Cited by 360Estrogen and related hormone effectsReceptor Mechanisms and SignalingEffects and risks of endocrine disrupting chemicals

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The unfolding stories of GPR30, a new membrane-bound estrogen receptor

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Maggiolini, Marcello, Picard, Didier·2010·Journal of Endocrinology

DOI 10.1677/joe-09-0242

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Abstract

Steroid hormones such as estrogens are known to signal through ligand-regulated transcription factors of the nuclear receptor superfamily. In addition, they elicit rapid nongenomic responses from membrane-associated receptors. One of these receptors belongs to an entirely different family of proteins. The G protein-coupled and seven-transmembrane receptor, GPR30, is now widely recognized as an estrogen receptor (ER), hence its official new acronym GPER. It appears to mediate a wide range of responses to estrogen in a large variety of cell types. Its functions are clearly distinct from those of the classical nuclear ERs, although these pathways may overlap and interact in some cases. Here, we review the history of the discovery of this new ER, the evidence for the claim that it is an ER, its signal transduction, and its potential functions in physiology and disease.

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Authors: Maggiolini, M., & Picard, D.
Affiliations: University of Calabria (IT)
University of Geneva (CH)
ORCID: Maggiolini, Marcello
Picard, Didier
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2009-09-18
Volume: 204
Issue: 2
Pages: 105-114
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1677/joe-09-0242
OpenAlex: W2123476163
Cited by: 360
References: 94
Citations by year: 2026: 5 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 24 · 2019: 22 · 2018: 20 · 2017: 21 · 2016: 22 · 2015: 37 · 2014: 30 · 2013: 38 · 2012: 35
FWCI: 3.18
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Associazione Italiana per la Ricerca sul Cancro
Fondation Medic
Regione Calabria
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: GPR30, G protein-coupled estrogen receptor, membrane-bound estrogen receptor, estrogen signaling, G protein-coupled receptors, signal transduction, nuclear estrogen receptor
MeSH terms: Animals, Carcinoma, Humans, Receptors, Estrogen, Signal Transduction, Receptors, G-Protein-Coupled

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The unfolding stories of GPR30, a new membrane-bound estrogen receptor

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