The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.
The unfolding stories of GPR30, a new membrane-bound estrogen receptor
Open accessAbstract
Steroid hormones such as estrogens are known to signal through ligand-regulated transcription factors of the nuclear receptor superfamily. In addition, they elicit rapid nongenomic responses from membrane-associated receptors. One of these receptors belongs to an entirely different family of proteins. The G protein-coupled and seven-transmembrane receptor, GPR30, is now widely recognized as an estrogen receptor (ER), hence its official new acronym GPER. It appears to mediate a wide range of responses to estrogen in a large variety of cell types. Its functions are clearly distinct from those of the classical nuclear ERs, although these pathways may overlap and interact in some cases. Here, we review the history of the discovery of this new ER, the evidence for the claim that it is an ER, its signal transduction, and its potential functions in physiology and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The estrogen receptor GPCR (GPR30) [23], which transmits estrogen signals from the membrane [24], has been renamed as G protein-coupled estrogen receptor 1 (GPER1) [25].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [25]
In the citing paper
“GPR30 is suggested as the cell membrane receptor for the steroid hormone estrogen by detection of the binding of fluorescence-labeled estrogen in Cos7 cells [25].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Vivacqua, A., Bonofiglio, D., Albanito, L., Madeo, A., Rago, V., Carpino, A., Musti, A. M., Picard, D., Andò, S., & Maggiolini, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.026344 · Cited by 280
Self-citationRetractedAlbanito, L., Lappano, R., Madeo, A., Chimento, A., Prossnitz, E. R., Cappello, A. R., Dolce, V., Abonante, S., Pezzi, V., & Maggiolini, M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11297 · Cited by 105
Self-citationRetractedBiochemical and Biophysical Research Communications
Rc, A. N., On Filamentous Bacteriophage, M., Hoffmann, S., & Willbold, D. (1960) · Nature · doi:10.1038/186124d0 · Cited by 6,690
Cloning of a novel receptor expressed in rat prostate and ovary.
Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,802
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
The structure and function of G-protein-coupled receptors
Rosenbaum, D. M., Rasmussen, S. G. F., & Kobilka, B. K. (2009) · Nature · doi:10.1038/nature08144 · Cited by 2,534
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
Environmental Health Perspectives at 50
Kaufman, J. D. (2022) · Environmental Health Perspectives · doi:10.1289/ehp11367 · Cited by 2,284
Molecular and cellular endocrinology
(1995) · Journal of Endocrinology · doi:10.1677/joe.0.147so19 · Cited by 1,986
Estrogen receptors: how do they signal and what are their targets
Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857
Cited by
Sorted by citations
The G-protein-coupled estrogen receptor GPER in health and disease
Prossnitz, E. R., & Barton, M. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.122 · Cited by 925
G protein-coupled receptors: novel targets for drug discovery in cancer
Lappano, R., & Maggiolini, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3320 · Cited by 742
Self-citationSex Hormones in Acquired Immunity and Autoimmune Disease
Moulton, V. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02279 · Cited by 641
Estrogen: A master regulator of bioenergetic systems in the brain and body
Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534
Molecular Mechanisms of Action of BPA
Acconcia, F., Pallottini, V., & Marino, M. (2015) · Dose-Response · doi:10.1177/1559325815610582 · Cited by 425
Estrogen Receptors: Therapies Targeted to Receptor Subtypes
Nilsson, S., & Gustafsson, J.-Å. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2010.226 · Cited by 381
Estrogenic control of mitochondrial function
Klinge, C. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101435 · Cited by 326
Pupo, M., Pisano, A., Lappano, R., Santolla, M. F., Francesco, E. M. D., Abonante, S., Rosano, C., & Maggiolini, M. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104526 · Cited by 303
Self-citationNeuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration
