Walker, B. R. (2006) · Endocrine · doi:10.1385/endo:29:1:101 · Cited by 32

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in subcutaneous adipose tissue of lean and obese women with and without polycystic ovary syndrome

Svendsen, P. F., Madsbad, S., Nilas, L., Paulsen, S. K., & Pedersen, S. B. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.165 · Cited by 31

Possible involvement of glucocorticoids in 5α-dihydrotestosterone-induced PCOS-like metabolic disturbances in the rat visceral adipose tissue

Nikolič, M., Μacut, D., Djordjevic, A. D., Veličković, N. A., Nestorović, N. M., Bursać, B. N., Antić, I. B., Macut, J. B., Matić, G. M., & Milutinović, D. V. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.08.013 · Cited by 31

Topical 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Corrects Cutaneous Features of Systemic Glucocorticoid Excess in Female Mice

Tiganescu, A., Hupe, M., Uchida, Y., Mauro, T., Elias, P. M., & Holleran, W. M. (2017) · Endocrinology · doi:10.1210/en.2017-00607 · Cited by 31

Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency

Livingstone, D. E. W., Grassick, S. L., Currie, G. L., Walker, B. R., & Andrew, R. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0003 · Cited by 30

11β Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle

Jang, C., Obeyesekere, V. R., Dilley, R. J., ALFORD, F. P., & Inder, W. J. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02669.x · Cited by 30

Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation

Li, J., Berk, M. P., Alyamani, M., Sabharwal, N., Goins, C. M., Alvarado, J., Baratchian, M., Zhu, Z., Stauffer, S. R., Klein, E. A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe8226 · Cited by 29

Testosterone Stimulates Adipose Tissue 11β-Hydroxysteroid Dehydrogenase Type 1 Expression in a Depot-Specific Manner in Children

Zhu, L., Hou, M., Sun, B., Burén, J., Zhang, L., Yi, J., Hernell, O., & Li, X. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2708 · Cited by 29

Sucrose Access Differentially Modifies 11β-Hydroxysteroid Dehydrogenase-1 and Hexose-6-Phosphate Dehydrogenase Message in Liver and Adipose Tissue in Rats ,

London, E., Lala, G., Berger, R., Panzenbeck, A., Kohli, A., Renner, M., Jackson, A., Raynor, T., Loya, K., & Castonguay, T. W. (2007) · Journal of Nutrition · doi:10.1093/jn/137.12.2616 · Cited by 28

Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes

Kardon, T., Senesi, S., Marcolongo, P., Legeza, B., Bánhegyi, G., Mandl, J., Fulceri, R., & Benedetti, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.04.045 · Cited by 28

Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endoplasmic reticulum

Marcolongo, P., Senesi, S., Gava, B., Fulceri, R., Sorrentino, V., Margittai, É., Lizák, B., Csala, M., Bánhegyi, G., & Benedetti, A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.027 · Cited by 28

The cross talk of adrenal and Leydig cell steroids in Leydig cells

Wang, Y., Li, H., Zhu, Q., Li, X., Lin, Z., & Ge, R. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105386 · Cited by 28

G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome

Czegle, I. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i4.129 · Cited by 27

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

Coutinho, A. E., Kipari, T. M. J., Zhang, Z., Esteves, C. L., Lucas, C. D., Gilmour, J. S., Webster, S. P., Walker, B. R., Hughes, J., Savill, J., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1118 · Cited by 27

Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition

Vítků, J., Stárka, L., Bičı́ková, M., Hill, M., Heráček, J., Kolátorová, L., & Hampl, R. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.07.007 · Cited by 27

Increased 11beta-hydroxysteroid dehydrogenase type-1 and hexose-6-phosphate dehydrogenase in liver and adipose tissue of rat offspring exposed to alcohol in utero.

