Cited by 317Growth Hormone and Insulin-like Growth FactorsMuscle Physiology and DisordersNutrition and Health in Aging

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The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

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Perrini, Sebastio, Laviola, Luigi, Carreira, Marcos C, Cignarelli, Angelo, Natalicchio, Annalisa, Giorgino, Francesco·2010·Journal of Endocrinology

DOI 10.1677/joe-09-0431

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Abstract

The widespread increase in life expectancy is accompanied by an increased prevalence of features of physical frailty. Signs and symptoms may include sarcopenia and osteopenia, reduced exercise capacity, and diminished sense of well-being. The pathogenesis of age-associated sarcopenia and osteopenia is multifactorial, and hormonal decline may be a contributing factor. Aging is associated with a progressive decrease in GH secretion, and more than 30% of elderly people have circulating IGF1 levels below the normal range found in the young. GH acts directly on target tissues, including skeletal muscle and bone among many others, but many effects are mediated indirectly by circulating (liver-derived) or locally produced IGF1. Aging is also associated with reduced insulin sensitivity which, in turn, may contribute to the impairment of IGF1 action. Recent experimental evidence suggests that besides the age-dependent decline in GH and IGF1 serum levels, the dysregulation of GH and IGF1 actions due to impairment of the post-receptor signaling machinery may contribute to the loss of muscle mass and osteopenia. This article will focus on the molecular mechanisms of impaired GH and IGF1 signaling and action in aging, and their role in the pathogenesis of sarcopenia and osteoporosis.

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Authors: Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F.
Affiliations: University of Bari Aldo Moro (IT)
ORCID: Perrini, Sebastio
Laviola, Luigi
Carreira, Marcos C
Cignarelli, Angelo
Natalicchio, Annalisa
Giorgino, Francesco
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2010-03-02
Volume: 205
Issue: 3
Pages: 201-210
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1677/joe-09-0431
OpenAlex: W2132915404
Cited by: 317
References: 112
Citations by year: 2026: 8 · 2025: 11 · 2024: 13 · 2023: 12 · 2022: 17 · 2021: 18 · 2020: 14 · 2019: 15 · 2018: 23 · 2017: 17 · 2016: 25 · 2015: 23 · 2014: 29 · 2013: 27 · 2012: 36
FWCI: 4.19
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: growth hormone, insulin-like growth factor I, somatotropic axis, sarcopenia, osteoporosis, osteopenia, aging, muscle atrophy, bone loss, insulin resistance, post-receptor signaling, frailty, skeletal muscle, bone
MeSH terms: Animals, Bone and Bones, Disease Models, Animal, Humans, Insulin-Like Growth Factor I, Osteoporosis, Growth Hormone, Signal Transduction, Muscle, Skeletal, Sarcopenia

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The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

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