Spence, R. D., & Voskuhl, R. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.001 · Cited by 259
Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives
Barton, M., Filardo, E. J., Lolait, S. J., Thomas, P., Maggiolini, M., & Prossnitz, E. R. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.021 · Cited by 262
Self-citationFollicular assembly: mechanisms of action
Pepling, M. E. (2011) · Reproduction · doi:10.1530/rep-11-0299 · Cited by 243
A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings
Gogos, A., Sbisa, A. M., Sun, J., Gibbons, A. S., Udawela, M., & Dean, B. (2015) · International Journal of Endocrinology · doi:10.1155/2015/615356 · Cited by 245
Estrogen action and prostate cancer
Nelles, J. L., Hu, W., & Prins, G. S. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.20 · Cited by 224
Frick, K. M., Kim, J., Tuscher, J. J., & Fortress, A. M. (2015) · Learning & Memory · doi:10.1101/lm.037267.114 · Cited by 219
Mechanisms of estradiol in fear circuitry: implications for sex differences in psychopathology
Cover, K. K., Maeng, L. Y., Lebrón‐Milad, K., & Milad, M. R. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.67 · Cited by 196
Copper activates HIF-1α/GPER/VEGF signalling in cancer cells
Rigiracciolo, D. C., Scarpelli, A., Lappano, R., Pisano, A., Santolla, M. F., Marco, P. D., Cirillo, F., Cappello, A. R., Dolce, V., Belfiore, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5779 · Cited by 185
Self-citationThe structural biology of oestrogen metabolism
THOMAS, M. P., & Potter, B. V. L. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.12.014 · Cited by 181
Madeo, A., & Maggiolini, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0408 · Cited by 183
Self-citationGingerich, S., Kim, G. L., Chalmers, J. A., Koletar, M. M., Wang, X., Wang, Y., & Belsham, D. D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.076 · Cited by 171
Thomas, P. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.11.032 · Cited by 164
Chung, E., Genco, M. C., Megrelis, L., & RUDERMAN, J. V. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115187108 · Cited by 152
Estrogen Receptors Modulation of Anxiety-Like Behavior
Borrow, A. P., & Handa, R. J. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.08.004 · Cited by 146
Akama, K. T., Thompson, L. I., Milner, T. A., & McEwen, B. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412478 · Cited by 140
Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P., & Pezzi, V. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200503 · Cited by 143
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 146
Estrogen Receptor Signaling in Lung Cancer
Siegfried, J. M., Hershberger, P. A., & Stabile, L. P. (2009) · Seminars in Oncology · doi:10.1053/j.seminoncol.2009.10.004 · Cited by 137
GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer
Mo, Z., Liu, M., Yang, F., Luo, H., Li, Z., Tu, G., & Yang, G. (2013) · Breast Cancer Research · doi:10.1186/bcr3581 · Cited by 134
GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Francesco, E. M. D., PELLEGRINO, M. A., Santolla, M. F., Lappano, R., Ricchio, E., Abonante, S., & Maggiolini, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3590 · Cited by 133
Self-citationExercise and the Regulation of Endocrine Hormones
Hackney, A. C., & Lane, A. R. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.001 · Cited by 140
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells
Lappano, R., Rosano, C., Marco, P. D., Francesco, E. M. D., Pezzi, V., & Maggiolini, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.006 · Cited by 129
Self-citationKim, J., Szinte, J. S., Boulware, M. I., & Frick, K. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0257-15.2016 · Cited by 129
Pöllänen, E., Sipilä, S., Alén, M., Ronkainen, P. H. A., Ankarberg‐Lindgren, C., Puolakka, J. O., Suominen, H., Hämäläinen, E. K., Turpeinen, U., Konttinen, Y. T., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00701.x · Cited by 121
Kane, M. A., Folias, A. E., Pingitore, A., Perri, M., Obrochta, K. M., Krois, C. R., Cione, E., Ryu, J. Y., & Napoli, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008859107 · Cited by 120
The G-protein coupled estrogen receptor, GPER: The inside and inside-out story
Gaudet, H. M., Cheng, S., Christensen, E. M., & Filardo, E. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.016 · Cited by 117