Nammi, S., Dembélé, K., & Nyomba, B. L. G. (2007) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00255.2006 · Cited by 31

Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome

Draper, N., Powell, B. L., Franks, S., Conway, G. S., Stewart, P. M., & McCarthy, M. I. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02547.x · Cited by 27

Localisation of 11β‐Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei

Haque, M. R. U., Wilson, R. A., Sharma, K., Mills, N. J., & Teruyama, R. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12325 · Cited by 25

Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11β-hydroxysteroid dehydrogenase 1

Balázs, Z., Nashev, L. G., Chandsawangbhuwana, C., Baker, M. E., & Odermatt, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.021 · Cited by 25

The Role of 11ß-Hydroxysteroid Dehydrogenase 1 in Adipogenesis in Thyroid-Associated Ophthalmopathy

Tomlinson, J., Durrani, O. M., Bujalska, I. J., Gathercole, L., Tomlins, P. J., Reuser, T. T. Q., Rose, G. E., Curnow, J., Stewart, P. M., Walker, E. A., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0873 · Cited by 25

Involvement of GR and p300 in the Induction of H6PD by Cortisol in Human Amnion Fibroblasts

Wang, W., Guo, C., Li, W., Li, J., Wang, W., Myatt, L., & Sun, K. (2012) · Endocrinology · doi:10.1210/en.2012-1531 · Cited by 25

Functional Effects of Polymorphisms in the Human Gene Encoding 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1): A Sequence Variant at the Translation Start of 11β-HSD1 Alters Enzyme Levels

Malavasi, E. L. V., Kelly, V., Nath, N., Gambineri, A., Dakin, R. S., Pagotto, U., Pasquali, R., Walker, B. R., & Chapman, K. E. (2009) · Endocrinology · doi:10.1210/en.2009-0663 · Cited by 24

11β-Hydroxysteroid dehydrogenase expression and activities in bovine granulosa cells and corpora lutea implicate corticosteroids in bovine ovarian physiology

Thurston, L. M., Abayasekara, D. R. E., & Michael, A. E. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07025 · Cited by 24

PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells

Chandras, C., Harris, T. E., Bernal, A. L., Abayasekara, D. R. E., & Michael, A. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0128 · Cited by 25

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis

Zhang, Z., Coutinho, A. E., Man, T. Y., Kipari, T. M. J., Hadoke, P. W. F., Salter, D. M., Seckl, J. R., & Chapman, K. E. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0223 · Cited by 22

Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats

Teofilović, A., Veličković, N. A., Bursać, B. N., Djordjevic, A. D., Milutinović, D. V., Nestorović, N. M., & Matić, G. M. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.04.001 · Cited by 23

UVB induces epidermal 11β‐hydroxysteroid dehydrogenase type 1 activity in vivo

Tiganescu, A., Hupe, M., Jiang, Y. J., Celli, A., Uchida, Y., Mauro, T. M., Bikle, D. D., Elias, P. M., & Holleran, W. M. (2015) · Experimental Dermatology · doi:10.1111/exd.12682 · Cited by 22

Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: A natural approach in the management of stress and metabolic disorders?

Schloms, L., Smith, C., Storbeck, K., Marnewick, J. L., Swart, P., & Swart, A. C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300463 · Cited by 22

Induction of hepatic 11β‐hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease

Ahmed, A., Saksena, S., Sherlock, M., Olliff, S. P., Elias, E., & Stewart, P. M. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03125.x · Cited by 24

Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism

White, P. C., Rogoff, D., McMillan, D. R., & Lavery, G. G. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.022 · Cited by 48

Hexose‐6‐phosphate dehydrogenase determines the reaction direction of 11β‐hydroxysteroid dehydrogenase type 1 as an oxoreductase

Atanasov, A. G., Nashev, L. G., Schweizer, R. A. S., Frick, C., & Odermatt, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.065 · Cited by 208

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

Draper, N., Walker, E. A., Bujalska, I. J., Tomlinson, J. W., Chalder, S. M., Arlt, W., Lavery, G. G., Bedendo, O., Ray, D. W., Laing, I., et al. (2003) · Nature Genetics · doi:10.1038/ng1214 · Cited by 285

Minireview: Hexose-6-Phosphate Dehydrogenase and Redox Control of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity

Hewitt, K. N., Walker, E. A., & Stewart, P. M. (2005) · Endocrinology · doi:10.1210/en.2005-0117 · Cited by 149

Regulation of 11 beta-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes

Ricketts, M., Shoesmith, K., Hewison, M., Strain, A. J., Eggo, M. C., & Stewart, P. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560159 · Cited by 80