Recchia, A. G., Francesco, E. M. D., Vivacqua, A., Sisci, D., Panno, M. L., Andò, S., & Maggiolini, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.172247 · Cited by 117
Self-citationPosition paper: The membrane estrogen receptor GPER – Clues and questions
Barton, M. (2012) · Steroids · doi:10.1016/j.steroids.2012.04.001 · Cited by 112
Lappano, R., & Maggiolini, M. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.183 · Cited by 110
Self-citationAnalysis, occurrence, and function of 9-cis-retinoic acid
Kane, M. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.012 · Cited by 111
Estrogen, a female hormone involved in spermatogenesis
Carreau, S., Bouraïma-Lelong, H., & Delalande, C. (2012) · Advances in Medical Sciences · doi:10.2478/v10039-012-0005-y · Cited by 109
GPER Function in Breast Cancer: An Overview
Lappano, R., Pisano, A., & Maggiolini, M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00066 · Cited by 108
Self-citationSex hormones and skeletal muscle weakness
Sipilä, S., Narici, M., Kjaer, M., Pöllänen, E., Atkinson, R. A., Hansen, M., & Kovanen, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9425-8 · Cited by 106
Santolla, M. F., Lappano, R., Marco, P. D., Pupo, M., Vivacqua, A., Sisci, D., Abonante, S., Iacopetta, D., Cappello, A. R., Dolce, V., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.417303 · Cited by 106
Self-citationChevalier, N., Vega, A., Bouskine, A., Siddeek, B., Michiels, J., Chevallier, D., & Fénichel, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034672 · Cited by 101
Insulin-like growth factor-I regulates GPER expression and function in cancer cells
Marco, P. D., Bartella, V., Vivacqua, A., Lappano, R., Santolla, M. F., Morcavallo, A., Pezzi, V., Belfiore, A., & Maggiolini, M. (2012) · Oncogene · doi:10.1038/onc.2012.97 · Cited by 101
Self-citationFord, J. J., Hajibeigi, A., Long, M., Hahner, L., Gore, C., Hsieh, J.-T., Clegg, D. J., Zerwekh, J. E., & Öz, O. K. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.209 · Cited by 106
Atherosclerosis and sex hormones: current concepts.
Villablanca, A., Jayachandran, M., & Banka, C. (2010) · Clinical science · doi:10.1042/cs20100248 · Cited by 115
Kang, X.-L., Zhang, J.-Y., Wang, D., Zhao, Y.-M., Han, X.-L., Wang, J.-X., & Zhao, X.-F. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008331 · Cited by 96
Rigiracciolo, D. C., Santolla, M. F., Lappano, R., Vivacqua, A., Cirillo, F., Galli, G. R., Talia, M., Muglia, L., PELLEGRINO, M. A., Nohata, N., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1056-8 · Cited by 96
Self-citationAcconcia, F., & Marino, M. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00030 · Cited by 95
Vivacqua, A., Romeo, E., Marco, P. D., Francesco, E. M. D., Abonante, S., & Maggiolini, M. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1901-8 · Cited by 96
Self-citationEstrogens and atherosclerosis: insights from animal models and cell systems.
Nofer, J. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0145 · Cited by 91
MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells
Lappano, R., Santolla, M. F., Pupo, M., Sinicropi, M. S., Caruso, A., Rosano, C., & Maggiolini, M. (2012) · Breast Cancer Research · doi:10.1186/bcr3096 · Cited by 94
Self-citationChimento, A., Casaburi, I., Rosano, C., Avena, P., Luca, A. D., Campana, C., Martire, E., Santolla, M. F., Maggiolini, M., Pezzi, V., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300323 · Cited by 94
Self-citationLosa-Ward, S. M., Todd, K. L., Sullivan, A. W., Cao, J., Mickens, J. A., & Patisaul, H. B. (2010) · Reproductive Toxicology · doi:10.1016/j.reprotox.2010.10.002 · Cited by 93
Estrogen and the aging brain: an elixir for the weary cortical network
Dumitriu, D., Rapp, P. R., McEwen, B. S., & Morrison, J. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05529.x · Cited by 92
Cipolletti, M., Fernandez, V. S., Montalesi, E., Marino, M., & Fiocchetti, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092624 · Cited by 98
Bartella, V., Marco, P. D., Malaguarnera, R., Belfiore, A., & Maggiolini, M. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.03.012 · Cited by 92
Self-citationClède, S., Lambert, F., Sandt, C., Kaščáková, S., Unger, M. V., Harté, E., Plamont, M., Saint‐Fort, R., Deniset‐Besseau, A., Gueroui, Z., et al. (2013) · The Analyst · doi:10.1039/c3an00807j · Cited by 92
GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes
Lee, E.-S., Sidoryk‐Wȩgrzynowicz, M., Wang, N., Webb, A., Son, D.-S., Lee, K., & Aschner, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.341867 · Cited by 92
Albanito, L., Lappano, R., Madeo, A., Chimento, A., Prossnitz, E. R., Cappello, A. R., Dolce, V., Abonante, S., Pezzi, V., & Maggiolini, M. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408586 · Cited by 91
Self-citationCross-talk between GPER and growth factor signaling
Lappano, R., Marco, P. D., Francesco, E. M. D., Chimento, A., Pezzi, V., & Maggiolini, M. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.03.005 · Cited by 92
Self-citationCome Fly with Me: An overview of dopamine receptors in Drosophila melanogaster
Karam, C. S., Jones, S. K., & Javitch, J. A. (2019) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13277 · Cited by 90
SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
Santolla, M. F., Avino, S., PELLEGRINO, M. A., Francesco, E. M. D., Marco, P. D., Lappano, R., Vivacqua, A., Cirillo, F., Rigiracciolo, D. C., Scarpelli, A., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.201 · Cited by 92
Self-citationG‐Protein Oestrogen Receptor 1: Trials and Tribulations of a Membrane Oestrogen Receptor
Srivastava, D. P., & Evans, P. D. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12071 · Cited by 89
Thomas, P., Alyea, R. A., Pang, Y., Peyton, C., Dong, J., & Berg, H. (2009) · Steroids · doi:10.1016/j.steroids.2009.11.005 · Cited by 89
Hypoxia: The force of endometriosis
Wu, M., Hsiao, K., & Tsai, S. (2019) · Journal of Obstetrics and Gynaecology Research · doi:10.1111/jog.13900 · Cited by 88
Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS
Alexander, A., Irving, A. J., & Harvey, J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.003 · Cited by 89
Jain, S., Gollapalli, S., Agrawal, A. K., Kushwah, V., & Thanki, K. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00281 · Cited by 86
Sex Steroid Receptors in Male Human Bladder: Expression and Biological Function
Chavalmane, A. K., Comeglio, P., Morelli, A., Filippi, S., Fibbi, B., Vignozzi, L., Sarchielli, E., Marchetta, M., Failli, P., Sandner, P., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01811.x · Cited by 84
Marco, P. D., Lappano, R., Francesco, E. M. D., Cirillo, F., Pupo, M., Avino, S., Vivacqua, A., Abonante, S., Picard, D., & Maggiolini, M. (2016) · Scientific Reports · doi:10.1038/srep24354 · Cited by 83
Self-citationLiedert, A., Wagner, L., Seefried, L., Ebert, R., Jakob, F. J., & Ignatius, A. A. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.065 · Cited by 80
17β-estradiol signaling and regulation of Sertoli cell function
Lucas, T. F. G., Pimenta, M. T., Pisolato, R., Lazari, M. F. M., & Porto, C. S. (2011) · Spermatogenesis · doi:10.4161/spmg.1.4.18903 · Cited by 79
The Interplay of Sex Steroids, the Immune Response, and the Intestinal Microbiota
de Pace, F., & Watnick, P. I. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.11.001 · Cited by 79
Estrogenic involvement in social learning, social recognition and pathogen avoidance
Choleris, E., Clipperton‐Allen, A. E., Phan, A., Valsecchi, P., & Kavaliers, M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.02.001 · Cited by 83
Fitzgerald, A. C., Peyton, C., Dong, J., & Thomas, P. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.115.132316 · Cited by 76
Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders
Crider, A., & Pillai, A. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237412 · Cited by 76
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms
Griggs, R. B., Donahue, R. R., Morgenweck, J., Grace, P. M., Sutton, A., Watkins, L. R., & Taylor, B. K. (2015) · Pain · doi:10.1097/01.j.pain.0000460333.79127.be · Cited by 75
Ji, Y., Tang, B., & Traub, R. J. (2011) · Pain · doi:10.1016/j.pain.2011.01.046 · Cited by 74
DeCourten, B. M., Forbes, J. P., Roark, H. K., Burns, N. P., Major, K. M., White, J. W., Li, J., Mehinto, A. C., Connon, R. E., & Brander, S. M. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.0c02892 · Cited by 76
Ruiz-Palmero, I., Hernando, M. J., García‐Segura, L. M., & Arévalo, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.018 · Cited by 72
Yaman, O., & Dalbayrak, S. (2013) · Turkish Neurosurgery · doi:10.5137/1019-5149.jtn.8838-13.0 · Cited by 71
Rigiracciolo, D. C., Scarpelli, A., Lappano, R., Pisano, A., Santolla, M. F., Avino, S., Marco, P. D., Bussolati, B., Maggiolini, M., & Francesco, E. M. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6475 · Cited by 70
Self-citationLai, S., Collins, B. C., Colson, B. A., Kararigas, G., & Lowe, D. A. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00439.2015 · Cited by 70
Chimento, A., Sirianni, R., Zolea, F., Bois, C., Delalande, C., Andò, S., Maggiolini, M., Aquila, S., Carreau, S., & Pezzi, V. (2010) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01100.x · Cited by 69
Self-citationPupo, M., Vivacqua, A., Perrotta, I. D., Pisano, A., Aquila, S., Abonante, S., Gasperi‐Campani, A., Pezzi, V., & Maggiolini, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.023 · Cited by 72
Self-citationIdentification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
Rago, V., Romeo, F., Giordano, F., Maggiolini, M., & Carpino, A. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-135 · Cited by 68
Self-citationMeccariello, R., Chianese, R., Chioccarelli, T., Ciaramella, V., Fasano, S., Pierantoni, R., & Cobellis, G. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00069 · Cited by 69
SHANG, D., Li, Z., Zhu-xia, Z., Chen, H., Zhao, L., Wang, X., & Chen, Y. (2015) · Oncology Reports · doi:10.3892/or.2015.3786 · Cited by 67
Hall, J. M., & Korach, K. S. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21913 · Cited by 68
Estrogen Facilitates Spinal Cord Synaptic Transmission via Membrane-bound Estrogen Receptors
Zhang, Y., Xiao, X., Zhang, X.-M., Zhao, Z.-Q., & Zhang, Y.-Q. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368142 · Cited by 62
Deciphering the selective androgen receptor modulators paradigm
Zhang, X., & Sui, Z. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.741582 · Cited by 66
GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)
Pupo, M., Pisano, A., Abonante, S., Maggiolini, M., & Musti, A. M. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.11.011 · Cited by 64
Self-citationNeuronal Control of Breathing: Sex and Stress Hormones
Behan, M., & Kinkead, R. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100027 · Cited by 76
Chuang, S., Chen, C., Chou, Y., Ho, M., & Chang, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186490 · Cited by 63
Tropea, T., Francesco, E. M. D., Rigiracciolo, D. C., Maggiolini, M., Wareing, M., Osol, G., & Mandalà, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141997 · Cited by 62
Self-citationPathological functions of hypoxia in endometriosis
Hsiao, K.-Y. (2015) · Frontiers in Bioscience · doi:10.2741/e736 · Cited by 61
17β-estradiol inhibits the production of infectious particles of hepatitis C virus
Hayashida, K., Shoji, I., Deng, L., Jiang, D., Ide, Y.-H., & Hotta, H. (2010) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2010.00268.x · Cited by 61
Krakstad, C., Trovik, J., Wik, E., Engelsen, I. B., Werner, H. M. J., Birkeland, E. E., Raeder, M. B., Oyan, A. M., Stefansson, I. M., Kalland, K. H., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.91 · Cited by 61
Welsh, T. N., Johnson, M. D., Yi, L., Tan, H., Rahman, R., Merlino, A. A., Zakár, T., & Mesiano, S. A. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0358 · Cited by 61
Zhao, X.-F. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00620-y · Cited by 60
Metadata
- Authors
- Maggiolini, M., & Picard, D.
- Affiliations
- University of Calabria (IT)
- University of Geneva (CH)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2009-09-18
- Volume
- 204
- Issue
- 2
- Pages
- 105-114
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2123476163
- Cited by
- 360
- References
- 94
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 24 · 2019: 22 · 2018: 20 · 2017: 21 · 2016: 22 · 2015: 37 · 2014: 30 · 2013: 38 · 2012: 35
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Associazione Italiana per la Ricerca sul Cancro
- Fondation Medic
- Regione Calabria
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- GPR30, G protein-coupled estrogen receptor, membrane-bound estrogen receptor, estrogen signaling, G protein-coupled receptors, signal transduction, nuclear estrogen receptor
- MeSH terms
- Animals, Carcinoma, Humans, Receptors, Estrogen, Signal Transduction, Receptors, G-Protein-Coupled
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
